A convenient synthesis of novel pyranosyl homo-C-nucleosides and their antidiabetic activities

Carbohydrate Research

Volumn 346, Issue 10, 2011, Pages 1191-1201

  Bisht, Surendra Singh ^a   Jaiswal, Natasha ^a   Sharma, Anindra ^a   Fatima, Seerat ^a   Sharma, Rahul ^a   Rahuja, Neha ^a   Srivastava, A K ^a   Bajpai, Vikas ^a   Kumar, Brijesh ^a   Tripathi, Rama P ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Glucosidase; Glucose 6 phosphatase; Glycogen phosphorylase; Glycosylmethyl pyridines; Glycosylmethyl pyridones; Homo C nucleoside

Indexed keywords

GLUCOSE-6-PHOSPHATASE; GLUCOSIDASE; GLYCOGEN PHOSPHORYLASE; GLYCOSYLMETHYL PYRIDINES; HOMO-C-NUCLEOSIDE; PYRIDONES;

ADDITION REACTIONS; CYCLIZATION; ENZYME ACTIVITY; GLUCOSE; PHOSPHATASES; PHOSPHORYLATION; PYRIDINE; SODIUM; SYNTHESIS (CHEMICAL);

BIOMOLECULES;

1 (BETA DEXTRO GLUCOPYRANOSYL) 4 (ARYL)BUT 3 EN 2 ONE; 3 CYANO 4 ( 2' NAPHTHYL) 6 [( 2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 3 CYANO 4 ( 3',4' DIMETHOXYPHENYL) 6 [( 2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 3 CYANO 4 ( 3',4' DIMETHOXYPHENYL) 6 [(BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 3 CYANO 4 ( 4' FLUOROPHENYL) 6 [( 2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 3 CYANO 4 ( 4' FLUOROPHENYL) 6 [(BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 3 CYANO 4 ( 4' METHOXYPHENYL) 6 [( 2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 3 CYANO 4 ( 4' METHOXYPHENYL) 6 [(BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 3 CYANO 4 PHENYL 6 [( 2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 3 CYANO 6 [( 2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL)METHYL] 4 ( 3',4',5' TRIMETHOXYPHENYL)PYRIDONE; 4 ( 4' ACETYLPHENYL) 3 CYANO 6 [( 2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 4 ( 4' BENZYLOXYPHENYL) 3 CYANO 6 [( 2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 4 ( 4' BENZYLOXYPHENYL) 3 CYANO 6 [(BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 4 ( 4' BROMOPHENYL) 3 CYANO 6 [( 2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 4 ( 4' BROMOPHENYL) 3 CYANO 6 [(BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 4 ( 4' CHLOROPHENYL) 3 CYANO 6 [( 2'',3'',4'',6'' TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; 4 ( 4' CHLOROPHENYL) 3 CYANO 6 [(BETA DEXTRO GLUCOPYRANOSYL)METHYL]PYRIDONE; ACETAMIDE DERIVATIVE; ALPHA GLUCOSIDASE; CYANOACETAMIDE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN PHOSPHORYLASE; GLYCOSIDE; METFORMIN; NUCLEOSIDE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIDONE DERIVATIVE; STREPTOZOCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANADATE SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; AROMATIZATION; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CONTROLLED STUDY; CYCLIZATION; DRUG EFFECT; DRUG INHIBITION; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; GLUCOSE METABOLISM; HYPERGLYCEMIA; IN VITRO STUDY; MALE; MICHAEL ADDITION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

ALPHA-GLUCOSIDASES; ANIMALS; CYCLIZATION; DIABETES MELLITUS, EXPERIMENTAL; ENZYME INHIBITORS; GLUCOSE-6-PHOSPHATASE; GLYCOGEN PHOSPHORYLASE; GLYCOSYLATION; HYPOGLYCEMIC AGENTS; METFORMIN; MODELS, CHEMICAL; NUCLEOSIDES; PYRANS; PYRIDINES; PYRIDONES; RATS;

RATTUS;

EID: 79957616873     PISSN: 00086215     EISSN: 1873426X     Source Type: Journal    
DOI: 10.1016/j.carres.2011.03.006     Document Type: Article

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