Multiple distinct signal pathways, including an autocrine neurotrophic mechanism, contribute to the survival-promoting effect of depolarization on spiral ganglion neurons in vitro

Journal of Neuroscience

Volumn 21, Issue 7, 2001, Pages 2256-2267

  Hansen, Marlan R ^a   Zha, Xiang Ming ^a   Bok, Jinwoong ^a   Green, Steven H ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Autocrine mechanism; BDNF; cAMP; Cell survival; ERK; MAP kinase; Membrane depolarization; Neurotrophic factor; NT 3; Phosphatidylinositol 3 OH kinase; Signal transduction; Spiral ganglion neuron

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ADENOSINE 3',5' PHOSPHOROTHIOATE; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP; IMMUNOGLOBULIN G; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NEUROTROPHIN 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOCRINE EFFECT; CELL MEMBRANE DEPOLARIZATION; CELL SURVIVAL; CONTROLLED STUDY; IN VITRO STUDY; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SPIRAL GANGLION;

EID: 0035313237     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-07-02256.2001     Document Type: Article

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