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Volumn 12, Issue 5, 2011, Pages 675-680

Pharmacogenomic biomarkers: Validation needed for both the molecular genetic mechanism and clinical effect

Author keywords

biomarkers; gene expression; pharmacogenomics; serotonin transporter; structural RNA polymorphisms

Indexed keywords

BIOLOGICAL MARKER; MESSENGER RNA; SEROTONIN TRANSPORTER;

EID: 79957630478     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.11.23     Document Type: Review
Times cited : (11)

References (21)
  • 1
    • 15344340688 scopus 로고    scopus 로고
    • Polymorphisms affecting gene regulation and mRNA processing: Broad implications for pharmacogenetics
    • DOI 10.1016/j.pharmthera.2004.11.001
    • Johnson AD, Wang D, Sadee W: Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics. Pharmacol. Ther. 106, 19-38 (2005). (Pubitemid 40392460)
    • (2005) Pharmacology and Therapeutics , vol.106 , Issue.1 , pp. 19-38
    • Johnson, A.D.1    Wang, D.2    Sadee, W.3
  • 2
    • 78650565725 scopus 로고    scopus 로고
    • Measuring ra-acting regulatory variants genome-wide: New insight into expression genetics and disease susceptibility
    • Sadee W: Measuring ra-acting regulatory variants genome-wide: new insight into expression genetics and disease susceptibility Genome Med. 1, 116 (2009).
    • (2009) Genome Med. , vol.1 , pp. 116
    • Sadee, W.1
  • 3
    • 79951813946 scopus 로고    scopus 로고
    • Pharmacogenomics of the RNA world: Structural RNA polymorphisms in drug therapy
    • Sadee W, Wang D, Papp AC et al\ Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy. Clin. Pharmacol. Ther. 89(3), 355-365 (2011).
    • (2011) Clin. Pharmacol. Ther. , vol.89 , Issue.3 , pp. 355-365
    • Sadee, W.1    Wang, D.2    Papp, A.C.3
  • 4
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff LA, Sethupathy P, Junkins HAet al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl Acad. Sa. USA 106, 9362-9367 (2009).
    • (2009) Proc. Natl Acad. Sa. USA , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3
  • 5
    • 76049102972 scopus 로고    scopus 로고
    • Genome-wide analysis of allelic expression imbalance in human primary cells by high throughput transcriptome resequencing
    • Heap GA, Yang JH, Downes Ket al. Genome-wide analysis of allelic expression imbalance in human primary cells by high throughput transcriptome resequencing. Hum. Mol. Genet. 19, 122-134 (2010).
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 122-134
    • Heap, G.A.1    Yang, J.H.2    Downes, K.3
  • 6
    • 25444491710 scopus 로고    scopus 로고
    • Allelic expression imbalance of human u opioid receptor (OPRMl) caused by variant A118G
    • Zhang Y, Wang DX, Johnson AD, Papp AC, Sadee W: Allelic expression imbalance of human u opioid receptor (OPRMl) caused by variant A118G. J. Biol. Chem. 280, 32618-3224 (2005).
    • (2005) J. Biol. Chem. , vol.280 , pp. 32618-3224
    • Zhang, Y.1    Wang, D.X.2    Johnson, A.D.3    Papp, A.C.4    Sadee, W.5
  • 7
    • 78650055308 scopus 로고    scopus 로고
    • Nicotinic a5 receptor subunk mRNA expression is associated with distant 5' upstream polymorphisms
    • Smith RM, Alachkar H, Papp ACet al. Nicotinic a5 receptor subunk mRNA expression is associated with distant 5' upstream polymorphisms. Eur. J. Hum. Gen. 19(1), 76-83 (2011).
    • (2011) Eur. J. Hum. Gen. , vol.19 , Issue.1 , pp. 76-83
    • Smith, R.M.1    Alachkar, H.2    Papp, A.C.3
  • 8
    • 51649084617 scopus 로고    scopus 로고
    • Regulatory polymorphism in vitamin K epoxide reductase complex subunk 1 {VKORCl) affects gene expression and warfarin dose requirement
    • Wang D, Chen H, Momary KM, Cavallari LH, Johnson JA, Sadee W: Regulatory polymorphism in vitamin K epoxide reductase complex subunk 1 {VKORCl) affects gene expression and warfarin dose requirement. Blood 112, 1013-1021 (2008).
    • (2008) Blood , vol.112 , pp. 1013-1021
    • Wang, D.1    Chen, H.2    Momary, K.M.3    Cavallari, L.H.4    Johnson, J.A.5    Sadee, W.6
  • 9
    • 53049101481 scopus 로고    scopus 로고
    • Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: Detection through allelic expression imbalance in human target tissues
    • Johnson AD, Zhang Y, Papp ACet al. Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues. Pharmacogenet. Genomics 18,781-791 (2008).
    • (2008) Pharmacogenet. Genomics , vol.18 , pp. 781-791
    • Johnson, A.D.1    Zhang, Y.2    Papp, A.C.3
  • 10
    • 70350651269 scopus 로고    scopus 로고
    • Global patterns of cis variation in human cells revealed by high-density allelic expression analysis
    • Ge B, Pokholok DK, Kwan T et ah. Global patterns of cis variation in human cells revealed by high-density allelic expression analysis. Nat. Genet. 41, 1216-1222 (2009).
    • (2009) Nat. Genet. , vol.41 , pp. 1216-1222
    • Ge, B.1    Pokholok, D.K.2    Kwan, T.3
  • 12
    • 34548758543 scopus 로고    scopus 로고
    • Splicing in disease: Disruption of the splicing code and the decoding machinery
    • DOI 10.1038/nrg2164, PII NRG2164
    • Wang GS, Cooper TA: Splicing in disease: disruption of the splicing code and the decoding machinery. Nat. Rev. Genet. 8, 749-761 (2007). (Pubitemid 47429207)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.10 , pp. 749-761
    • Wang, G.-S.1    Cooper, T.A.2
  • 13
    • 33748144418 scopus 로고    scopus 로고
    • Highly variable mRNA expression and splicing of L-type voltage-dependent calcium channel alpha subunit 1C in human heart tissues
    • DOI 10.1097/01.fpc.0000230119.34205.8a, PII 0121301120061000000006
    • Wang D, Papp AC, Binkley PF, Johnson JA, Sadee W: Highly variable mRNA expression and splicing of L-type voltage-dependent calcium channel a subunk 1C (CACNAlC) in human heart tissues. Pharmacogent. Genomics 16,735-745 (2006). (Pubitemid 44454868)
    • (2006) Pharmacogenetics and Genomics , vol.16 , Issue.10 , pp. 735-745
    • Wang, D.1    Papp, A.C.2    Binkley, P.F.3    Johnson, J.A.4    Sadee, W.5
  • 14
    • 38049172954 scopus 로고    scopus 로고
    • Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory
    • Zhang Y, Bertolino A, Fazio Let al. Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proc. Natl Acad. Sci. USA 104, 20552-20557 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 20552-20557
    • Zhang, Y.1    Bertolino, A.2    Fazio, L.3
  • 15
    • 79951510133 scopus 로고    scopus 로고
    • Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse
    • Moyer RA, Wang D, Papp ACet al. Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse. Neuropsychopharmacology 36(4), 753-762 (2011).
    • (2011) Neuropsychopharmacology , vol.36 , Issue.4 , pp. 753-762
    • Moyer, R.A.1    Wang, D.2    Papp, A.C.3
  • 16
    • 57749200718 scopus 로고    scopus 로고
    • Promoter polymorphisms in ACE (angiotensin-I converting enzyme) associated wkh clinical outcomes in hypertension
    • Johnson AD, Gong Y, Wang Det al. Promoter polymorphisms in ACE (angiotensin-I converting enzyme) associated wkh clinical outcomes in hypertension. Clin. Pharmacol. Ther. 85, 36-44 (2009).
    • (2009) Clin. Pharmacol. Ther. , vol.85 , pp. 36-44
    • Johnson, A.D.1    Gong, Y.2    Wang, D.3
  • 17
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing herkabilky of complex diseases
    • Manolio TA, Collins FS, Cox NJet al. Finding the missing herkabilky of complex diseases. Nature461, 747-753 (2009).
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1    Collins, F.S.2    Cox, N.J.3
  • 19
    • 0006463359 scopus 로고    scopus 로고
    • Association of anxiety-related traits wkh a polymorphism in the serotonin transporter gene regulatory region
    • LeschKP, Bengel D, W&Ws Aet al. Association of anxiety-related traits wkh a polymorphism in the serotonin transporter gene regulatory region. Science 274, 1527-1531 (1996).
    • (1996) Science , vol.274 , pp. 1527-1531
    • Lesch, K.P.1    Bengel, D.2    Ws, A.3
  • 20
    • 67649206975 scopus 로고    scopus 로고
    • Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis
    • Risch N, Herrell R, Lehner Tet al. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA 301,2462-2471 (2009).
    • (2009) JAMA , vol.301 , pp. 2462-2471
    • Risch, N.1    Herrell, R.2    Lehner, T.3
  • 21
    • 33745599585 scopus 로고    scopus 로고
    • Allelic expression of serotonin transporter (SERT) mRNA in human pons: Lack of correlation with the polymorphism SERTLPR
    • DOI 10.1038/sj.mp.4001797, PII 4001797
    • Lim JE, Papp A, Pinsonneault J, Sadee W, Saffen D: Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correlation wkh the polymorphism SERTLPR. Mol. Psychiatry 11, 649-662 (2006). (Pubitemid 43989812)
    • (2006) Molecular Psychiatry , vol.11 , Issue.7 , pp. 649-662
    • Lim, J.-E.1    Papp, A.2    Pinsonneault, J.3    Sadee, W.4    Saffen, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.