Structural and functional characterization of Schistosoma mansoni thioredoxin

Protein Science

Volumn 20, Issue 6, 2011, Pages 1069-1076

  Boumis, Giovanna ^a   Angelucci, Francesco ^a   Bellelli, Andrea ^a   Brunori, Maurizio ^a   Dimastrogiovanni, Daniela ^a   Miele, Adriana E ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Detoxification metabolism; Schistosomiasis; Structural genomics; Thioredoxin; X ray crystallography

Indexed keywords

GLUTATHIONE; ISOPROTEIN; THIOREDOXIN;

ARTICLE; CRYSTAL STRUCTURE; ENZYME METABOLISM; ESCHERICHIA COLI; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SCHISTOSOMA MANSONI; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; HELMINTH PROTEINS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PROTEIN ISOFORMS; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SEQUENCE ALIGNMENT; THIOREDOXINS;

SCHISTOSOMA; SCHISTOSOMA MANSONI; SCHISTOSOMATIDAE;

EID: 79956194079     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.634     Document Type: Article

References (24)

1. Alger HM, Williams DL (2002) The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase. Mol Biochem Parasitol 121:129-139. (Pubitemid 34457840)
2. Alger HM, Sayed AA, Stadecker MJ, Williams DL (2002) Molecular and enzymatic characterisation of Schistosoma mansoni thioredoxin. Int J Parasitol 32:1285-1292. (Pubitemid 35232180)
3. Gourlay LJ, Angelucci F, Baiocco P, Boumis G, Brunori M, Bellelli A, Miele AE (2007) The three-dimensional structure of two redox states of cyclophilin A from Schistosoma mansoni. Evidence for redox regulation of peptidyl-prolyl cis-trans isomerase activity. J Biol Chem 282:24851-24857. (Pubitemid 47347521)
4. Cioli D, Valle C, Angelucci F, Miele AE (2008) Will new antischistosomal drugs finally emerge? Trends Parasitol 24:379-382.
5. Angelucci F, Miele AE, Boumis G, Dimastrogiovanni D, Brunori M, Bellelli A (2008) Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase. Proteins 72:936-945. (Pubitemid 352000871)
6. Angelucci F, Sayed AA, Williams DL, Boumis G, Brunori M, Dimastrogiovanni D, Miele AE, Pauly F, Bellelli A (2009) Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects. J Biol Chem 284:28977-28985.
7. Angelucci F, Dimastrogiovanni D, Boumis G, Brunori M, Miele AE, Saccoccia F, Bellelli A (2010) Mapping the catalytic cycle of Schistosoma mansoni thioredoxin glutathione reductase by X-ray crystallography. J Biol Chem 285:32557-32567.
8. Dimastrogiovanni D, Anselmi M, Miele AE, Boumis G, Petersson L, Angelucci F, Di Nola A, Brunori M, Bellelli A (2010) Combining crystallography and molecular dynamics: the case of Schistosoma mansoni phospholipid glutathione peroxidase. Proteins 78:259-270.
9. Yoshioka J, Schreiter ER, Lee RT (2006) Role of thioredoxin in cell growth through interactions with signalling molecules. Antioxid Redox Signal 8:2143-2151. (Pubitemid 46489637)
10. Wahl MC, Irmler A, Hecker B, Schirmer RH, Becker K (2005) Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster. J Mol Biol 345:1119-1130. (Pubitemid 40092229)
11. Krissinel E, Henrick K (2004) Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr D Biol Crystallogr 60 (Pt 12 Pt 1):2256-2268.
12. Bonilla M, Denicola A, Marino SM, Gladyshev VN, Salinas G (2011) Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation. J Biol Chem 286:4959-4967.
13. Kanzok SM, Schirmer RH, Türbachova I, Iozef R, Becker K (2000) The thioredoxin system of the Malaria Parasite Plasmodium falciparum. Glutathione reduction revisited. J Biol Chem 275:40180-40186. (Pubitemid 32064647)
14. Kanzok SM, Fechner A, Bauer H, Ulschmid JK, Müller HM, Botella-Munoz J, Schneuwly S, Schirmer R, Becker K (2001) Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster. Science 291:643-646. (Pubitemid 32150421)
15. Corona M, Robinson GE (2006) Genes of the antioxidant system of the honey bee: annotation and phylogeny. Insect Mol Biol 15:687-701. (Pubitemid 44652094)
16. Collaborative Computational Project, Number 4 (1994) The CCP4 Suite: Programs for Protein Crystallography. Acta Crystallogr D 50:760-763.
17. Vagin AA, Steiner RS, Lebedev AA, Potterton L, McNicholas S, Long F, Murshudov GN (2004) REFMAC5 dictionary: organisation of prior chemical knowledge and guidelines for its use. Acta Crystallogr D 60:2284-2295.
18. Emsley P, Lohkamp B, Scott WG, Cowtan K (2010) Features and development of Coot. Acta Crystallogr D 66:486-501.
19. Chen VB, Arendall WB, III, Headd JJ, Keedy DA, Immormino RM, Kapral GJ, Murray LW, Richardson JS, Richardson DC (2010) MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D 66:12-21.
20. Laskowski RA, MacArthur MW, Moss DS, Thornton JM (1993) PROCHECK - a program to check the stereochemical quality of protein structures. J Appl Crystallogr 26:283-291.
21. Potterton L, McNicholas S, Krissinel E, Gruber J, Cowtan K, Emsley P, Murshudov GN, Cohen S, Perrakis A, Noble M (2004) Developments in the CCP4 moleculargraphics project. Acta Crystallogr D 60:2288-2294.
22. Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG (2007) Clustal W and Clustal X version 2.0. Bioinformatics (Oxford, England) 23:2947-2498.
23. Holmgren A (1979) Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide. J Biol Chem 254:9627-9632.
24. Nelson JW, Creighton TE (1994) Reactivity and ionization of the active site cysteine residues of DsbA, a protein required for disulfide bond formation in vivo. Biochemistry 33:5974-5983. (Pubitemid 24184604)