TGF-βi promotes islet β-cell function and regeneration

Journal of Immunology

Volumn 186, Issue 10, 2011, Pages 5833-5844

  Han, Bing ^a   Qi, Shijie ^a   Hu, Bing ^b   Luo, Hongyu ^a   Wu, Jiangping ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b QUEST DIAGNOSTICS NICHOLS INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA MICROARRAY; GENE; GENE EXPRESSION; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; TGF BETA I GENE;

ANIMALS; BLOOD GLUCOSE; CELL SURVIVAL; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; FOCAL ADHESION KINASE 1; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; REGENERATION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 79956213850     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002303     Document Type: Article

References (50)

1. Bosco, D., L. Orci, and P. Meda. 1989. Homologous but not heterologous contact increases the insulin secretion of individual pancreatic B-cells. Exp. Cell Res. 184: 72-80.
2. Halban, P. A., S. L. Powers, K. L. George, and S. Bonner-Weir. 1987. Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets. Diabetes 36: 783-790. (Pubitemid 17146577)
3. Hopcroft, D. W., D. R. Mason, and R. S. Scott. 1985. Structure-function relationships in pancreatic islets: support for intraislet modulation of insulin secretion. Endocrinology 117: 2073-2080.
4. Pinkse, G. G., W. P. Bouwman, R. Jiawan-Lalai, O. T. Terpstra, J. A. Bruijn, and E. de Heer. 2006. Integrin signaling via RGD peptides and anti-beta1 antibodies confers resistance to apoptosis in islets of Langerhans. Diabetes 55: 312-317. (Pubitemid 43343258)
5. Matter, M. L., and E. Ruoslahti. 2001. A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription. J. Biol. Chem. 276: 27757-27763.
6. Zhang, Z., K. Vuori, J. C. Reed, and E. Ruoslahti. 1995. The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc. Natl. Acad. Sci. USA 92: 6161-6165.
7. Kaido, T., M. Yebra, V. Cirulli, and A. M. Montgomery. 2004. Regulation of human beta-cell adhesion, motility, and insulin secretion by collagen IV and its receptor alpha1beta1. J. Biol. Chem. 279: 53762-53769.
8. Wang, R. N., and L. Rosenberg. 1999. Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship. J. Endocrinol. 163: 181-190.
9. Wang, R. N., S. Paraskevas, and L. Rosenberg. 1999. Characterization of integrin expression in islets isolated from hamster, canine, porcine, and human pancreas. J. Histochem. Cytochem. 47: 499-506.
10. Hauge-Evans, A. C., P. E. Squires, S. J. Persaud, and P. M. Jones. 1999. Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets. Diabetes 48: 1402-1408.
11. Cirulli, V., D. Baetens, U. Rutishauser, P. A. Halban, L. Orci, and D. G. Rouiller. 1994. Expression of neural cell adhesion molecule (N-CAM) in rat islets and its role in islet cell type segregation. J. Cell Sci. 107: 1429-1436.
12. Bernard-Kargar, C., N. Kassis, M. F. Berthault, W. Pralong, and A. Ktorza. 2001. Sialylated form of the neural cell adhesion molecule (NCAM): a new tool for the identification and sorting of beta-cell subpopulations with different functional activity. Diabetes 50(Suppl 1): S125-S130.
13. Dahl, U., A. Sjødin, and H. Semb. 1996. Cadherins regulate aggregation of pancreatic beta-cells in vivo. Development 122: 2895-2902. (Pubitemid 26326520)
14. Skonier, J., M. Neubauer, L. Madisen, K. Bennett, G. D. Plowman, and A. F. Purchio. 1992. cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta. DNA Cell Biol. 11: 511-522.
15. Skonier, J., K. Bennett, V. Rothwell, S. Kosowski, G. Plowman, P. Wallace, S. Edelhoff, C. Disteche, M. Neubauer, H. Marquardt, et al. 1994. beta ig-h3: a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attachment in vitro and suppresses the growth of CHO cells in nude mice. DNA Cell Biol. 13: 571-584.
16. Billings, P. C., D. J. Herrick, U. Kucich, B. N. Engelsberg, W. R. Abrams, E. J. Macarak, J. Rosenbloom, and P. S. Howard. 2000. Extracellular matrix and nuclear localization of beta ig-h3 in human bladder smooth muscle and fibroblast cells. J. Cell. Biochem. 79: 261-273.
17. Park, S. W., J. S. Bae, K. S. Kim, S. H. Park, B. H. Lee, J. Y. Choi, J. Y. Park, S. W. Ha, Y. L. Kim, T. H. Kwon, et al. 2004. Beta ig-h3 promotes renal proximal tubular epithelial cell adhesion, migration and proliferation through the interaction with alpha3beta1 integrin. Exp. Mol. Med. 36: 211-219.
18. Gilbert, R. E., J. L. Wilkinson-Berka, D. W. Johnson, A. Cox, T. Soulis, L. L. Wu, D. J. Kelly, G. Jerums, C. A. Pollock, and M. E. Cooper. 1998. Renal expression of transforming growth factor-beta inducible gene-h3 (beta ig-h3) in normal and diabetic rats. Kidney Int. 54: 1052-1062.
19. Lee, S. H., J. S. Bae, S. H. Park, B. H. Lee, R. W. Park, J. Y. Choi, J. Y. Park, S. W. Ha, Y. L. Kim, T. H. Kwon, and I. S. Kim. 2003. Expression of TGF-beta-induced matrix protein betaig-h3 is up-regulated in the diabetic rat kidney and human proximal tubular epithelial cells treated with high glucose. Kidney Int. 64: 1012-1021.
20. Schorderet, D. F., M. Menasche, S. Morand, S. Bonnel, V. Büchillier, D. Marchant, K. Auderset, C. Bonny, M. Abitbol, and F. L. Munier. 2000. Genomic characterization and embryonic expression of the mouse Bigh3 (Tgfbi) gene. Biochem. Biophys. Res. Commun. 274: 267-274.
21. Hashimoto, K., M. Noshiro, S. Ohno, T. Kawamoto, H. Satakeda, Y. Akagawa, K. Nakashima, A. Okimura, H. Ishida, T. Okamoto, et al. 1997. Characterization of a cartilage-derived 66-kDa protein (RGD-CAP/beta ig-h3) that binds to collagen. Biochim. Biophys. Acta 1355: 303-314.
22. Hanssen, E., B. Reinboth, and M. A. Gibson. 2003. Covalent and non-covalent interactions of betaig-h3 with collagen VI. Beta ig-h3 is covalently attached to the amino-terminal region of collagen VI in tissue microfibrils. J. Biol. Chem. 278: 24334-24341.
23. Thapa, N., K. B. Kang, and I. S. Kim. 2005. Beta ig-h3 mediates osteoblast adhesion and inhibits differentiation. Bone 36: 232-242.
24. Oh, J. E., J. K. Kook, and B. M. Min. 2005. Beta ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha3beta1 and the phosphatidylinositol 3-kinase/Akt signaling pathway. J. Biol. Chem. 280: 21629-21637.
25. Kim, J. E., S. J. Kim, H. W. Jeong, B. H. Lee, J. Y. Choi, R. W. Park, J. Y. Park, and I. S. Kim. 2003. RGD peptides released from beta ig-h3, a TGF-beta-induced cell-adhesive molecule, mediate apoptosis. Oncogene 22: 2045-2053.
26. Ruoslahti, E. 1996. RGD and other recognition sequences for integrins. Annu. Rev. Cell Dev. Biol. 12: 697-715.
27. Hynes, R. O. 2002. Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687. (Pubitemid 35283958)
28. Ohno, S., M. Noshiro, S. Makihira, T. Kawamoto, M. Shen, W. Yan, Y. Kawashima-Ohya, K. Fujimoto, K. Tanne, and Y. Kato. 1999. RGD-CAP ((beta)ig-h3) enhances the spreading of chondrocytes and fibroblasts via integrin alpha(1)beta(1). Biochim. Biophys. Acta 1451: 196-205.
29. Kim, M. O., S. J. Yun, I. S. Kim, S. Sohn, and E. H. Lee. 2003. Transforming growth factor-beta-inducible gene-h3 (beta(ig)-h3) promotes cell adhesion of human astrocytoma cells in vitro: implication of alpha6beta4 integrin. Neurosci. Lett. 336: 93-96.
30. Ferguson, J. W., B. S. Thoma, M. F. Mikesh, R. H. Kramer, K. L. Bennett, A. Purchio, B. J. Bellard, and R. G. LeBaron. 2003. The extracellular matrix protein betaIG-H3 is expressed at myotendinous junctions and supports muscle cell adhesion. Cell Tissue Res. 313: 93-105.
31. Kim, J. E., S. J. Kim, B. H. Lee, R. W. Park, K. S. Kim, and I. S. Kim. 2000. Identification of motifs for cell adhesion within the repeated domains of transforming growth factor-beta-induced gene, betaig-h3. J. Biol. Chem. 275: 30907-30915.
32. Klintworth, G. K. 2009. Corneal dystrophies. Orphanet J. Rare Dis. 4: 7.
33. Wu, Y., B. Han, H. Luo, R. Roduit, T. W. Salcedo, P. A. Moore, J. Zhang, and J. Wu. 2003. DcR3/TR6 effectively prevents islet primary nonfunction after transplantation. Diabetes 52: 2279-2286. (Pubitemid 37059498)
34. Han, B., P. A. Moore, J. Wu, and H. Luo. 2007. Overexpression of human decoy receptor 3 in mice results in a systemic lupus erythematosus-like syndrome. Arthritis Rheum. 56: 3748-3758. (Pubitemid 350100708)
35. Zhang, N., A. Richter, J. Suriawinata, S. Harbaran, J. Altomonte, L. Cong, H. Zhang, K. Song, M. Meseck, J. Bromberg, and H. Dong. 2004. Elevated vascular endothelial growth factor production in islets improves islet graft vascularization. Diabetes 53: 963-970. (Pubitemid 38436608)
36. Luther, M. J., E. Davies, D. Muller, M. Harrison, A. J. Bone, S. J. Persaud, and P. M. Jones. 2005. Cell-to-cell contact influences proliferative marker expression and apoptosis in MIN6 cells grown in islet-like structures. Am. J. Physiol. Endocrinol. Metab. 288: E502-E509.
37. Parsons, J. T. 2003. Focal adhesion kinase: the first ten years. J. Cell Sci. 116: 1409-1416. (Pubitemid 36527488)
38. Kenmochi, T., M. Miyamoto, and Y. Mullen. 1996. Protection of mouse islet isografts from nonspecific inflammatory damage by recipient treatment with nicotinamide and 15-deoxyspergualin. Cell Transplant. 5: 41-47. (Pubitemid 26075373)
39. Wahoff, D. C., B. E. Papalois, J. S. Najarian, D. M. Kendall, A. C. Farney, J. P. Leone, J. Jessurun, D. L. Dunn, R. P. Robertson, and D. E. Sutherland. 1995. Autologous islet transplantation to prevent diabetes after pancreatic resection. Ann. Surg. 222: 562-575, discussion 575-579.
40. Shapiro, A. M., J. R. Lakey, E. A. Ryan, G. S. Korbutt, E. Toth, G. L. Warnock, N. M. Kneteman, and R. V. Rajotte. 2000. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343: 230-238.
41. Witkowski, P., S. B. Zakai, A. Rana, Z. Sledzinski, and M. A. Hardy. 2006. Pancreatic islet transplantation, what has been achieved since Edmonton breakthrough. Ann. Transplant. 11: 5-13, discussion 32-43.
42. Gruessner, A. C., and D. E. Sutherland. 2005. Pancreas transplant outcomes for United States (US) and non-US cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR) as of June 2004. Clin. Transplant. 19: 433-455.
43. Rosenberg, L. 1998. Clinical islet cell transplantation. Are we there yet? Int. J. Pancreatol. 24: 145-168.
44. Rosenberg, L., R. Wang, S. Paraskevas, and D. Maysinger. 1999. Structural and functional changes resulting from islet isolation lead to islet cell death. Surgery 126: 393-398. (Pubitemid 29382809)
45. Thomas, F. T., J. L. Contreras, G. Bilbao, C. Ricordi, D. Curiel, and J. M. Thomas. 1999. Anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation. Surgery 126: 299-304.
46. Lupi, R., F. Dotta, L. Marselli, S. Del Guerra, M. Masini, C. Santangelo, G. Patané, U. Boggi, S. Piro, M. Anello, et al. 2002. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51: 1437-1442. (Pubitemid 34826609)
47. Prentki, M., E. Joly, W. El-Assaad, and R. Roduit. 2002. Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. Diabetes 51(Suppl 3): S405-S413. (Pubitemid 35403424)
48. Soon-Shiong, P., E. Feldman, R. Nelson, J. Komtebedde, O. Smidsrod, G. Skjak-Braek, T. Espevik, R. Heintz, and M. Lee. 1992. Successful reversal of spontaneous diabetes in dogs by intraperitoneal microencapsulated islets. Transplantation 54: 769-774.
49. Lanza, R. P., S. J. Sullivan, and W. L. Chick. 1992. Perspectives in diabetes. Islet transplantation with immunoisolation. Diabetes 41: 1503-1510.
50. Rygiel, K. A., H. Robertson, H. L. Marshall, M. Pekalski, L. Zhao, T. A. Booth, D. E. Jones, A. D. Burt, and J. A. Kirby. 2008. Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease. Lab. Invest. 88: 112-123.