Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions

Journal of Genetics and Genomics

Volumn 38, Issue 5, 2011, Pages 181-191

  Kido, Tatsuo ^a   Schubert, Stephanie ^b   Schmidtke, Jörg ^b   Chris Lau, Yun Fai ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

CASK; Neuron; Testis; TSPX; TSPY; Y chromosome

Indexed keywords

DNA; PROTEIN; TESTIS SPECIFIC PROTEIN Y ENCODED PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN FUNCTION; FEMALE; GENE; GENE EXPRESSION; GERM CELL; GONADOBLASTOMA; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE CELL; NONHUMAN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTO ONCOGENE; TESTIS; TESTIS SPECIFIC PROTEIN Y ENCODED GENE; TISSUE SPECIFICITY; TRANSGENE; TRANSGENIC MOUSE; Y CHROMOSOME;

ANIMALS; BRAIN; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CHROMOSOMES, HUMAN, X; CHROMOSOMES, HUMAN, Y; DNA; FEMALE; GENE EXPRESSION; GUANYLATE KINASE; HUMANS; MALE; MICE; MICE, TRANSGENIC; NEURONS; NUCLEAR PROTEINS; ORGAN SPECIFICITY; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; TESTIS;

MUS MUSCULUS;

EID: 79957554541     PISSN: 16738527     EISSN: 18735533     Source Type: Journal    
DOI: 10.1016/j.jgg.2011.04.002     Document Type: Article

References (54)

1. Andreano J.M., Cahill L. Sex influences on the neurobiology of learning and memory. Learn. Mem. 2009, 16:248-266.
2. Cahill L. Why sex matters for neuroscience. Nat. Rev. Neurosci. 2006, 7:477-484.
3. Chai Z., Sarcevic B., Mawson A., Toh B.H. SET-related cell division autoantigen-1 (CDA1) arrests cell growth. J. Biol. Chem. 2001, 276:33665-33674.
4. Delbridge M.L., Longepied G., Depetris D., Mattei M.G., Disteche C.M., Marshall Graves J.A., Mitchell M.J. TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X - implications for Y chromosome evolution. Chromosome Res. 2004, 12:345-356.
5. Frotscher M. Role for reelin in stabilizing cortical architecture. Trends Neurosci. 2010, 33:407-414.
6. Gallagher W.M., Bergin O.E., Rafferty M., Kelly Z.D., Nolan I.M., Fox E.J., Culhane A.C., McArdle L., Fraga M.F., Hughes L., Currid C.A., O'Mahony F., Byrne A., Murphy A.A., Moss C., McDonnell S., Stallings R.L., Plumb J.A., Esteller M., Brown R., Dervan P.A., Easty D.J. Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies. Carcinogenesis 2005, 26:1856-1867.
7. Hajszan T., Milner T.A., Leranth C. Sex steroids and the dentate gyrus. Prog. Brain Res. 2007, 163:399-415.
8. Hoei-Hansen C.E., Sehested A., Juhler M., Lau Y.F., Skakkebaek N.E., Laursen H., Rajpert-de Meyts E. New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers. J. Pathol. 2006, 209:25-33.
9. Honecker F., Stoop H., de Krijger R.R., Chris Lau Y.F., Bokemeyer C., Looijenga L.H. Pathobiological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells. J. Pathol. 2004, 203:849-857.
10. Hsueh Y.P. The role of the MAGUK protein CASK in neural development and synaptic function. Curr. Med. Chem. 2006, 13:1915-1927.
11. Hsueh Y.P. Calcium/calmodulin-dependent serine protein kinase and mental retardation. Ann. Neurol. 2009, 66:438-443.
12. Hsueh Y.P., Wang T.F., Yang F.C., Sheng M. Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2. Nature 2000, 404:298-302.
13. Kandalaft L.E., Zudaire E., Portal-Nunez S., Cuttitta F., Jakowlew S.B. Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis. Carcinogenesis 2008, 29:1282-1289.
14. Kersemaekers A.M., Honecker F., Stoop H., Cools M., Molier M., Wolffenbuttel K., Bokemeyer C., Li Y., Lau Y.F., Oosterhuis J.W., Looijenga L.H. Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. Hum. Pathol. 2005, 36:512-521.
15. Kido T., Lau Y.F. A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons. Genesis 2005, 42:263-275.
16. Kido T., Lau Y.F. The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein. Int. J. Cancer 2008, 123:1573-1585.
17. Kuroki Y., Toyoda A., Noguchi H., Taylor T.D., Itoh T., Kim D.S., Kim D.W., Choi S.H., Kim I.C., Choi H.H., Kim Y.S., Satta Y., Saitou N., Yamada T., Morishita S., Hattori M., Sakaki Y., Park H.S., Fujiyama A. Comparative analysis of chimpanzee and human Y chromosomes unveils complex evolutionary pathway. Nat. Genet. 2006, 38:158-167.
18. Lau Y., Chou P., Iezzoni J., Alonzo J., Komuves L. Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma. Cytogenet. Cell Genet. 2000, 91:160-164.
19. Lau Y.F. Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. Am. J. Hum. Genet. 1999, 64:921-927.
20. Lau Y.F., Kido T., Li Y. The TSPY Gene Family. The Y Chromosome and Male Germ Cell Biology in Health and Diseases 2007, 73-90. World Scientific Publishing Co. Pvt. Ltd, Hackensack, NJ. Y.F. Lau, W.Y. Chan (Eds.).
21. Lau Y.F., Lau H.W., Komüves L.G. Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer. Cytogenet. Genome. Res. 2003, 101:250-260.
22. Lau Y.F., Li Y., Kido T. Gonadoblastoma locus and the TSPY gene on the human Y chromosome. Birth Defects Res. C Embryo Today 2009, 87:114-122.
23. Lau Y.F., Li Y., Kido T. Role of the Y-located putative gonadoblastoma gene in human spermatogenesis. Syst. Biol. Reprod. Med. 2011, 57:27-34.
24. Li Y., Lau Y.F. TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin-dependent kinase 1 activities. Oncogene 2008, 27:6141-6150.
25. Li Y., Vilain E., Conte F., Rajpert-De Meyts E., Lau Y.F. Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ. Urol. Oncol. 2007, 25:141-146.
26. Lockstone H.E., Harris L.W., Swatton J.E., Wayland M.T., Holland A.J., Bahn S. Gene expression profiling in the adult down syndrome brain. Genomics 2007, 90:647-660.
27. Martinez A., Ozbun L.L., Angdisen J., Jakowlew S.B. Expression of differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) in adult mouse tissues. Dev. Dyn. 2002, 224:186-199.
28. Mazeyrat S., Mitchell M.J. Rodent Y chromosome TSPY gene is functional in rat and non-functional in mouse. Hum. Mol. Genet. 1998, 7:557-562.
29. Mukherjee K., Sharma M., Urlaub H., Bourenkov G.P., Jahn R., Sudhof T.C., Wahl M.C. CASK Functions as a Mg2+ independent neurexin kinase. Cell 2008, 133:328-339.
30. Najm J., Horn D., Wimplinger I., Golden J.A., Chizhikov V.V., Sudi J., Christian S.L., Ullmann R., Kuechler A., Haas C.A., Flubacher A., Charnas L.R., Uyanik G., Frank U., Klopocki E., Dobyns W.B., Kutsche K. Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum. Nat. Genet. 2008, 40:1065-1067.
31. Olsen O., Moore K.A., Nicoll R.A., Bredt D.S. Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex. Curr. Opin. Cell Biol. 2006, 18:223-227.
32. Oram S.W., Liu X.X., Lee T.L., Chan W.Y., Lau Y.F. TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells. BMC Cancer 2006, 6:154.
33. Ozbun L.L., Martinez A., Angdisen J., Umphress S., Kang Y., Wang M., You M., Jakowlew S.B. Differentially expressed nucleolar TGF-beta1 target (DENTT) in mouse development. Dev. Dyn. 2003, 226:491-511.
34. Ozbun L.L., Martinez A., Jakowlew S.B. Differentially expressed nucleolar TGF-beta1 target (DENTT) shows tissue-specific nuclear and cytoplasmic localization and increases TGF-beta1-responsive transcription in primates. Biochim. Biophys. Acta 2005, 1728:163-180.
35. Ozbun L.L., You L., Kiang S., Angdisen J., Martinez A., Jakowlew S.B. Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily. Genomics 2001, 73:179-193.
36. Page D.C. Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads. Development 1987, 101(Suppl.):151-155.
37. Park Y.J., Luger K. Histone chaperones in nucleosome eviction and histone exchange. Curr. Opin. Struct. Biol. 2008, 18:282-289.
38. Puffenberger E.G., Hu-Lince D., Parod J.M., Craig D.W., Dobrin S.E., Conway A.R., Donarum E.A., Strauss K.A., Dunckley T., Cardenas J.F., Melmed K.R., Wright C.A., Liang W., Stafford P., Flynn C.R., Morton D.H., Stephan D.A. Mapping of sudden infant death with dysgenesis of the testes syndrome (SIDDT) by a SNP genome scan and identification of TSPYL loss of function. Proc. Natl. Acad. Sci. USA 2004, 101:11689-11694.
39. Rogner U.C., Spyropoulos D.D., Le Novere N., Changeux J.P., Avner P. Control of neurulation by the nucleosome assembly protein-1-like 2. Nat. Genet. 2000, 25:431-435.
40. Ryan M.M., Lockstone H.E., Huffaker S.J., Wayland M.T., Webster M.J., Bahn S. Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes. Mol. Psychiatry 2006, 11:965-978.
41. Salo P., Kaariainen H., Petrovic V., Peltomaki P., Page D.C., de la Chapelle A. Molecular mapping of the putative gonadoblastoma locus on the Y chromosome. Genes Chromosomes Cancer 1995, 14:210-214.
42. Schnieders F., Dork T., Arnemann J., Vogel T., Werner M., Schmidtke J. Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues. Hum. Mol. Genet. 1996, 5:1801-1807.
43. Schubert S., Dechend F., Skawran B., Kunze B., Winking H., Weile C., Romer I., Hemberger M., Fundele R., Sharma T., Schmidtke J. Silencing of the Y-chromosomal gene tspy during murine evolution. Mamm. Genome 2000, 11:288-291.
44. Schubert S., Skawran B., Dechend F., Nayernia K., Meinhardt A., Nanda I., Schmid M., Engel W., Schmidtke J. Generation and characterization of a transgenic mouse with a functional human TSPY. Biol. Reprod. 2003, 69:968-975.
45. Swaab D.F., Chung W.C., Kruijver F.P., Hofman M.A., Ishunina T.A. Structural and functional sex differences in the human hypothalamus. Horm. Behav. 2001, 40:93-98.
46. Swaab D.F., Hofman M.A. Sexual differentiation of the human hypothalamus in relation to gender and sexual orientation. Trends Neurosci. 1995, 18:264-270.
47. Tsuchiya K., Reijo R., Page D.C., Disteche C.M. Gonadoblastoma: molecular definition of the susceptibility region on the Y chromosome. Am. J. Hum. Genet. 1995, 57:1400-1407.
48. Tu Y., Wu W., Wu T., Cao Z., Wilkins R., Toh B.H., Cooper M.E., Chai Z. Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways. J. Biol. Chem. 2007, 282:11722-11731.
49. Turner D.L., Weintraub H. Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev. 1994, 8:1434-1447.
50. Turner J.M. Meiotic sex chromosome inactivation. Development 2007, 134:1823-1831.
51. Vogel T., Dittrich O., Mehraein Y., Dechend F., Schnieders F., Schmidtke J. Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family. Cytogenet. Cell Genet. 1998, 81:265-270.
52. Wang G.S., Hong C.J., Yen T.Y., Huang H.Y., Ou Y., Huang T.N., Jung W.G., Kuo T.Y., Sheng M., Wang T.F., Hsueh Y.P. Transcriptional modification by a CASK-interacting nucleosome assembly protein. Neuron 2004, 42:113-128.
53. Yin Y.H., Li Y.Y., Qiao H., Wang H.C., Yang X.A., Zhang H.G., Pang X.W., Zhang Y., Chen W.F. TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma. Br. J. Cancer 2005, 93:458-463.
54. Zhang J.S., Yang-Feng T.L., Muller U., Mohandas T.K., de Jong P.J., Lau Y.F. Molecular isolation and characterization of an expressed gene from the human Y chromosome. Hum. Mol. Genet. 1992, 1:717-726.