Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris

Journal of Dermatological Science

Volumn 63, Issue 1, 2011, Pages 33-39

  Hata, Tsuyoshi ^a,b   Nishifuji, Koji ^a   Shimoda, Kouji ^a   Sasaki, Takashi ^a   Yamada, Taketo ^a   Nishikawa, Takeji ^a   Koyasu, Shigeo ^a   Amagai, Masayuki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Cutaneous Research Section   (Japan)

Author keywords

Autoantibody; Autoimmunity; Cadherin; Mouse model

Indexed keywords

DESMOGLEIN 1; DESMOGLEIN 3;

ACANTHOLYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DSG1 GENE; DSG3 GENE; EPIDERMIS; GENE EXPRESSION; HAIR FOLLICLE; HAIR LOSS; HISTOPATHOLOGY; KERATINOCYTE; MOUSE; MOUTH MUCOSA; NONHUMAN; PEMPHIGUS VULGARIS; PRIORITY JOURNAL; SURVIVAL RATE; TRANSGENE; TRANSGENIC MOUSE; WEIGHT REDUCTION;

EID: 79957538229     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2011.04.010     Document Type: Article

References (28)

1. Stanley J.R. Pemphigus and pemphigoid as paradigms of organ-specific, autoantibody-mediated diseases. J Clin Invest 1989, 83:1443-1448.
2. Amagai M., Koch P.J., Nishikawa T., Stanley J.R. Pemphigus vulgaris antigen (desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients. J Invest Dermatol 1996, 106:351-355.
3. Amagai M., Klaus-Kovtun V., Stanley J.R. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 1991, 67:869-877.
4. Anhalt G.J., Labib R.S., Voorhees J.J., Beals T.F., Diaz L.A. Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Engl J Med 1982, 306:1189-1196.
5. Amagai M., Karpati S., Prussick R., Klaus-Kovtun V., Stanley J.R. Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic. J Clin Invest 1992, 90:919-926.
6. Shirakata Y., Amagai M., Hanakawa Y., Nishikawa T., Hashimoto K. Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1. J Invest Dermatol 1998, 110:76-78.
7. Brennan D., Hu Y., Kljuic A., Choi Y., Joubeh S., Bashkin M., et al. Differential structural properties and expression patterns suggest functional significance for multiple mouse desmoglein 1 isoforms. Differentiation 2004, 72:434-449.
8. Koch P.J., Mahoney M.G., Ishikawa H., Pulkkinen L., Uitto J., Shultz L., et al. Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol 1997, 137:1091-1102.
9. Amagai M., Tsunoda K., Suzuki H., Nishifuji K., Koyasu S., Nishikawa T. Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus. J Clin Invest 2000, 105:625-631.
10. Grebe S.C., Streilein J.W. Graft-versus-Host reactions: a review. Adv Immunol 1976, 22:119-221.
11. Bemelman F., Yong S.L., Tissingh R., Schellekens P., ten Berge I. Suppression extends to major histocompatibility antigens linked to tolerizing minor histocompatibility antigens, but not the other way round. Transpl Int 2005, 18:423-428.
12. Warrens A.N., Lombardi G., Lechler R.I. Presentation and recognition of major and minor histocompatibility antigens. Transpl Immunol 1994, 2:103-107.
13. Amagai M. Autoimmunity against desmosomal cadherins in pemphigus. J Dermatol Sci 1999, 20:92-102.
14. Mahoney M.G., Wang Z., Rothenberger K., Koch P.J., Amagai M., Stanley J.R. Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J Clin Invest 1999, 103:461-468.
15. Wu H., Wang Z.H., Yan A., Lyle S., Fakharzadeh S., Wahl J.K., et al. Protection against pemphigus foliaceus by desmoglein 3 in neonates. N Engl J Med 2000, 343:31-35.
16. Hanakawa Y., Matsuyoshi N., Stanley J.R. Expression of desmoglein 1 compensates for genetic loss of desmoglein 3 in keratinocyte adhesion. J Invest Dermatol 2002, 119:27-31.
17. Tarutani M., Itami S., Okabe M., Ikawa M., Tezuka T., Yoshikawa K., et al. Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development. Proc Natl Acad Sci U S A. 1997, 94:7400-7405.
18. Tsunoda K., Ota T., Aoki M., Yamada T., Nagai T., Nakagawa T., et al. Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3. J Immunol 2003, 170:2170-2178.
19. Ishii K., Amagai M., Hall R.P., Hashimoto T., Takayanagi A., Gamou S., et al. Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins. J Immunol 1997, 159:2010-2017.
20. Garrod D.R., Merritt A.J., Nie Z. Desmosomal cadherins. Curr Opin Cell Biol 2002, 14:537-545.
21. Elias P.M., Matsuyoshi N., Wu H., Lin C., Wang Z.H., Brown B.E., et al. Desmoglein isoform distribution affects stratum corneum structure and function. J Cell Biol 2001, 153:243-249.
22. Merritt A.J., Berika M.Y., Zhai W., Kirk S.E., Ji B., Hardman M.J., et al. Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation. Mol Cell Biol 2002, 22:5846-5858.
23. Aoki-Ota M., Tsunoda K., Ota T., Iwasaki T., Koyasu S., Amagai M., et al. A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice. Br J Dermatol 2004, 151:346-354.
24. Tsunoda K., Ota T., Suzuki H., Ohyama M., Nagai T., Nishikawa T., et al. Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris. Eur J Immunol 2002, 32:627-633.
25. Nagao K., Ginhoux F., Leitner W.W., Motegi S., Bennett C.L., Clausen B.E., et al. Murine epidermal Langerhans cells langerin-expressing dermal dendritic cells are unrelate exhibit distinct functions. Proc Natl Acad Sci U S A 2009, 106:3312-3317.
26. Coquerelle C., Moser M. DC subsets in positive and negative regulation of immunity. Immunol Rev 2010, 234:317-334.
27. Takahashi H., Amagai M., Nishikawa T., Fujii Y., Kawakami Y., Kuwana M. Novel system evaluating in vivo pathogenicity of desmoglein 3-reactive T cell clones using murine pemphigus vulgaris. J Immunol 2008, 181:1526-1535.
28. Takahashi H., Kuwana M., Amagai M. A single helper T cell clone is sufficient to commit polyclonal naive B cells to produce pathogenic IgG in experimental pemphigus vulgaris. J Immunol 2009, 182:1740-1745.