More than a biomarker: CA125 may contribute to ovarian cancer pathogenesis

Gynecologic Oncology

Volumn 121, Issue 3, 2011, Pages 429-430

  Bast Jr , Robert C ^a   Spriggs, David R ^b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CA 125 ANTIGEN; MESOTHELIN; OVARIAN CANCER 125; TUMOR MARKER; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; BINDING AFFINITY; CANCER DIAGNOSIS; CHROMOSOME 19P; EDITORIAL; EPSTEIN BARR VIRUS; GENE AMPLIFICATION; HUMAN; MUC16; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; TUMOR GENE;

EID: 79957519171     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.04.032     Document Type: Editorial

References (23)

1. Kohler G, and Milstein C Continuous cultures of fused cells secreting antibody of predefined specificity Nature 256 1975 495 497
2. Bast RC Jr, Feeney M, Lazarus H, Nadler LM, Colvin RB, and Knapp RC Reactivity of a monoclonal antibody with human ovarian carcinoma J Clin Invest 68 1981 1331 1337 PMID: 7028788 (Pubitemid 12235035)
3. Moore RG, McLaughlan S, and Bast RC Jr Current state of biomarker development for clinical application in epithelial ovarian cancer Gynecol Oncol 116 2010 240 245 PMID: 19879639
4. Bast RC Jr, Klug TL, St.John E, Jenison E, Niloff JM, Lazarus H, Berkowitz RS, Leavitt T, Griffiths CT, Parker L, Zurawski VR Jr, and Knapp RC A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer New Engl J Med 309 1983 883 887 PMID: 6310399 (Pubitemid 13014028)
5. Davis HM, Zurawski VR Jr, Bast RC Jr, and Klug TL Characterization of the CA 125 antigen associated with human epithelial ovarian carcinomas Cancer Res 46 1986 6143?6148 PMID: 2430690
6. Yin BW, and Lloyd KO Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16 J Biol Chem 276 2001 27371 27375
7. O'Brien TJ, Beard JB, Underwood LJ, Dennis RA, Santin AD, and York L The CA 125 gene: an extracellular superstructure dominated by repeat sequences Tumour Biol 22 2001 348 366 (Pubitemid 34062947)
8. Rosen D, Wang L, Atkinson JN, Yu Y, Lu K, Diamandis EP, Hellstrom I, Mok SC, Liu J, and Bast RC Jr Potential markers that complement expression of CA 125 in epithelial ovarian cancer Gynecol Oncol 99 2005 267 277 PMID: 16061277 (Pubitemid 41502830)
9. Hollingsworth M, and Swanson B Mucins in cancer: protection and control of the cell surface Nature Rviews: Cancer 4 2004 45 60 (Pubitemid 38082153)
10. Rump A, Morikawa Y, Tanaka M, Minami S, Umesaki N, Takeuchi M, and Miyajima A Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion J Biol Chem 279 2004 9190 9198 (Pubitemid 38295982)
11. Bast RC Jr, Hennessy B, and Mills GB The biology of ovarian cancer: new opportunities for translation Nature Rev Cancer 9 2009 415 428 PMID: 19461667
12. Seelenmeyer C, Wegehingel S, Lechner J, and Nickel W The cancer antigen CA125 represents a novel counter receptor for galectin-1 J Cell Sci 116 2003 1305 1318 (Pubitemid 36410668)
13. Argueso P, Guzman-Aranguez A, Mantelli F, Cao Z, Ricciuto J, and Panjwani N Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier J Biol Chem 284 2009 23037 23045
14. Lloyd KO, and Yin BW Synthesis and secretion of the ovarian cancer antigen CA 125 by the human cancer cell line NIH:OVCAR-3 Tumour Biol 22 2001 77 82 (Pubitemid 32008964)
15. Karlan B, Amin W, Casper SE, and Littlefield SA Hormonal regulation of CA125 tumor marker expression in human ovarian carcinoma cells: inhibition by glucocorticoids Cancer Res 48 1988 3502 3506
16. Theriault C, Pinard M, Comamala M, Migneault M, Beaudin J, Matte I, Boivin M, Piche A, and Rancourt C MUC16 (CA125) regulates epithelial ovarian cancer cell growth, tumorigenesis and metastasis Gynecol Oncol 2011
17. Ren J, Li Y, and Kufe D Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling J Biol Chem 277 2002 17616 17622 (Pubitemid 34967564)
18. Chaturvedi P, Singh AP, Chakraborty S, Chauhan SC, Bafna S, Meza JL, Singh PK, Hollingsworth MA, Mehta PP, and Batra SK MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells Cancer Res 68 2008 2065 2070 (Pubitemid 351521776)
19. Zorn KK, Tian C, McGuire WP, Hoskins WJ, Markman M, Muggia FM, Rose PG, Ozols RF, Spriggs D, and Armstrong DK The prognostic value of pretreatment CA 125 in patients with advanced ovarian carcinoma: a Gynecologic Oncology Group study Cancer 115 2009 1028 1035
20. Wang Y, Cheon D-J, Lu Z, Chen C-M, Xing D, Orsulic S, Bast RC Jr, and Behringer RR CA125 (MUC16) expression during embryogenesis, in adult tissue and ovarian cancers in the mouse Differentiation 76 2008 1081 1092 PMID: 18637025
21. Cheon DJ, Wang Y, Deng JM, Lu Z, Xiao L, Chen CM, Bast RC, and Behringer RR CA125/MUC16 is dispensable for mouse development and reproduction PLoS One 4 2009 e4675
22. Patankar MS, Jing Y, Morrison JC, Belisle JA, Lattanzio FA, Deng Y, Wong NK, Morris HR, Dell A, and Clark GF Potent suppression of natural killer cell response mediated by ovarian tumor marker CA125 Gynecol Oncol 99 2005 704 713 (Pubitemid 41686556)
23. Belisle JA, Horibata S, Jennifer GA, Petrie S, Kapur A, André S, Gabius HJ, Rancourt C, Connor J, Paulson JC, and Patankar MS Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells and monocytes Mol Cancer 9 2010 May 24 118