Nimodipine prevents transient cognitive dysfunction after moderate hypoxia in adult mice

Journal of Neurosurgical Anesthesiology

Volumn 21, Issue 2, 2009, Pages 140-144

  Haile, Michael ^b   Limson, Fred ^a   Gingrich, Kevin ^b   Li, Yong Sheng ^a   Quartermain, David ^a   Blanck, Thomas ^b   Bekker, Alex ^b  

^a NEW YORK UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium influx; Cognitive dysfunction; Moderate hypoxia; Nimodipine; Object recognition; Short term memory; Working memory

Indexed keywords

NIMODIPINE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN HYPOXIA; COGNITION; CONTROL GROUP; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; MALE; MEMORY DISORDER; MOUSE; NONHUMAN; OXYGEN SATURATION; PLACE PREFERENCE; PRIORITY JOURNAL; RECOGNITION; SHORT TERM MEMORY; SWISS WEBSTER MOUSE; TASK PERFORMANCE; WORKING MEMORY; ANIMAL; ATTENTION; BLOOD GAS ANALYSIS; COGNITIVE DEFECT; DRUG EFFECT; MEMORY; MOTOR ACTIVITY; OXYGEN CONSUMPTION; PSYCHOLOGICAL ASPECT;

ANIMALS; ATTENTION; BLOOD GAS ANALYSIS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; COGNITION DISORDERS; HYPOXIA, BRAIN; MALE; MEMORY; MICE; MOTOR ACTIVITY; NIMODIPINE; OXYGEN CONSUMPTION; RECOGNITION (PSYCHOLOGY);

EID: 65649133580     PISSN: 08984921     EISSN: None     Source Type: Journal    
DOI: 10.1097/ANA.0b013e3181920d28     Document Type: Article

References (30)

1. Trzepacz PT. Is there a final common neural pathway in delirium? Focus on acetylcholine and dopamine. Semin Clin Neuropsychiatry. 2000;5:132-148.
2. Bickler PE, Hansen BM. Causes of calcium accumulation in rat cortical brain slices during hypoxia and ischemia: role of ion channels and membrane damage. Brain Res. 1994;665:269-276.
3. Silver IA, Erecinska M. Intracellular and extracellular changes of (Ca2 + ) in hypoxia and ischemia in rat brain in vivo. J Gen Physiol. 1990;95:837-866.
4. Brown RC, Mark KS, Egleton RD, et al. Protection against hypoxia-induced blood-brain barrier disruption: changes in intracellular calcium. Am J Physiol Cell Physiol. 2004;286:C1045-C1052.
5. Jiang RG, Eyzaguirre C. Calcium channels of cultured rat glomus cells in normoxia and acute hypoxia. Brain Res. 2005;1031:56-66.
6. Yamauchi T. Neuronal Ca2/Calmodulin-Dependent Protein Kinase II-Discovery, progress in a quarter of a century, and perspective: implication for learning and memory. Biol Pharm Bull. 2005;28:1342-1354.
7. Pisani A, Calabresi P, Tozzi A, et al. L-Type Ca2+ channel blockers attenuate electrical changes and Ca2+ rise induced by oxygen/glucose deprivation in cortical neurons. Stroke. 1998;29:196-202.
8. Calabresi P, Pisani A, Mercuri NB, et al. On the mechanisms underlying hypoxia-induced membrane depolarization in striatal neurons. Brain. 1995;118:1027-1038.
9. Ennaceur A, Delacour J. A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data. Behavioral Brain Res. 1988;31:47-59.
10. Bekker A, Haile M, Gingrich K, et al. Physostigmine reverses cognitive dysfunction caused by moderate hypoxia in adult mice. Anesth Analg. 2007;105:739-743.
11. Simon P, Dupuis R, Costentin J. Thigmotaxis as an index of anxiety in mice. Influence of dopaminergic transmissions. Behavioral Brain Res. 1994;61:59-64.
12. Zupan G, Mrsic J, Simonic A. Effects of nicardipine, felodipine and nifedipine on passive avoidance behavior of intact and hypoxia- exposed rats. Arch Int Pharm Therapie. 1993;325:61-69.
13. Mrsic J, Zupan G, Erakovic V, et al. The influence of nimodipine and MK-801 on the brain free arachidonic acid level and the learning ability in hypoxia-exposed rats. Prog Neuropsychopharma- col Biol Psychiatry. 1997;21:345-358.
14. Hoffmeister F, Benz U, Heise A, et al. Behavioral effects of nimodipine in animals. Arzneimittelforschung. 1982;32:347-360.
15. Brooks SP, Hennebry G, McAlpin GPR, et al. Nimodipine prevents the effects of ethanol in tests of memory. Neuropharmacology. 2002; 42:577-585.
16. Norman G, Brooks SP, Hennebry GM, et al. Nimodipine prevents scopolamine-induced impairments in object recognition. J Psycho- pharmacol. 2002;16:153-161.
17. Quartermain D, Garcia deSoria V. The effects of calcium channel antagonists on short and long-term retention in mice using spontaneous alternation behavior. Neurobiol Learning Mem. 2001; 76:117-124.
18. Quartermain D, Garcia deSoria V, Kwan A. Calcium channel antagonists enhance retention of passive avoidance and maze learning in mice. Neurobiol Learning Mem. 2001;75:77-90.
19. Laatu S, Revonsuo A, Jaykka H, et al. Visual object recognition in early Alzheimer's disease: deficits in semantic processing. Acta Neurol Scand. 2003;108:82-89.
20. Reed J, Squire L. Impaired recognition memory in patients with lesions limited to the hippocampal formation. Behavioral Neurosci. 1997;111:667-675.
21. Squire LR, Zola-Morgan S. The neuropsychology of memory: new link between human and experimental animals. Ann N Y Acad Sci. 1985;444:137-149.
22. Gibson GE, Pulsinelli W, Blass JP, et al. Brain dysfunction in mild to moderate hypoxia. Am J Med. 1981;70:1247-1254.
23. Erecinska M, Silver IA. Tissue oxygen tension and brain sensitivity to hypoxia. Resp Physiol. 2001;128:263-276.
24. Yao H, Haddad GG. Calcium and pH homeostasis in neurons during hypoxia and ischemia. Cell Calcium. 2004;36:247-255.
25. Premkumar DR, Mishra RR, Overholt JL, et al. L-type Ca (2 + ) channel activation regulates induction of c-fos transcription by hypoxia. J Applied Physiol. 2000;88:1898-1906.
26. Stefani G, Onofri F, Valtorta F, et al. Kinetic analysis of the phosphorylation-dependent interactions of synapsin I with rat brain synaptic vesicles. J Physiol. 1997;504(Pt 3):501-515.
27. Broderick PA, Gibson GE. Dopamine and serotonin in rat striatum during in vivo hypoxic hypoxia. Metabol Brain Dis. 1989;4:143-153.
28. Micale V, Incognito T, Ignoto A, et al. Dopaminergic drugs may counteract behavioral and biochemical changes induced by models of brain injury. Eur Neuropsychopharmacol. 2006;16:195-203.
29. Furey ML, Pietrini P, Alexander GE, et al. Cholinergic enhancement improves performance on working memory by modulating the functional activity in distinct brain regions: a positron emission tomography regional cerebral blood flow study in healthy humans- the role of the hippocampus. Brain Res Bull. 2000;51:213-218.
30. Shukitt-Hale B, Stillman MJ, Levy A, et al. Nimodipine prevents the in vivo decrease in hippocampal extracellular acetylcholine produced by hypobaric hypoxia. Brain Res. 1993;621:291-295.