Calcium antagonists decrease capillary wall damage in aging hypertensive rat brain

Neurobiology of Aging

Volumn 22, Issue 2, 2001, Pages 299-309

  Farkas, Eszter ^a   De Jong, Gineke I ^a   Apró, Etelka ^a   Keuker, Jeanine I H ^a   Luiten, Paul G M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Calcium channel antagonist; Cerebral capillary; Cerebrovascular protection; Hypertension; Ultrastructure

Indexed keywords

CALCIUM ANTAGONIST; NIFEDIPINE; NIMODIPINE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD PRESSURE; BRAIN CAPILLARY; BRAIN PROTECTION; CAPILLARY BASEMENT MEMBRANE; CAPILLARY WALL; CEREBROVASCULAR DISEASE; COGNITION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; HISTOPATHOLOGY; HYPERTENSION; ISCHEMIA; LONG TERM CARE; NONHUMAN; PRIORITY JOURNAL; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR DISEASE;

AGING; ANIMALS; BEHAVIOR, ANIMAL; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CAPILLARIES; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR CIRCULATION; DRINKING; EATING; EXPLORATORY BEHAVIOR; HYPERTENSION; MALE; MICROSCOPY, ELECTRON; NIFEDIPINE; NIMODIPINE; RATS; RATS, INBRED SHR; RATS, INBRED WKY;

EID: 0035112484     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(00)00225-6     Document Type: Article

References (55)

1. Calcium channels in cerebral arteries
2. The double-edged role of nitric oxide in brain function and superoxide-mediated injury
3. Voltage-gated Ca entry in isolated bovine capillary endothelial cells: Evidence of a new type of BAY K 8644-sensitive channel
4. Serotonin in the regulation of brain microcirculation
5. Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: Molecular and pharmacologic characterization
6. Microvascular changes in aged rat forebrain. Effects of chronic nimodipine treatment
7. Effects of early onset of nimodipine treatment on microvascular integrity in the aging rat brain
8. Nimodipine effects on cerebral microvessels and sciatic nerve in aging rats
9. Formation of cerebrovascular anomalies in the aging rat is delayed by chronic nimodipine application
10. Reduced cytochrome oxidase and memory dysfunction after chronic brain ischemia in aged rats
11. Calcium-dependent afterhyperpolarization and learning in young and aging hippocampus
12. Functional acetylcholine muscarinic receptor subtypes in human brain microcirculation: Identification and cellular localization
13. Pathological features of cerebral cortical capillaries are doubled in Alzheimer's disease and Parkinson's disease
14. Similar ultrastructural breakdown of cerebrocortical capillaries in Alzheimer's disease, Parkinson's disease, and experimental hypertension
15. Are Alzheimer's disease, hypertension and cerebrocapillary damage related?
16. Mechanisms of action of calcium antagonists in heart and vascular smooth muscle
17. 'Second generation' dihydropyridine calcium antagonists. Greater vascular selectivity and some unique applications
18. Calcium antagonists. Their physiological differences
19. Cerebral blood flow and brain function in hypertension
20. Nifedipine and nimodipine: Effect on blood pressure and regional cerebral blood flow in conscious normotensive and hypertensive rats
21. Hypoxia-induced brain angiogenesis in the adult rat
22. Hypertension and coronary circulation. With special attention to endothelial regulation
23. Blood flow in the cerebral capillary network: A review emphasizing observations with intravital microscopy
24. The influence of oxygen free radicals on the permeability of the monolayer of cultured brain endothelial cells
25. Single-dose kinetics of nifedipine in rat plasma and brain
26. The blood-brain barrier: Cellular basis
27. Decreased local cerebral blood flow in young and aged spontaneously hypertensive rats
28. Cellular actions and pharmacology of calcium-channel blockers
29. Microvascular pericyte contractility in vitro: Comparison with other cells of the vascular wall
30. Effects of aging on the structural and permeability characteristics of cerebrovasculature in normotensive and hypertensive strains of rats
31. Transendothelial permeability changes induced by free radicals in an in vitro model of the blood-brain barrier
32. Dihydropyridine calcium antagonist in mice: Blood and brain pharmacokinetics and efficacy against pentylenetetrazol seizures
33. Calcium antagonists in prevention of hypertension and stroke in stroke-prone spontaneously hypertensive rats
34. Oxidative stress in brain ischemia
35. Cerebrovascular, neuronal, and behavioral effects of long-term Ca2+ channel blockade in aging normotensive and hypertensive rat strains
36. Calcium homeostasis, nimodipine, and stroke
37. Phorbol-stimulated influx of extracellular calcium in rat pulmonary artery endothelial cells
38. Cerebral blood flow and metabolism in hypertensive patients with cerebral infarction
39. Regional cerebral blood flow in chronic hypertension. A correlative study
40. Acute effects of antihypertensive agents on cerebral blood flow in hypertensive rats
41. Blood-brain barrier biology and methodology
42. Altered expression of collagen type VI in brain vessels of patients with chronic hypertension. A comparison with the distribution of collagen IV and procollagen III
43. The use of ion-sensitive electrodes and fluorescence imaging in hippocampal slices for studying pathological changes of intracellular Ca2+ regulation
44. Calcium antagonists in aging brain
45. Pharmacological basis for the use of nimodipine in central nervous system disorders
46. Pharmacology of nimodipine. A review
47. Glutamate, calcium, and free radicals as mediators of ischemic brain damage
48. Effect of an antihypertensive drug, budralazine, on the cerebral circulation in spontaneously hypertensive rats
49. Effect of the calcium antagonist felodipine and nimodipine on cortical blood flow in the spontaneously hypertensive rat
50. Brain pharmacokinetics and in vivo receptor binding of 1,4-dihydropyridine calcium channel antagonists
51. Similarities and differences between calcium antagonists: Pharmacological aspects
52. O2 radicals in arachidonate-induced increased blood-brain barrier permeability to proteins
53. Effects of nimodipine and verapamil on cerebral blood flow and cerebrovascular reactivity in conscious rabbits
54. Vascular basement membrane pathology and Alzheimer's disease
55. Nimodipine inhibits calcium-independent nitric oxide synthase activity in transient focal cerebral ischemia rats and cultured mouse astroglial cells