Pharmacodynamic Model of Parathyroid Hormone Modulation by a Negative Allosteric Modulator of the Calcium-Sensing Receptor

AAPS Journal

Volumn 13, Issue 2, 2011, Pages 265-273

  Abraham, Anson K ^a   Maurer, Tristan S ^b   Kalgutkar, Amit S ^b   Gao, Xiang ^b   Li, Mei ^b   Healy, David R ^b   Petersen, Donna N ^b   Griffith, David A ^b   Mager, Donald E ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b PFIZER INC   (United States)

Author keywords

allosteric; bone; calcium sensing receptor; ionized calcium; osteoporosis; parathyroid hormone; pharmacodynamics; pharmacokinetics

Indexed keywords

2 CHLORO 6 [[3 [[1,1 DIMETHYL 2 [4 (METHYLOXY)PHENYL]ETHYL]AMINO] 2 HYDROXYPROPYL]OXY]BENZONITRILE; CALCIUM ANTAGONIST; CALCIUM ION; CALCIUM SENSING RECEPTOR; PARATHYROID HORMONE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CALCIUM BINDING; CALCIUM HOMEOSTASIS; COMPARTMENT MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG STRUCTURE; DRUG TARGETING; DRUG TOLERANCE; HORMONAL REGULATION; JUGULAR VEIN; NEGATIVE FEEDBACK; NONHUMAN; NUCLEOTIDE SEQUENCE; PARATHYROID HORMONE BLOOD LEVEL; PHARMACODYNAMICS; PLASMA CONCENTRATION-TIME CURVE; RAT; SINGLE DRUG DOSE;

ALLOSTERIC REGULATION; ANIMALS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HOMEOSTASIS; HUMANS; INJECTIONS, SUBCUTANEOUS; MALE; MODELS, BIOLOGICAL; NITRILES; PARATHYROID HORMONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CALCIUM-SENSING;

EID: 79957480786     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-011-9266-9     Document Type: Article

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