Expression of desmoglein 1 compensates for genetic loss of desmoglein 3 in keratinocyte adhesion

Journal of Investigative Dermatology

Volumn 119, Issue 1, 2002, Pages 27-31

  Hanakawa, Yasushi ^a   Matsuyoshi, Norihisa ^a   Stanley, John R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cadherin; Desmosome; Hair

Indexed keywords

DESMOGLEIN 1; DESMOGLEIN 3; KERATIN;

ANIMAL EXPERIMENT; BODY WEIGHT; CELL ADHESION; CELL ASSAY; CONFERENCE PAPER; CONTROLLED STUDY; GENETIC ANALYSIS; HAIR; HAIR LOSS; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; KERATINOCYTE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSGENE; TRANSGENIC MOUSE; VALIDATION PROCESS;

EID: 0036418383     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2002.01780.x     Document Type: Conference Paper

References (16)

1. Amagai M, Hashimoto T, Shimizu N, Nishikawa T: Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus. J Clin Invest 94:59-67, 1994
2. Amagai M, Hashimoto T, Green KJ, Shimizu N, Nishikawa T: Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus. J Invest Dermatol 104:895-901, 1995
3. Amagai M, Matsuyoshi N, Wang ZH, Andl C, Stanley JR: Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. Nat Med 6:1275-1277, 2000
4. Anhalt GJ, Labib RS, Voorhees JJ, Beals TF, Diaz LA: Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Engl J Med 306:1189-1196, 1982
5. Bowden P, Hainey SD, Parker G, Jones DO, Zimonjic D, Popescu N, Hodgins MB: Characterization and chromosomal localization of human hair-specific keratin genes cycle and comparative expression during the hair growth. J Invest Dermatol 110:158-164, 1998
6. Elias PM, Matsuyoshi N, Wu H, Lin C, Wang ZH, Brown BE, Stanley JR: Desmoglein isoform distribution affects stratum corneum structure and function. J Cell Biol 153:243-249, 2001
7. Green KJ, Gaudry CA: Are desmosomes more than tethers for intermediate filaments? Nat Rev Mol Cell Biol 1:208-216, 2000
8. Koch PJ, Mahoney MG, Ishikawa H, et al: Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol 137:1091- 1102, 1997
9. Koch PJ, Mahoney MG, Cotsarelis G, Rothenberger K, Lavker RM, Stanley JR: Desmoglein 3 anchors telogen hair in the follicle. J Cell Sci 111:2529-2537, 1998
10. Kowalczyck AP, Bornslaeger EA, Norvell SM, Palka HL, Green KJ: Desmosomes: Intercellular adhesive junctions specialized for attachment of intermediate filaments. Int Rev Cytol 185:237-302, 1999
11. Mahoney MG, Wang Z, Rothenberger K, Koch PJ, Amagai M, Stanley JR: Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J Clin Invest 103:461-468, 1999
12. Saitou M, Sugai S, Tanaka T, Shimouchi K, Fuchs E, Narumiya S, Kakizuka A: Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature 374:159-162, 1995
13. Schiltz JR, Michel B: Production of epidermal acantholysis in normal human skin in vitro by the IgG fraction from pemphigus serum. J Invest Dermatol 67:254-260, 1976
14. Udey MC, Stanley JR: Pemphigus - Diseases of antidesmosomal autoimmunity. J Am Med Assoc 282:572-576, 1999
15. Vassar R, Rosenberg M, Ross S, Tyner A, Fuchs E: Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc Natl Acad Sci USA 86:1563-1567, 1989
16. Wu H, Wang ZH, Yan A, et al: Protection against pemphigus foliaceus by desmoglein 3 in neonates. N Engl J Med 343:31-35, 2000