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Volumn 2, Issue 4, 2008, Pages 855-864

The insulin-like growth factor system and its receptors: A potential novel anticancer target

Author keywords

Clinical trials; Growth factor; IGF 1; Insulin

Indexed keywords


EID: 79956273577     PISSN: 11775475     EISSN: 11775491     Source Type: Journal    
DOI: 10.2147/btt.s3841     Document Type: Review
Times cited : (6)

References (92)
  • 1
    • 33845357793 scopus 로고    scopus 로고
    • Phase I trial involving the pharmacodynamic (PD) study of circulating tumor cells, of CP-751,871 (C), a monoclonal antibody against the insulin-like growth factor 1 receptor (IGF-1R), with docetaxel (D) in patients with advanced cancer. ASCO Annual Meeting Proceedings part I [abstract]
    • Attard G, Fong PC, Molife R, et al. 2006. Phase I trial involving the pharmacodynamic (PD) study of circulating tumor cells, of CP-751,871 (C), a monoclonal antibody against the insulin-like growth factor 1 receptor (IGF-1R), with docetaxel (D) in patients with advanced cancer. ASCO Annual Meeting Proceedings part I [abstract]. J Clin Oncol, 24(18S):3023.
    • (2006) J Clin Oncol , vol.24 , Issue.18 S , pp. 3023
    • Attard, G.1    Fong, P.C.2    Molife, R.3
  • 2
    • 0033920612 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-binding proteins: Interactions with IGFs and intrinsic bioactivities
    • Baxter RC. 2000. Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities. Physiol Endocrinol Metab, 278:E967-E976.
    • (2000) Physiol Endocrinol Metab , vol.278
    • Baxter, R.C.1
  • 3
    • 27944485762 scopus 로고    scopus 로고
    • Lifetime recreational exercise activity and breast cancer risk among black women and white women
    • Bernstein L, Patel AV, Ursin G, et al. 2005. Lifetime recreational exercise activity and breast cancer risk among black women and white women. J Natl Cancer Institute, 97:1671-9.
    • (2005) J Natl Cancer Institute , vol.97 , pp. 1671-1679
    • Bernstein, L.1    Patel, A.V.2    Ursin, G.3
  • 4
    • 0038521255 scopus 로고    scopus 로고
    • The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript
    • Bohula EA, Salisbury AJ, Sohail M, et al. 2003. The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript. J Biol Chem, 278:15991-7.
    • (2003) J Biol Chem , vol.278 , pp. 15991-15997
    • Bohula, E.A.1    Salisbury, A.J.2    Sohail, M.3
  • 5
    • 0037037391 scopus 로고    scopus 로고
    • The association of breast mitogens with mammographic densities
    • Boyd NF, Stone J, Martin LJ, et al. 2002. The association of breast mitogens with mammographic densities. Br J Cancer, 87:876-82.
    • (2002) Br J Cancer , vol.87 , pp. 876-882
    • Boyd, N.F.1    Stone, J.2    Martin, L.J.3
  • 6
    • 9144234724 scopus 로고    scopus 로고
    • A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo
    • Burtrum D, Zhu Z, Lu D, et al. 2003. A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res, 63:8912-21.
    • (2003) Cancer Res , vol.63 , pp. 8912-8921
    • Burtrum, D.1    Zhu, Z.2    Lu, D.3
  • 7
    • 0034823316 scopus 로고    scopus 로고
    • Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study
    • Chan JM, Stampfer MJ, Ma J, et al. 2001. Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study. Am J Clin Nutr, 74:549-54.
    • (2001) Am J Clin Nutr , vol.74 , pp. 549-554
    • Chan, J.M.1    Stampfer, M.J.2    Ma, J.3
  • 8
    • 0034115368 scopus 로고    scopus 로고
    • Treatment of human breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor inhibits cell growth, suppresses tumorigenesis, alters the metastatic potential, and prolongs survival in vivo
    • Chernicky CL, Yi L, Tan H, et al. 2000. Treatment of human breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor inhibits cell growth, suppresses tumorigenesis, alters the metastatic potential, and prolongs survival in vivo. Cancer Gene Ther, 7:384-95.
    • (2000) Cancer Gene Ther , vol.7 , pp. 384-395
    • Chernicky, C.L.1    Yi, L.2    Tan, H.3
  • 9
    • 20144386856 scopus 로고    scopus 로고
    • Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871
    • Cohen BD, Baker DA, Soderstrom C, et al. 2005. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res, 11:2063-73.
    • (2005) Clin Cancer Res , vol.11 , pp. 2063-2073
    • Cohen, B.D.1    Baker, D.A.2    Soderstrom, C.3
  • 10
    • 0029830082 scopus 로고    scopus 로고
    • The role of the insulin-like growth factor binding proteins and the IGFBP proteases in modulating IGF action
    • Collett-Solberg PF, Cohen P. 1996. The role of the insulin-like growth factor binding proteins and the IGFBP proteases in modulating IGF action. Endocrinol Metab Clin North Am, 25:591-614.
    • (1996) Endocrinol Metab Clin North Am , vol.25 , pp. 591-614
    • Collett-Solberg, P.F.1    Cohen, P.2
  • 11
    • 34250783291 scopus 로고    scopus 로고
    • Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor
    • De Bono JS, Attard G, Adjei A, et al. 2007. Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor. Clin Cancer Res, 13:3611-6.
    • (2007) Clin Cancer Res , vol.13 , pp. 3611-3616
    • de Bono, J.S.1    Attard, G.2    Adjei, A.3
  • 12
    • 0025967857 scopus 로고
    • Parental imprinting of the mouse insulin-like growth factor II gene
    • DeChiara TM, Robertson EJ, Efstratiadis A. 1991. Parental imprinting of the mouse insulin-like growth factor II gene. Cell, 64:849-59.
    • (1991) Cell , vol.64 , pp. 849-859
    • DeChiara, T.M.1    Robertson, E.J.2    Efstratiadis, A.3
  • 13
    • 12944335316 scopus 로고    scopus 로고
    • Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice
    • DiGiovanni J, Kiguchi K, Frijhoff A, et al. 2000. Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice. Proc Natl Acad Sci U S A, 97:3455-60.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 3455-3460
    • DiGiovanni, J.1    Kiguchi, K.2    Frijhoff, A.3
  • 14
    • 0030666921 scopus 로고    scopus 로고
    • Mitogenic signalling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase
    • Dufourny B, Alblas J, van Teeffelen HA, et al. 1997. Mitogenic signalling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase. J Biol Chem, 272:31163-71.
    • (1997) J Biol Chem , vol.272 , pp. 31163-31171
    • Dufourny, B.1    Alblas, J.2    van Teeffelen, H.A.3
  • 15
    • 0030727705 scopus 로고    scopus 로고
    • Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice
    • Dunn SE, Kari FW, French J, et al. 1997. Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res, 57:4667-72.
    • (1997) Cancer Res , vol.57 , pp. 4667-4672
    • Dunn, S.E.1    Kari, F.W.2    French, J.3
  • 16
    • 0032146711 scopus 로고    scopus 로고
    • A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer
    • Dunn SE, Ehrlich M, Sharp NJ, et al. 1998. A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer. Cancer Res, 58:3353-61.
    • (1998) Cancer Res , vol.58 , pp. 3353-3361
    • Dunn, S.E.1    Ehrlich, M.2    Sharp, N.J.3
  • 17
    • 0028335643 scopus 로고
    • Alterations in serum levels of insulin-like growth factors and insulin-like growth-factor-binding proteins in patients with colorectal cancer
    • El Atiq F, Garrouste F, Remacle-Bonnet M, et al. 1994. Alterations in serum levels of insulin-like growth factors and insulin-like growth-factor-binding proteins in patients with colorectal cancer. Int J Cancer, 57:491-7.
    • (1994) Int J Cancer , vol.57 , pp. 491-497
    • El Atiq, F.1    Garrouste, F.2    Remacle-Bonnet, M.3
  • 18
    • 0242298218 scopus 로고    scopus 로고
    • Height, body mass index, and prostate cancer: A follow-up of 950000 Norwegian men
    • Engeland A, Tretli S, Bjorge T. 2003. Height, body mass index, and prostate cancer: a follow-up of 950000 Norwegian men. Br J Cancer, 89:1237-42.
    • (2003) Br J Cancer , vol.89 , pp. 1237-1242
    • Engeland, A.1    Tretli, S.2    Bjorge, T.3
  • 19
    • 0028812792 scopus 로고
    • Insulin-like growth factor-I (IGF-I) and IGF-binding proteins blood serum levels in women with early-and late-stage breast cancer: Mutual relationship and possible correlations with patients' hormonal status
    • Favoni RE, de Cupis A, Perrotta A, et al. 1995. Insulin-like growth factor-I (IGF-I) and IGF-binding proteins blood serum levels in women with early-and late-stage breast cancer: mutual relationship and possible correlations with patients' hormonal status. J Cancer Res Clin Oncol, 121:674-82.
    • (1995) J Cancer Res Clin Oncol , vol.121 , pp. 674-682
    • Favoni, R.E.1    de Cupis, A.2    Perrotta, A.3
  • 20
    • 0030996802 scopus 로고    scopus 로고
    • Distribution of insulin/insulin-like growth factor-1 hybrid receptors in human tissues
    • Federici M, Porzio O, Zucaro L, et al. 1997. Distribution of insulin/insulin-like growth factor-1 hybrid receptors in human tissues. Mol Cell Endocrinol, 129:121-6.
    • (1997) Mol Cell Endocrinol , vol.129 , pp. 121-126
    • Federici, M.1    Porzio, O.2    Zucaro, L.3
  • 21
    • 0036905115 scopus 로고    scopus 로고
    • Cellular actions of the insulin-like growth factor binding proteins
    • Firth SM, Baxter RC. 2002. Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev, 23:824-54.
    • (2002) Endocr Rev , vol.23 , pp. 824-854
    • Firth, S.M.1    Baxter, R.C.2
  • 22
    • 0029961734 scopus 로고    scopus 로고
    • Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients
    • Freudenheim JL, Marshall JR, Vena JE, et al. 1996. Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients. J Natl Cancer Institute, 88:340-8.
    • (1996) J Natl Cancer Institute , vol.88 , pp. 340-348
    • Freudenheim, J.L.1    Marshall, J.R.2    Vena, J.E.3
  • 23
    • 0028314962 scopus 로고
    • Insulin-like growth factor I induces cyclin D1 expression MG63 human osteosarcoma cells in vitro
    • Furlanetto RW, Harwell SE, Frick K. 1994. Insulin-like growth factor I induces cyclin D1 expression MG63 human osteosarcoma cells in vitro. Mol Endocrinol, 8:510-7.
    • (1994) Mol Endocrinol , vol.8 , pp. 510-517
    • Furlanetto, R.W.1    Harwell, S.E.2    Frick, K.3
  • 24
    • 12144285705 scopus 로고    scopus 로고
    • In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase
    • Garcia-Echeverria C, Pearson MA, Marti A, et al. 2004. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell, 5:231-9.
    • (2004) Cancer Cell , vol.5 , pp. 231-239
    • Garcia-Echeverria, C.1    Pearson, M.A.2    Marti, A.3
  • 25
    • 12244280783 scopus 로고    scopus 로고
    • Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men
    • Giovanucci E, Pollak M, Liu Y, et al. 2003. Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men. Cancer Epidemiol Biomarkers Prev, 12:84-9.
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , pp. 84-89
    • Giovanucci, E.1    Pollak, M.2    Liu, Y.3
  • 26
    • 0029960090 scopus 로고    scopus 로고
    • Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability
    • Guerra FK, Eijan AM, Puricelli L, et al. 1996. Varying patterns of expression of insulin-like growth factors I and II and their receptors in murine mammary adenocarcinomas of different metastasizing ability. Int J Cancer, 65:812-20.
    • (1996) Int J Cancer , vol.65 , pp. 812-820
    • Guerra, F.K.1    Eijan, A.M.2    Puricelli, L.3
  • 27
    • 0023276184 scopus 로고
    • Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults
    • Guler HP, Zapf J, Froesch ER. 1987. Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults. N Engl J Med, 317:137-40.
    • (1987) N Engl J Med , vol.317 , pp. 137-140
    • Guler, H.P.1    Zapf, J.2    Froesch, E.R.3
  • 28
    • 31544464616 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417
    • Haluska P, Carboni JM, Loegering DA, et al. 2006. In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417. Cancer Res, 66:362-71.
    • (2006) Cancer Res , vol.66 , pp. 362-371
    • Haluska, P.1    Carboni, J.M.2    Loegering, D.A.3
  • 29
    • 35348815620 scopus 로고    scopus 로고
    • Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors
    • Haluska P, Shaw HM, Batzel GN, et al. 2007. Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors. Clin Cancer Res, 13:5834-40.
    • (2007) Clin Cancer Res , vol.13 , pp. 5834-5840
    • Haluska, P.1    Shaw, H.M.2    Batzel, G.N.3
  • 30
    • 0032497030 scopus 로고    scopus 로고
    • Insulin-like growth factor-I and risk of breast cancer
    • Hankinson L, Strohm O, Osterziel K, et al. 1998. Insulin-like growth factor-I and risk of breast cancer. Lancet, 352:489-99.
    • (1998) Lancet , vol.352 , pp. 489-499
    • Hankinson, L.1    Strohm, O.2    Osterziel, K.3
  • 31
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 2
    • Herbst RS, Giaccone G, Schiller JH, et al. 2004. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2. J Clin Oncol, 22:785-94.
    • (2004) J Clin Oncol , vol.22 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3
  • 32
    • 35148889523 scopus 로고    scopus 로고
    • A Phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors [abstract]
    • Higano CS, Yu EY, Whiting MS, et al. 2007. A Phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors [abstract]. ASCO Prostate Cancer Symposium, 269.
    • (2007) ASCO Prostate Cancer Symposium , pp. 269
    • Higano, C.S.1    Yu, E.Y.2    Whiting, M.S.3
  • 33
    • 18944367562 scopus 로고    scopus 로고
    • Physical activity and survival after breast cancer diagnosis
    • Holmes MD, Chen WY, Feskanich D, et al. 2005. Physical activity and survival after breast cancer diagnosis. JAMA, 293:2479-86.
    • (2005) JAMA , vol.293 , pp. 2479-2486
    • Holmes, M.D.1    Chen, W.Y.2    Feskanich, D.3
  • 34
    • 0029593458 scopus 로고
    • Regional loss of imprinting of the insulin-like growth factor II gene occurs in human prostate tissues
    • Jarrard DF, Bussemakers MJ, Bova GS, et al. 1995. Regional loss of imprinting of the insulin-like growth factor II gene occurs in human prostate tissues. Clin Cancer Res, 1:1471-8.
    • (1995) Clin Cancer Res , vol.1 , pp. 1471-1478
    • Jarrard, D.F.1    Bussemakers, M.J.2    Bova, G.S.3
  • 35
    • 34548058890 scopus 로고    scopus 로고
    • A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo
    • Ji QS, Mulvihil MJ, Rosenfeld-Franklin M, et al. 2007. A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo. Mol Cancer Ther, 6:2158-67.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2158-2167
    • Ji, Q.S.1    Mulvihil, M.J.2    Rosenfeld-Franklin, M.3
  • 36
    • 0028958031 scopus 로고
    • Insulin-like growth factora and their binding proteins: Iological actions
    • Jones JI, Clemmons DR. 1995. Insulin-like growth factora and their binding proteins: iological actions. Endocr Rev, 16:3-34.
    • (1995) Endocr Rev , vol.16 , pp. 3-34
    • Jones, J.I.1    Clemmons, D.R.2
  • 37
    • 36348954086 scopus 로고    scopus 로고
    • Efficacy of the anti-insulin like growth factor I receptor (IGF-IR) antibody CP-751,871 in combination with paclitaxel and carboplatin as first-line treatment for advanced non-small cell lung cancer (NSCLC). ASCO Annual Meeting Proceedings part I [abstract]
    • Karp DD, Paz-Ares LG, Blakely LJ, et al. 2007. Efficacy of the anti-insulin like growth factor I receptor (IGF-IR) antibody CP-751,871 in combination with paclitaxel and carboplatin as first-line treatment for advanced non-small cell lung cancer (NSCLC). ASCO Annual Meeting Proceedings part I [abstract]. J Clin Oncol, 25(18S):7506.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 7506
    • Karp, D.D.1    Paz-Ares, L.G.2    Blakely, L.J.3
  • 38
    • 0029930716 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics
    • Kelley KM, Oh Y, Gargosky SE, et al. 1996. Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics. Int J Biochem Cell Biol, 28:619-37.
    • (1996) Int J Biochem Cell Biol , vol.28 , pp. 619-637
    • Kelley, K.M.1    Oh, Y.2    Gargosky, S.E.3
  • 39
    • 0034453098 scopus 로고    scopus 로고
    • The effects of insulin-like growth factors on tumorigenesis and neoplastic growth
    • Khandwala HM, McCutcheon IE, Flyvbjerg A, et al. 2000. The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr Rev, 21:215-44.
    • (2000) Endocr Rev , vol.21 , pp. 215-244
    • Khandwala, H.M.1    McCutcheon, I.E.2    Flyvbjerg, A.3
  • 40
    • 35348815424 scopus 로고    scopus 로고
    • Phase I first-in-human dose escalation study of CP-751,871, a specific monoclonal antibody against the insulin like growth factor 1 receptor. ASCO Annual Meeting Proceedings part I [abstract]
    • Lacy M, Alsina M, Melvin CL, et al. 2006. Phase I first-in-human dose escalation study of CP-751,871, a specific monoclonal antibody against the insulin like growth factor 1 receptor. ASCO Annual Meeting Proceedings part I [abstract]. J Clin Oncol, 24(18S):7609.
    • (2006) J Clin Oncol , vol.24 , Issue.18 S , pp. 7609
    • Lacy, M.1    Alsina, M.2    Melvin, C.L.3
  • 41
    • 0027935871 scopus 로고
    • Serum insulin-like growth factor I in a random population sample of men and women: Relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin
    • Landin-Wilhelmsen K, Wilhelmsen L, Lapps G, et al. 1994. Serum insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin. Clin Endocrinol, 41:351-7.
    • (1994) Clin Endocrinol , vol.41 , pp. 351-357
    • Landin-Wilhelmsen, K.1    Wilhelmsen, L.2    Lapps, G.3
  • 42
    • 0041343295 scopus 로고    scopus 로고
    • Associations of adult measures of childhood growth with breast cancer: Findings from the British Women's Heart and Health Study
    • Lawlor DA, Okasha M, Gunnell D, et al. 2003. Associations of adult measures of childhood growth with breast cancer: findings from the British Women's Heart and Health Study. Br J Cancer, 89:81-7.
    • (2003) Br J Cancer , vol.89 , pp. 81-87
    • Lawlor, D.A.1    Okasha, M.2    Gunnell, D.3
  • 43
    • 0028957113 scopus 로고
    • Molecular and cellular aspects of the insulin-like growth factor I receptor
    • LeRoith D, Werner H, Beitner-Johnson D, et al. 1995. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev, 16:143-63.
    • (1995) Endocr Rev , vol.16 , pp. 143-163
    • LeRoith, D.1    Werner, H.2    Beitner-Johnson, D.3
  • 44
    • 0038398622 scopus 로고    scopus 로고
    • The insulin-like growth factor system and cancer
    • LeRoith D, Roberts Jr. CT. 2003. The insulin-like growth factor system and cancer. Cancer Lett, 195:127-37.
    • (2003) Cancer Lett , vol.195 , pp. 127-137
    • LeRoith, D.1    Roberts Jr., C.T.2
  • 45
    • 0037417815 scopus 로고    scopus 로고
    • Growth hormonereleasing hormone (GHRH) antagonists inhibit the proliferation of androgen-dependent and-independent prostate cancers
    • Letsch M, Schally AV, Busto R, et al. 2003. Growth hormonereleasing hormone (GHRH) antagonists inhibit the proliferation of androgen-dependent and-independent prostate cancers. Proc Natl Acad Sci U S A, 100:1250-5.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 1250-1255
    • Letsch, M.1    Schally, A.V.2    Busto, R.3
  • 46
    • 0033929947 scopus 로고    scopus 로고
    • Single-chain antibodies against human insulin-like growth factor I receptor: Expression, purification, and effect on tumor growth
    • Li SL, Liang SJ, Guo N, et al. 2000. Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth. Cancer Immunol Immunother, 49:243-52.
    • (2000) Cancer Immunol Immunother , vol.49 , pp. 243-252
    • Li, S.L.1    Liang, S.J.2    Guo, N.3
  • 47
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (IGFI) and type I IGF receptor (IGFIr)
    • Liu JP, Baker J, Perkins AS, et al. 1993. Mice carrying null mutations of the genes encoding insulin-like growth factor I (IGFI) and type I IGF receptor (IGFIr). Cell, 75:59-72.
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3
  • 48
    • 0037338296 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein-1 over-expression in transgenic mice inhibits hepatic preneoplasia
    • Lu S, Archer MC. 2003. Insulin-like growth factor binding protein-1 over-expression in transgenic mice inhibits hepatic preneoplasia. Mol Carcinogen, 36:142-6.
    • (2003) Mol Carcinogen , vol.36 , pp. 142-146
    • Lu, S.1    Archer, M.C.2
  • 49
    • 0033531765 scopus 로고    scopus 로고
    • Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    • Ma J, Pollak M, Giovannucci E, et al. 1999. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst, 91:628-9.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 628-629
    • Ma, J.1    Pollak, M.2    Giovannucci, E.3
  • 50
    • 0023846016 scopus 로고
    • A single receptor binds both insulin-like growth factor II and mannose-6-phosphate
    • Macdonald RG, Pfeffer SR, Coussens L, et al. 1988. A single receptor binds both insulin-like growth factor II and mannose-6-phosphate. Science, 239:1134-7.
    • (1988) Science , vol.239 , pp. 1134-1137
    • McDonald, R.G.1    Pfeffer, S.R.2    Coussens, L.3
  • 51
    • 3042853470 scopus 로고    scopus 로고
    • Lit is the first germ-line mutation to reduce prostate cancer risk and prolong survival in the TRAMP transgenic model
    • Majeed N, Kaplan P, Blouin M, et al. 2003. Lit is the first germ-line mutation to reduce prostate cancer risk and prolong survival in the TRAMP transgenic model. Proc Am Assoc Cancer Res, 44:877.
    • (2003) Proc Am Assoc Cancer Res , vol.44 , pp. 877
    • Majeed, N.1    Kaplan, P.2    Blouin, M.3
  • 52
    • 0042515293 scopus 로고    scopus 로고
    • An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation
    • Maloney EK, McLaughlin JL, Dagdigian NE, et al. 2003. An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation. Cancer Res, 63:5073-83.
    • (2003) Cancer Res , vol.63 , pp. 5073-5083
    • Maloney, E.K.1    McLaughlin, J.L.2    Dagdigian, N.E.3
  • 53
    • 0242425922 scopus 로고    scopus 로고
    • A cross-sectional investigation of breast density and insulin-like growth factor I
    • Maskarinec G, William AE, Kaaks R. 2003. A cross-sectional investigation of breast density and insulin-like growth factor I. Int J Cancer, 107:996.
    • (2003) Int J Cancer , vol.107 , pp. 996
    • Maskarinec, G.1    William, A.E.2    Kaaks, R.3
  • 54
    • 0035829692 scopus 로고    scopus 로고
    • Insulin-like growth factor I stimulates motility in human neuroblastoma cells
    • Meyer GE, Shelden E, Kim B, et al. 2001. Insulin-like growth factor I stimulates motility in human neuroblastoma cells. Oncogene, 20:7542-50.
    • (2001) Oncogene , vol.20 , pp. 7542-7550
    • Meyer, G.E.1    Shelden, E.2    Kim, B.3
  • 55
    • 33845355343 scopus 로고    scopus 로고
    • Longitudinal study of birthweight and the incidence of breast cancer in adulthood
    • Michels KB, Xue F, Terry KL, et al. 2006. Longitudinal study of birthweight and the incidence of breast cancer in adulthood. Carcinogenesis, 27:2464-8.
    • (2006) Carcinogenesis , vol.27 , pp. 2464-2468
    • Michels, K.B.1    Xue, F.2    Terry, K.L.3
  • 56
    • 0031205542 scopus 로고    scopus 로고
    • IL-4 and insulin-like growth factor I inhibit the decline in Bcl-2 and promote the survival of IL-3 deprived myeloid progenitors
    • Minshall C. Arkins S, Straza J, et al. 1997. IL-4 and insulin-like growth factor I inhibit the decline in Bcl-2 and promote the survival of IL-3 deprived myeloid progenitors. J Immunol, 159:1225-32.
    • (1997) J Immunol , vol.159 , pp. 1225-1232
    • Minshall, C.1    Arkins, S.2    Straza, J.3
  • 57
    • 12144290914 scopus 로고    scopus 로고
    • Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors
    • Mitsiades CS, Mitsiades NS, McMullan CJ, et al. 2004. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell, 5:221-30.
    • (2004) Cancer Cell , vol.5 , pp. 221-230
    • Mitsiades, C.S.1    Mitsiades, N.S.2    McMullan, C.J.3
  • 58
    • 34249049000 scopus 로고    scopus 로고
    • Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib
    • Morgillo F, Kim WY, Kim ES, et al. 2007. Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res, 13:2795-803.
    • (2007) Clin Cancer Res , vol.13 , pp. 2795-2803
    • Morgillo, F.1    Kim, W.Y.2    Kim, E.S.3
  • 59
    • 0030032795 scopus 로고    scopus 로고
    • Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes
    • Moses AC, Young SC, Morrow LA, et al. 1996. Recombinant human insulin-like growth factor I increases insulin sensitivity and improves glycemic control in type II diabetes. Diabetes, 45:91-100.
    • (1996) Diabetes , vol.45 , pp. 91-100
    • Moses, A.C.1    Young, S.C.2    Morrow, L.A.3
  • 60
    • 28244432561 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
    • Nahta R, Yuan LX, Zhang B, et al. 2005. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res, 65:11118-28.
    • (2005) Cancer Res , vol.65 , pp. 11118-11128
    • Nahta, R.1    Yuan, L.X.2    Zhang, B.3
  • 61
    • 0031964262 scopus 로고    scopus 로고
    • The mannose 6-phosphate/ insulin-like growth factor 2 receptor (M6P/IGF2R), a putative breast tumor suppressor gene
    • Oates AJ, Schumaker LM, Jenkins SB, et al. 1998. The mannose 6-phosphate/ insulin-like growth factor 2 receptor (M6P/IGF2R), a putative breast tumor suppressor gene. Breast Cancer Res Treat, 47:269-81.
    • (1998) Breast Cancer Res Treat , vol.47 , pp. 269-281
    • Oates, A.J.1    Schumaker, L.M.2    Jenkins, S.B.3
  • 62
    • 0031551971 scopus 로고    scopus 로고
    • Loss of imprinting of the IGF2 gene in a Wilms' tumor in an adult
    • Oda H, Shimizu S, Minami K, et al. 1997. Loss of imprinting of the IGF2 gene in a Wilms' tumor in an adult. J Natl Cancer Institute, 89:1813-4.
    • (1997) J Natl Cancer Institute , vol.89 , pp. 1813-1814
    • Oda, H.1    Shimizu, S.2    Minami, K.3
  • 63
    • 0036097379 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells
    • Oh JS, Kucab JE, Bushel PR, et al. 2002. Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells. Neoplasia, 4:204-17.
    • (2002) Neoplasia , vol.4 , pp. 204-217
    • Oh, J.S.1    Kucab, J.E.2    Bushel, P.R.3
  • 64
    • 0036112482 scopus 로고    scopus 로고
    • Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: A prospective study in northern Sweden
    • Palmqvist R, Hallmans G, Rinaldi S, et al. 2002. Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden. Gut, 50:642-6.
    • (2002) Gut , vol.50 , pp. 642-646
    • Palmqvist, R.1    Hallmans, G.2    Rinaldi, S.3
  • 65
    • 0031047044 scopus 로고    scopus 로고
    • Insulin-like growth factor I inhibition of apoptosis is associated with increased expression of the bcl-xL gene product. Endocrinology, 138:1355-8. Patel BB, Sengupta R, Qazi S, et al. Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R
    • Parrizas M, LeRoith D. 1997. Insulin-like growth factor I inhibition of apoptosis is associated with increased expression of the bcl-xL gene product. Endocrinology, 138:1355-8. Patel BB, Sengupta R, Qazi S, et al. Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R. Int J Cancer, 122:267-73.
    • (1997) Int J Cancer , vol.122 , pp. 267-273
    • Parrizas, M.1    LeRoith, D.2
  • 66
    • 0027454914 scopus 로고
    • Plasma insulin-like growth factor-I (IGFI) concentrations in himan breast cancer
    • Peyrat JP, Bonneterre J, Hecquet B, et al. 1993. Plasma insulin-like growth factor-I (IGFI) concentrations in himan breast cancer. Eur J Cancer, 29A:492-7.
    • (1993) Eur J Cancer , vol.29 A , pp. 492-497
    • Peyrat, J.P.1    Bonneterre, J.2    Hecquet, B.3
  • 67
    • 0034806357 scopus 로고    scopus 로고
    • Insulin-like growth factors and prostate cancer
    • Pollak M. 2001. Insulin-like growth factors and prostate cancer. Epidemiol Rev, 23:59-66.
    • (2001) Epidemiol Rev , vol.23 , pp. 59-66
    • Pollak, M.1
  • 68
    • 0031941299 scopus 로고    scopus 로고
    • Mechanisms of antineoplastic action of somatostatin analogs
    • Pollak MN, Schally AV. 1998. Mechanisms of antineoplastic action of somatostatin analogs. Proc Soc Exp Med Biol, 217:143-52.
    • (1998) Proc Soc Exp Med Biol , vol.217 , pp. 143-152
    • Pollak, M.N.1    Schally, A.V.2
  • 70
    • 37049013701 scopus 로고    scopus 로고
    • Cancer incidence and mortality in relation to body mass index in the Million Women Study: Cohort study
    • Reeves GK, Pirie K, Beral V, et al. 2007. Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ, 335:1134.
    • (2007) BMJ , vol.335 , pp. 1134
    • Reeves, G.K.1    Pirie, K.2    Beral, V.3
  • 71
    • 0036793827 scopus 로고    scopus 로고
    • Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer
    • Reinmuth N, Liu W, Fan F, et al. 2002. Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer. Clin Cancer Res, 8:3259-69.
    • (2002) Clin Cancer Res , vol.8 , pp. 3259-3269
    • Reinmuth, N.1    Liu, W.2    Fan, F.3
  • 72
    • 0028318189 scopus 로고
    • Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice
    • Rogler CE, Yang D, Rossetti L, et al. 1994. Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice. J Biol Chem, 269:13779-84.
    • (1994) J Biol Chem , vol.269 , pp. 13779-13784
    • Rogler, C.E.1    Yang, D.2    Rossetti, L.3
  • 73
    • 34848903049 scopus 로고    scopus 로고
    • IMC-A12, a human IgG1 monoclonal antibod to the insulin-like growth factor I receptor
    • Rowinsky EK, Youssoufian H, Tonra JR, et al. 2007. IMC-A12, a human IgG1 monoclonal antibod to the insulin-like growth factor I receptor. Clin Cancer Res, 13(18 Pt 2):5549s-5555s.
    • (2007) Clin Cancer Res , vol.13 , Issue.18 PART 2
    • Rowinsky, E.K.1    Youssoufian, H.2    Tonra, J.R.3
  • 74
    • 0028006108 scopus 로고
    • Serum insulin-like growth factor I in healthy older men in relation to physical activity
    • Rudman D, Mattson DE. 1994. Serum insulin-like growth factor I in healthy older men in relation to physical activity. J Am Geriatr Soc, 42:71-6.
    • (1994) J Am Geriatr Soc , vol.42 , pp. 71-76
    • Rudman, D.1    Mattson, D.E.2
  • 75
    • 0037308651 scopus 로고    scopus 로고
    • A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I
    • Sachdev D, Li SL, Hartell JS, et al. 2003. A chimeric humanized single-chain antibody against the type I insulin-like growth factor (IGF) receptor renders breast cancer cells refractory to the mitogenic effects of IGF-I. Cancer Res, 63:627-35.
    • (2003) Cancer Res , vol.63 , pp. 627-635
    • Sachdev, D.1    Li, S.L.2    Hartell, J.S.3
  • 76
    • 0036716902 scopus 로고    scopus 로고
    • Self-reported birth weight and subsequent risk of colorectal cancer
    • Sandhu MS, Luben R, Day NE, et al. 2002. Self-reported birth weight and subsequent risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev, 11:935-8.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 935-938
    • Sandhu, M.S.1    Luben, R.2    Day, N.E.3
  • 77
    • 0036193571 scopus 로고    scopus 로고
    • Insulin-like growth factor-I-induced migration of melanoma cells is mediated by interleukin-8 induction
    • Satyamoorthy K, Li G, Vaidya B, et al. 2002. Insulin-like growth factor-I-induced migration of melanoma cells is mediated by interleukin-8 induction. Cell Growth Differ, 13:87-93.
    • (2002) Cell Growth Differ , vol.13 , pp. 87-93
    • Satyamoorthy, K.1    Li, G.2    Vaidya, B.3
  • 78
    • 0026081969 scopus 로고
    • In vivo metabolic action of insulin-like growth factor I in adult rats
    • Schmitz F, Hartmann H, Stumpel F, et al. 1991. In vivo metabolic action of insulin-like growth factor I in adult rats. Diabetologia, 34:144-9.
    • (1991) Diabetologia , vol.34 , pp. 144-149
    • Schmitz, F.1    Hartmann, H.2    Stumpel, F.3
  • 79
    • 0036722799 scopus 로고    scopus 로고
    • Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells
    • Scotlandi K, Avnet S, Benini S, et al. 2002. Expression of an IGF-I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells. Int J Cancer, 101:11-6.
    • (2002) Int J Cancer , vol.101 , pp. 11-16
    • Scotlandi, K.1    Avnet, S.2    Benini, S.3
  • 80
    • 0028332092 scopus 로고
    • Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts
    • Sell C, Dumenil G, Deveaud C, et al. 1994. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol, 14:3604-12.
    • (1994) Mol Cell Biol , vol.14 , pp. 3604-3612
    • Sell, C.1    Dumenil, G.2    Deveaud, C.3
  • 81
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. 2001. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med, 344:783-92.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 82
    • 4143057115 scopus 로고    scopus 로고
    • High levels of circulating insulin-like growth factor-I increase prostate cancer risk: A prospective study in a population-based non-screened cohort
    • Stattin P, Rinaldi S, Biessy C, et al. 2004. High levels of circulating insulin-like growth factor-I increase prostate cancer risk: a prospective study in a population-based non-screened cohort. J Clin Oncol, 22:3104-12.
    • (2004) J Clin Oncol , vol.22 , pp. 3104-3112
    • Stattin, P.1    Rinaldi, S.2    Biessy, C.3
  • 83
    • 0029826841 scopus 로고    scopus 로고
    • Protein and messenger ribonucleic acid (mRNA) for the type 1 insulin-like growth factor (IGF) receptor is decreased and IGF-II mRNA is increased in human prostate carcinoma compared to benign prostate epithelium
    • Tennant MK, Thrasher JB, Twomey PA, et al. 1996. Protein and messenger ribonucleic acid (mRNA) for the type 1 insulin-like growth factor (IGF) receptor is decreased and IGF-II mRNA is increased in human prostate carcinoma compared to benign prostate epithelium. J Clin Endocrinol Metab, 81:3774-82.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3774-3782
    • Tennant, M.K.1    Thrasher, J.B.2    Twomey, P.A.3
  • 84
    • 0029072776 scopus 로고
    • High birthweight as a predictor of prostate cancer risk
    • Tibblin G, Eriksson M, Cnattingius S, et al. 1995. High birthweight as a predictor of prostate cancer risk. Epidemiology, 6:423-4.
    • (1995) Epidemiology , vol.6 , pp. 423-424
    • Tibblin, G.1    Eriksson, M.2    Cnattingius, S.3
  • 85
    • 0025836230 scopus 로고
    • Induction of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice
    • Tornell J, Rymo L, Isakkson OG. 1991. Induction of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice. Int J Cancer, 49:114-7.
    • (1991) Int J Cancer , vol.49 , pp. 114-117
    • Tornell, J.1    Rymo, L.2    Isakkson, O.G.3
  • 86
    • 0032702836 scopus 로고    scopus 로고
    • Plasma insulin-like growth factor-I and serum IGF-binding protein 3 can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in African-American and Hispanic women
    • Vadgama JV, Wu Y, Datta G, et al. 1999. Plasma insulin-like growth factor-I and serum IGF-binding protein 3 can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in African-American and Hispanic women. Oncology, 57:330-40.
    • (1999) Oncology , vol.57 , pp. 330-340
    • Vadgama, J.V.1    Wu, Y.2    Datta, G.3
  • 87
    • 33845959800 scopus 로고    scopus 로고
    • Antibody targeting of the insulin-like growth factor I receptor enhances the anti-tumor response of multiple myeloma to chemotherapy through inhibition of tumor proliferation and angiogenesis
    • Wu KD, Zhou L, Burtrum D, et al. 2007. Antibody targeting of the insulin-like growth factor I receptor enhances the anti-tumor response of multiple myeloma to chemotherapy through inhibition of tumor proliferation and angiogenesis. Cancer Immunol Immunother, 56:343-57.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 343-357
    • Wu, K.D.1    Zhou, L.2    Burtrum, D.3
  • 88
    • 0042090507 scopus 로고    scopus 로고
    • Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors. Cancer Res, 63:4384-8. Xia Y, Jin L, Zhang B, et al. The potentiation of curcumin on insulin-like growth factor-1 action in MCF-7 human breast carcinoma cells
    • Wu Y, Cui K, Miyoshi K, et al. 2003. Reduced circulating insulin-like growth factor I levels delay the onset of chemically and genetically induced mammary tumors. Cancer Res, 63:4384-8. Xia Y, Jin L, Zhang B, et al. The potentiation of curcumin on insulin-like growth factor-1 action in MCF-7 human breast carcinoma cells. Life Sci, 80:2161-9.
    • (2003) Life Sci , vol.80 , pp. 2161-2169
    • Wu, Y.1    Cui, K.2    Miyoshi, K.3
  • 89
    • 0033179378 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor-1 receptor in synovial sarcoma: Association with an aggressive phenotype
    • Xie Y, Skytting B, Nilsson G, et al. 1999. Expression of insulin-like growth factor-1 receptor in synovial sarcoma: association with an aggressive phenotype. Cancer Res, 59:3588-91.
    • (1999) Cancer Res , vol.59 , pp. 3588-3591
    • Xie, Y.1    Skytting, B.2    Nilsson, G.3
  • 90
    • 33344467985 scopus 로고    scopus 로고
    • Targeting insulin-like growth factor pathways
    • Yee D. 2006. Targeting insulin-like growth factor pathways. Br J Cancer, 94:465-8.
    • (2006) Br J Cancer , vol.94 , pp. 465-468
    • Yee, D.1
  • 91
    • 0034692430 scopus 로고    scopus 로고
    • Role of the insulin-like growth factor family in cancer development and progression
    • Yu H, Rohan T. 2000. Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst, 92:1472-89.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1472-1489
    • Yu, H.1    Rohan, T.2
  • 92
    • 0030962307 scopus 로고    scopus 로고
    • Gene expression profiles in normal and cancer cells
    • Zhang L, Zhou W, Velculescu VE, et al. 1997. Gene expression profiles in normal and cancer cells. Science, 276:1268-72.
    • (1997) Science , vol.276 , pp. 1268-1272
    • Zhang, L.1    Zhou, W.2    Velculescu, V.E.3


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