Frequent detection of escape from cytotoxic T-lymphocyte recognition in perinatal human immunodeficiency virus (HIV) type 1 transmission: The Ariel project for the prevention of transmission of HIV from mother to infant

Journal of Virology

Volumn 73, Issue 5, 1999, Pages 3975-3985

  Wilson, Cara C ^a,k   Brown, R Clark ^b   Korber, Bette T ^c,d   Wilkes, Barbara M ^a   Ruhl, Debbie J ^a   Sakamoto, Doreen ^b   Kunstman, Kevin ^b   Luzuriaga, Katherine ^e   Hanson, I Celine ^f   Widmayer, Susan M ^g   Wiznia, Andrew ^h   Clapp, Sheila ⁱ   Ammann, Arthur J ^j   Koup, Richard A ^a,l   Wolinsky, Steven M ^a,b   Walker, Bruce D ^a,b   Van Dyke, Russell B ^m   Bardeguez, Arlene ⁿ   Viscarello, Richard R ^o   Ho, David ^p   Koup, Rick ^p   Chen, Irvin ^q   Krogstad, Paul ^q   Mullins, James ^r   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c SANTA FE INSTITUTE   (United States)

^d LOS ALAMOS NATIONAL LABORATORY   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^f BAYLOR COLLEGE OF MEDICINE   (United States)

^g Children's Diagnostic and Treatment Center   (United States)

^h BRONX LEBANON HOSPITAL CENTER   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j ROCKEFELLER UNIVERSITY   (United States)

^k UNIVERSITY OF COLORADO   (United States)

^l UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^m TULANE UNIVERSITY   (United States)

ⁿ RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^o PC   (United States)

^p AARON DIAMOND AIDS RESEARCH CENTER   (United States)

^q UNIVERSITY OF CALIFORNIA   (United States)

^r UNIVERSITY OF WASHINGTON   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENE FREQUENCY; HOST RESISTANCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; INFECTION PREVENTION; MAJOR CLINICAL STUDY; MOLECULAR CLONING; PLACENTAL TRANSFER; PRIORITY JOURNAL; VIRUS DETECTION; VIRUS TRANSMISSION;

EID: 0032901060     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.5.3975-3985.1999     Document Type: Article

References (64)

1. Back, N. K., L. Smit, M. Schutten, P. L. Nara, M. Tersmette, and J. Goudsmit. 1993. Mutations in human immunodeficiency virus type 1 gp41 affect sensitivity to neutralization by gp120 antibodies. J. Virol. 67:6897-6902.
2. Bertoletti, A., A. Sette, F. V. Chisari, A. Penna, M. Levrero, M. De Carli, F. Fiaccadori, and C. Ferrari. 1994. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 369:407-410.
3. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J. Virol. 68:6103-6110.
4. Borrow, P., H. Lewicki, X. Wei, M. S. Horwitz, N. Peffer, H. Meyers, J. A. Nelson, J. E. Gairin, B. H. Hahn, M. B. Oldstone, and G. M. Shaw. 1997. Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat. Med. 3:205-211.
5. Bryson, Y. J. 1996. Perinatal HIV-1 transmission: recent advances and therapeutic interventions. AIDS 10:S33-S42.
6. Cao, Y., P. Krogslad, B. T. Korber, R. A. Koup, M. Muldoon, C. Macken, J. L. Song, Z. Jin, J. Q. Zhao, S. Clapp, I. S. Chen, D. D. Ho, and A. J. Ammann. 1997. Maternal HIV-1 viral load and vertical transmission of infection: the Ariel Project for the prevention of HIV transmission from mother to infant. Nat. Med. 3:549-552.
7. Centers for Disease Control and Prevention. 1992. 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Morbid. Mortal. Weekly Rep. 41:RR-17.
8. Clerici, M., and G. M. Shearer. 1993. A TH1→TH2 switch is a critical step in the etiology of HIV infection. Immunol. Today 14:107-111.
9. Clerici, M., A. V. Sison, J. A. Berzofsky, T. A. Rakusan, C. D. Brandt, M. Ellaurie, M. Villa, C. Colie, D. J. Venzon, J. L. Sever, and G. M. Shearer. 1993. Cellular immune factors associated with mother-to-infant transmission of HIV. AIDS 7:1427-1433.
10. Coffin, J. M. 1995. HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267:483-489.
11. Coll, O., M. Hernandez, C. A. Boucher, C. Fortuny, B. M. de Tejada, Y. Canet, I. Caragol, J. Tijnagel, J. M. Bertran, and T. Espanol. 1997. Vertical HIV-1 transmission correlates with a high maternal viral load at delivery. J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 14:25-30.
12. Collins, K. L., B. K. Chen, S. A. Kalams, B. D. Walker, and D. Baltimore. 1998. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391:397-401.
13. Connor, E. M., R. S. Sperling, R. Gelber, P. Kiselev, G. Scott, M. J. O'Sullivan, R. VanDyke, M. Bey, W. Shearer, R. L. Jacobson, E. Jimenez, E. O'Neill, B. Bazin, J. Delfraissy, M. Culnane, R. Coombs, M. Elkins, J. Moye, P. Stratton, and J. Balsley. 1994. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N. Engl. J. Med. 331:1173-1180.
14. Devash, Y., T. A. Calvelli, D. G. Wood, K. J. Reagan, and A. Rubinstein. 1990. Vertical transmission of human immunodeficiency virus is correlated with the absence of high-affinity/avidity maternal antibodies to the gp120 principal neutralizing domain. Proc. Natl. Acad. Sci. USA 87:3445-3449.
15. DiBrino, M., K. C. Parker, J. Shiloach, M. Knierman, J. Lukszo, R. V. Turner, W. E. Biddison, and J. E. Coligan. 1993. Endogenous peptides bound to HLA-A3 possess a specific combination of anchor residues that permit identification of potential antigenic peptides. Proc. Natl. Acad. Sci. USA 90:1508-1512.
16. Dickover, R. E., E. M. Garratty, S. A. Herman, M. S. Sim, S. Plaeger, P. J. Boyer, M. Keller, A. Deveikis, E. R. Stiehm, and Y. J. Bryson. 1996. Identification of levels of maternal HIV-1 RNA associated with risk of perinatal transmission. Effect of maternal zidovudine treatment on viral load. JAMA 275:599-605.
17. Ehrnst, A., S. Lindgren, E. Belfrage, A. Sonnerborg, M. Dictor, B. Johansson, and A. B. Bohlin. 1992. Intrauterine and intrapartum transmission of HIV. Lancet 339:245-246.
18. Ehrnst, A., S. Lindgren, M. Dictor, B. Johansson, A. Sonnerborg, J. Czajkowski, G. Sundin, and A. B. Bohlin. 1991. HIV in pregnant women and their offspring: evidence for late transmission. Lancet 338:203-207.
19. Fang, G., H. Burger, R. Grimson, P. Tropper, S. Nachman, D. Mayers, O. Weislow, R. Moore, C. Reyelt, N. Hutcheon, D. Baker, and B. Weiser. 1995. Maternal plasma human immunodeficiency virus type 1 RNA level: a determinant and projected threshold for mother-to-child transmission. Proc. Natl. Acad. Sci. USA 92:12100-12104.
20. Faulkner, D. V., and J. Jurka. 1988. Multiple aligned sequence editor (MASE). Trends Biochem. Sci. 13:321-322.
21. Felsenstein, J. 1993. Phylogeny Inference Package (PHYLIP), version 3.5c. Department of Genetics, University of Washington, Seattle, Wash.
22. Ganeshan, S., R. E. Dickover, B. T. Korber, Y. J. Bryson, and S. M. Wolinsky. 1997. Human immunodeficiency virus type 1 genetic evolution in children with different rates of development of disease. J. Virol. 71:663-677.
23. Garrity, R. R., G. Rimmelzwaan, A. Minassian, W. P. Tsai, G. Lin, J. J. de Jong, J. Goudsmit, and P. L. Kara. 1997. Refocusing neutralizing antibody response by targeted dampening of an immunodominant epitope. J. Immunol. 159:279-289.
24. Goulder, P. J., R. E. Phillips, R. A. Colbert, S. McAdam, G. Ogg, M. A. Nowak, P. Giangrande, G. Luzzi, B. Morgan, A. Edwards, A. J. McMichael, and S. Rowland-Jones. 1997. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nat. Med. 3:212-217.
25. Goulder, P. J., A. K. Sewell, D. G. Lalloo, D. A. Price, J. A. Whelan, J. Evans, G. P. Taylor, G. Luzzi, P. Giangrande, R. E. Phillips, and A. J. McMichael. 1997. Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation. J. Exp. Med. 185:1423-1433.
26. Hahn, B. H., G. M. Shaw, S. K. Arya, M. Popovic, R. C. Gallo, and F. Wong-Staal. 1984. Molecular cloning and characterization of the HTLV-III virus associated with AIDS. Nature 312:166-169.
27. Harrer, T., E. Harrer, S. A. Kalams, P. Barbosa, A. Trocha, R. P. Johnson, T. Elbeik, M. B. Feinberg, S. P. Buchbinder, and B. D. Walker. 1996. Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load. J. Immunol. 156:2616-2623.
28. Hay, C. M., D. J. Ruhl, N. O. Basgoz, C. C. Wilson, J. M. Billingsley, M. P. DePasquale, R. T. D'Aquila, and B. D. Walker. Lack of viral escape and defective in vivo activation of HIV-1-specific CTL in rapidly progressive HIV-1 infection. Submitted for publication.
29. Huang, Y., W. A. Paxton, S. M. Wolinsky, A. U. Neumann, L. Zhang, T. He, S. Kang, D. Ceradini, Z. Jin, K. Yazdanbakhsh, K. Kunstman, D. Erickson, E. Dragon, N. R. Landau, J. Phair, D. D. Ho, and R. A. Koup. 1996. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat. Med. 2:1240-1243.
30. Husson, R. N., Y. Lan, E. Kojima, D. Venzon, H. Mitsuya, and K. McIntosh. 1995. Vertical transmission of human immunodeficiency virus type 1: autologous neutralizing antibody, virus load, and virus phenotype. J. Pediatr. 126:865-871.
31. Johnson, R. P., A. Trocha, T. M. Buchanan, and B. D. Walker. 1993. Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone. J. Virol. 67:438-445.
32. Johnson, R. P., A. Trocha, L. Yang, G. P. Mazzara, D. L. Panicali, T. M. Buchanan, and B. D. Walker. 1991, HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mono-nuclear cells and cloned effector cells. J. Immunol. 147:1512-1521.
33. Kalams, S. A., R. P. Johnson, M. J. Dynan, K. E. Hartman, T. Harrer, E. Harrer, A. K. Trocha, W. A. Blattner, S. P. Buchbinder, and B. D. Walker. 1996. T cell receptor usage and fine specificity of human immunodeficiency virus 1-specific cytotoxic T lymphocyte clones: analysis of quasispecies recognition reveals a dominant response directed against a minor in vivo variant. J. Exp. Med. 183:1669-1679.
34. Khouri, Y. F., K. McIntosh, L. Cavaclni, M. Posner, M. Pagano, R. Tuomala, and W. A. Marasco. 1995. Vertical transmission of HIV-1. Correlation with maternal viral load and plasma levels of CD4 binding site anti-gp120 anti-bodies. J. Clin. Investig. 95:732-737.
35. Klein, M. R., C. A. van Baalen, A. M. Holwerda, S. R. Kerkhof Garde, R. J. Bende, I. P. Keet, J. K. Eeftinck-Schattenkerk, A. D. Osterhaus, H. Schultemaker, and F. Miedema. 1995. Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics. J. Exp. Med. 181:1365-1372.
36. Klenerman, P., S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Koppe, W. Rosenberg, D. Boyd, A. Edwards, P. Giangrande, R. E. Phillips, and A. J. McMichael. 1994. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants. Nature 369:403-407.
37. Korber, B. T., C. Brander, B. F. Haynes, J. P. Moore, R. Koup, and B. D. Walker (ed.). 1997. HIV molecular immunology database 1997. Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, N.Mex.
38. Korber, B. T., K. J. Kunstman, B. K. Patterson, M. Furtado, M. M. McEvilly, R. Levy, and S. M. Wolinsky. 1994. Genetic differences between blood- and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences. J. Virol. 68:7467-7481.
39. Koup, R. A., J. T. Safrit, Y. Cao, C. A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D. D. Ho. 1994. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:4650-4655.
40. Kwok, S., and R. Higuchi. 1989. Avoiding false positives with PCR. Nature 339:237-238.
41. Landesman, S. H., L. A. Kalish, D. N. Burns, H. Minkoff, H. E. Fox, C. Zorrilla, P. Garcia, M. G. Fowler, L. Mofenson, and R. Tuomala. 1996. Obstetrical factors and the transmission of human immunodeficiency virus type 1 from mother to child. The Women and Infants Transmission Study. N. Engl. J. Med. 334:1617-1623.
42. Learn, G. H., Jr., B. T. Korber, B. Foley, B. H. Hahn, S. M. Wolinsky, and J. I. Mullins. 1996. Maintaining the integrity of human immunodeficiency virus sequence databases. J. Virol. 70:5720-5730.
43. Lu, Z., J. F. Berson, Y. Chen, J. D. Turner, T. Zhang, M. Sharron, M. H. Jenks, Z. Wang, J. Kim, J. Rucker, J. A. Hoxie, S. C. Peiper, and R. W. Doms. 1997. Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains. Proc. Natl. Acad. Sci. USA 94:6426-6431.
44. Luzuriaga, K., P. McQuilken, A. Alimenti, M. Somasundaran, R. Hesselton, and J. L. Sullivan. 1993. Early viremia and immune responses in vertical human immunodeficiency virus type 1 infection. J. Infect. Dis. 167:1008-1013.
45. Mofenson, L. M. 1997. Interaction between timing of perinatal human immunodeficiency virus infection and the design of preventive and therapeutic interventions. Acta Paediatr. Suppl. 421:1-9.
46. Mulder-Kampinga, G. A., A. Simonon, C. L. Kuiken, J. Dekker, H. J. Scherpbier, P. van de Perre, K. Boer, and J. Goudsmit. 1995. Similarity in env and gag genes between genomic RNAs of human immunodeficiency virus type 1 (HIV-1) from mother and infant is unrelated to time of HIV-1 RNA positivity in the child. J. Virol. 69:2285-2296.
47. Peckham, C., and D. Gibb. 1995. Mother-to-child transmission of the human immunodeficiency virus. N. Engl. J. Med. 333:298-302.
48. Phillips, R. E., S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. 1991. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 354:453-459.
49. Price, D. A., P. J. Goulder, P. Klenerman, A. K. Sewell, P. J. Easterbrook, M. Troop, C. R. Bangham, and R. E. Phillips. 1997. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc. Natl. Acad. Sci. USA 94:1890-1895.
50. Rammensee, H. G., T. Friede, and S. Stevanoviic. 1995. MHC ligands and peptide motifs: first listing, Immunogenetics 41:178-228.
51. Rinaldo, C., X. L. Huang, Z. F. Fan, M. Ding, L. Beltz, A. Logar, D. Panicali, G. Mazzara, J. Liebmann, M. Cottrill, and P. Gupta. 1995. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors. J. Virol. 49:5838-5842.
52. Robertson, C. A., J. Y. Mok, K. S. Froebel, P. Simmonds, S. M. Burns, H. S. Marsden, and S. Graham. 1992. Maternal antibodies to gp120 V3 sequence do not correlate with protection against vertical transmission of human immunodeficiency virus. J. Infect. Dis. 166:704-709.
53. Rossi, P., V. Moschese, P. A. Broliden, C. Fundaro, I. Quinti, A. Plebani, C. Giaquinto, P. A. Tovo, K. Ljunggren, J. Rosen, H. Wigzell, M. Jondal, and B. Wahren. 1989. Presence of maternal antibodies to human immunodeficiency virus 1 envelope glycoprotein gp120 epitopes correlates with the uninfected status of children born to seropositive mothers. Proc. Natl. Acad. Sci. USA 86:8055-8058.
54. Rowland-Jones, S. L., D. F. Nixon, M. C. Aldhous, F. Gotch, K. Ariyoshi, N. Hallam, J. S. Kroll, K. Froebel, and A. McMichael. 1993. HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant. Lancet 341:860-861.
55. Scarlatti, G., T. Leitner, E. Halapi, J. Wahlberg, P. Marchisio, M. A. Clerici· Schoeller, H. Wigzell, E. M. Fenyo, J. Albert, M. Uhlen, and P. Rossi. 1993. Comparison of variable region 3 sequences of human immunodeficiency virus type 1 from infected children with the RNA and DNA sequences of the virus populations of their mothers. Proc. Natl. Acad. Sci. USA 90:1721-1725.
56. Sperling, R. S., D. E. Shapiro, R. W. Coombs, J. A. Todd, S. A. Herman, G. D. McSherry, M. J. O'Sullivan, R. B. Van Dyke, E. Jimenez, C. Rouzioux, P. M. Flynn, and J. L. Sullivan. 1996. Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N. Engl. J. Med. 335:1621-1629.
57. Walker, B. D., C. Flexner, K. Birch-Limberger, L. Fisher, T. J. Paradis, A. Aldovini, R. Young, B. Moss, and R. T. Schooley. 1989. Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 86:9514-9518.
58. Weiser, B., S. Nachman, P. Tropper, K. H. Viscosi, R. Grimson, G. Baxter, G. Fang, C. Reyelt, N. Hutcheon, and H. Burger. 1994. Quantitation of human immunodeficiency virus type 1 during pregnancy: relationship of viral titer to mother-to-child transmission and stability of viral load. Proc. Natl. Acad. Sci. USA 91:8037-8041.
59. Wilson, C. C., S. A. Kalams, B. M. Wilkes, D. J. Ruhl, F. Gao, B. H. Hahn, I. C. Hanson, K. Luzuriaga, S. Wolinsky, R. Koup, S. P. Buchbinder, R. P. Johnson, and B. D. Walker. 1997. Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules: effects of viral variation on cytotoxic T-lymphocyte recognition. J. Virol. 71:1256-1264.
60. Wilson, C. C, and B. D. Walker. Unpublished data.
61. Wolinsky, S. M., B. T. Korber, A. U. Neumann, M. Daniels, K. J. Kunstman, A. J. Whetsell, M. R. Furtado, Y. Cao, D. D. Ho, and J. T. Safrit. 1996. Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection. Science 272:537-542.
62. Wolinsky, S. M., C. M. Wike, B. T. Korber, C. Hutto, W. P. Parks, L. L. Rosenblum, K. J. Kunstman, M. R. Furtado, and J. L. Munoz. 1992. Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants. Science 255:1134-1137.
63. Wong, J. T., and R. B. Colvin. 1987. Bi-specific monoclonal antibodies: selective binding and complement fixation to cells that express two different surface antigens. J. Immunol. 139:1369-1374.
64. + cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms. J. Virol. 71:3120-3128.