Use of calcium channel blockers is associated with better cognitive performance in older hypertensive patients with subjective memory complaints

Journal of Hypertension

Volumn 28, Issue 12, 2010, Pages 2485-2493

  Watfa, Ghassan ^a,b,c   Rossignol, Patrick ^a,b,c   Kearney Schwartz, Anna ^a,b   Fay, Renaud ^a   Bracard, Serge ^c,d,e   Felblinger, Jacques ^c,e   Boivin, Jean M ^a,c   Lacolley, Patrick ^b,c   Zannad, Faïez ^a,b,c   Benetos, Athanase ^a,b,c  

^a UNIVERSITY HOSPITAL OF NANCY   (France)

^b INSERM   (France)

^c UNIVERSITÉ DE LORRAINE   (France)

^d CENTRE HOSPITALIER   (France)

^e CHU NANCY BRABOIS   (France)

Author keywords

Calcium channel blockers; Cognitive impairment; Elderly; Hypertension; White matter hyperintensities

Indexed keywords

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTICOAGULANT AGENT; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; VERAPAMIL;

ADULT; AGED; ANTIHYPERTENSIVE THERAPY; ARTICLE; BENTON VISUAL RETENTION TEST; BLOOD PRESSURE MONITORING; COGNITION; COGNITIVE DIFFICULTIES SCALE OF MCNAIR; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GROBER BUSCHKE TEST; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; NEUROPROTECTION; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; RATING SCALE; VERBAL BEHAVIOR; VERBAL FLUENCY TEST; VISUAL MEMORY; WHITE MATTER; ANIMAL; COGNITIVE DEFECT; CROSS-SECTIONAL STUDY; MIDDLE AGED; PATHOLOGY;

AGED; ANIMALS; CALCIUM CHANNEL BLOCKERS; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; HUMANS; HYPERTENSION; MAGNETIC RESONANCE IMAGING; MIDDLE AGED;

EID: 79956329625     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32833e4108     Document Type: Article

References (44)

1. O'Brien JT, Erkinjuntti T, Reisberg B, Roman G, Sawada T, Pantoni L, et al. Vascular cognitive impairment. Lancet Neurol 2003; 2:89-98. (Pubitemid 37443329)
2. Manolio TA, Olson J, Longstreth WT. Hypertension and cognitive function: Pathophysiologic effects of hypertension on the brain. Curr Hypertens Rep 2003; 5:255-261. (Pubitemid 38914969)
3. Elias MF, Wolf PA, D'Agostino RB, Cobb J, White LR. Untreated blood pressure level is inversely related to cognitive functioning: The Framingham Study. Am J Epidemiol 1993; 138:353-364. (Pubitemid 23289288)
4. Skoog I, Lernfelt B, Landahl S, Palmertz B, Andreasson LA, Nilsson L, et al. 15-year longitudinal study of blood pressure and dementia. Lancet 1996; 347:1141-1145. (Pubitemid 126512042)
5. Launer LJ, Ross GW, Petrovitch H, Masaki K, Foley D, White LR, Havlik RJ. Midlife blood pressure and dementia: The Honolulu-Asia Aging study. Neurobiol Aging 2000; 21:49-55. (Pubitemid 30224785)
6. Awad IA, Spetzler RF, Hodak JA, Awad CA, Carey R. Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors. Stroke 1986; 17:1084-1089. (Pubitemid 17008934)
7. Sierra C, De La Sierra A, Salamero M, Sobrino J, Gomez-Angelats E, Coca A. Silent cerebral white matter lesions and cognitive function in middleaged essential hypertensive patients. Am J Hypertens 2004; 17:529-534. (Pubitemid 38726169)
8. Mosley TH Jr, Knopman DS, Catellier DJ, Bryan N, Hutchinson RG, Grothues CA, et al. Cerebral MRI findings and cognitive functioning: The Atherosclerosis Risk in Communities study. Neurology 2005; 64:2056-2062. (Pubitemid 40880992)
9. Forette F, Seux ML, Staessen JA, Thijs L, Birkenhager WH, Babarskiene MR, et al. Prevention of dementia in randomised double-blind placebocontrolled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet 1998; 352:1347-1351. (Pubitemid 28510916)
10. Tzourio C, Anderson C, Chapman N, Woodward M, Neal B, MacMahon S, Chalmers J. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med 2003; 163:1069-1075. (Pubitemid 36548935)
11. Forette F, Seux ML, Staessen JA, Thijs L, Babarskiene MR, Babeanu S, et al. The prevention of dementia with antihypertensive treatment: New evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med 2002; 162:2046-2052. (Pubitemid 35168212)
12. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the systolic hypertension in the elderly program (SHEP). SHEP Cooperative Research Group. JAMA 1991; 265:3255-3264.
13. Lithell H, Hansson L, Skoog I, Elmfeldt D, Hofman A, Olofsson B, et al. The Study onCognition and Prognosis in the Elderly(SCOPE): Principal results of a randomizeddouble-blindintervention trial. JHypertens2003;21:875-886. (Pubitemid 36677151)
14. Peters R, Beckett N, Forette F, Tuomilehto J, Clarke R, Ritchie C, et al. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial Cognitive Function Assessment (HYVET-cog): A doubleblind, placebo controlled trial. Lancet Neurol 2008; 7:683-689.
15. Derouesne C. Dementia. Diagnostic problems. Therapie 1993; 48:189-193.
16. Kearney-Schwartz A, Rossignol P, Bracard S, Felblinger J, Fay R, Boivin JM, et al. Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints. Stroke 2009; 40:1229-1236.
17. Folstein MF, Folstein SE, McHugh PR. 'Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198.
18. Verdelho A, Henon H, Lebert F, Pasquier F, Leys D. Depressive symptoms after stroke and relationship with dementia: A three-year follow-up study. Neurology 2004; 62:905-911. (Pubitemid 38435777)
19. Grober E, Buschke H, Crystal H, Bang S, Dresner R. Screening for dementia by memory testing. Neurology 1988; 38:900-903.
20. Spreen O, Benton AL. Simulation of mental deficiency on a visual memory test. Am J Ment Defic 1963; 67:909-913.
21. Peigneux P, Van Der Linden M, Andres-Benito P, Sadzot B, Franck G, Salmon E. A neuropsychological and functional brain imaging study of visuo-imitative apraxia. Rev Neurol (Paris) 2000; 156:459-472. (Pubitemid 30390006)
22. Spreen O. Prognosis of learning disability. J Consult Clin Psychol 1988; 56:836-842.
23. Kerber KA, Whitman GT, Brown DL, Baloh RW. Increased risk of death in community-dwelling older people with white matter hyperintensities on MRI. J Neurol Sci 2006; 250:33-38. (Pubitemid 44665927)
24. Hachinski VC, Potter P, Merskey H. Leuko-araiosis: An ancient term for a new problem. Can J Neurol Sci 1986; 13:533-534. (Pubitemid 17212716)
25. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5T in Alzheimer's dementia and normal aging. AJR 1987; 149:351-356. (Pubitemid 17104996)
26. Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, et al. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med 2003; 139:137-147.
27. Ahmed A, Husain A, Love TE, Gambassi G, Dell'Italia LJ, Francis GS, et al. Heart failure, chronic diuretic use, and increase in mortality and hospitalization: An observational study using propensity score methods. Eur Heart J 2006; 27:1431-1439. (Pubitemid 43998077)
28. Masur DM, Fuld PA, Blau AD, Thal LJ, Levin HS, Aronson MK. Distinguishing normal and demented elderly with the selective reminding test. J Clin Exp Neuropsychol 1989; 11:615-630. (Pubitemid 19271845)
29. Hanon O, Pequignot R, Seux ML, Lenoir H, Bune A, Rigaud AS, et al. Relationship between antihypertensive drug therapy and cognitive function in elderly hypertensive patients with memory complaints. J Hypertens 2006; 24:2101-2107. (Pubitemid 44371278)
30. Pantoni L, del Ser T, Soglian AG, Amigoni S, Spadari G, Binelli D, Inzitari D. Efficacy and safety of nimodipine in subcortical vascular dementia: A randomized placebo-controlled trial. Stroke 2005; 36:619-624. (Pubitemid 40344166)
31. Tisaire-Sanchez J, Roma J, Camacho-Azcargorta I, Bueno-Gomez J, Mora- Macia J, Navarro A. Assessment of cognitive function in patients with essential hypertension treated with lercanidipine. Vasc Health Risk Manag 2006; 2:491-498. (Pubitemid 46231279)
32. Maxwell CJ, Hogan DB, Ebly EM. Calcium-channel blockers and cognitive function in elderly people: Results from the Canadian Study of Health and Aging. CMAJ 1999; 161:501-506. (Pubitemid 29433523)
33. Heckbert SR, Longstreth WT Jr, Psaty BM, Murros KE, Smith NL, Newman AB, et al. The association of antihypertensive agents with MRI white matter findings and with modified Mini-Mental State Examination in older adults. J Am Geriatr Soc 1997; 45:1423-1433. (Pubitemid 127747111)
34. Angeli F, Verdecchia P, Reboldi GP, Gattobigio R, BentivoglioM, Staessen JA, Porcellati C. Calcium channel blockade to prevent stroke in hypertension: A meta-analysis of 13 studies with 103 793 subjects. Am J Hypertens 2004; 17:817-822. (Pubitemid 39201098)
35. Foster TC. Calcium homeostasis and modulation of synaptic plasticity in the aged brain. Aging Cell 2007; 6:319-325. (Pubitemid 46785137)
36. Toescu EC, Verkhratsky A. The importance of being subtle: small changes in calcium homeostasis control cognitive decline in normal aging. Aging Cell 2007; 6:267-273. (Pubitemid 46785132)
37. Holscher C. Possible causes of Alzheimer's disease: Amyloid fragments, free radicals, and calcium homeostasis. Neurobiol Dis 1998; 5:129-141. (Pubitemid 28520948)
38. Zhao W, Wang J, Ho L, Ono K, Teplow DB, Pasinetti GM. Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization. J Alzheimers Dis 2009; 16:49-57.
39. Haile M, Limson F, Gingrich K, Li YS, Quartermain D, Blanck T, Bekker A. Nimodipine prevents transient cognitive dysfunction after moderate hypoxia in adult mice. J Neurosurg Anesthesiol 2009; 21:140-144.
40. Farkas E, De Jong GI, Apro E, Keuker JI, Luiten PG. Calcium antagonists decrease capillary wall damage in aging hypertensive rat brain. Neurobiol Aging 2001; 22:299-309. (Pubitemid 32162979)
41. Prince MJ, Bird AS, Blizard RA, Mann AH. Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's trial of hypertension in older adults. BMJ 1996; 312:801-805. (Pubitemid 26099297)
42. Guo Z, Fratiglioni L, Zhu L, Fastbom J, Winblad B, Viitanen M. Occurrence and progression of dementia in a community population aged 75 years and older: Relationship of antihypertensive medication use. Arch Neurol 1999; 56:991-996. (Pubitemid 29374817)
43. in't Veld BA, Ruitenberg A, Hofman A, Stricker BH, Breteler MM. Antihypertensive drugs and incidence of dementia: The Rotterdam study. Neurobiol Aging 2001; 22:407-412. (Pubitemid 32510912)
44. Peila R, White LR, Masaki K, Petrovitch H, Launer LJ. Reducing the risk of dementia: efficacy of long-term treatment of hypertension. Stroke 2006; 37:1165-1170. (Pubitemid 43731856)