Oleanolic acid derivative Dex-OA has potent anti-tumor and anti-metastatic activity on osteosarcoma cells in vitro and in vivo

Investigational New Drugs

Volumn 29, Issue 2, 2011, Pages 258-265

  Hua, Yingqi ^a   Zhang, Zhiyu ^b   Li, Jianxin ^c   Li, Quan ^d   Hu, Shuo ^d   Li, Jaan ^d   Sun, Mengxiong ^d   Cai, Zhengdong ^a,d,e  

^a TONGJI UNIVERSITY   (China)

^b CHINA MEDICAL UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

^d SECOND MILITARY MEDICAL UNIVERSITY   (China)

^e TENTH PEOPLE S HOSPITAL OF TONGJI UNIVERSITY   (China)

Author keywords

Anti tumor; Chemotherapy; Oleanolic acid; Osteosarcoma

Indexed keywords

GLUCOSE; OLEANOLIC ACID DERIVATIVE; TETRAZOLIUM; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; OLEANOLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; METASTASIS POTENTIAL; MOUSE; NONHUMAN; OSTEOSARCOMA CELL; PRIORITY JOURNAL; TUMOR VOLUME; ANIMAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; IC 50; LUNG TUMOR; METASTASIS; OSTEOSARCOMA; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; MICE; OLEANOLIC ACID; OSTEOSARCOMA; S PHASE;

EID: 79957484238     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-009-9354-1     Document Type: Article

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