MicroRNAs as new maestro conducting the expanding symphony orchestra of regenerative and reparative medicine

Physiological Genomics

Volumn 43, Issue 10, 2011, Pages 517-520

  Sen, Chandan K ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Regenerative medicine; Therapeutics; Wound

Indexed keywords

ANGIOMIR; ANTISENSE OLIGONUCLEOTIDE; HYPOXAMIR; LOCKED NUCLEIC ACID; MICRORNA; MIRAVIRSEN; MIRNA 210; UNCLASSIFIED DRUG;

ANGIOGENESIS; CLINICAL TRIAL (TOPIC); CONTROL SYSTEM; DRUG TARGETING; EDITORIAL; EPIGENETICS; GENOME; HEPATITIS C; HUMAN; HYPOXIA; INFLAMMATION; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; SKIN INJURY; TISSUE REPAIR; WOUND HEALING;

ANOXIA; HUMANS; INFLAMMATION; MICRORNAS; NEOVASCULARIZATION, PHYSIOLOGIC; REGENERATION; REGENERATIVE MEDICINE; STEM CELLS; WOUND HEALING;

EID: 79957667709     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00037.2011     Document Type: Editorial

References (37)

1. Asirvatham AJ, Magner WJ, Tomasi TB. MiRNA regulation of cyto-kine genes. Cytokine 45: 58-69, 2009.
2. Banerjee J, Chan YC, Sen CK. MicroRNAs in skin and wound healing. Physiol Genomics October 19, 2010, doi:10.1152/ physiolgenomics.00157.2010.
3. Bibikova M, Laurent LC, Ren B, Loring JF, Fan JB. Unraveling epigenetic regulation in embryonic stem cells. Cell Stem Cell 2: 123-134, 2008.
4. Biswas S, Roy S, Banerjee J, Hussain SR, Khanna S, Meenaksh-isundaram G, Kuppusamy P, Friedman A, Sen CK. Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds. Proc Natl Acad Sci USA 107: 6976-6981, 2010.
5. Chan SY, Loscalzo J. MicroRNA-210: a unique and pleiotropic hypox-amir. Cell Cycle 9: 2010.
6. Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab 10: 273-284, 2009.
7. Chan YC, Khanna S, Roy S, Sen CK. MiR-200b targets Ets-1 and is down-regulated by hypoxia to induce angiogenic response of endothelial cells. J Biol Chem 286: 2047-2056, 2011.
8. Crosby ME, Kulshreshtha R, Ivan M, Glazer PM. MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res 69: 1221-1229, 2009.
9. Favaro E, Ramachandran A, McCormick R, Gee H, Blancher C, Crosby M, Devlin C, Blick C, Buffa F, Li JL, Vojnovic B, Pires das Neves R, Glazer P, Iborra F, Ivan M, Ragoussis J, Harris AL. MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS One 5: e10345, 2010.
10. Giraud-Triboult K, Rochon-Beaucourt C, Nissan X, Champon B, Aubert S, Pietu G. Combined mRNA and microRNA profiling reveals that miR-148a and miR-20b control human mesenchymal stem cell phe-notype via EPAS1. Physiol Genomics 43: 77-86, 2011.
11. Hata A, Davis BN. Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus. Cytokine Growth Factor Rev 20: 517-521, 2009.
12. Jafarifar F, Yao P, Eswarappa SM, Fox PL. Repression of VEGFA by CA-rich element-binding microRNAs is modulated by hnRNP L. EMBO J [Epub ahead of print].
13. Kashyap V, Rezende NC, Scotland KB, Shaffer SM, Persson JL, Gudas LJ, Mongan NP. Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cells Dev 18: 1093-1108, 2009.
14. Knelangen JM, van der Hoek MB, Kong WC, Owens JA, Fischer B, Navarrete Santos A. MicroRNA expression profile during adipogenic differentiation in mouse embryonic stem cells. Physiol Genomics January 18, 2011, doi:10.1152/physiolgenomics.00116.2010.
15. Lanford RE, Hildebrandt-Eriksen ES, Petri A, Persson R, Lindow M, Munk ME, Kauppinen S, Orum H. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 327: 198-201, 2010.
16. Leung AK, Young AG, Bhutkar A, Zheng GX, Bosson AD, Nielsen CB, Sharp PA. Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs. Nat Struct Mol Biol 18: 237-244, 2011.
17. Li Z, Yang CS, Nakashima K, Rana TM. Small RNA-mediated regulation of iPS cell generation. EMBO J 30: 823-834, 2011.
18. Liu C, Kelnar K, Liu B, Chen X, Calhoun-Davis T, Li H, Patrawala L, Yan H, Jeter C, Honorio S, Wiggins JF, Bader AG, Fagin R, Brown D, Tang DG. The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med 17: 211-215, 2011.
19. Liu C, Teng ZQ, Santistevan NJ, Szulwach KE, Guo W, Jin P, Zhao X. Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell 6: 433-444, 2010.
20. Liu NK, Xu XM. MicroRNA in central nervous system trauma and degenerative disorders. Physiol Genomics March 8, 2011, doi: 10.1152/physiolgenomics.00168.2010.
21. Loscalzo J. The cellular response to hypoxia: tuning the system with microRNAs. J Clin Invest 120: 3815-3817, 2010.
22. Mallanna SK, Rizzino A. Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells Dev Biol 344: 16-25, 2010.
23. Nakasa T, Nagata Y, Yamasaki K, Ochi M. A mini-review: microRNA in arthritis. Physiol Genomics February 15, 2011 doi:10.1152/physiolgenomics.00142.2010.
24. O'Neill LJ. A renaissance of interest innate immunity: will new treatments for rheumatoid arthritis emerge? Rheumatol 3: 203-205, 2008.
25. Obad S, Dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, Kauppinen S. Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet 43: 371-378, 2011.
26. Pasquinelli AE. Molecular biology. Paring miRNAs through pairing Science 328: 1494-1495, 2010.
27. Ponomarev ED, Veremeyko T, Barteneva N, Krichevsky AM, Weiner HL. MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-alpha-PU.1 pathway. Na Med 17: 64-70, 2011.
28. Recchiuti A, Krishnamoorthy S, Fredman G, Chiang N, Serhan CN. MicroRNAs in resolution of acute inflammation: identification of nove resolvin D1-miRNA circuits. FASEB J 25: 544-560, 2011.
29. Rink C, Khanna S. MicroRNA in ischemic stroke etiology and pathology. Physiol Genomics September 14, 2010, doi:10.1152 physiolgenomics.00158.2010.
30. Roy S, Sen CK. MiRNA in innate immune responses: novel players in wound inflammation. Physiol Genomics December 7, 2010, doi:10.1152/physiolgenomics.00160.2010.
31. Sen CK. Wound healing essentials: let there be oxygen. Wound Repair Regen 17: 1-18, 2009.
32. Sen CK, Gordillo GM, Khanna S, Roy S. Micromanaging vascular biology: tiny microRNAs play big band. J Vasc Res 46: 527-540, 2009.
33. Shilo S, Roy S, Khanna S, Sen CK. Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells. Arterioscler Thromb Vasc Biol 28: 471-477, 2008.
34. Tiscornia G, Izpisua Belmonte JC. MicroRNAs in embryonic stem cell function and fate. Genes Dev 24: 2732-2741, 2010.
35. Tsuchiya S, Fujiwara T, Sato F, Shimada Y, Tanaka E, Sakai Y, Shimizu K, Tsujimoto G. MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1). J Biol Chem 286: 420-428, 2011.
36. Wang S, Olson EN. AngiomiRs-key regulators of angiogenesis. Curr Opin Genet Dev 19: 205-211, 2009.
37. Zhu N, Zhang D, Chen S, Liu X, Lin L, Huang X, Guo Z, Liu J, Wang Y, Yuan W, Qin Y. Endothelial enriched microRNAs regulate angioten-sin II-induced endothelial inflammation and migration. Atherosclerosis [Epub ahead of print].