16-Hydroxycleroda-3,13-dien-15,16-olide deregulates PI3K and Aurora B activities that involve in cancer cell apoptosis

Toxicology

Volumn 285, Issue 1-2, 2011, Pages 72-80

  Lin, Yi Hsiung ^a   Lee, Chien Chih ^a   Chan, Wen Li ^b   Chang, Wen Hsin ^c   Wu, Yang Chang ^a,d,e   Chang, Jan Gowth ^c,f  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

16 Hydroxycleroda 3,13 dien 15,16 olide; Apoptosis; Aurora B; Mitotic block; PI3K

Indexed keywords

16 HYDROXYCLERODA 3,13 DIEN 15,16 OLIDE; AURORA B KINASE; IMATINIB; NATURAL PRODUCT; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES; DNA DAMAGE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PIPERAZINES; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; SIGNAL TRANSDUCTION;

EID: 79956198599     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2011.04.004     Document Type: Article

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