Molecular mechanisms of HIV-1 mother-to-child transmission and infection in neonatal target cells

Life Sciences

Volumn 88, Issue 21-22, 2011, Pages 980-986

  Ahmad, Nafees ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

HIV disease progression; HIV 1 features associated with and lack of vertical transmission; HIV 1 genotypes and phenotypes; HIV 1 mother to child transmission; HIV 1 replication in neonatal mononuclear cells; Host factors; Pediatric AIDS; Viral load

Indexed keywords

CHEMOKINE RECEPTOR CCR5; COCAINE; CYCLIN DEPENDENT KINASE 9; CYCLIN T1; CYTOKINE; DIAMORPHINE; DNA POLYMERASE; EPITOPE; GAG PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE 14; METHAMPHETAMINE; OPIATE; PROTEIN P17; STAT3 PROTEIN; STAT5A PROTEIN; TRANSCRIPTION FACTOR E2F; VPR PROTEIN;

CD4+ T LYMPHOCYTE; CELL HETEROGENEITY; CYTOTOXIC T LYMPHOCYTE; DISEASE COURSE; DRUG ABUSE; GENE EXPRESSION; GENE MUTATION; GENE REPLICATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; IMMUNE RESPONSE; INFECTION RISK; INTRAPARTUM CARE; LYMPHOCYTE COUNT; MACROPHAGE; MONOCYTE; MOTHER TO CHILD TRANSMISSION; NEWBORN INFECTION; OLIGOMERIZATION; PLACENTAL TRANSFER; PNEUMOCYSTIS CARINII; PNEUMOCYSTIS PNEUMONIA; PROTEIN EXPRESSION; PUERPERIUM; REVIEW; SMOKING; SUBSTANCE ABUSE; T LYMPHOCYTE; TARGET CELL; VERTICAL TRANSMISSION; VIRUS INFECTIVITY; VIRUS LOAD; VIRUS REPLICATION; VIRUS TRANSMISSION;

EPITOPES; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; RECEPTORS, HIV; SUBSTANCE-RELATED DISORDERS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79956221791     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.09.023     Document Type: Review

References (67)

1. N. Ahmad, B.M. Baroudy, R.C. Baker, and C. Chappey Genetic analysis of human immunodeficiency virus type 1 envelope V3 region isolates from mothers and infants after perinatal transmission J Virol 69 2 1995 1001 1012
2. N. Ahmad The vertical transmission of human immunodeficiency virus type 1: molecular and biological properties of the virus Crit Rev s Clin Lab Sci 42 1 2005 1 34 (Pubitemid 41656708)
3. N. Ahmad Molecular mechanisms of HIV-1 vertical transmission and pathogenesis in infants Adv Pharmacol 56 2008 453 508
4. N. Ahmad Molecular mechansims of HIV-1 vertical transmission and pathogenesis in infants Adv Pharmacol 56 2008 453 508
5. A.M. Amedee, N. Lacour, J.L. Gierman, L.N. Martin, J.E. Clements, R. Bohm Jr., R.M. Harrison, and M. Murphey-Corb Genotypic selection of simian immunodeficiency virus in macaque infants infected transplacentally J Virol 69 12 1995 7982 7990
6. R.E. Bawdon, M. Gravell, R. Hamilton, J. Sever, R. Miller, and C.J. Gibbs Studies on the placental transfer of cell-free human immunodeficiency virus and p24 antigen in an ex vivo human placental model J Soc Gynecol Investig 1 1 1994 45 48 (Pubitemid 2064198)
7. P. Becquart, H. Hocini, M. Levy, A. Sepou, M.D. Kazatchkine, and L. Belec Secretory anti-human immunodeficiency virus (HIV) antibodies in colostrum and breast milk are not a major determinant of the protection of early postnatal transmission of HIV J Infect Dis 181 2 2000 532 539 (Pubitemid 30131820)
8. M. Bulterys, S. Landesman, D.N. Burns, A. Rubinstein, and J.J. Goedert Sexual behavior and injection drug use during pregnancy and vertical transmission of HIV-1 J Acquir Immune Defic Syndr Hum Retrovirol 15 1 1997 76 82
9. F. Buseyne, D. Scott-Algara, B. Corre, F. Porrot, E. Monchatre, N. Bellal, M. Burgard, C. Rouzioux, S. Blanche, and Y. Riviere Poor recognition of HIV-1 Nef protein by CD8 T cells from HIV-1-infected children: impact of age Virology 354 2 2006 271 279 (Pubitemid 44527966)
10. G.A. Cabral Drugs of abuse, immune modulation, and AIDS J Neuroimmune Pharmacol 1 3 2006 280 295 (Pubitemid 44244133)
11. Y. Cao, P. Krogstad, B.T. Korber, R.A. Koup, M. Muldoon, C. Macken, J.L. Song, Z. Jin, J.Q. Zhao, S. Clapp, I.S. Chen, D.D. Ho, and A.J. Ammann Maternal HIV-1 viral load and vertical transmission of infection: the Ariel Project for the prevention of HIV transmission from mother to infant Nat Med 3 5 1997 549 552 (Pubitemid 27198654)
12. C.H. Contag, A. Ehrnst, J. Duda, A.B. Bohlin, S. Lindgren, G.H. Learn, and J.I. Mullins Mother-to-infant transmission of human immunodeficiency virus type 1 involving five envelope sequence subtypes J Virol 71 2 1997 1292 1300 (Pubitemid 27030303)
13. E.R. Cooper, R.P. Nugent, C. Diaz, J. Pitt, C. Hanson, L.A. Kalish, H. Mendez, C. Zorrilla, R. Hershow, J. Moye, V. Smeriglio, and M.G. Fowler After AIDS clinical trial 076: the changing pattern of zidovudine use during pregnancy, and the subsequent reduction in the vertical transmission of human immunodeficiency virus in a cohort of infected women and their infants. Women and Infants Transmission Study Group J Infect Dis 174 6 1996 1207 1211 (Pubitemid 26393898)
14. K.F. Copeland Modulation of HIV-1 transcription by cytokines and chemokines Mini-Rev Med Chem 5 12 2005 1093 1101 (Pubitemid 41723566)
15. Y. Devash, T.A. Calvelli, D.G. Wood, K.J. Reagan, and A. Rubinstein Vertical transmission of human immunodeficiency virus is correlated with the absence of high-affinity/avidity maternal antibodies to the gp120 principal neutralizing domain Proc Natl Acad Sci USA 87 9 1990 3445 3449
16. N.K. Dhillon, R. Williams, F. Peng, Y.J. Tsai, S. Dhillon, B. Nicolay, M. Gadgil, A. Kumar, and S.J. Buch Cocaine-mediated enhancement of virus replication in macrophages: implications for human immunodeficiency virus-associated dementia J Neurovirol 13 6 2007 483 495
17. R.E. Dickover, E.M. Garratty, S. Plaeger, and Y.J. Bryson Perinatal transmission of major, minor, and multiple maternal human immunodeficiency virus type 1 variants in utero and intrapartum J Virol 75 5 2001 2194 2203 (Pubitemid 32147558)
18. P.M. Garcia, L.A. Kalish, J. Pitt, H. Minkoff, T.C. Quinn, S.K. Burchett, J. Kornegay, B. Jackson, J. Moye, C. Hanson, C. Zorrilla, and J.F. Lew Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. Women and Infants Transmission Study Group N Engl J Med 341 6 1999 394 402 (Pubitemid 29362512)
19. P.J. Goulder, C. Brander, Y. Tang, C. Tremblay, R.A. Colbert, M.M. Addo, E.S. Rosenberg, T. Nguyen, R. Allen, A. Trocha, M. Altfeld, S. He, M. Bunce, R. Funkhouser, S.I. Pelton, S.K. Burchett, K. McIntosh, B.T. Korber, and B.D. Walker Evolution and transmission of stable CTL escape mutations in HIV infection Nature 412 6844 2001 334 338 (Pubitemid 32694384)
20. L.A. Guay, P. Musoke, T. Fleming, D. Bagenda, M. Allen, C. Nakabiito, J. Sherman, P. Bakaki, C. Ducar, M. Deseyve, L. Emel, M. Mirochnick, M.G. Fowler, L. Mofenson, P. Miotti, K. Dransfield, D. Bray, F. Mmiro, and J.B. Jackson Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial Lancet 354 9181 1999 795 802 (Pubitemid 29415583)
21. T. Hahn, and N. Ahmad Genetic characterization of HIV type 1 gag p17 matrix genes in isolates from infected mothers lacking perinatal transmission AIDS Res Hum Retroviruses 17 17 2001 1673 1680 (Pubitemid 34072824)
22. T. Hahn, E. Matala, C. Chappey, and N. Ahmad Characterization of mother-infant HIV type 1 gag p17 sequences associated with perinatal transmission AIDS Res Hum Retroviruses 15 10 1999 875 888 (Pubitemid 29297679)
23. T. Hahn, R. Ramakrishnan, and N. Ahmad Evaluation of genetic diversity of human immunodeficiency virus type 1 NEF gene associated with vertical transmission J Biomed Sci 10 4 2003 436 450 (Pubitemid 36736983)
24. M.A. Huestis, and R.E. Choo Drug abuse's smallest victims: in utero drug exposure Forensic Sci Int 128 1-2 2002 20 30
25. M. Husain, T. Hahn, V.R. Yedavalli, and N. Ahmad Characterization of HIV type 1 tat sequences associated with perinatal transmission AIDS Res Hum Retroviruses 17 8 2001 765 773 (Pubitemid 32692415)
26. S.S. Hwang, T.J. Boyle, H.K. Lyerly, and B.R. Cullen Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1 Science 253 5015 1991 71 74 (Pubitemid 21917121)
27. V.A. Johnson, C.J. Petropoulos, C.R. Woods, J.D. Hazelwood, N.T. Parkin, C.D. Hamilton, and S.A. Fiscus Vertical transmission of multidrug-resistant human immunodeficiency virus type 1 (HIV-1) and continued evolution of drug resistance in an HIV-1-infected infant J Infect Dis 183 11 2001 1688 1693 (Pubitemid 32466710)
28. R.A. Koup, and C.B. Wilson Clinical immunology of HIV-infected children P.A. Pizzo, C.M. Wilfert, Pediatric AIDS: the challenge of HIV infection in infants, children, and adolescents 1993 Williams and Wilkins 158 165
29. A.P. Kourtis, F.K. Lee, E.J. Abrams, D.J. Jamieson, and M. Bulterys Mother-to-child transmission of HIV-1: timing and implications for prevention Lancet Infect Dis 6 11 2006 726 732 (Pubitemid 44601992)
30. S.L. Lamers, J.W. Sleasman, J.X. She, K.A. Barrie, S.M. Pomeroy, D.J. Barrett, and M.M. Goodenow Persistence of multiple maternal genotypes of human immunodeficiency virus type I in infants infected by vertical transmission J Clin Investig 93 1 1994 380 390 (Pubitemid 24030859)
31. K. Little, C. Thorne, C. Luo, M. Bunders, N. Ngongo, P. McDermott, and M.L. Newell Disease progression in children with vertically-acquired HIV infection in sub-Saharan Africa: reviewing the need for HIV treatment Curr HIV Res 5 2 2007 139 153 (Pubitemid 46488193)
32. B.L. Lohman, J.A. Slyker, B.A. Richardson, C. Farquhar, J.M. Mabuka, C. Crudder, T. Dong, E. Obimbo, D. Mbori-Ngacha, J. Overbaugh, S. Rowland-Jones, and G. John-Stewart Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infants J Virol 79 13 2005 8121 8130 (Pubitemid 40853515)
33. E. Matala, K.A. Crandall, R.C. Baker, and N. Ahmad Limited heterogeneity of HIV type 1 in infected mothers correlates with lack of vertical transmission AIDS Res Hum Retroviruses 16 15 2000 1481 1489
34. E. Matala, T. Hahn, V.R. Yedavalli, and N. Ahmad Biological characterization of HIV type 1 envelope V3 regions from mothers and infants associated with perinatal transmission AIDS Res Hum Retroviruses 17 18 2001 1725 1735 (Pubitemid 34114210)
35. Mehta R, Harris, DT, Ahmad, N. Differential HIV-1 replication in naïve and memory T lymphocytes from neonatal and adult blood is influenced at the level of HIV-1 gene expression. (2010, unpublished observation).
36. H. Mo, S. Monard, H. Pollack, J. Ip, G. Rochford, L. Wu, J. Hoxie, W. Borkowsky, D.D. Ho, and J.P. Moore Expression patterns of the HIV type 1 coreceptors CCR5 and CXCR4 on CD4+ T cells and monocytes from cord and adult blood AIDS Res Hum Retroviruses 14 7 1998 607 617 (Pubitemid 28196788)
37. G.A. Mulder-Kampinga, A. Simonon, C.L. Kuiken, J. Dekker, H.J. Scherpbier, P. van de Perre, K. Boer, and J. Goudsmit Similarity in env and gag genes between genomic RNAs of human immunodeficiency virus type 1 (HIV-1) from mother and infant is unrelated to time of HIV-1 RNA positivity in the child J Virol 69 4 1995 2285 2296
38. M.P. Nair, K.C. Chadha, R.G. Hewitt, S. Mahajan, A. Sweet, and S.A. Schwartz Cocaine differentially modulates chemokine production by mononuclear cells from normal donors and human immunodeficiency virus type 1-infected patients Clincal Diagn Lab Immunol 7 1 2000 96 100 (Pubitemid 30051469)
39. R. Narwa, P. Roques, C. Courpotin, F. Parnet-Mathieu, F. Boussin, A. Roane, D. Marce, G. Lasfargues, and D. Dormont Characterization of human immunodeficiency virus type 1 p17 matrix protein motifs associated with mother-to-child transmission J Virol 70 7 1996 4474 4483
40. B.S. Parekh, N. Shaffer, C.P. Pau, E. Abrams, P. Thomas, H. Pollack, M. Bamji, A. Kaul, G. Schochetman, M. Rogers, and M. George NYC, Collaborative Group. Lack of correlation between maternal antibodies to V3 loop peptides of gp120 and perinatal HIV-1 transmission. The NYC Perinatal HIV Transmission Collaborative Study AIDS 5 10 1991 1179 1184
41. H. Petropoulou, A.J. Stratigos, and A.D. Katsambas Human immunodeficiency virus infection and pregnancy Clincal Dermatol 24 6 2006 536 542 (Pubitemid 44755475)
42. S. Philpott, H. Burger, T. Charbonneau, R. Grimson, S.H. Vermund, A. Visosky, S. Nachman, A. Kovacs, P. Tropper, H. Frey, and B. Weiser CCR5 genotype and resistance to vertical transmission of HIV-1 J Acquiried Immune Defic Syndr Hum Retrovirol 21 3 1999 189 193 (Pubitemid 29331212)
43. R. Ramakrishnan, M. Hussain, A. Holzer, R. Mehta, V. Sundaravaradan, and N. Ahmad Evaluations of HIV type 1 rev gene diversity and functional domains following perinatal transmission AIDS Res Hum Retroviruses 21 12 2005 1035 1045 (Pubitemid 43069187)
44. R. Ramakrishnan, R. Mehta, V. Sundaravaradan, T. Davis, and N. Ahmad Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission Retrovirology 3 2006 42
45. J.D. Reeves, S.A. Gallo, N. Ahmad, J.L. Miamidian, P.E. Harvey, M. Sharron, S. Pohlmann, J.N. Sfakianos, C.A. Derdeyn, R. Blumenthal, E. Hunter, and R.W. Doms Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics Proc Natl Acad Sci USA 99 25 2002 16249 16254 (Pubitemid 35462781)
46. Report Report of a Consensus Workshop, Siena, Italy, January 17-18, 1992. Maternal factors involved in mother-to-child transmission of HIV-1 J Acquir Immune Defic Syndr 5 10 1992 1019 1029
47. E.M. Rodriguez, L.M. Mofenson, B.H. Chang, K.C. Rich, M.G. Fowler, V. Smeriglio, S. Landesman, H.E. Fox, C. Diaz, K. Green, and I.C. Hanson Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission AIDS 10 3 1996 273 282 (Pubitemid 26093487)
48. G. Scarlatti, T. Leitner, E. Halapi, J. Wahlberg, P. Marchisio, M.A. Clerici-Schoeller, H. Wigzell, E.M. Fenyo, J. Albert, M. Uhlen, and P. Rossi Comparison of variable region 3 sequences of human immunodeficiency virus type 1 from infected children with the RNA and DNA sequences of the virus populations of their mothers Proc Natl Academcy Sciencs USA 90 5 1993 1721 1725 (Pubitemid 23069928)
49. N. Shaffer, R. Chuachoowong, P.A. Mock, C. Bhadrakom, W. Siriwasin, N.L. Young, T. Chotpitayasunondh, S. Chearskul, A. Roongpisuthipong, P. Chinayon, J. Karon, T.D. Mastro, and R.J. Simonds Short-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: a randomised controlled trial. Bangkok Collaborative Perinatal HIV Transmission Study Group Lancet 353 9155 1999 773 780 (Pubitemid 29110401)
50. T. Shioda, J.A. Levy, and C. Cheng-Mayer Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene Nature 349 6305 1991 167 169 (Pubitemid 21912038)
51. J.W. Sleasman, L.F. Aleixo, A. Morton, S. Skoda-Smith, and M.M. Goodenow CD4+ memory T cells are the predominant population of HIV-1-infected lymphocytes in neonates and children AIDS 10 13 1996 1477 1484 (Pubitemid 26370660)
52. V. Sundaravaradan, T. Hahn, and N. Ahmad Conservation of functional domains and limited heterogeneity of HIV-1 reverse transcriptase gene following vertical transmission Retrovirology 2 2005 36
53. V. Sundaravaradan, S.K. Saxena, R. Ramakrishnan, V.R.K. Yedavalli, D.T. Harris, and N. Ahmad Differential HIV-1 replication in neonatal and adult blood mononuclear cells is influenced at the level of HIV-1 gene expression Proc Natl Acad Sci USA 103 31 2006 11701 11706 (Pubitemid 44182514)
54. V. Sundaravaradan, R. Mehta, D.T. Harris, J.A. Zack, and N. Ahmad Differential expression and interaction of host factors augment HIV-1 gene expression in neonatal mononuclear cells Virology 400 1 2010 32 43
55. T.E. Taha, J. Kumwenda, S.R. Cole, D.R. Hoover, G. Kafulafula, M.G. Fowler, M.C. Thigpen, Q. Li, N.I. Kumwenda, and L. Mofenson Postnatal HIV-1 transmission after cessation of infant extended antiretroviral prophylaxis and effect of maternal highly active antiretroviral therapy J Infect Dis 200 10 2009 1490 1497
56. C.T. Tiemessen, and L. Kuhn Immune pathogenesis of pediatric HIV-1 infection Curr HIV/AIDS Rep 3 1 2006 13 19 (Pubitemid 44623925)
57. B.P. Wellensiek, V. Sundaravaradan, R. Ramakrishnan, and N. Ahmad Molecular characterization of the HIV-1 gag nucleocapsid gene associated with vertical transmission Retrovirology 3 2006 21
58. B.P. Wellensiek, R. Ramakrishnan, V. Sundaravaradan, R. Mehta, D.T. Harris, and N. Ahmad Differential HIV-1 integration targets more actively transcribed host genes in neonatal than adult blood mononuclear cells Virology 385 1 2009 28 38
59. C.C. Wilson, R.C. Brown, B.T. Korber, B.M. Wilkes, D.J. Ruhl, D. Sakamoto, K. Kunstman, K. Luzuriaga, I.C. Hanson, S.M. Widmayer, A. Wiznia, S. Clapp, A.J. Ammann, R.A. Koup, S.M. Wolinsky, and B.D. Walker Frequent detection of escape from cytotoxic T-lymphocyte recognition in perinatal human immunodeficiency virus (HIV) type 1 transmission: the Ariel Project for the prevention of transmission of HIV from mother to infant J Virol 73 5 1999 3975 3985 (Pubitemid 29189842)
60. S.M. Wolinsky, C.M. Wike, B.T. Korber, C. Hutto, W.P. Parks, L.L. Rosenblum, K.J. Kunstman, M.R. Furtado, and J.L. Munoz Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants Science 255 5048 1992 1134 1137
61. X. Wu, A.B. Parast, B.A. Richardson, R. Nduati, G. John-Stewart, D. Mbori-Ngacha, S.M. Rainwater, and J. Overbaugh Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant J Virol 80 2 2006 835 844 (Pubitemid 43062895)
62. V.R. Yedavalli, and N. Ahmad Low conservation of functional domains of HIV type 1 vif and vpr genes in infected mothers correlates with lack of vertical transmission AIDS Res Hum Retroviruses 17 10 2001 911 923 (Pubitemid 32881334)
63. V.R. Yedavalli, C. Chappey, and N. Ahmad Maintenance of an intact human immunodeficiency virus type 1 vpr gene following mother-to-infant transmission J Virol 72 8 1998 6937 6943 (Pubitemid 28324021)
64. V.R. Yedavalli, C. Chappey, E. Matala, and N. Ahmad Conservation of an intact vif gene of human immunodeficiency virus type 1 during maternal-fetal transmission J Virol 72 2 1998 1092 1102 (Pubitemid 28116889)
65. V.R. Yedavalli, M. Husain, A. Horodner, and N. Ahmad Molecular characterization of HIV type 1 vpu genes from mothers and infants after perinatal transmission AIDS Res Hum Retroviruses 17 11 2001 1089 1098 (Pubitemid 32881329)
66. M.B. Zaitseva, S. Lee, R.L. Rabin, H.L. Tiffany, J.M. Farber, K.W. Peden, P.M. Murphy, and H. Golding CXCR4 and CCR5 on human thymocytes: biological function and role in HIV-1 infection J Immunol 161 6 1998 3103 3113 (Pubitemid 28425738)
67. T. Zhu, H. Mo, N. Wang, D.S. Nam, Y. Cao, R.A. Koup, and D.D. Ho Genotypic and phenotypic characterization of HIV-1 patients with primary infection Science 261 5125 1993 1179 1181 (Pubitemid 23300886)