Induction of antimalaria immunity by pyrimethamine prophylaxis during exposure to sporozoites is curtailed by parasite resistance

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 6, 2011, Pages 2760-2767

  Friesen, Johannes ^a   Borrmann, Steffen ^b,c   Matuschewski, Kai ^a  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

Author keywords

[No Author keywords available]

Indexed keywords

PYRIMETHAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; BITE; BRAIN MALARIA; CONTROLLED STUDY; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; INOCULATION; MALARIA; MOSQUITO; MOUSE; NONHUMAN; PARASITE IMMUNITY; PARASITEMIA; PLASMODIUM BERGHEI; PRIORITY JOURNAL; SPOROZOITE;

ANIMALS; ANTIMALARIALS; CULICIDAE; DRUG RESISTANCE; HEPATOCYTES; IMMUNIZATION; INSECT BITES AND STINGS; MALARIA; MICE; MICE, INBRED C57BL; PYRIMETHAMINE; SPOROZOITES;

EID: 79956334182     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01717-10     Document Type: Article

References (41)

1. Alonso, P. L., et al. 1993. A malaria control trial using insecticide-treated bed nets and targeted chemoprophylaxis in a rural area of The Gambia, West Africa. 2. Mortality and morbidity from malaria in the study area. Trans. R. Soc. Trop. Med. Hyg. 87(Suppl. 2):13-17.
2. Amin, A. A., et al. 2007. The challenges of changing national malaria drug policy to artemisinin-based combinations in Kenya. Malar. J. 6:72.
3. Aponte, J. J., et al. 2007. Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentation. PLoS Med. 4:e242.
4. Aponte, J. J., et al. 2009. Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials. Lancet 374: 1533-1542.
5. Barnes, K. I., et al. 2006. Sulfadoxine-pyrimethamine pharmacokinetics in malaria: pediatric dosing implications. Clin. Pharmacol. Ther. 80:582-596.
6. Beaudoin, R. L., C. P. A. Strome, F. Mitchell, and T. A. Tubergen. 1977. Plasmodium berghei - immunization of mice against Anka strain using unaltered sporozoite as an antigen. Exp. Parasitol. 42:1-5.
7. Belnoue, E., et al. 2004. Protective T cell immunity against malaria liver stage after vaccination with live sporozoites under chloroquine treatment. J. Immunol. 172:2487-2495. (Pubitemid 38182399)
8. Bray, R. S., R. W. Burgess, R. M. Fox, and M. J. Miller. 1959. Effect of pyrimethamine upon sporogony and pre-erythrocytic schizogony of Laverania falciparum. Bull. World Health Organ. 21:233-238.
9. Bruña-Romero, O., et al. 2001. Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR. Int. J. Parasitol. 31:1499-1502.
10. Ceesay, S. J., et al. 2008. Changes in malaria indices between 1999 and 2007 in The Gambia: a retrospective analysis. Lancet 372:1545-1554.
11. Certain, L. K., et al. 2008. Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987-2006. J. Infect. Dis. 197:1743-1751.
12. + T cell responses against malaria liver stage parasites. PLoS Pathog. 6:e1000877.
13. D'Alessandro, U., et al. 1995. Mortality and morbidity from malaria in Gambian children after introduction of an impregnated bednet programme. Lancet 345:479-483.
14. Dicko, A., et al. 2011. Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Mali: a randomised, double-blind, placebo-controlled trial. PLoS Med. 8:e1000407.
15. Donald, R. G., and D. S. Roos. 1993. Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase-thymidylate synthase marker based on drug-resistance mutations in malaria. Proc. Natl. Acad. Sci. U. S. A. 90:11703-11707.
16. Friesen, J., et al. 2010. Natural immunization against malaria: causal prophylaxis with antibiotics. Sci. Transl. Med. 2:40ra49.
17. Fryauff, D. J., et al. 1997. Malaria in a nonimmune population after extended chloroquine or primaquine prophylaxis. Am. J. Trop. Med. Hyg. 56:137-140.
18. Greenwood, B. 2007. Intermittent preventive antimalarial treatment in infants. Clin. Infect. Dis. 45:26-28.
19. + T cell responses following immunization with heat-killed Plasmodium sporozoites. Eur. J. Immunol. 36:1179-1186.
20. Hay, S. I., et al. 2010. Estimating the global clinical burden of Plasmodium falciparum malaria in 2007. PLoS Med. 7:e1000290.
21. Kumar, K. A., et al. 2006. The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites. Nature 444:937-940.
22. Matuschewski, K., J. C. Hafalla, S. Borrmann, and J. Friesen. 2011. Arrested Plasmodium liver stages as experimental anti-malaria vaccines. Hum. Vaccin. 7(Suppl. 1):16-21.
23. Menendez, C., et al. 1997. Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants. Lancet 350:844-850. (Pubitemid 27404345)
24. Most, H., R. Herman, and C. Schoenfeld. 1967. Chemotherapy of sporozoite-and blood-induced Plasmodium berghei infections with selected antimalarial agents. Am. J. Trop. Med. Hyg. 16:572-575.
25. Mueller, A. K., M. Labaied, S. H. Kappe, and K. Matuschewski. 2005. Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Nature 433:164-167.
26. Njagi, J. K., P. Magnussen, B. Estambale, J. Ouma, and B. Mugo. 2003. Prevention of anaemia in pregnancy using insecticide-treated bednets and sulfadoxine-pyrimethamine in a highly malarious area of Kenya: a randomized controlled trial. Trans. R. Soc. Trop. Med. Hyg. 97:277-282.
27. Nussenzweig, R. S., J. Vanderberg, H. Most, and C. Orton. 1967. Protective immunity produced by the injection of X-irradiated sporozoites of Plasmodium berghei. Nature 216:160-162.
28. Ocaña-Morgner, C., M. M. Mota, and A. Rodriguez. 2003. Malaria blood stage suppression of liver stage immunity by dendritic cells. J. Exp. Med. 197:143-151.
29. O'Meara, W. P., et al. 2008. Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya. Lancet 372:1555-1562.
30. Orjih, A. U., and R. S. Nussenzweig. 1979. Plasmodium berghei: suppression of antibody response to sporozoite stage by acute blood stage infection. Clin. Exp. Immunol. 38:1-8.
31. Putrianti, E. D., et al. 2010. The Plasmodium serine-type SERA proteases display distinct expression patterns and non-essential in vivo roles during life cycle progression of the malaria parasite. Cell. Microbiol. 12:725-739.
32. Putrianti, E. D., O. Silvie, M. Kordes, S. Borrmann, and K. Matuschewski. 2009. Vaccine-like immunity against malaria by repeated causal-prophylactic treatment of liver-stage Plasmodium parasites. J. Infect. Dis. 199:899-903.
33. Roestenberg, M., et al. 2009. Protection against a malaria challenge by sporozoite inoculation. N. Engl. J. Med. 361:468-477.
34. Roper, C., et al. 2004. Intercontinental spread of pyrimethamine- resistant malaria. Science 305:1124. (Pubitemid 39100317)
35. Schellenberg, D., et al. 2005. Intermittent preventive antimalarial treatment for Tanzanian infants: follow-up to age 2 years of a randomised, placebo-controlled trial. Lancet 365:1481-1483. (Pubitemid 40591693)
36. Schellenberg, J. R., et al. 2001. Effect of large-scale social marketing of insecticide-treated nets on child survival in rural Tanzania. Lancet 357: 1241-1247. (Pubitemid 32539052)
37. Sergent, E. 1910. Sur l'immunité dans le paludisme des oiseaux. Conservation in vitro des sporozoites de Plasmodium relictum. Immunité relative obtenue par inoculation de ces sporozoites. C. R. Hebd. Seances Acad. Sci. 151:407-409.
38. Sutherland, C. J., C. J. Drakeley, and D. Schellenberg. 2007. How is childhood development of immunity to Plasmodium falciparum enhanced by certain antimalarial interventions? Malar. J. 6:161.
39. Tsuji, M., D. Mattei, R. S. Nussenzweig, D. Eichinger, and F. Zavala. 1994. Demonstration of heat-shock protein 70 in the sporozoite stage of malaria parasites. Parasitol. Res. 80:16-21.
40. Vallely, A., L. Vallely, J. Changalucha, B. Greenwood, and D. Chandramohan. 2007. Intermittent preventive treatment for malaria in pregnancy in Africa: what's new, what's needed? Malar. J. 6:16.
41. White, N. J. 2005. Intermittent presumptive treatment for malaria. PLoS Med. 2:e3.