-
1
-
-
35348850734
-
Hematopoietic cytokine receptor signaling
-
DOI 10.1038/sj.onc.1210757, PII 1210757
-
Baker SJ, Rane SG, Reddy EP: Hematopoietic cytokine receptor signaling. Oncogene 2007;26:6724-6737. (Pubitemid 47585098)
-
(2007)
Oncogene
, vol.26
, Issue.47
, pp. 6724-6737
-
-
Baker, S.J.1
Rane, S.G.2
Reddy, E.P.3
-
2
-
-
1542327277
-
Inhibitors of JAKs/STATs and the kinases: A possible new cluster of drugs
-
DOI 10.1016/S1359-6446(03)03014-9, PII S1359644603030149
-
Luo C, Laaja P: Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs. Drug Discov Today 2004;4:268-275. (Pubitemid 38328513)
-
(2004)
Drug Discovery Today
, vol.9
, Issue.6
, pp. 268-275
-
-
Luo, C.1
Laaja, P.2
-
3
-
-
0037071409
-
JAKs, STATs and Src kinases in hematopoiesis
-
DOI 10.1038/sj.onc.1205398
-
Rane SG, Reddy E: JAKs, STATs and Src kinases in hematopoiesis. Oncogene 2002;21:3334-3358. (Pubitemid 34587707)
-
(2002)
Oncogene
, vol.21
, Issue.21 REV. ISSUE 2
, pp. 3334-3358
-
-
Rane, S.G.1
Reddy, E.P.2
-
4
-
-
3142707259
-
Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological grade
-
DOI 10.1158/0008-5472.CAN-03-3499
-
Li H, Zhang Y, Glass A, Zellweger T, Gehan E, Bubendorf L, et al.: Activation of signal transducer and activator of transcription 5 in human prostrate cancer is associated with high histological grade. Cancer Res 2004;64: 4774-4782. (Pubitemid 38924520)
-
(2004)
Cancer Research
, vol.64
, Issue.14
, pp. 4774-4782
-
-
Li, H.1
Ahonen, T.J.2
Alanen, K.3
Xie, J.4
LeBaron, M.J.5
Pretlow, T.G.6
Ealley, E.L.7
Zhang, Y.8
Nurmi, M.9
Singh, B.10
Martikainen, P.M.11
Nevalainen, M.T.12
-
5
-
-
1042302005
-
The stats of cancer - New molecular targets come of age
-
Yu H, Jove R: The STATs of cancer-new molecular targets come of age. Nat Rev Cancer 2004;4:97-105. (Pubitemid 38198738)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.2
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
6
-
-
28644445445
-
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
-
DOI 10.1038/nm1325
-
Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, et al.: Inhibiting STAT3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 2005;11:1314-1321. (Pubitemid 41752912)
-
(2005)
Nature Medicine
, vol.11
, Issue.12
, pp. 1314-1321
-
-
Kortylewski, M.1
Kujawski, M.2
Wang, T.3
Wei, S.4
Zhang, S.5
Pilon-Thomas, S.6
Niu, G.7
Kay, H.8
Mule, J.9
Kerr, W.G.10
Jove, R.11
Pardoll, D.12
Yu, H.13
-
7
-
-
34247154498
-
A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo
-
DOI 10.1038/sj.onc.1210031, PII 1210031
-
Iwamaru A, Szymanski S, Iwado E, Aoki H, Yokoyama T, Fokt I, et al.: A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene 2007;26:2435-2444. (Pubitemid 46597261)
-
(2007)
Oncogene
, vol.26
, Issue.17
, pp. 2435-2444
-
-
Iwamaru, A.1
Szymanski, S.2
Iwado, E.3
Aoki, H.4
Yokoyama, T.5
Fokt, I.6
Hess, K.7
Conrad, C.8
Madden, T.9
Sawaya, R.10
Kondo, S.11
Priebe, W.12
Kondo, Y.13
-
8
-
-
33847368558
-
Targeting of Jak/STAT pathway in antigen presenting cells in cancer
-
DOI 10.2174/156800907780006887
-
Nefedova Y, Gabrilovich DI: Targeting of JAK/STAT pathway in antigen presenting cells in cancer. Curr Cancer Drug Targets 2007;7:71-77. (Pubitemid 46345509)
-
(2007)
Current Cancer Drug Targets
, vol.7
, Issue.1
, pp. 71-77
-
-
Nefedova, Y.1
Gabrilovich, D.I.2
-
9
-
-
38949165127
-
Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas
-
DOI 10.1182/blood-2007-04-087734
-
Ding B, Yu JJ, Yu RY, Mendez LM, Shaknovich R, Zhang Y, et al.: Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse B-cell lymphomas. Blood 2008;111: 1515-1523. (Pubitemid 351213441)
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1515-1523
-
-
Ding, B.B.1
Yu, J.J.2
Yu, R.Y.-L.3
Mendez, L.M.4
Shaknovich, R.5
Zhang, Y.6
Cattoretti, G.7
Ye, B.H.8
-
10
-
-
0038820386
-
Signal transducer and activator of transcription proteins in leukemias
-
DOI 10.1182/blood-2002-04-1204
-
Benekli M, Baer MR, Baumann H, Wetzler M: Signal transducer and activator of transcription proteins in leukemias. Blood 2003;101:2940-2954. (Pubitemid 36857978)
-
(2003)
Blood
, vol.101
, Issue.8
, pp. 2940-2954
-
-
Benekli, M.1
Baer, M.R.2
Baumann, H.3
Wetzler, M.4
-
11
-
-
42249091014
-
Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia
-
DOI 10.1084/jem.20072182
-
Flex E, Petrangeli V, Stella L, Chiaretti S, Hornakova T, Knoops L, et al.: Somatically acquired JAK1 mutations in adult lymphoblastic leukemia. J ExpMed 2008;205:751-758. (Pubitemid 351549874)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.4
, pp. 751-758
-
-
Flex, E.1
Petrangeli, V.2
Stella, L.3
Chiaretti, S.4
Hornakova, T.5
Knoops, L.6
Ariola, C.7
Fodale, V.8
Clappier, E.9
Paoloni, F.10
Martinelli, S.11
Fragale, A.12
Sanchez, M.13
Tavolaro, S.14
Messina, M.15
Cazzaniga, G.16
Camera, A.17
Pizzolo, G.18
Tornesello, A.19
Vignetti, M.20
Battistini, A.21
Cave, H.22
Gelb, B.D.23
Renauld, J.-C.24
Biondi, A.25
Constantinescu, S.N.26
Foa, R.27
Tartaglia, M.28
more..
-
12
-
-
33750627651
-
JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model
-
Mercher T, Wernig G, Moore SA, Levine RL, Gu T-L, Frohling S, et al.: JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model. Blood 2006;108:2770-2779.
-
(2006)
Blood
, vol.108
, pp. 2770-2779
-
-
Mercher, T.1
Wernig, G.2
Moore, S.A.3
Levine, R.L.4
Gu, T.-L.5
Frohling, S.6
-
13
-
-
33745713168
-
Activating alleles of JAK3 in acute megakaryoblastic leukemia
-
Walters DK, Mercher T, Gu T-L, OHare T, Tyner JW, Loriaux M, et al.: Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell 2006;10:65-75.
-
(2006)
Cancer Cell
, vol.10
, pp. 65-75
-
-
Walters, D.K.1
Mercher, T.2
Gu, T.-L.3
Ohare, T.4
Tyner, J.W.5
Loriaux, M.6
-
14
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
DOI 10.1016/S0140-6736(05)71142-9
-
Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S, et al.: Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005;365:1054-1061. (Pubitemid 40386783)
-
(2005)
Lancet
, vol.365
, Issue.9464
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
East, C.4
Fourouclas, N.5
Swanton, S.6
Vassiliou, G.S.7
Bench, A.J.8
Boyd, E.M.9
Curtin, N.10
Scott, M.A.11
Erber, W.N.12
Avis, T.13
Barthorpe, A.14
Bignell, G.15
Blow, M.16
Brackenbury, L.17
Buck, G.18
Clegg, S.19
Clements, J.20
Cole, J.21
Davies, H.22
Edkins, S.23
Gray, K.24
Gorton, M.25
O'Meara, S.26
Halliday, K.27
Harrison, R.28
Haynes, W.29
Hills, K.30
Hunter, C.31
Jones, D.32
Kosmidou, V.33
Laman, R.34
Lugg, R.35
Parker, A.36
Perry, J.37
Petty, R.38
Small, A.39
Solomon, H.40
Stephens, P.41
Stephens, Y.42
Stevens, C.43
Smith, R.44
Tarpey, P.45
Tofts, C.46
Varian, J.47
West, S.48
Widaa, S.49
Bamford, S.50
Butler, A.51
Dawson, E.52
Dicks, E.53
Edwards, K.54
Forbes, S.55
Greenman, C.56
Hinton, J.57
Menzies, A.58
Raine, K.59
Shepherd, R.60
Teague, J.61
Yates, A.62
Wooster, R.63
Futreal, A.64
Stratton, M.65
Green, A.R.66
more..
-
15
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
DOI 10.1038/nature03546
-
James C, Ugo V, Le CJP, Staerk J, Delhommeau F, Lacout C, et al.: A unique clonal JAK2 mutation leading of constitutive signaling causes polycythaemia vera. Nature 2005;434:1144-1148. (Pubitemid 40663494)
-
(2005)
Nature
, vol.434
, Issue.7037
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.-P.3
Staerk, J.4
Delhommeau, F.5
Lacout, C.6
Garcon, L.7
Raslova, H.8
Berger, R.9
Bennaceur-Griscelli, A.10
Villeval, J.L.11
Constantinescu, S.N.12
Casadevall, N.13
Vainchenker, W.14
-
16
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
DOI 10.1056/NEJMoa051113
-
Kralovics R, Passamonti F, Buser AS, Buser AS, Teo SS, Tiedt R, et al.: A gain-offunction mutation of JAK2 in myeloproliferative disorders. N Engl J Med 2005;352:1779-1790. (Pubitemid 40570926)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.17
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
Teo, S.-S.4
Tiedt, R.5
Passweg, J.R.6
Tichelli, A.7
Cazzola, M.8
Skoda, R.C.9
-
17
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
DOI 10.1016/j.ccr.2005.03.023
-
Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, et al.: Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 2005;387-397. (Pubitemid 40544655)
-
(2005)
Cancer Cell
, vol.7
, Issue.4
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
Ebert, B.L.4
Wernig, G.5
Huntly, B.J.P.6
Boggon, T.J.7
Wlodarska, I.8
Clark, J.J.9
Moore, S.10
Adelsperger, J.11
Koo, S.12
Lee, J.C.13
Gabriel, S.14
Mercher, T.15
D'Andrea, A.16
Frohling, S.17
Dohner, K.18
Marynen, P.19
Vandenberghe, P.20
Mesa, R.A.21
Tefferi, A.22
Griffin, J.D.23
Eck, M.J.24
Sellers, W.R.25
Meyerson, M.26
Golub, T.R.27
Lee, S.J.28
Gilliland, D.G.29
more..
-
18
-
-
51849083849
-
Cellular LanthaScreen and blactamase reporter assays for high-throughput screening of JAK2 inhibitors
-
Robers MB, Machleidt T, Carlson CB, Bi K: Cellular LanthaScreen and blactamase reporter assays for high-throughput screening of JAK2 inhibitors. Assay Drug Dev Technol 2008;6:519-529.
-
(2008)
Assay Drug Dev Technol
, vol.6
, pp. 519-529
-
-
Robers, M.B.1
MacHleidt, T.2
Carlson, C.B.3
Bi, K.4
-
19
-
-
0033003760
-
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
-
DOI 10.1177/108705719900400206
-
Zhang J-H, Chung TDY, Oldenburg KR: A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 1999;4:67-73. (Pubitemid 29278954)
-
(1999)
Journal of Biomolecular Screening
, vol.4
, Issue.2
, pp. 67-73
-
-
Zhang, J.-H.1
Chung, T.D.Y.2
Oldenburg, K.R.3
-
20
-
-
0037156334
-
Photochemical preparation of a pyridone containing tetracycle: A Jak protein kinase inhibitor
-
DOI 10.1016/S0960-894X(02)00106-3, PII S0960894X02001063
-
Thompson JE, Cubbon RM, Cummings RT, Wicker LS, Frankshun R, Cunningham BR, et al.: Photochemical preparation of a pyridine containing tetracycle: a JAK protein kinase inhibitor. Biorg Med Chem Lett 2002;12:1219-1223. (Pubitemid 34270567)
-
(2002)
Bioorganic and Medicinal Chemistry Letters
, vol.12
, Issue.8
, pp. 1219-1223
-
-
Thompson, J.E.1
Cubbon, R.M.2
Cummings, R.T.3
Wicker, L.S.4
Frankshun, R.5
Cunningham, B.R.6
Cameron, P.M.7
Meinke, P.T.8
Liverton, N.9
Weng, Y.10
DeMartino, J.A.11
-
21
-
-
77954619670
-
Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805
-
Baffert F, Regnier CH, De Pover, AD, Pissot-Soldermann, C, Tavares, GA, Blasco F, et al.: Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther 2010;9: 1945-1955.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1945-1955
-
-
Baffert, F.1
Regnier, C.H.2
De Pover, A.D.3
Pissot-Soldermann, C.4
Tavares, G.A.5
Blasco, F.6
-
22
-
-
40749112317
-
Optimization and utilization of the SureFire phospho-STAT5 assay for a cell-based screening campaign
-
DOI 10.1089/adt.2007.111
-
Binder C, Lafayette A, Archibeque I, Sun Y, Plewa C, Sinclair A, et al.: Optimization and utilization of the SureFire Phospho-STAT5 assay for a cellbased screening campaign. Assay Drug Dev Technol 2008;6:27-37. (Pubitemid 351380169)
-
(2008)
Assay and Drug Development Technologies
, vol.6
, Issue.1
, pp. 27-37
-
-
Binder, C.1
Lafayette, A.2
Archibeque, I.3
Sun, Y.4
Plewa, C.5
Sinclair, A.6
Emkey, R.7
|