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Volumn 121, Issue 3, 2011, Pages 434-443

MUC16 (CA125) regulates epithelial ovarian cancer cell growth, tumorigenesis and metastasis

Author keywords

CA125; Invasion; MUC16; Mucins; Ovarian cancer; Tumorigenesis

Indexed keywords

CA 125 ANTIGEN; MUC16 PROTEIN; MUCIN; NERVE CELL ADHESION MOLECULE; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

EID: 79957525887     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.02.020     Document Type: Article
Times cited : (151)

References (51)
  • 2
    • 12944315020 scopus 로고    scopus 로고
    • Epithelial ovarian cancer: Prevention, diagnosis, and treatment
    • E.E. Partridge, and M.N. Barnes Epithelial ovarian cancer: prevention, diagnosis, and treatment CA Cancer J Clin 49 1999 297 320
    • (1999) CA Cancer J Clin , vol.49 , pp. 297-320
    • Partridge, E.E.1    Barnes, M.N.2
  • 4
    • 0020559574 scopus 로고
    • A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer
    • R.C. Bast Jr., T.L. Klug, and E. St-John A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer N Eng J Med 309 1983 883 887 (Pubitemid 13014028)
    • (1983) New England Journal of Medicine , vol.309 , Issue.15 , pp. 883-887
    • Bast Jr., R.C.1    Klug, T.L.2    St. John, E.3
  • 5
    • 0021702359 scopus 로고
    • Ovarian cancer antigen CA125: A prospective clinical assessment of its role as a tumour marker
    • P.A. Canney, M. Moore, P.M. Wilkinson, and R.D. James Ovarian cancer antigen CA125: a prospective clinical assessment of its role as a tumour marker Br J Cancer 50 1984 765 769 (Pubitemid 15221441)
    • (1984) British Journal of Cancer , vol.50 , Issue.6 , pp. 765-769
    • Canney, P.A.1    Moore, M.2    Wilkinson, P.M.3    James, R.D.4
  • 7
    • 0020682587 scopus 로고
    • Immunopathologic characterization of a monoclonal antibody that recognizes common surface antigens of human ovarian tumors of serous, endometrial, and clear cell types
    • S.E. Kabawat, R.C. Bast Jr., and W.R. Welch Immunopathologic characterization of a monoclonal antibody that recognizes common surface antigens of human ovarian tumors of serous, endometrioid, and clear cell types Am J Clin Pathol 79 1983 98 104 (Pubitemid 13222196)
    • (1983) American Journal of Clinical Pathology , vol.79 , Issue.1 , pp. 98-104
    • Kabawat, S.E.1    Bast, R.C.2    Welch, W.R.3
  • 8
    • 33846897016 scopus 로고    scopus 로고
    • CA125 expression pattern, prognosis and correlation with serum CA125 in ovarian tumor patients. from the Danish "mALOVA" Ovarian Cancer Study
    • E.V. Hogdall, L. Christensen, and S.K. Kjaer CA125 expression pattern, prognosis and correlation with serum CA125 in ovarian tumor patients. From the Danish "MALOVA" Ovarian Cancer Study Gynecol Oncol 104 2007 508 515
    • (2007) Gynecol Oncol , vol.104 , pp. 508-515
    • Hogdall, E.V.1    Christensen, L.2    Kjaer, S.K.3
  • 9
    • 0032743220 scopus 로고    scopus 로고
    • Ovarian cancer antigen CA 125 enhances the invasiveness of the endometriotic cell line EEC 145
    • DOI 10.1016/S1071-5576(99)00027-1, PII S1071557699000271
    • R. Gaetje, D.W. Winnekendonk, A. Scharl, and M. Kaufmann Ovarian cancer antigen CA125 enhances the invasiveness of the endometriotic cell line EEC 145 J Soc Gynecol Investig 6 1999 278 281 (Pubitemid 29494936)
    • (1999) Journal of the Society for Gynecologic Investigation , vol.6 , Issue.5 , pp. 278-281
    • Gaetje, R.1    Winnekendonk, D.W.2    Scharl, A.3    Kaufmann, M.4
  • 12
    • 70350572867 scopus 로고    scopus 로고
    • CA125 (MUC16) tumor antigen selectively modulates the sensitivity of ovarian cancer cells to genotoxic drug-induced apoptosis
    • M. Boivin, D. Lane, A. Piché, and C. Rancourt CA125 (MUC16) tumor antigen selectively modulates the sensitivity of ovarian cancer cells to genotoxic drug-induced apoptosis Gynecol Oncol 115 2009 407 413
    • (2009) Gynecol Oncol , vol.115 , pp. 407-413
    • Boivin, M.1    Lane, D.2    Piché, A.3    Rancourt, C.4
  • 13
    • 0022829825 scopus 로고
    • Characterization of the CA 125 antigen associated with human epithelial ovarian carcinomas
    • H.M. Davis, V.R. Zurawski, R.C. Bast Jr., and T.L. Klug Characterization of the CA125 antigen associated with human epithelial ovarian carcinomas Cancer Res 46 1986 6143 6148 (Pubitemid 17221746)
    • (1986) Cancer Research , vol.46 , Issue.I12 , pp. 6143-6148
    • Davis, H.M.1    Zurawski Jr., V.R.2    Bast Jr., R.C.3    Klug, T.L.4
  • 14
    • 0027312461 scopus 로고
    • Purification and characterization of the CA 125 tumor-associated antigen from human ascites
    • de los Frailes MT, S. Stark, W. Jaeger, A. Hoerauf, and L. Wildt Purification and characterization of the CA125 tumor-associated antigen from human ascites Tumor Biol 14 1993 18 29 (Pubitemid 23192947)
    • (1993) Tumor Biology , vol.14 , Issue.1 , pp. 18-29
    • De Los Frailes, M.T.1    Stark, S.2    Jaeger, W.3    Hoerauf, A.4    Wildt, L.5
  • 15
    • 0027378770 scopus 로고
    • Molecular characteristics of the CA 125 antigen produced by human endometrial epithelial cells: Comparison between eutopic and heterotopic epithelial cells
    • H. Kobayashi, W. Ida, T. Terao, and Y. Kawashima Molecular characteristics of the CA125 antigen produced by human endometrial epithelial cells: comparison between eutopic and heterotopic epithelial cells Am J Obstet Gynecol 169 1993 725 730 (Pubitemid 23290200)
    • (1993) American Journal of Obstetrics and Gynecology , vol.169 , Issue.3 , pp. 725-730
    • Kobayashi, H.1    Ida, W.2    Terao, T.3    Kawashima, Y.4
  • 17
    • 0025941062 scopus 로고
    • Molecular nature and possible presence of a membranous glycan-phosphatidylinositol anchor of CA125 antigen
    • A. Nagata, N. Hirota, T. Sakai, M. Fujimoto, and T. Komoda Molecular nature and possible presence of a membranous glycan-phosphatidylinositol anchor of CA125 antigen Tumor Biol 12 1991 279 286
    • (1991) Tumor Biol , vol.12 , pp. 279-286
    • Nagata, A.1    Hirota, N.2    Sakai, T.3    Fujimoto, M.4    Komoda, T.5
  • 18
    • 0035920171 scopus 로고    scopus 로고
    • Molecular cloning of the CA125 ovarian cancer antigen: Identification as a new mucin (Muc16)
    • B.W. Yin, and K.O. Lloyd Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin (Muc16) J Biol Chem 276 2001 27371 27375
    • (2001) J Biol Chem , vol.276 , pp. 27371-27375
    • Yin, B.W.1    Lloyd, K.O.2
  • 19
    • 0037051691 scopus 로고    scopus 로고
    • Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene
    • DOI 10.1002/ijc.10250
    • B.W. Yin, A. Dnistrian, and K.O. Lloyd Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene Int J Cancer 98 2002 737 740 (Pubitemid 34225625)
    • (2002) International Journal of Cancer , vol.98 , Issue.5 , pp. 737-740
    • Yin, B.W.T.1    Dnistrian, A.2    Lloyd, K.O.3
  • 20
    • 0042206865 scopus 로고    scopus 로고
    • Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125
    • N. Kui Wong, and R.L. Easton Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125 J Biol Chem 278 2003 28619 286334
    • (2003) J Biol Chem , vol.278 , pp. 28619-286334
    • Kui Wong, N.1    Easton, R.L.2
  • 22
    • 0036560755 scopus 로고    scopus 로고
    • The CA 125 gene: A newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure
    • DOI 10.1159/000064032
    • T.J. O'Brien, J.B. Beard, L.J. Underwood, and K. Shigemasa The CA125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure Tumour Biol 23 2002 154 169 (Pubitemid 44858307)
    • (2002) Tumor Biology , vol.23 , Issue.3 , pp. 154-169
    • O'Brien, T.J.1    Beard, J.B.2    Underwood, L.J.3    Shigemasa, K.4
  • 24
    • 0033761311 scopus 로고    scopus 로고
    • Enhancement of metastatic properties of pancreatic cancer cells by MUC1 gene encoding an anti-adhesion molecule
    • S. Satoh, Y. Hinoda, and T. Hayashi Enhancement of metastatic properties of pancreatic cancer cells by MUC1 gene encoding an anti-adhesion molecule Int J Cancer 88 2000 507 518
    • (2000) Int J Cancer , vol.88 , pp. 507-518
    • Satoh, S.1    Hinoda, Y.2    Hayashi, T.3
  • 25
    • 1642475141 scopus 로고    scopus 로고
    • Inhibition of MUC4 Expression Suppresses Pancreatic Tumor Cell Growth and Metastasis
    • DOI 10.1158/0008-5472.CAN-03-2636
    • A.P. Singh, N. Moniaux, S.C. Chauhan, J.L. Meza, and S.K. Batra Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis Cancer Res 64 2004 622 630 (Pubitemid 38120902)
    • (2004) Cancer Research , vol.64 , Issue.2 , pp. 622-630
    • Singh, A.P.1    Moniaux, N.2    Chauhan, S.C.3    Meza, J.L.4    Batra, S.K.5
  • 26
    • 0035945663 scopus 로고    scopus 로고
    • Muc4/sialomucin complex, an intramembrane modulator of ErbB2/HER2/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor
    • DOI 10.1038/sj.onc.1204106
    • M. Komatsu, S. Jepson, and M.E. Arango Muc4/sialomucin complex, an intramembrane modulator of ErbB2/HER2/Neu potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor Oncogene 20 2001 461 470 (Pubitemid 32158226)
    • (2001) Oncogene , vol.20 , Issue.4 , pp. 461-470
    • Komatsu, M.1    Jepson, S.2    Arango, M.E.3    Carothers Carraway, C.A.4    Carraway, K.L.5
  • 27
    • 0028950808 scopus 로고
    • Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components
    • J. Wesseling, S.W. van der Valk, and H.L. Vos Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components J Cell Biol 129 1995 255 265
    • (1995) J Cell Biol , vol.129 , pp. 255-265
    • Wesseling, J.1    Van Der Valk, S.W.2    Vos, H.L.3
  • 28
    • 77949876005 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in ovarian cancer
    • D. Vergara, B. Merlot, and J.P. Lucot Epithelial-mesenchymal transition in ovarian cancer Cancer Lett 291 2010 59 66
    • (2010) Cancer Lett , vol.291 , pp. 59-66
    • Vergara, D.1    Merlot, B.2    Lucot, J.P.3
  • 30
    • 27644473229 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition
    • D.C. Radisky Epithelial-mesenchymal transition J Cell Sci 118 2005 4325 4326
    • (2005) J Cell Sci , vol.118 , pp. 4325-4326
    • Radisky, D.C.1
  • 31
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumor progression
    • J.P. Thiery Epithelial-mesenchymal transitions in tumor progression Nat Rev Cancer 2 2002 442 454
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 32
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • DOI 10.1016/j.ceb.2005.08.001, PII S0955067405001043
    • M.A. Huber, N. Kraut, and H. Beug Molecular requirements for epithelial-mesenchymal transition during tumor progression Curr Opin Cell Biol 17 2005 548 558 (Pubitemid 41267170)
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.SPEC. ISS. 5 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 33
    • 1042267263 scopus 로고    scopus 로고
    • Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
    • U. Cavallaro, and G. Christofori Cell adhesion and signaling by cadherins and Ig-CAMs in cancer Nat Rev Cancer 4 2004 118 132 (Pubitemid 38198740)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.2 , pp. 118-132
    • Cavallaro, U.1    Christofori, G.2
  • 36
    • 0028972499 scopus 로고
    • Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
    • M.L. Hermiston, and J.I. Gordon Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin Science 270 1995 1203 1207
    • (1995) Science , vol.270 , pp. 1203-1207
    • Hermiston, M.L.1    Gordon, J.I.2
  • 37
    • 0034671367 scopus 로고    scopus 로고
    • Truncation of the extracellular region abrogrates cell contact but retains the growth-suppressive activity of E-cadherin
    • C.Y. Sasaki, H. Lin, P.J. Morin, and D.L. Longo Truncation of the extracellular region abrogates cell contact but retains the growth-suppressive activity of E-cadherin Cancer Res 60 2000 7057 7065 (Pubitemid 32059185)
    • (2000) Cancer Research , vol.60 , Issue.24 , pp. 7057-7065
    • Sasaki, C.Y.1    Lin, H.2    Morin, P.J.3    Longo, D.L.4
  • 39
    • 0033230475 scopus 로고    scopus 로고
    • N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression
    • M.T. Nieman, R.S. Prudoff, K.R. Johnson, and M.J. Wheelock N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression J Cell Biol 147 1999 631 644
    • (1999) J Cell Biol , vol.147 , pp. 631-644
    • Nieman, M.T.1    Prudoff, R.S.2    Johnson, K.R.3    Wheelock, M.J.4
  • 40
    • 0030981146 scopus 로고    scopus 로고
    • Isolation and characterization of ovarian cancer antigen CA 125 using a new monoclonal antibody (VK-8): Identification as a mucin-type molecule
    • DOI 10.1002/(SICI)1097-0215(19970529)71:5<842::AID-IJC24>3.0.CO;2-8
    • K.O. Lloyd, B.W.T. Yin, and V. Kudryashov Isolation and characterization of ovarian cancer antigen CA 125 using a new monoclonal antibody (VK-8): identification as a mucin-type molecule Int J Cancer 71 1997 842 850 (Pubitemid 27237208)
    • (1997) International Journal of Cancer , vol.71 , Issue.5 , pp. 842-850
    • Lloyd, K.O.1    Yin, B.W.T.2    Kudryashov, V.3
  • 41
    • 0032523945 scopus 로고    scopus 로고
    • Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7
    • A. Piché, J. Grim, and C. Rancourt Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7 Cancer Res 58 1998 2134 2140 (Pubitemid 28232899)
    • (1998) Cancer Research , vol.58 , Issue.10 , pp. 2134-2140
    • Piche, A.1    Grim, J.2    Rancourt, C.3    Gomez-Navarro, J.4    Reed, J.C.5    Curiel, D.T.6
  • 43
    • 0028021979 scopus 로고
    • Differential expression of the cell-cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells
    • DOI 10.1002/ijc.2910580315
    • A.L. Veatch, L.F. Carson, and S. Ramakrishnan Differential expression of the cell-cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells Int J Cancer 58 1994 393 399 (Pubitemid 24254650)
    • (1994) International Journal of Cancer , vol.58 , Issue.3 , pp. 393-399
    • Veatch, A.L.1    Carson, L.F.2    Ramakrishnan, S.3
  • 44
    • 0030761757 scopus 로고    scopus 로고
    • Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: A clinicopathologic study of 60 cases
    • DOI 10.1016/S0046-8177(97)90007-1
    • E. Darai, J.Y. Scoazec, and F. Walker-Combrouze Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: a clinicopathologic study of 60 cases Hum Pathol 28 1997 922 928 (Pubitemid 27355552)
    • (1997) Human Pathology , vol.28 , Issue.8 , pp. 922-928
    • Darai, E.1    Scoazec, J.-Y.2    Walker-Combrouze, F.3    Mlika-Cabanne, N.4    Feldmann, G.5    Madelenat, P.6    Potet, F.7
  • 45
    • 77958451128 scopus 로고    scopus 로고
    • MUC-4 mucin-induced epithelial to mesenchymal transition: A novel mechanism for metastasis of human ovarian cancer cells
    • M.P. Ponnusamy, I. Lakshmanan, and M. Jain MUC-4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells Oncogene 2010 10.1038/onc.2010.309
    • (2010) Oncogene
    • Ponnusamy, M.P.1    Lakshmanan, I.2    Jain, M.3
  • 46
    • 0029584106 scopus 로고
    • Increased cell-substratum adhesion, and decreased gelatinase secretion and cell growth, induced by E-cadherin transfection of human colon carcinoma cells
    • M. Miyaki, K. Tanaka, R. Kikuchi-Yanoshita, M. Muraoka, M. Konishi, and M. Takeichi Increased cell-substratum adhesion, and decreased gelatinase secretion and cell growth, induced by E-cadherin transfection of human colon carcinoma cells Oncogene 11 1995 2547 2552 (Pubitemid 26023822)
    • (1995) Oncogene , vol.11 , Issue.12 , pp. 2547-2552
    • Miyaki, M.1    Tanaka, K.2    Kikuchi-Yanoshita, R.3    Muraoka, M.4    Konishi, M.5    Takeichi, M.6
  • 49
    • 0037422201 scopus 로고    scopus 로고
    • MUC1 alters β-catenin-dependent tumor formation and promotes cellular invasion
    • DOI 10.1038/sj.onc.1206291
    • J.A. Schroeder, M.C. Adriance, M.C. Thompson, T.D. Camenisch, and S.J. Gendler MUC1 alters β-catenin-dependent tumor formation and promotes cellular invasion Oncogene 22 2003 1324 1332 (Pubitemid 36384593)
    • (2003) Oncogene , vol.22 , Issue.9 , pp. 1324-1332
    • Schroeder, J.A.1    Adriance, M.C.2    Thompson, M.C.3    Camenisch, T.D.4    Gendler, S.J.5
  • 50
    • 0035918199 scopus 로고    scopus 로고
    • Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland
    • J.A. Schroeder, M.C. Thompson, M.M. Gardner, and S.J. Gendler Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland J Biol Chem 276 2001 13057 13064
    • (2001) J Biol Chem , vol.276 , pp. 13057-13064
    • Schroeder, J.A.1    Thompson, M.C.2    Gardner, M.M.3    Gendler, S.J.4


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