Separation of fast from slow anabolism by site-specific PEGylation of insulin-like growth factor I (IGF-I)

Journal of Biological Chemistry

Volumn 286, Issue 22, 2011, Pages 19501-19510

  Metzger, Friedrich ^a   Sajid, Waseem ^b   Saenger, Stefanie ^a   Staudenmaier, Christian ^a   Van Der Poel, Chris ^c   Sobottka, Bettina ^a   Schuler, Angelika ^a   Sawitzky, Mandy ^d   Poirier, Raphael ^a   Tuerck, Dietrich ^a   Schick, Eginhard ^a   Schaubmar, Andreas ^e   Hesse, Friederike ^e   Amrein, Kurt ^a   Loetscher, Hansruedi ^a   Lynch, Gordon S ^c   Hoeflich, Andreas ^d   De Meyts, Pierre ^b   Schoenfeld, Hans Joachim ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b HAGEDORN RESEARCH INSTITUTE   (Denmark)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^e ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASSOCIATION RATES; CLINICAL APPLICATION; IGF-BINDING PROTEINS; IN-VITRO; IN-VIVO; INSULIN RECEPTORS; INSULIN-LIKE GROWTH FACTOR-I; MUSCLE INJURIES; MUSCULOSKELETAL DISORDERS; PEGYLATION; SITE-SPECIFIC; SKELETAL MUSCLE;

AMINO ACIDS; DISEASE CONTROL; GLYCOLS; MEDICAL PROBLEMS; METABOLISM; MUSCLE; PEPTIDES; PHYSIOLOGY; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES;

INSULIN;

INSULIN RECEPTOR; LYSINE; MACROGOL; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG RECEPTOR BINDING; EMBRYO; HUMAN; HUMAN CELL; HYPOGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; MUSCLE CONTRACTION; MUSCLE INJURY; MUSCLE METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT; RISK REDUCTION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CELL LINE; DOGS; HALF-LIFE; HUMANS; HYPOGLYCEMIA; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; MUSCLE, SKELETAL; MUSCULOSKELETAL DISEASES; POLYETHYLENE GLYCOLS; RECEPTOR, INSULIN;

EID: 79957622089     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.172189     Document Type: Article

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