CA125 (MUC16) tumor antigen selectively modulates the sensitivity of ovarian cancer cells to genotoxic drug-induced apoptosis

Gynecologic Oncology

Volumn 115, Issue 3, 2009, Pages 407-413

  Boivin, Marianne ^a   Lane, Denis ^a   Piché, Alain ^a   Rancourt, Claudine ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

CA125 MUC16; Drug resistance; Genotoxic drugs; Ovarian cancer

Indexed keywords

CA 125 ANTIGEN; CASPASE 3; CASPASE 9; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; EPITHELIAL OVARY CANCER; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; CA-125 ANTIGEN; CASPASES; CELL LINE, TUMOR; CISPLATIN; CYCLOPHOSPHAMIDE; DOWN-REGULATION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; ETOPOSIDE; FEMALE; HUMANS; IMMUNOGLOBULIN FRAGMENTS; INHIBITORY CONCENTRATION 50; OVARIAN NEOPLASMS;

EID: 70350572867     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2009.08.007     Document Type: Article

References (22)

1. Perez R.P., Godwin A.K., Hamilton T.C., and Ozols R.F. Ovarian cancer biology. Semin. Oncol. 18 (1991) 186-204
2. Partridge E.E., and Barnes M.N. Epithelial ovarian cancer: prevention, diagnosis, and treatment. CA Cancer J. Clin. 49 (1999) 297-320
3. Yin B.W.T., and Lloyd K.O. Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. J. Biol. Chem. 276 (2001) 27371-27375
4. Yin B.W.T., Dnistrian A., and Lloyd K.O. Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene. Int. J. Cancer 98 (2002) 737-740
5. O'Brien T.J., Beard J.B., Underwood L.J., Dennis R.A., Santin A.D., and York L. The CA 125 gene: an extracellular superstructure dominated by repeat sequences. Tumour. Biol. 22 (2001) 348-366
6. O'Brien T.J., Beard J.B., Underwood L.J., and Shigemasa K. The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure. Tumour Biol. 23 (2002) 154-169
7. Kabawat S.E., Bast R.C., Welch W.R., Knapp R.C., and Colvin R.B. Immunopathologic characterization of a monoclonal antibody that recognizes common surface antigens of human ovarian tumors of serous, endometrioid, and clear cell types. Am. J. Clin. Pathol. 79 (1983) 98-104
8. Bast Jr. R.C., Klug T.L., St-John E., Jenison E., Niloff J.M., Lazarus H., et al. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N. Eng. J. Med. 309 (1983) 883-887
9. Hogdall E.V., Christensen L., Kjaer S.K., Blaakaer J., Kjaerby-Thygesen A., and Gayther S. CA125 expression pattern, prognosis and correlation with serum CA125 in ovarian tumor patients from the Danish "MALOVA" Ovarian Cancer Study. Gynecol. Oncol. 104 (2007) 506-513
10. Gendler S.J., and Spicer A.P. Epithelial mucin genes. Annu. Rev. Physiol. 57 (1995) 607-634
11. Satoh S., Hinoda Y., Hayashi T., Burdick M.D., Imai K., and Hollingsworth M.A. Enhancement of metastatic properties of pancreatic cancer cells by MUC1 gene encoding an anti-adhesion molecule. Int. J. Cancer 88 (2000) 507-518
12. Singh A.P., Moniaux N., Chauhan S.C., Meza J.L., and Batra S.K. Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Res. 64 (2004) 622-630
13. Li Y., Liu D., Chen D., Kharbanda S., and Kufe D. Human DF3/MUC1 carcinoma-associated protein functions as an oncogene. Oncogene 22 (2003) 6107-6110
14. Wesseling J., van der Valk S.W., Vos H.L., Sonnenberg A., and Hikens J. (1995) Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extrecellular matrix components. J. Cell Biol. 129 (1995) 255-265
15. Bélanger S., Côté M., Lane D., L'Espérance S., Rancourt C., and Piché A. Bcl-2 decreases cell proliferation and promotes accumulation of cells in S phase without affecting the rate of apoptosis in human ovarian cancer cells. Gynecol. Oncol. 97 (2005) 796-806
16. Lloyd K.O., Yin B.W.T., and Kudryashov V. Isolation and characterization of ovarian cancer antigen CA125 using a new monoclonal antibody (VK-8): identification as a mucin-type molecule. Int. J. Cancer 71 (1997) 842-859
17. Singh P.K., and Hollingsworth M.A. Cell surface-associated mucins in signal transduction. Trends Cell Biol. 16 (2006) 467-476
18. Yin L., Huang L., and Kufe D. MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress. J. Biol. Chem. 279 (2004) 45721-45727
19. Nemoto S., and Finkel T. Redox regulation of Forkhead proteins through a p66shc-dependent signaling pathway. Science 295 (2002) 2450-2452
20. Tran H., Brunet A., Grenier J.M., Datta S.R., Fornace A.J., DiStefano P.S., et al. DNA repair pathway stimulated by the Forkhead transcription factor FOX O3a through the Gadd45 protein. Science 296 (2002) 530-534
21. Ren J., Agata N., Cehn D., Li Y., Yu W.H., Huang L., et al. Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents. Cancer Cell 5 (2004) 163-175
22. Raina D., Kharbanda S., and Kufe D. The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-XL pathways in rat 3Y1 fibroblast. J. Biol. Chem. 279 (2004) 20607-20612