Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4] triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2011, Pages 2955-2963

  Deng, Xian Qing ^a   Quan, Li Na ^a   Song, Ming Xia ^a   Wei, Cheng Xi ^b   Quan, Zhe Shan ^a  

^a YANBIAN UNIVERSITY   (China)

^b INNER MONGOLIA UNIVERSITY FOR NATIONALITIES   (China)

Author keywords

Anticonvulsant; Imidazo 1,2 a pyrimidin; Maximal electroshock; Pyrazolo 1,5 a pyrimidin; Synthesis; Triazolo 1,5 a pyrimidin

Indexed keywords

4 BENZYL 7 PHENYL 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 4 HEXYL 7 PHENYL 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 4 METHYL 7 PHENYL 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 5 (2 BROMOPHENYL) 5,6 DIHYDROIMIDAZO[1,2 A]PYRIMIDIN 7(8H) ONE; 5 (2 CHLOROPHENYL) 5,6 DIHYDROIMIDAZO[1,2 A]PYRIMIDIN 7(8H) ONE; 5 (2 FLUOROPHENYL) 5,6 DIHYDROIMIDAZO[1,2 A]PYRIMIDIN 7(8H) ONE; 5 PHENYL 5,6 DIHYDROIMIDAZO[1,2 A]PYRIMIDIN 7(8H) ONE; 7 (2 BROMOPHENYL) 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (2 BROMOPHENYL) 6,7 DIHYDROPYRAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (2 CHLOROPHENYL) 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (2 CHLOROPHENYL) 6,7 DIHYDROPYRAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (2 FLUOROPHENYL) 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (2 FLUOROPHENYL) 6,7 DIHYDROPYRAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (2 FLUOROPHENYL) 7,8 DIHYDROIMIDAZO[1,2 A]PYRIMIDIN 9(10H) ONE; 7 (2 METHOXYPHENYL) 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (2,4 DICHLOROPHENYL) 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (3 BROMOPHENYL) 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (3 CHLOROPHENYL) 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (3 FLUOROPHENYL) 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (4 BROMOPHENYL) 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (4 CHLOROPHENYL) 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (4 FLUOROPHENYL) 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (4 METHOXYPHENYL) 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 (4 METHYLPHENYL) 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 [3 (TRIFLUOROMETHYL)PHENYL] 6,7 DIHYDRO[1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 PHENYL 6,7 DIHYDRO [1,2,4]TRIAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE DERIVATIVE; 7 PHENYL 6,7 DIHYDROPYRAZOLO[1,5 A]PYRIMIDIN 5(4H) ONE; 7 PHENYL 7,8 DIHYDROPHENYL[D]IMIDAZO[1,2 A]PYRIMIDIN 9(10H) ONE; ANTICONVULSIVE AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; 3 MERCAPTOPROPIONIC ACID; BICUCULLINE; ISONIAZID; PENTETRAZOLE; PYRIMIDINONE DERIVATIVE; SEMICARBAZIDE DERIVATIVE; THIOSEMICARBAZIDE; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CLONIC SEIZURE; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; MOUSE; NEUROTOXICITY; NONHUMAN; STRUCTURE ACTIVITY RELATION; TONIC SEIZURE; ANIMAL; CHEMICALLY INDUCED; ELECTRIC SHOCK; PATHOPHYSIOLOGY; SEIZURES; SYNTHESIS;

3-MERCAPTOPROPIONIC ACID; ANIMALS; ANTICONVULSANTS; BICUCULLINE; ELECTROSHOCK; ISONIAZID; MICE; PENTYLENETETRAZOLE; PYRIMIDINONES; SEIZURES; SEMICARBAZIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 79957464826     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.020     Document Type: Article

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