Assessment of Risk Factors for Multi-Drug Resistant Organisms to Guide Empiric Antibiotic Selection in Long Term Care: A Dilemma

Journal of the American Medical Directors Association

Volumn 12, Issue 5, 2011, Pages 321-325

  Drinka, Paul ^a   Niederman, Michael S ^b   El Solh, Ali A ^c   Crnich, Christopher J ^d  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b WINTHROP UNIVERSITY HOSPITAL   (United States)

^c VA WESTERN NEW YORK HEALTHCARE SYSTEM   (United States)

^d WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTAZIDIME; CIPROFLOXACIN; EXTENDED SPECTRUM BETA LACTAMASE; IMIPENEM; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; BACTERIAL COLONIZATION; BACTERIUM CULTURE; DISEASE COURSE; DISEASE SEVERITY; DRUG CHOICE; DRUG EFFICACY; EDITORIAL; ESCHERICHIA COLI; EXPOSURE VARIABLE; HOSPITALIZATION; HUMAN; INFECTION RISK; KLEBSIELLA; LONG TERM CARE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MULTIDRUG RESISTANCE; NONHUMAN; PNEUMONIA; PRACTICE GUIDELINE; PROGNOSIS; RISK ASSESSMENT; RISK FACTOR; TREATMENT DURATION; TREATMENT OUTCOME;

EID: 79956262311     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2010.06.012     Document Type: Editorial

References (51)

1. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005, 117:388-416.
2. Micek S.T., Kollef K.E., Reichley R.M., et al. Health care-associated pneumonia and community acquired pneumonia: a single center experience. Antimicrob Agents Chemother 2007, 51:3568-3573.
3. Ibrahim E.H., Sherman G., Ward S., et al. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU. Chest 2000, 118:146-155.
4. Garnacho-Montero J., Garcia-Garmendia J.L., Barrero-Almodovar A., et al. Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the ICU with sepsis. Crit Care Med 2003, 31:2742-2751.
5. Kollef M.H., Morrow L.E., Baughman R.P. Health care-associated pneumonia (HCAP): A critical appraisal to improve identification, management, and outcomes-proceedings of the HCAP summit. Clin Infect Dis 2008, 46:S296-334.
6. Safdar N., Bradley E.A. The risk of infection after nasal colonization with Staphylococcus aureus. Am J Med 2008, 121:310-315.
7. Drinka P.J., Faulks J.T., Gaurke C., et al. Adverse events associated with methicillin-resistant Staphylococcus aureus in a nursing home. Arch Intern Med 2001, 161:2371-2377.
8. Schweizer M.L., Furuno J.P., Harris A.D., et al. Clinical utility of infection control documentation of prior MRSA colonization or infection for optimization of empirical antibiotic therapy. Infect Control Hosp Epidemiol 2008, 29:972-974.
9. McCarthy N.L., Sullivan P.S., Gaynes R., et al. Risk factors associated with methicillin resistance in Staphylococcus aureus in veterans. Infect Control Hosp Epidemiol 2010, 31:36-41.
10. Herzke C.A., Chen L.F., Anderson D.J., et al. Empirical antimicrobial therapy for bloodstream infection due to MRSA: No better than a coin toss. Infect Control Hosp Epidemiol 2009, 30:1056-1061.
11. Pacio G.A., Visintaintainer P., Maguire G., et al. Natural history of colonization with vancomycin-resistant enterococci, MRSA, and resistant gram negative bacilli among LTCF residents. Infect Control Hosp Epidemiol 2003, 24:246-250.
12. Ben-Ami R., Schwaber M.J., Navon-Venezia D., et al. Influx of extended-spectrum B-lactimase-producing Enterobacteraciae into the hospital. Clin Infect Dis 2006, 42:925-934.
13. El-Solh Ali A.A., Pietrantoni C., Bhat A., et al. Colonization of dental plaques: A reservoir of respiratory pathogens for hospital-acquired pneumonia in institutionalized elders. Chest 2004, 126:1575-1582.
14. O'Fallon E., PopVicus A., D'Agata E. The emerging threat of multidrug resistant gram-negative organisms in long-term care facilities. J Gerontol A Biol Sci Med Sci 2009, 64A:138-141.
15. Pop-Vicas A., Tacconelli E., Gravenstein S., et al. Influx of multidrug-resistant, gram-negative bacteria in the hospital setting and the role of elderly patients with bacterial bloodstream infection. Infect Control Hosp Epidemiol 2009, 30:325-331.
16. Lautenbach E., Marsicano R., Tolomeo P. Epidemiology of antimicrobial resistance among gram negative organisms recovered from patients in a multistate network of long-term care facilities. Infect Control Hosp Epidemiol 2009, 30:790-793.
17. Merrer J., Santoli F., Appere de Vecchi C., et al. " Colonization pressure" and risk of acquisition of MRSA in a medical ICU. Infect Control Hosp Epidemiol 2000, 21:718-723.
18. Williams V.R., Callery S., Vearncombe M., et al. The role of colonization pressure in nosocomial transmission of MRSA. Am J Infect Control 2009, 37:106-110.
19. Dubberke E.R., Reske K.A., Olsen M.A., et al. Evaluation of Clostridium difficile-associated disease as a risk factor for C difficile-associated disease. Arch Intern Med 2007, 167:1092-1097.
20. Drinka P.J., Stemper M.E., Gauerke C.D., et al. Clustering of multiple endemic strains of methicillin resistant Staphylococcus aureus in a nursing home: An eight year study. Infect Control Hosp Epidemiol 2005, 26:215-218.
21. Drinka P.J. Methicillin-resistant Staphylococcus aureus in a nursing home [letter]. J Am Med Dir Assoc 2001, 2:201.
22. Loeb M.B., Craven S., McGeer A.J., et al. Risk factors for resistance to antimicrobial agents among nursing home residents. Am J Epidemiol 2003, 157:40-47.
23. Thomas J.K., Forrest A., Bhavnani S.M., et al. Pharmacodynamic evaluation of factors associated with the development of bacterial resistance in acutely ill patients during therapy. Antimicrob Agents Chemother 1998, 42:521-527.
24. Fish D.N., Piscitelli S.C., Danziger L.H.D. Development of resistance during antimicrobial therapy: A review of antibiotic classes and patient characteristics in 173 studies. Pharmacotherapy 1995, 15:279-291.
25. Drinka P.J., Gauerke C., Le D. Antimicrobial use and methicillin-resistant Staphylococcus aureus in a large nursing home. J Am Med Dir Assoc 2004, 5:256-258.
26. Drinka P.J., Faulks J.T., Gauerke C., Goodman B. A comparison of previous antibiotic therapy following isolation of MRSA versus MSSA in nursing home residents. J Am Med Dir Assoc 2002, 3:356-359.
27. Mandell L.A., Wunderink R.G., Anzueto A., et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007, 44:S27-S72.
28. Mulhausen P.L., Harrell L.J., Weinberger M., et al. Contrasting MRSA colonization in VA and community nursing homes. Am J Med 1996, 100:24-31.
29. O'Fallon E., Gautam S., D'Agata E.M. Colonization with multidrug-resistant gram-negative bacteria: Prolonged duration and frequent colonization. Clin Infect Dis 2009, 48:1375-1381.
30. Crnich CJ, Drinka P, Zimmerman DR, et al. Persistence of colonization with antibiotic-resistant bacteria among nursing home residents [Abstract #838]. In: Program and Abstracts of the 47th Annual Meeting of the Infectious Disease Society of America. Philadelphia: Infectious Disease Society of America, 2009.
31. Safdar N., Maki D.G. The commonality of risk factors for nosocomial colonization and infection with antimicrobial-resistant Staphylococcus aureus, Enterococcus, gram-negative bacilli, Clostridium difficile, and Candida. Ann Intern Med 2002, 136:834-844.
32. Shorr A.F., Zilerberg M.D., Micek S.T., et al. Prediction of infection due to antibiotic resistant bacteria by select risk factors for health care-associated pneumonia. Arch Intern Med 2008, 168:2205-2210.
33. El-Solh Ali A.A., Pietrantoni C., Bhat A., et al. Indicators of potentially drug-resistant bacteria in severe nursing home-acquired pneumonia. Clin Infect Dis 2004, 39:474-480.
34. Brito V., Niederman M.S. Healthcare-associated pneumonia is a heterogeneous disease, and all patients do not need the same broad-spectrum antibiotic therapy as complex nosocomial pneumonia. Curr Opin Infect Dis 2009, 22:316-325.
35. Drinka P. Preventing aspiration in the nursing home: The role of biofilm and data from the ICU. J Am Med Dir Assoc 2010, 11:70-77.
36. Marik P.E. Aspiration pneumonitis and aspiration pneumonia. N Engl J Med 2001, 344:665-671.
37. Mylotte J.M., Goodnough S., Gould M. Pneumonia versus aspiration pneumonitis in nursing home residents: Prospective application of a clinical algorithm. J Am Geriatr Soc 2005, 53:755-761.
38. El-Solh Ali A.A., Pietrantoni C., Bhat A., et al. Microbiology of severe aspiration pneumonia in institutionalized elderly. Am J Respir Crit Care Med 2003, 167:1650-1654.
39. Jaoude P.A., Knight P.R., Ohtake P., et al. Biomarkers in the diagnosis of aspiration syndrome. Expert Rev Mol Diagn 2010, 10:309-319.
40. El-Solh Ali A.A., Akinnumsi M.E., Alfarah Z., et al. Effect of antibiotic guidelines on outcomes of hospitalized patients with nursing home-acquired pneumonia. J Am Geriatr Soc 2009, 57:1030-1035.
41. Loeb M., Carusone S.C., Goeree R., et al. Effect of a clinical pathway to reduce hospitalizations in nursing home residents with pneumonia. JAMA 2006, 295:2503-2510.
42. Paladino J.A., Eubanks D.A., Adelman M.H., et al. Once daily cefepine versus ceftriaxone for nursing home acquired pneumonia. J Am Geriatr Soc 2007, 55:651-657.
43. Marcus E.L., Clarfield A.M., Moses A.E. Ethical issues relating to the use of antimicrobial therapy in older adults. Clin Infect Dis 2001, 33:1697-1705.
44. Fabiszewski K.J., Volcier B., Volcier L. Effect of antibiotic treatment on outcome of fevers in institutionalized Alzheimer patients. JAMA 1990, 263:3168-3172.
45. D'Agata E., Mitchell S.L. Patterns of antimicrobial use among nursing home residents with advanced dementia. Arch Intern Med 2008, 168:357-362.
46. McCarty C.E., Volcer L. Hospice access for individuals with dementia. Am J Alzheimers Dis Other Demen 2010, 24:476-485.
47. Mitchell S.L., Kiely D.L., Hamel M.B., et al. Estimating prognosis for nursing home residents with advanced dementia. JAMA 2004, 291:2734-2740.
48. Hooton T.M., Bradley S.F., Cardenas D.D., et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis 2010, 50:624-663.
49. Drinka P. Treatment of bacteriuria without urinary signs, symptoms, or a systemic infectious illness [editorial]. J Am Med Dir Assoc 2009, 10:516-519.
50. Drinka P.J., Hanlon J. Aspiration of gastric contents [editorial]. J Am Med Dir Assoc 2007, 8:345-346.
51. Drinka P. Limiting the impact of antibiotic resistance in nursing homes [editorial]. J Am Med Dir Assoc 2010, 11:537-539.