Adult neurogenesis in the hypothalamus: Evidence, functions and implications

CNS and Neurological Disorders - Drug Targets

Volumn 10, Issue 4, 2011, Pages 433-439

  Yuan, Ti Fei ^a   Arias Carrión, Oscar ^b  

^a NCI ^*  (China)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Bromodeoxyuridine; Cell transplantation; Hypothalamus; Ki67; Neural stem cell; Neurogenesis; Proliferating cell nuclear antigen; Proliferation; Third ventricle

Indexed keywords

CYTOKINE; NEUROTROPHIC FACTOR;

ANIMAL MODEL; ARTICLE; BRAIN; BRAIN CORTEX; BRAIN THIRD VENTRICLE; DEGENERATIVE DISEASE; GENETIC IDENTIFICATION; HIPPOCAMPUS; HYPOTHALAMUS; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE FUNCTION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; REGULATORY MECHANISM; SUBVENTRICULAR ZONE;

EID: 79956272052     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/187152711795563985     Document Type: Article

References (80)

1. Zhao, C.; Deng, W.; Gage, F.H. Mechanisms and functional implications of adult neurogenesis. Cell, 2008, 132, 645-660.
2. Ihrie, R.A.; Alvarez-Buylla, A. Cells in the astroglial lineage are neural stem cells. Cell Tissue Res., 2008, 331, 179-191.
3. Chojnacki, A.K.; Mak, G.K.; Weiss, S. Identity crisis for adult periventricular neural stem cells: subventricular zone astrocytes, ependymal cells or both? Nat. Rev. Neurosci., 2009, 10, 153-163.
4. Lie, D.C.; Song, H.; Colamarino, S.A.; Ming, G.L.; Gage, F.H. Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu. Rev. Pharmacol. Toxicol., 2004, 44, 399-421.
5. Johansson, C.B.; Momma, S.; Clarke, D.L.; Risling, M.; Lendahl, U.; Frisén J. Identification of a neural stem cell in the adult mammalian central nervous system. Cell, 1999, 96, 25-34.
6. Seress, L. Postnatal neurogenesis in the rat hypothalamus. Brain Res., 1985, 354, 156-160.
7. Davis, F.C.; Boada, R.; LeDeaux, J. Neurogenesis of the hamster suprachiasmatic nucleus. Brain Res., 1990, 519, 192-199.
8. Iqbal, J.; Elmquist, J.K.; Ross, L.R.; Ackermann, M.R.; Jacobson, C.D. Postnatal neurogenesis of the hypothalamic paraventricular and supraoptic nuclei in the Brazilian opossum brain. Brain Res. Dev. Brain Res., 1995, 85, 151-160.
9. Huang, L.; DeVries, G.J.; Bittman, E.L. Photoperiod regulates neuronal bromodeoxyuridine labeling in the brain of a seasonally breeding mammal. J. Neurobiol., 1998, 36, 410-420.
10. Fowler, C.D.; Liu, Y.; Ouimet, C.; Wang, Z. The effects of social environment on adult neurogenesis in the female prairie vole. J. Neurobiol., 2002, 51, 115-128.
11. Kokoeva, M.V.; Yin, H.; Flier, J.S. Evidence for constitutive neural cell proliferation in the adult murine hypothalamus. J. Comp. Neurol., 2007, 505, 209-220.
12. Pierce, A.A.; Xu, A.W. De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance. J. Neurosci., 2010, 30, 723-730.
13. Xu, Y.; Tamamaki, N.; Noda, T.; Kimura, K.; Itokazu, Y.; Matsumoto, N.; Dezawa, M.; Ide, C. Neurogenesis in the ependymal layer of the adult rat 3rd ventricle. Exp. Neurol., 2005, 192, 251-264.
14. Raymond, A.D.; Kucherepa, N.N.; Fisher, K.R.; Halina, W.G.; Partlow, G.D. Neurogenesis of oxytocin-containing neurons in the paraventricular nucleus (PVN) of the female pig in 3 reproductive states: puberty gilts, adult gilts and lactating sows. Brain Res., 2006, 1102, 44-51.
15. Rankin, S.L.; Partlow, G.D.; McCurdy, R.D.; Giles, E.D.; Fisher, K.R. Postnatal neurogenesis in the vasopressin and oxytocincontaining nucleus of the pig hypothalamus. Brain Res., 2003, 971, 189-196.
16. Pencea, V.; Bingaman, K.D.; Wiegand, S.J.; Luskin, M.B. Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J. Neurosci., 2001, 21, 6706-6717.
17. Kokoeva, M.V.; Yin, H.; Flier, J.S. Neurogenesis in thehypothalamus of adult mice: potential role in energy balance. Science, 2005, 310, 679-683.
18. Alvarez-Buylla, A.; Garcia-Verdugo, J.M. Neurogenesis in adult subventricular zone. J. Neurosci., 2002, 22, 629-634.
19. Ming, G.L.; Song, H. Adult neurogenesis in the mammalian central nervous system. Annu. Rev. Neurosci., 2005, 28, 223-250.
20. Arias-Carrion, O.; Freundlieb, N.; Oertel, W.H.; Hoglinger, G.U. Adult neurogenesis and Parkinson's disease. CNS Neurol. Disord. Drug Targets, 2007, 6, 326-335.
21. Cho, K.O.; Kim, S.Y. Effects of brain insults and pharmacological manipulations on the adult hippocampal neurogenesis. Arch. Pharm. Res., 2010, 33, 1475-1488.
22. Mu, Y.; Lee, S.W.; Gage, F.H. Signaling in adult neurogenesis. Curr. Opin. Neurobiol., 2010, 20, 416-423.
23. Bath, K.G.; Lee, F.S. Neurotrophic factor control of adult SVZ neurogenesis. Dev. Neurobiol., 2010, 70, 339-349.
24. Zhang, L.; Yang, X.; Yang, S.; Zhang, J. The Wnt /beta-catenin signaling pathway in the adult neurogenesis. Eur. J. Neurosci., 2011, 33, 1-8.
25. Arias-Carrion, O.; Yamada, E.; Freundlieb, N.; Djufri, M.; Maurer, L.; Hermanns, G.; Ipach, B.; Chiu, W.H.; Steiner, C.; Oertel, W.H.; Höglinger, G.U. Neurogenesis in substantia nigra of parkinsonian brains? J. Neural Transm. Suppl., 2009, 279-285.
26. Arias-Carrión, O.D.-C.R. Neurogenesis as a therapeutic strategy to regenerate central nervous system. Rev. Neurol., 2007, 45, 739-745.
27. Parent, J.M. Injury-induced neurogenesis in the adult mammalian brain. Neuroscientist, 2003, 9, 261-272.
28. Hallbergson, A.F.; Gnatenco, C.; Peterson, D.A. Neurogenesis and brain injury: managing a renewable resource for repair. J. Clin. Invest., 2003, 112, 1128-1133.
29. Richardson, R.M.; Sun, D.; Bullock, M.R. Neurogenesis after traumatic brain injury. Neurosurg. Clin. N. Am., 2007, 18, 169-181, xi.
30. Arias-Carrion, O.; Yuan, T.F. Autologous neural stem cell transplantation: a new treatment option for Parkinson's disease? Med. Hypotheses, 2009, 73, 757-759.
31. Lopez-Toledano, M.A.; Ali Faghihi, M.; Patel, N.S.; Wahlestedt, C. Adult neurogenesis: a potential tool for early diagnosis in Alzheimer's disease? J. Alzheimers Dis., 2010, 20, 395-408.
32. Seri, B.; Garcia-Verdugo, J.M.; Collado-Morente, L.; McEwen, B.S.; Alvarez-Buylla, A. Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus. J. Comp. Neurol., 2004, 478, 359-378.
33. Doetsch, F.; Garcia-Verdugo, J.M.; Alvarez-Buylla, A. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J. Neurosci., 1997, 17, 5046-5061.
34. De Vitry, F.; Picart, R.; Jacque, C.; Legault, L.; Dupouey, P.; Tixier-Vidal, A. Presumptive common precursor for neuronal and glial cell lineages in mouse hypothalamus. Proc. Natl. Acad. Sci. USA, 1980, 77, 4165-4169.
35. Fowler, C.D.; Johnson, F.; Wang, Z. Estrogen regulation of cell proliferation and distribution of estrogen receptor-alpha in the brains of adult female prairie and meadow voles. J. Comp. Neurol., 2005, 489, 166-179.
36. Fowler, C.D.; Liu, Y.; Wang, Z. Estrogen and adult neurogenesis in the amygdala and hypothalamus. Brain Res. Rev., 2008, 57, 342-351.
37. Geoghegan, D.; Carter, D.A. A novel site of adult doublecortin expression: neuropeptide neurons within the suprachiasmatic nucleus circadian clock. BMC Neurosci., 2008, 9, 2.
38. Padilla, S.L.; Carmody, J.S.; Zeltser, L.M. Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits. Nat. Med., 2010, 16, 403-405.
39. Becker, S.; Wojtowicz, J.M. A model of hippocampal neurogenesis in memory and mood disorders. Trends Cogn. Sci., 2007, 11, 70-76.
40. Doetsch, F.; Hen, R. Young and excitable: the function of new neurons in the adult mammalian brain. Curr. Opin. Neurobiol., 2005, 15, 121-128.
41. Lledo, P.M.; Saghatelyan, A. Integrating new neurons into the adult olfactory bulb: joining the network, life-death decisions, and the effects of sensory experience. Trends Neurosci., 2005, 28, 248-254.
42. Shepherd, G.M.; Chen, W.R.; Willhite, D.; Migliore, M.; Greer, C.A. The olfactory granule cell: from classical enigma to central role in olfactory processing. Brain Res. Rev., 2007, 55, 373-382.
43. Yuan, T.F. Smell with new neurons. Cell Tissue Res., 2010, 340, 211-214.
44. Lazarini, F.; Lledo, P.M. Is adult neurogenesis essential for olfaction? Trends Neurosci., 2011, 34, 20-30.
45. Loseva, E.; Yuan, T.F.; Karnup, S. Neurogliogenesis in the mature olfactory system: A possible protective role against infection and toxic dust. Brain Res. Rev., 2009, 59, 374-387.
46. Hawken, P.A.; Jorre de St Jorre, T.; Rodger, J.; Esmaili, T.; Blache, D.; Martin, G.B. Rapid Induction of Cell Proliferation in the Adult Female Ungulate Brain (Ovis aries) Associated with Activation of the Reproductive Axis by Exposure to Unfamiliar Males. Biol. Reprod., 2009, 80(6), 1146-1151.
47. Jansen, H.T.; Iwamoto, G.A.; Jackson, G.L. Central connections of the ovine olfactory bulb formation identified using wheat germ agglutinin-conjugated horseradish peroxidase. Brain Res. Bull., 1998, 45, 27-39.
48. Price, J.L.; Slotnick, B.M.; Revial, M.F. Olfactory projections to the hypothalamus. J. Comp. Neurol., 1991, 306, 447-461.
49. Hess, D.C.; Borlongan, C.V. Stem cells and neurological diseases. Cell Prolif., 2008, 41(Suppl 1), 94-114.
50. Taupin, P. The therapeutic potential of adult neural stem cells. Curr. Opin. Mol. Ther., 2006, 8, 225-231.
51. Sun, D.; Bullock, M.R.; McGinn, M.J.; Zhou, Z.; Altememi, N.; Hagood, S.; Hamm, R.; Colello, R.J. Basic fibroblast growth factor-enhanced neurogenesis contributes to cognitive recovery in rats following traumatic brain injury. Exp. Neurol., 2009, 216, 56-65.
52. Fan, Y.; Liu, Z.; Weinstein, P.R.; Fike, J.R.; Liu, J. Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation. Eur. J. Neurosci., 2007, 25, 38-46.
53. Dhanushkodi, A.; Shetty, A.K. Is exposure to enriched environment beneficial for functional post-lesional recovery in temporal lobe epilepsy? Neurosci. Biobehav. Rev., 2008, 32, 657-674.
54. Chow, T.W.; Pollock, B.G.; Milgram, N.W. Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer's disease. Neuropsychiatr. Dis. Treat., 2007, 3, 627-636.
55. Kokaia, Z.; Lindvall, O. Neurogenesis after ischaemic brain insults. Curr. Opin. Neurobiol., 2003, 13, 127-132.
56. Zhang, R.L.; Zhang, Z.G.; Chopp, M. Neurogenesis in the adult ischemic brain: generation, migration, survival, and restorative therapy. Neuroscientist, 2005, 11, 408-416.
57. Chen, G.; Bonder, E.M.; Cheng, M.F. Lesion-induced neurogenesis in the hypothalamus is involved in behavioral recovery in adult ring doves. J. Neurobiol., 2006, 66, 537-551.
58. Cameron, H.A.; Dayer, A.G. New interneurons in the adult neocortex: small, sparse, but significant? Biol. Psychiatry, 2008, 63, 650-655.
59. Belsham, D.D.; Fick, L.J.; Dalvi, P.S.; Centeno, M.L.; Chalmers, J.A.; Lee, P.K.; Wang, Y.; Drucker, D.J.; Koletar, M.M. Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons. FASEB J., 2009, 23, 4256-4265.
60. Young, K.M.; Merson, T.D.; Sotthibundhu, A.; Coulson, E.J.; Bartlett, P.F. p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells. J. Neurosci., 2007, 27, 5146-5155.
61. Snapyan, M.; Lemasson, M.; Brill, M.S.; Blais, M.; Massouh, M.; Ninkovic, J.; Gravel, C.; Berthod, F.; Götz, M.; Barker, P.A.; Parent, A.; Saghatelyan, A. Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling. J. Neurosci., 2009, 29, 4172-4188.
62. Alonso, M.; Viollet, C.; Gabellec, M.M.; Meas-Yedid, V.; Olivo- Marin, J.C.; Lledo, P.M. Olfactory discrimination learning increases the survival of adult-born neurons in the olfactory bulb. J. Neurosci., 2006, 26, 10508-10513.
63. Chen, K.; Henry, R.A.; Hughes, S.M.; Connor, B. Creating a neurogenic environment: the role of BDNF and FGF2. Mol. Cell Neurosci., 2007, 36, 108-120.
64. Altman, J.; Das, G.D. Autoradiographic and histolo gical evidenceof postnatal hippocampal neurogenesis in rats. J. Comp. Neurol., 1965, 124, 319-335.
65. Altman, J. Autoradiographic and histological studi es of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J. Comp. Neurol., 1969, 137, 433-457.
66. Gould, E.; Reeves, A.J.; Graziano, M.S.; Gross, C.G. Neurogenesis in the neocortex of adult primates. Science, 1999, 286, 548-552.
67. Kornack, D.R.; Rakic, P. Cell proliferation without neurogenesis in adult primate neocortex. Science, 2001, 294, 2127-2130.
68. Eisch, A.J.; Mandyam, C.D. Adult neurogenesis: can analysis of cell cycle proteins move us Beyond BrdU? Curr. Pharm. Biotechnol., 2007, 8, 147-165.
69. Gould, E. How widespread is adult neurogenesis in mammals? Nat. Rev. Neurosci., 2007, 8, 481-488.
70. Bhardwaj, R.D.; Curtis, M.A.; Spalding, K.L.; Buchholz, B.A.; Fink, D.; Björk-Eriksson, T.; Nordborg, C.; Gage, F.H.; Druid, H.; Eriksson, P.S.; Frisén, J. Neocortical neurogenesis in humans is restricted to development. Proc. Natl. Acad. Sci. USA, 2006, 103, 12564-12568.
71. Breunig, J.J.; Arellano, J.I.; Macklis, J.D.; Rakic, P. Everything that glitters isn't gold: a critical review of postnatal neural precursor analyses. Cell Stem Cell, 2007, 1, 612-627.
72. Sakaue-Sawano, A.; Kurokawa, H.; Morimura, T.; Hanyu, A.; Hama, H.; Osawa, H.; Kashiwagi, S.; Fukami, K.; Miyata, T.; Miyoshi, H.; Imamura, T.; Ogawa, M.; Masai, H.; Miyawaki, A. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell, 2008, 132, 487-498.
73. Breton-Provencher, V.; Lemasson, M.; Peralta, M.R., 3rd; Saghatelyan, A. Interneurons produced in adulthood are required for the normal functioning of the olfactory bulb network and for the execution of selected olfactory behaviors. J. Neurosci., 2009, 29, 15245-15257.
74. Lazarini, F.; Mouthon, M.A.; Gheusi, G.; de Chaumont, F.; Olivo- Marin, J.C.; Lamarque, S.; Abrous, D.N.; Boussin, F.D.; Lledo, P.M. Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice. PLoS One, 2009, 4, e7017.
75. Saxe, M.D.; Battaglia, F.; Wang, J.W.; Malleret, G.; David, D.J.; Monckton, J.E.; Garcia, A.D.; Sofroniew, M.V.; Kandel, E.R.; Santarelli, L.; Hen, R.; Drew, M.R. Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc. Natl. Acad. Sci. USA, 2006, 103, 17501-17506.
76. Jin, K.; Wang, X.; Xie, L.; Mao, X.O.; Greenberg, D.A. Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice. Proc. Natl. Acad. Sci. USA, 2010, 107, 7993-7998.
77. Jiao, J.; Chen, D.F. Induction of neurogenesis in nonconventional neurogenic regions of the adult central nervous system by niche astrocyte-produced signals. Stem Cells, 2008, 26, 1221-1230.
78. Bernier, P.J.; Bedard, A.; Vinet, J.; Levesque, M.; Parent, A. Newly generated neurons in the amygdala and adjoining cortex of adult primates. Proc. Natl. Acad. Sci. USA, 2002, 99, 11464-11469.
79. Thompson, C.K.; Brenowitz, E.A. Neurogenesis in an adult avian song nucleus is reduced by decreasing caspase-mediated apoptosis. J. Neurosci., 2009, 29, 4586-4591.
80. Moraes, J.C.; Coope, A.; Morari, J.; Cintra, D.E.; Roman, E.A.; Pauli, J.R.; Romanatto, T.; Carvalheira, J.B.; Oliveira, A.L.; Saad, M.J.; Velloso, L.A. High-fat diet induces apoptosis of hypothalamic neurons. PLoS One, 2009, 4, e5045.