Protonation of glutamate 208 induces the release of agmatine in an outward-facing conformation of an arginine/agmatine antiporter

Journal of Biological Chemistry

Volumn 286, Issue 22, 2011, Pages 19693-19701

  Zomot, Elia ^a   Bahar, Ivet ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC CONDITIONS; AGMATINE; ANTIPORTS; CARBONYL GROUPS; EXTRACELLULAR REGION; INTRACELLULAR PH; MOLECULAR DYNAMICS SIMULATIONS; SUBSTRATE BINDING; TIME-RESOLVED; TRANSMEMBRANES;

CONFORMATIONS; CYTOLOGY; ENZYME ACTIVITY; ESCHERICHIA COLI; ION EXCHANGE; MOLECULAR DYNAMICS; PROTONATION; SODIUM;

AMINO ACIDS;

AGMATINE; ANTIPORTER; ARGININE AGMATINE ANTIPORTER; GLUTAMIC ACID; ISOLEUCINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ESCHERICHIA COLI; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTON TRANSPORT;

AGMATINE; AMINO ACID TRANSPORT SYSTEMS; ANTIPORTERS; BINDING SITES; BIOLOGICAL TRANSPORT; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GLUTAMIC ACID; MODELS, MOLECULAR; PROTEIN STRUCTURE, SECONDARY;

ESCHERICHIA COLI;

EID: 79957625386     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.202085     Document Type: Article

References (28)

1. Law, C. J., Maloney, P. C., and Wang, D. N. (2008) Annu. Rev. Microbiol. 62, 289-305
2. Poolman, B. (1990) Mol. Microbiol. 4, 1629-1636
3. Yamashita, A., Singh, S. K., Kawate, T., Jin, Y., and Gouaux, E. (2005) Nature 437, 215-223
4. Faham, S., Watanabe, A., Besserer, G. M., Cascio, D., Specht, A., Hirayama, B. A., Wright, E. M., and Abramson, J. (2008) Science 321, 810-814
5. Ressl, S., Terwisscha van Scheltinga, A. C., Vonrhein, C., Ott, V., and Ziegler, C. (2009) Nature 458, 47-52
6. Schulze, S., Köster, S., Geldmacher, U., Terwisscha van Scheltinga, A. C., and Kühlbrandt, W. (2010) Nature 467, 233-236
7. Tang, L., Bai, L., Wang, W. H., and Jiang, T. (2010) Nat. Struct. Mol. Biol. 17, 492-496
8. Weyand, S., Shimamura, T., Yajima, S., Suzuki, S., Mirza, O., Krusong, K., Carpenter, E. P., Rutherford, N. G., Hadden, J. M., O'Reilly, J., Ma, P., Saidijam, M., Patching, S. G., Hope, R. J., Norbertczak, H. T., Roach, P. C., Iwata, S., Henderson, P. J., and Cameron, A. D. (2008) Science 322, 709-713
9. Gao, X., Lu, F., Zhou, L., Dang, S., Sun, L., Li, X., Wang, J., and Shi, Y. (2009) Science 324, 1565-1568
10. Shaffer, P. L., Goehring, A., Shankaranarayanan, A., and Gouaux, E. (2009) Science 325, 1010-1014
11. Jack, D. L., Paulsen, I. T., and Saier, M. H. (2000) Microbiology 146, 1797-1814
12. Audia, J. P., Webb, C. C., and Foster, J. W. (2001) Int. J. Med. Microbiol. 291, 97-106
13. Foster, J. W., Park, Y. K., Bang, I. S., Karem, K., Betts, H., Hall, H. K., and Shaw, E. (1994) Microbiology 140, 341-352
14. Gong, S., Richard, H., and Foster, J. W. (2003) J. Bacteriol. 185, 4402-4409
15. Iyer, R., Williams, C., and Miller, C. (2003) J. Bacteriol. 185, 6556-6561
16. Castanie-Cornet, M. P., Penfound, T. A., Smith, D., Elliott, J. F., and Foster, J. W. (1999) J. Bacteriol. 181, 3525-3535
17. Hersh, B. M., Farooq, F. T., Barstad, D. N., Blankenhorn, D. L., and Slonczewski, J. L. (1996) J. Bacteriol. 178, 3978-3981
18. Soksawatmaekhin, W., Kuraishi, A., Sakata, K., Kashiwagi, K., and Igarashi, K. (2004) Mol. Microbiol. 51, 1401-1412
19. Soksawatmaekhin, W., Uemura, T., Fukiwake, N., Kashiwagi, K., and Igarashi, K. (2006) J. Biol. Chem. 281, 29213-29220
20. Fang, Y., Jayaram, H., Shane, T., Kolmakova-Partensky, L., Wu, F., Williams, C., Xiong, Y., and Miller, C. (2009) Nature 460, 1040-1043
21. Gao, X., Zhou, L., Jiao, X., Lu, F., Yan, C., Zeng, X., Wang, J., and Shi, Y. (2010) Nature 463, 828-832
22. Fang, Y., Kolmakova-Partensky, L., and Miller, C. (2007) J. Biol. Chem. 282, 176-182
23. Li, H., Robertson, A. D., and Jensen, J. H. (2005) Proteins 61, 704-721
24. Bas, D. C., Rogers, D. M., and Jensen, J. H. (2008) Proteins 73, 765-783
25. Pettersen, E. F., Goddard, T. D., Huang, C. C., Couch, G. S., Greenblatt, D. M., Meng, E. C., and Ferrin, T. E. (2004) J. Comput. Chem. 25, 1605-1612
26. Humphrey, W., Dalke, A., and Schulten, K. (1996) J. Mol. Graph. 14, 33-38
27. Phillips, J. C., Braun, R., Wang, W., Gumbart, J., Tajkhorshid, E., Villa, E., Chipot, C., Skeel, R. D., Kalé, L., and Schulten, K. (2005) J. Comput. Chem. 26, 1781-1802
28. Casagrande, F., Ratera, M., Schenk, A. D., Chami, M., Valencia, E., Lopez, J. M., Torrents, D., Engel, A., Palacin, M., and Fotiadis, D. (2008) J. Biol. Chem. 283, 33240-33248