The immunosuppressive activity of polymeric micellar formulation of cyclosporine A: In vitro and in vivo studies

AAPS Journal

Volumn 13, Issue 2, 2011, Pages 159-168

  Hamdy, Samar ^a   Haddadi, Azita ^b   Shayeganpour, Anooshirvan ^a   Alshamsan, Aws ^a,c   Montazeri Aliabadi, Hamidreza ^a   Lavasanifar, Afsaneh ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

cyclosporine A; dendritic cells; polymeric micelles; T cells

Indexed keywords

CYCLOSPORIN A; GAMMA INTERFERON; POLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG DOSAGE FORM COMPARISON; DRUG EFFECT; DRUG FORMULATION; DRUG POTENCY; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MALE; MICELLE; MOUSE; NONHUMAN; T LYMPHOCYTE;

ANIMALS; CELL PROLIFERATION; CYCLOSPORINE; DENDRITIC CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON-GAMMA; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICELLES; POLYESTERS; T-LYMPHOCYTES;

EID: 79957534427     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-011-9259-8     Document Type: Article

References (29)

1. JL Italia V Bhardwaj MN Kumar 2006 Disease, destination, dose and delivery aspects of ciclosporin: the state of the art Drug Discov Today 11 17-18 846 854 16935754 10.1016/j.drudis.2006.07.015 1:CAS:528:DC%2BD28XoslOgtLk%3D (Pubitemid 44280030)
2. D Faulds KL Goa P Benfield 1993 Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders Drugs 45 6 953 1040 7691501 10.2165/00003495- 199345060-00007 1:CAS:528:DyaK3sXmtFKlsL0%3D (Pubitemid 23219075)
3. G Ismailos C Reppas JB Dressman P Macheras 1991 Unusual solubility behaviour of cyclosporin A in aqueous media J Pharm Pharmacol 43 4 287 289 1676746 10.1111/j.2042-7158.1991.tb06688.x 1:CAS:528:DyaK3MXktFGntL4%3D
4. PR Beauchesne NS Chung KM Wasan 2007 Cyclosporine A: a review of current oral and intravenous delivery systems Drug Dev Ind Pharm 33 3 211 220 17454054 10.1080/03639040601155665 1:CAS:528:DC%2BD2sXltVeisrc%3D (Pubitemid 46656047)
5. A Czogalla 2009 Oral cyclosporine A - the current picture of its liposomal and other delivery systems Cell Mol Biol Lett 14 1 139 152 19005620 10.2478/s11658-008-0041-6 1:CAS:528:DC%2BD1MXltVSltLg%3D
6. HM Aliabadi A Mahmud AD Sharifabadi A Lavasanifar 2005 Micelles of methoxy poly(ethylene oxide)-b-poly(epsilon-caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine A J Control Release 104 2 301 311 15907581 10.1016/j.jconrel.2005.02.015 1:CAS:528:DC%2BD2MXkt1agsr4%3D (Pubitemid 40724931)
7. HM Aliabadi DR Brocks A Lavasanifar 2005 Polymeric micelles for the solubilization and delivery of cyclosporine A: pharmacokinetics and biodistribution Biomaterials 26 35 7251 7259 16005061 10.1016/j.biomaterials. 2005.05.042 (Pubitemid 41133577)
8. HM Aliabadi S Elhasi DR Brocks A Lavasanifar 2008 Polymeric micellar delivery reduces kidney distribution and nephrotoxic effects of Cyclosporine A after multiple dosing J Pharm Sci 97 5 1916 1926 17786948 10.1002/jps.21036 1:CAS:528:DC%2BD1cXltlemsrY%3D
9. N Nishiyama Y Kato Y Sugiyama K Kataoka 2001 Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system Pharm Res 18 7 1035 1041 11496942 10.1023/A:1010908916184 1:CAS:528:DC%2BD3MXlsV2itb0%3D (Pubitemid 32799952)
10. GS Kwon M Yokoyama T Okano Y Sakurai K Kataoka 1993 Biodistribution of micelle-forming polymer-drug conjugates Pharm Res 10 7 970 974 8378259 10.1023/A:1018998203127 1:CAS:528:DyaK3sXlvVyntr0%3D (Pubitemid 23211417)
11. X Zhang HM Burt G Mangold D Dexter D Von Hoff L Mayer, et al. 1997 Anti-tumor efficacy and biodistribution of intravenous polymeric micellar paclitaxel Anticancer Drugs 8 7 696 701 9311446 10.1097/00001813-199708000-00008 1:CAS:528:DyaK2sXmvFSisLc%3D (Pubitemid 27404727)
12. S Ho N Clipstone L Timmermann J Northrop I Graef D Fiorentino, et al. 1996 The mechanism of action of cyclosporin A and FK506 Clin Immunol Immunopathol 80 3 Pt 2 S40 45 8811062 10.1006/clin.1996.0140 1:CAS:528:DyaK28XlvFKqsL0%3D (Pubitemid 26317357)
13. L Geng S Dong Y Fang G Jiang H Xie M Shen, et al. 2008 Cyclosporin a up-regulates B7-DC expression on dendritic cells in an IL-4-dependent manner in vitro, which is associated with decreased allostimulatory capacity of dendritic cells Immunopharmacol Immunotoxicol 30 2 399 409 18569092 10.1080/ 08923970701812746 1:CAS:528:DC%2BD1cXnsFart70%3D (Pubitemid 351882926)
14. T Chen J Guo M Yang C Han M Zhang W Chen, et al. 2004 Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression Blood 103 2 413 421 14504089 10.1182/blood-2003-07-2412 1:CAS:528:DC%2BD2cXmsFeqsA%3D%3D (Pubitemid 38145553)
15. K Duperrier A Farre J Bienvenu N Bleyzac J Bernaud L Gebuhrer, et al. 2002 Cyclosporin A inhibits dendritic cell maturation promoted by TNF-alpha or LPS but not by double-stranded RNA or CD40L J Leukoc Biol 72 5 953 961 12429717 1:CAS:528:DC%2BD38Xpt1Sisrw%3D (Pubitemid 35365169)
16. HM Aliabadi S Elhasi A Mahmud R Gulamhusein P Mahdipoor A Lavasanifar 2007 Encapsulation of hydrophobic drugs in polymeric micelles through co-solvent evaporation: the effect of solvent composition on micellar properties and drug loading Int J Pharm 329 1-2 158 165 17008034 10.1016/j.ijpharm.2006.08.018 1:CAS:528:DC%2BD28XhtlCmtLjM (Pubitemid 44937525)
17. MB Lutz N Kukutsch AL Ogilvie S Rossner F Koch N Romani, et al. 1999 An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow J Immunol Methods 223 1 77 92 10037236 10.1016/S0022-1759(98)00204-X 1:CAS:528:DyaK1MXksFOjsw%3D%3D (Pubitemid 29096240)
18. J Azzi L Tang R Moore R Tong N El Haddad T Akiyoshi, et al. 2010 Polylactide-cyclosporin A nanoparticles for targeted immunosuppression FASEB J 24 10 3927 3938 20547662 10.1096/fj.10-154690 1:CAS:528:DC%2BC3cXht12isb7K
19. S Vitko O Viklicky 2004 Cyclosporine renal dysfunction Transplant Proc 36 2 Suppl 243S 247 15041346 10.1016/j.transproceed.2004.01.033 1:CAS:528:DC%2BD2cXisVeltrY%3D (Pubitemid 38373870)
20. F Kalthoff A Elbe-Burger 2005 RE: effects of cyclosporine on human dendritic cell subsets Transplant Proc 37 10 4639 4640 16387189 10.1016/j.transproceed.2005.11.061 (Pubitemid 43016102)
21. S Ciesek BP Ringe CP Strassburg J Klempnauer MP Manns H Wedemeyer, et al. 2005 Effects of cyclosporine on human dendritic cell subsets Transplant Proc 37 1 20 24 15808533 10.1016/j.transproceed.2004.11.055 1:CAS:528: DC%2BD2MXivFShsr0%3D (Pubitemid 40459675)
22. K Tajima R Amakawa T Ito M Miyaji M Takebayashi S Fukuhara 2003 Immunomodulatory effects of cyclosporin A on human peripheral blood dendritic cell subsets Immunology 108 3 321 328 12603598 10.1046/j.1365-2567.2003.01585.x 1:CAS:528:DC%2BD3sXitlSksLo%3D (Pubitemid 36332390)
23. S Akool el A Doller A Babelova W Tsalastra K Moreth L Schaefer, et al. 2008 Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506 J Immunol 181 4 2831 2845
24. B Li PK Sehajpal A Khanna H Vlassara A Cerami KH Stenzel, et al. 1991 Differential regulation of transforming growth factor beta and interleukin 2 genes in human T cells: demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction J Exp Med 174 5 1259 1262 1682412 10.1084/jem.174.5.1259 1:CAS:528:DyaK3MXmtVGktrs%3D
25. A Haddadi P Elamanchili A Lavasanifar S Das J Shapiro J Samuel 2008 Delivery of rapamycin by PLGA nanoparticles enhances its suppressive activity on dendritic cells J Biomed Mater Res A 84 4 885 898 17647224 (Pubitemid 351294999)
26. J Hao M Kwissa B Pulendran N Murthy 2006 Peptide crosslinked micelles: a new strategy for the design and synthesis of peptide vaccines Int J Nanomedicine 1 1 97 103 17722267 10.2147/nano.2006.1.1.97 1:CAS:528:DC%2BD28XhtFSjsrvK
27. A Boudier A Aubert-Pouessel P Louis-Plence C Gerardin C Jorgensen JM Devoisselle, et al. 2009 The control of dendritic cell maturation by pH-sensitive polyion complex micelles Biomaterials 30 2 233 241 18851879 10.1016/j.biomaterials.2008.09.033 1:CAS:528:DC%2BD1cXht1yrsLfJ
28. YP Liao CC Wang LH Butterfield JS Economou A Ribas WS Meng, et al. 2004 Ionizing radiation affects human MART-1 melanoma antigen processing and presentation by dendritic cells J Immunol 173 4 2462 2469 15294960 1:CAS:528:DC%2BD2cXmt1Oltr0%3D (Pubitemid 39063103)
29. MC Varela M Guzman J Molpeceres M del Rosario Aberturas D Rodriguez-Puyol M Rodriguez-Puyol 2001 Cyclosporine-loaded polycaprolactone nanoparticles: immunosuppression and nephrotoxicity in rats Eur J Pharm Sci 12 4 471 478 11231114 10.1016/S0928-0987(00)00198-6 1:CAS:528:DC%2BD3MXkslyjs7g%3D (Pubitemid 32166746)