The effects of rifampicin on the pharmacokinetics and pharmacodynamics of orally administered nilvadipine to healthy subjects

British Journal of Clinical Pharmacology

Volumn 53, Issue 2, 2002, Pages 203-206

  Saima, S ^a   Furuie, K ^b   Yoshimoto, H ^a   Fukuda, J ^a   Hayashi, T ^a   Echizen, H ^b  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Calcium channel antagonist; CYP3A4; Drug interaction; Enzyme induction; Nilvadipine; Rifampicin

Indexed keywords

6BETA HYDROXYHYDROCORTISONE; HYDROCORTISONE; NILVADIPINE; RIFAMPICIN;

AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG URINE LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE URINE LEVEL; HYPOTENSION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; TACHYCARDIA; URINALYSIS;

ADMINISTRATION, ORAL; ADULT; ANTIBIOTICS, ANTITUBERCULAR; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; DRUG INTERACTIONS; FEMALE; HEART RATE; HUMANS; HYDROCORTISONE; MALE; NIFEDIPINE; RIFAMPIN;

EID: 0036210193     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0306-5251.2001.01545.x     Document Type: Article

References (9)

1. Gut metabolism of verapamil in older people: Effect of rifampicin-mediated enzyme induction
2. The nifedipine-rifampin interaction. Evidence of induction of gut wall metabolism
3. Influence of rifampicin on antihypertensive effects of dihydropyridine calcium channel blockers in four elderly patients
4. Nilvadipine. A review of its pharmacodynamic and pharmacokinetic properties, therapeutic use in hypertension and potential in cerebrovascular disease and angina
5. Determination of nilvadipine in plasma and urine by capillary column gas chromatography with electron-capture detection
6. A simple non-invasive procedure for the investigation of cytochrome P-450 IlIA dependent enzyme in humans
7. The increase in urinary excretion of 6β-hydroxycortisol as a maker of human hepatic cytochrome P450IIIA induction
8. Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: A new type of drug/drug interaction
9. Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein