Interferon γ and interleukin 4 have contrasting effects on immunopathology and the development of protective adaptive immunity against mycoplasma respiratory disease

Journal of Infectious Diseases

Volumn 202, Issue 1, 2010, Pages 39-51

  Bodhankar, Sheetal ^a   Sun, Xiangle ^a   Woolard, Matthew D ^b   Simecka, Jerry W ^a  

^a UNIVERSITY OF NORTH TEXAS   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 4; MESSENGER RNA; INTERLEUKIN 5;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FEMALE; IMMUNIZATION; IMMUNOPATHOLOGY; MOUSE; MYCOPLASMA PULMONIS; MYCOPLASMOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY TRACT INFECTION; TH1 CELL; TH2 CELL; VACCINATION; ANIMAL; BAGG ALBINO MOUSE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MOUSE MUTANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADAPTIVE IMMUNITY; ANIMALS; FEMALE; GENE EXPRESSION REGULATION; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-4; INTERLEUKIN-5; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MYCOPLASMA INFECTIONS; RESPIRATORY TRACT INFECTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 77953703539     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/653121     Document Type: Article

References (38)

1. Freymuth F, Vabret A, Brouard J, et al. Detection of viral, Chlamydia pneumoniae and Mycoplasma pneumoniae infections in exacerbations of asthma in children. J Clin Virol 1999; 13:131-139.
2. Martin RJ, Chu HW, Honour JM, Harbeck RJ. Airway inflammation and bronchial hyperresponsiveness after Mycoplasma pneumoniae infection in a murine model. Am J Respir Cell Mol Biol 2001; 24:577-582.
3. Lindsey JR, Baker HJ, Overcash RG, Cassell GH, Hunt CE. Murine chronic respiratory disease: significance as a research complication and experimental production with Mycoplasma pulmonis. Am J Pathol 1971; 64:675-708.
4. Taylor G, Taylor-Robinson D, Fernald GW. Reduction of Mycoplasma pneumoniae-induced pneumonia in hamsters by immunosuppressive treatment with antithymocyte sera. J Med Microbiol 1974; 7:343.
5. Cartner SC, Lindsey JR, Gibbs-Erwin J, Cassell GH, Simecka JW Roles of innate and adaptive immunity in respiratory mycoplasmosis. Infect Immun 1998;66:3485-3491. (Pubitemid 28347799)
6. Keystone EQ Taylor-Robinson D, Osborn MF, Ling L, Pope C, Fornasier V. Effect of T-cell deficiency on the chronicity of arthritis induced in mice by Mycoplasma pulmonis. Infect Immun 1980;27:192-196.
7. Cassell GH, Davis JK. Protective effect of vaccination against Mycoplasma pulmonis respiratory disease in rats. Infect Immun 1978; 21: 69-75.
8. Hodge LM, Simecka JW Role of upper and lower respiratory tract immunity in resistance to mycoplasma respiratory disease. J Infect Dis 2002; 186:290-294.
9. Jones HP, Tabor L, Sun X, Woolard MD, Simecka JW Depletion of CD8+ T cells exacerbates CD4+ Th cell-associated inflammatory lesions during murine mycoplasma respiratory disease. J Immunol 2002; 168:3493-3501. (Pubitemid 34250416)
10. Bodhankar S, Woolard MD, Sun X, Simecka JW NK cells interfere with the generation of resistance against mycoplasma respiratory infection following nasal-pulmonary immunization. J Immunol 2009; 183:2622-2631.
11. Infante-Duarte C, Kamradt T. Th1/Th2 balance in infection. Springer Semin Immunopathol 1999;21:317-338.
12. Jones H, Tabor L, Sun X, Woolard M, Simecka J. Depletion of CD8+ T cells exacerbates CD4+ Th cell associated inflammatory lesions during murine mycoplasma respiratory disease. J Immunol 2002; 168: 3493-3501. (Pubitemid 34250416)
13. Renauld JC. New insights into the role of cytokines in asthma. J Clin Pathol 2001;54:577-589. (Pubitemid 32756438)
14. Szabo SJ, Sullivan BM, Peng SL, Glimcher LH. Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol 2003; 21:713-758. (Pubitemid 37174546)
15. Woolard MD, Hodge LM, Jones HP, Schoeb TR, Simecka JW The upper and lower respiratory tracts differ in their requirement of IFNgamma and IL-4 in controlling respiratory mycoplasma infection and disease. J Immunol 2004; 172:6875-6883.
16. Davidson MK, Davis JK, Lindsey JR, Cassell GH. Clearance of different strains of Mycoplasma pulmonis from the respiratory tract of C3H/ HeN mice. Infect Immun 1988;56:2163-2168.
17. Simecka JW, Cassell GH. Serum antibody and cellular responses in LEW and F344 rats after immunization with Mycoplasma pulmonis antigens. Infect Immun 1987;55:731-735.
18. Sun X, Jones HP, Hodge LM, Simecka JW Cytokine and chemokine transcription profile during Mycoplasma pulmonis infection in susceptible and resistant strains of mice: macrophage inflammatory protein lbeta (CCL4) and monocyte chemoattractant protein 2 (CCL8) and accumulation of CCR5+ Th cells. Infect Immun 2006; 74:5943-5954.
19. Haas H, Falcone FH, Holland MJ, et al. Early interleukin-4: its role in the switch towards a Th2 response and IgE-mediated allergy. Int Arch Allergy Immunol 1999; 119:86-94. (Pubitemid 29304463)
20. Okahashi N, Yamamoto M, Vancott JL, et al. Oral immunization of interleukin-4 (IL-4) knockout mice with a recombinant Salmonella strain or cholera toxin reveals that CD4+ Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses. Infect Immun 1996;64:1516-1525.
21. Taguchi T, Aicher WK, Fujihashi K, et al. Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5. J Immunol 1991; 147:3736-3744.
22. Overcash RG, Lindsey JR, Cassel GH, Baker HJ. Enhancement of natural and experimental respiratory mycoplasmosis in rats by hexamethylphosphoramide. Am J Pathol 1976;82:171-189.
23. Simecka JW, Thorp RB, Cassell GH. Dendritic cells are present in the alveolar region of lungs from specific pathogen-free rats. Reg Immunol 1992;4:18-24.
24. Gajewski TF, Fitch FW Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J Immunol 1988; 140: 4245-4252.
25. Chensue SW, Warmington KS, Ruth J, Lincoln PM, Kunkel SL. Crossregulatory role of interferon-gamma (IFN-gamma), IL-4 and IL-10 in schistosome egg granuloma formation: in vivo regulation of Th activity and inflammation. Clin Exp Immunol 1994; 98:395-400. (Pubitemid 24374722)
26. Wohlleben G, Erb KJ. The absence of IFN-gamma leads to increased Th2 responses after influenza A virus infection characterized by an increase in CD4+ but not CD8+ T cells producing IL-4 or IL-5 in the lung. Immunol Lett 2004;95:161-166. (Pubitemid 39237661)
27. Jones H, Hodge L, Fujihashi K, Kiyono H, McGhee JR, Simecka JW The pulmonary environment promotes Th2 cell responses after nasalpulmonary immunization with antigen alone, but Th1 responses are induced during instances of intense immune stimulation. J Immunol 2001; 167:4518-4526. (Pubitemid 32954330)
28. Ma B, Zhu Z, Homer RJ, Gerard C, Strieter R, Elias JA. The C10/ CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 2004; 172: 1872-1881. (Pubitemid 38116837)
29. Cimolai N, Cheong AC, Morrison BJ, Taylor GP. Mycoplasma pneumoniae reinfection and vaccination: protective oral vaccination and harmful immunoreactivity after re-infection and parenteral immunization. Vaccine 1996;14:1479-1483.
30. Bodhankar S, Woolard MD, Sun X, Simecka JW NK cells interfere with the generation of resistance against mycoplasma respiratory infection following nasal-pulmonary immunization. J Immunol 2009; 183:2622-2631.
31. Woolard MD, Hudig D, Tabor L, Ivey JAm Simecka JW NK cells in gamma-interferon-deficient mice suppress lung innate immunity against Mycoplasma spp. Infect Immun 2005;73:6742-6751. (Pubitemid 41368841)
32. Ordway D, Henao-Tamayo M, Smith E, et al. Animal model of Mycobacterium abscessus lung infection. J Leukoc Biol 2008; 83:1502-1511.
33. Boelen A, Kwakkel J, Barends M, de Rond L, Dormans J, Kimman T. Effect of lack of interleukin-4, interleukin-12, interleukin-18, or the interferon-gamma receptor on virus replication, cytokine response, and lung pathology during respiratory syncytial virus infection in mice. J Med Virol 2002;66:552-560. (Pubitemid 34203247)
34. Sieve AN, Meeks KD, Bodhankar S, et al. A novel IL-17-dependent mechanism of cross protection: respiratory infection with mycoplasma protects against a secondary listeria infection. Eur J Immunol 2009; 39:426-438.
35. Wu Q, Martin RJ, Rino JG, Breed R, Torres RM, Chu HW IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection. Microbes Infect 2007; 9:78-86. (Pubitemid 46149421)
36. North RJ. Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosis. Clin Exp Immunol 1998;113:55-58.
37. Hernandez-Pando R, Aguilar D, Hernandez ML, Orozco H, Rook G. Pulmonary tuberculosis in BALB/c mice with non-functional IL-4 genes: changes in the inflammatory effects of TNF-alpha and in the regulation of fibrosis. Eur J Immunol 2004;34:174-183. (Pubitemid 38111533)
38. Buccheri S, Reljic R, Caccamo N, et al. IL-4 depletion enhances host resistance and passive IgA protection against tuberculosis infection in BALB/c mice. Eur J Immunol 2007; 37:729-737. (Pubitemid 46916939)