메뉴 건너뛰기




Volumn 64, Issue 1, 2011, Pages 38-46

Reward-related genes and personality traits in alcohol-dependent individuals: A pilot case control study

Author keywords

Alcoholism; Dopamine; Ghrelin; Nicotinic acetylcholine receptor; Personality; Single nucleotide polymorphism; Temperament and Character Inventory

Indexed keywords

DOPAMINE 2 RECEPTOR; GHRELIN; GHRELIN RECEPTOR; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BETA3; UNCLASSIFIED DRUG;

EID: 79956192403     PISSN: 0302282X     EISSN: 14230224     Source Type: Journal    
DOI: 10.1159/000324992     Document Type: Article
Times cited : (37)

References (52)
  • 1
    • 34447343509 scopus 로고    scopus 로고
    • Impact of the hormonal milieu on the neurobiology of alcohol dependence and withdrawal
    • DOI 10.3200/GENP.133.4.337-356
    • Devaud LL, Risinger FO, Selvage D: Impact of the hormonal milieu on the neurobiology of alcohol dependence and withdrawal. J Gen Psychol 2006; 133: 337-356. (Pubitemid 44825392)
    • (2006) Journal of General Psychology , vol.133 , Issue.4 , pp. 337-356
    • Devaud, L.L.1    Risinger, F.O.2    Selvage, D.3
  • 2
    • 0012742584 scopus 로고
    • Influence of age and hormones on the stimulatory and sedative effects of etha-nol
    • in Ryberg U, Alling C, Engel J (eds) New York, Raven Press
    • Engel JA: Influence of age and hormones on the stimulatory and sedative effects of etha-nol; in Ryberg U, Alling C, Engel J (eds): Alcohol and the Developing Brain. New York, Raven Press, 1985, pp 55-67.
    • (1985) Alcohol and the Developing Brain , pp. 55-67
    • Engel, J.A.1
  • 3
    • 34247867965 scopus 로고    scopus 로고
    • Genetic and environmental in-fluences on the development of alcoholism: Resilience vs. risk
    • Enoch MA: Genetic and environmental in-fluences on the development of alcoholism: resilience vs. risk. Ann NY Acad Sci 2006; 1094: 193-201.
    • (2006) Ann NY Acad Sci , vol.1094 , pp. 193-201
    • Enoch, M.A.1
  • 4
    • 36849038927 scopus 로고    scopus 로고
    • Approach to the genetics of alcoholism: A review based on pathophysiology
    • DOI 10.1016/j.bcp.2007.06.021, PII S0006295207003826, Addiction
    • Köhnke MD: Approach to the genetics of Alcoholism: a review based on pathophysiology. Biochem Pharmacol 2008; 75: 160-177. (Pubitemid 350235389)
    • (2008) Biochemical Pharmacology , vol.75 , Issue.1 , pp. 160-177
    • Kohnke, M.D.1
  • 5
    • 0033231660 scopus 로고    scopus 로고
    • The dopamine hypothesis of reward: Past and current status
    • DOI 10.1016/S0166-2236(99)01447-2
    • Spanagel R, Weiss F: The dopamine hypoth-esis of reward: past and current status. Trends Neurosci 1999; 22:521-527. (Pubitemid 29481853)
    • (1999) Trends in Neurosciences , vol.22 , Issue.11 , pp. 521-527
    • Spanagel, R.1    Weiss, F.2
  • 6
    • 9944260910 scopus 로고    scopus 로고
    • Dopamine and alcoholism: Neurobiological basis of ethanol abuse
    • DOI 10.1016/j.pnpbp.2004.06.022, PII S0278584604001447
    • Tupala E, Tiihonen J: Dopamine and alco-holism: neurobiological basis of ethanol abuse. Prog Neuropsychopharmacol Biol Psychiatry 2004; 28:1221-1247. (Pubitemid 39592920)
    • (2004) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.28 , Issue.8 , pp. 1221-1247
    • Tupala, E.1    Tiihonen, J.2
  • 7
    • 0017678005 scopus 로고
    • Catecholamines and behavior
    • in Essman W, Valzelli L (eds) New York, Spectrum
    • Engel JA, Carlsson A: Catecholamines and behavior; in Essman W, Valzelli L (eds): Cur-rent Developments in Pharmacology. New York, Spectrum, 1977, vol 4, pp 3-32.
    • (1977) Cur-rent Developments in Pharmacology , vol.4 , pp. 3-32
    • Engel, J.A.1    Carlsson, A.2
  • 9
    • 0002134940 scopus 로고
    • The involvement of different central neurotransmitters in medi-ating stimulatory and sedative effects of eth-anol
    • in Pohorecky L, Brick J (eds) Amsterdam Elsevier
    • Engel JA, Liljequist S: The involvement of different central neurotransmitters in medi-ating stimulatory and sedative effects of eth-anol; in Pohorecky L, Brick J (eds): Stress and Alcohol Use. Amsterdam, Elsevier, 1983, pp 153-169.
    • (1983) Stress and Alcohol Use , pp. 153-169
    • Engel, J.A.1    Liljequist, S.2
  • 10
    • 0026505857 scopus 로고
    • Neu-roendocrine evidence for reduced dopamine receptor sensitivity in alcoholism
    • Balldin JI, Berggren UC, Lindstedt G: Neu-roendocrine evidence for reduced dopamine receptor sensitivity in alcoholism. Alcohol Clin Exp Res 1992; 16: 71-74.
    • (1992) Alcohol Clin Exp Res , vol.16 , pp. 71-74
    • Balldin, J.I.1    Berggren, U.C.2    Lindstedt, G.3
  • 12
    • 0036747883 scopus 로고    scopus 로고
    • Role of dopamine in drug reinforcement and addiction in humans: Results from imaging studies
    • Volkow ND, Fowler JS, Wang GJ: Role of do-pamine in drug reinforcement and addiction in humans: results from imaging studies. Be-hav Pharmacol 2002; 13: 355-366. (Pubitemid 35178832)
    • (2002) Behavioural Pharmacology , vol.13 , Issue.5-6 , pp. 355-366
    • Volkow, N.D.1    Fowler, J.S.2    Wang, G.-J.3
  • 13
    • 34247542196 scopus 로고    scopus 로고
    • Association of the DRD2 gene Taq1A polymorphism and alcoholism: A meta-analysis of case-control studies and evidence of publication bias
    • DOI 10.1038/sj.mp.4001938, PII 4001938
    • Munafo MR, Matheson IJ, Flint J: Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-con-trol studies and evidence of publication bias. Mol Psychiatry 2007; 12:454-461. (Pubitemid 46652456)
    • (2007) Molecular Psychiatry , vol.12 , Issue.5 , pp. 454-461
    • Munafo, M.R.1    Matheson, I.J.2    Flint, J.3
  • 15
    • 0042827344 scopus 로고    scopus 로고
    • D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes
    • Noble EP: D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet B NeuroPsychiatr Genet 2003; 116B:103-125. (Pubitemid 37063624)
    • (2003) American Journal of Medical Genetics - Neuropsychiatric Genetics , vol.116 B , Issue.1 , pp. 103-125
    • Noble, E.P.1
  • 16
    • 0027438502 scopus 로고
    • The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamine
    • DOI 10.1016/0014-2999(93)90434-J
    • Blomqvist O, Engel JA, Nissbrandt H, Soder-palm B: The mesolimbic dopamine-activat-ing properties of ethanol are antagonized by mecamylamine. Eur J Pharmacol 1993; 249: 207-213. (Pubitemid 23328888)
    • (1993) European Journal of Pharmacology , vol.249 , Issue.2 , pp. 207-213
    • Blomqvist, O.1    Engel, J.A.2    Nissbrandt, H.3    Soderpalm, B.4
  • 18
    • 1042274886 scopus 로고    scopus 로고
    • Neurochemical and behavioral studies on ethanol and nicotine interactions
    • DOI 10.1016/j.neubiorev.2003.11.010
    • Larsson A, Engel JA: Neurochemical and be-havioral studies on ethanol and nicotine in-teractions. Neuroscience and Biobehavioral Reviews 2004; 27: 713-720. (Pubitemid 38202247)
    • (2004) Neuroscience and Biobehavioral Reviews , vol.27 , Issue.8 , pp. 713-720
    • Larsson, A.1    Engel, J.A.2
  • 19
    • 36348949690 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptors in the ventral tegmental area mediate the dopamine activating and reinforcing properties of ethanol cues
    • DOI 10.1007/s00213-007-0899-4
    • Löf E, Olausson P, deBejczy A, Stomberg R, McIntosh JM, Taylor JR, Söderpalm B: Nicotinic acetylcholine receptors in the ventral tegmental area mediate the dopamine acti-vating and reinforcing properties of ethanol cues. Psychopharmacology 2007; 195: 333-343. (Pubitemid 350160265)
    • (2007) Psychopharmacology , vol.195 , Issue.3 , pp. 333-343
    • Lof, E.1    Olausson, P.2    DeBejczy, A.3    Stomberg, R.4    McIntosh, J.M.5    Taylor, J.R.6    Soderpalm, B.7
  • 20
    • 0030824009 scopus 로고    scopus 로고
    • Accumbal dopamine overflow after ethanol: Localization of the antagonizing effect of mecamylamine
    • DOI 10.1016/S0014-2999(97)01220-X, PII S001429999701220X
    • Blomqvist O, Ericson M, Engel JA, Söder-palm B: Accumbal dopamine overflow after ethanol: localization of the antagonizing effect of mecamylamine. Eur J Pharmacol 1997; 334:149-156. (Pubitemid 27451983)
    • (1997) European Journal of Pharmacology , vol.334 , Issue.2-3 , pp. 149-156
    • Blomqvist, O.1    Ericson, M.2    Engel, J.A.3    Soderpalm, B.4
  • 21
    • 0037466294 scopus 로고    scopus 로고
    • Ethanol elevates accumbal dopamine levels via indirect activation of ventral tegmental nicotinic acetylcholine receptors
    • DOI 10.1016/S0014-2999(03)01564-4
    • Ericson M, Molander A, Löf E, Engel JA, Sö-derpalm B: Ethanol elevates accumbal dopa-mine levels via indirect activation of ventral tegmental nicotinic acetylcholine receptors. Eur J Pharmacol 2003; 467: 85-93. (Pubitemid 36426936)
    • (2003) European Journal of Pharmacology , vol.467 , Issue.1-3 , pp. 85-93
    • Ericson, M.1    Molander, A.2    Lof, E.3    Engel, J.A.4    Soderpalm, B.5
  • 22
    • 0036874670 scopus 로고    scopus 로고
    • Role of different nicotinic acetylcholine receptors in mediating behavioral and neurochemical effects of ethanol in mice
    • DOI 10.1016/S0741-8329(02)00244-6, PII S0741832902002446
    • Larsson A, Svensson L, Söderpalm B, Engel JA: Role of different nicotinic acetylcholine receptors in mediating behavioral and neu-rochemical effects of ethanol in mice. Alcohol 2002; 28:157-167. (Pubitemid 36124008)
    • (2002) Alcohol , vol.28 , Issue.3 , pp. 157-167
    • Larsson, A.1    Svensson, L.2    Soderpalm, B.3    Engel, J.A.4
  • 23
    • 33748803585 scopus 로고    scopus 로고
    • Role of the subunit composition of central nicotinic acetylcholine receptors for the stimulatory and dopamine-enhancing effects of ethanol
    • DOI 10.1093/alcalc/agl049
    • Jerlhag E, Grötli M, Luthman K, Svensson L, Engel JA: Role of the subunit composition of central nicotinic acetylcholine receptors for the stimulatory and dopamine-enhancing effects of ethanol. Alcohol Alcohol 2006; 41: 486-493. (Pubitemid 44404464)
    • (2006) Alcohol and Alcoholism , vol.41 , Issue.5 , pp. 486-493
    • Jerlhag, E.1    Grotli, M.2    Luthman, K.3    Svensson, L.4    Engel, J.A.5
  • 24
    • 67649124250 scopus 로고    scopus 로고
    • Targeting the ghrelin receptor to regulate food intake
    • Depoortere I: Targeting the ghrelin receptor to regulate food intake. Regul Pept 2009; 156: 13-23.
    • (2009) Regul Pept , vol.156 , pp. 13-23
    • Depoortere, I.1
  • 25
    • 49349099488 scopus 로고    scopus 로고
    • Systemic administration of ghre-lin induces conditioned place preference and stimulates accumbal dopamine
    • Jerlhag E: Systemic administration of ghre-lin induces conditioned place preference and stimulates accumbal dopamine. Addict Biol 2008; 13: 358-363.
    • (2008) Addict Biol , vol.13 , pp. 358-363
    • Jerlhag, E.1
  • 26
    • 33947139281 scopus 로고    scopus 로고
    • Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens
    • DOI 10.1111/j.1369-1600.2006.00041.x
    • Jerlhag E, Egecioglu E, Dickson S, Douhan A, Svensson L, Engel JA: Ghrelin adminis-tration into tegmental areas stimulates loco-motor activity and increases extracellular concentration of dopamine in the nucleus accumbens. Addict Biol 2007; 12: 6-16. (Pubitemid 46405994)
    • (2007) Addiction Biology , vol.12 , Issue.1 , pp. 6-16
    • Jerlhag, E.1    Egecioglu, E.2    Dickson, S.L.3    Douhan, A.4    Svensson, L.5    Engel, J.A.6
  • 27
    • 44249109981 scopus 로고    scopus 로고
    • Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors are in-volved in mediating the ghrelin-induced lo-comotor stimulation and dopamine over-flow in nucleus accumbens
    • Jerlhag E, Egecioglu E, Dickson SL, Svensson L, Engel JA: Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors are in-volved in mediating the ghrelin-induced lo-comotor stimulation and dopamine over-flow in nucleus accumbens. Eur Neuropsy-chopharmacol 2008; 18: 508-518.
    • (2008) Eur Neuropsy-chopharmacol , vol.18 , pp. 508-518
    • Jerlhag, E.1    Egecioglu, E.2    Dickson, S.L.3    Svensson, L.4    Engel, J.A.5
  • 29
    • 33748362868 scopus 로고    scopus 로고
    • Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: Implications for its involvement in brain reward
    • DOI 10.1111/j.1369-1600.2006.00002.x
    • Jerlhag E, Egecioglu E, Dickson S, Andersson M, Svensson L, Engel JA: Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: Implications for its involvement in brain reward. Addict Biol 2006; 11:45-54. (Pubitemid 46696736)
    • (2006) Addiction Biology , vol.11 , Issue.1 , pp. 45-54
    • Jerlhag, E.1    Egecioglu, E.2    Dickson, S.L.3    Andersson, M.4    Svensson, L.5    Engel, J.A.6
  • 33
    • 33746886179 scopus 로고    scopus 로고
    • Subtypes of substance dependence and abuse: Implications for diagnostic classification and empirical research
    • DOI 10.1111/j.1360-0443.2006.01595.x
    • Babor TF, Caetano R: Subtypes of substance dependence and abuse: implications for diagnostic classification and empirical research. Addiction 2006; 101(suppl 1):104-110. (Pubitemid 44199501)
    • (2006) Addiction , vol.101 , Issue.SUPPL. 1 , pp. 104-110
    • Babor, T.F.1    Caetano, R.2
  • 34
    • 0028267212 scopus 로고
    • Temperament and personal-ity
    • Cloninger CR: Temperament and personal-ity. Curr Opin Neurobiol 1994; 4: 266-273.
    • (1994) Curr Opin Neurobiol , vol.4 , pp. 266-273
    • Cloninger, C.R.1
  • 36
    • 60249096629 scopus 로고    scopus 로고
    • An overview of genetic influ-ences in alcoholism
    • Schuckit MA: An overview of genetic influ-ences in alcoholism. J Subst Abuse Treat 2009; 36:S5-S14.
    • (2009) J Subst Abuse Treat , vol.36
    • Schuckit, M.A.1
  • 37
    • 52649181637 scopus 로고    scopus 로고
    • Self-reported health functioning in Swedish alcohol-dependent individuals: Age and gen-der perspectives
    • Berglund K, Berggren U, Fahlke C, Balldin J: Self-reported health functioning in Swedish alcohol-dependent individuals: age and gen-der perspectives. Nordic J Psychiatry 2008; 62: 405-412.
    • (2008) Nordic J Psychiatry , vol.62 , pp. 405-412
    • Berglund, K.1    Berggren, U.2    Fahlke, C.3    Balldin, J.4
  • 44
    • 0033006003 scopus 로고    scopus 로고
    • Allelic discrimination using fluorogenic probes and the 5' nuclease assay
    • DOI 10.1016/S1050-3862(98)00019-9, PII S1050386298000199
    • Livak KJ: Allelic discrimination using fluo-rogenic probes and the 5' nuclease assay. Genet Anal 1999; 14:143-149. (Pubitemid 29095371)
    • (1999) Genetic Analysis - Biomolecular Engineering , vol.14 , Issue.5-6 , pp. 143-149
    • Livak, K.J.1
  • 45
    • 79959503826 scopus 로고    scopus 로고
    • HapMap-Consortium: The International HapMap Project
    • HapMap-Consortium: The International HapMap Project. Nature 2003; 426:789-796.
    • (2003) Nature , vol.426 , pp. 789-796
  • 46
    • 67649111982 scopus 로고    scopus 로고
    • The Taqi A DRD2 polymorphism in type II alcohol dependence: A marker of age at onset or of a familial disease?
    • Pinto E, Reggers J, Gorwood P, Boni C, Scan-tamburlo G, Pitchot W, Ansseau M: The Taqi A DRD2 polymorphism in type II alcohol dependence: a marker of age at onset or of a familial disease? Alcohol 2009; 43: 271-275.
    • (2009) Alcohol , vol.43 , pp. 271-275
    • Pinto, E.1    Reggers, J.2    Gorwood, P.3    Boni, C.4    Scan-Tamburlo, G.5    Pitchot, W.6    Ansseau, M.7
  • 49
    • 24044510845 scopus 로고    scopus 로고
    • Voluntary ethanol intake increases extracellular acetylcholine levels in the ventral tegmental area in the rat
    • DOI 10.1093/alcalc/agh180
    • Larsson A, Edström L, Svensson L, Söder-palm B, Engel JA: Voluntary ethanol intake increases extracellular acetylcholine levels in the ventral tegmental area in the rat. Alcohol Alcohol 2005; 40: 349-358. (Pubitemid 41222392)
    • (2005) Alcohol and Alcoholism , vol.40 , Issue.5 , pp. 349-358
    • Larsson, A.1    Edstrom, L.2    Svensson, L.3    Soderpalm, B.4    Engel, J.A.5
  • 50
    • 14344260723 scopus 로고    scopus 로고
    • Is an α-conotoxin MII-sensitive mechanism involved in the neurochemical, stimulatory, and rewarding effects of ethanol?
    • DOI 10.1016/j.alcohol.2004.10.002
    • Larsson A, Jerlhag E, Svensson L, Söderpalm B, Engel JA: Is an α-conotoxin MII-sensitive mechanism involved in the neurochemical, stimulatory, and rewarding effects of ethanol? Alcohol 2004; 34: 239-250. (Pubitemid 40292783)
    • (2004) Alcohol , vol.34 , Issue.2-3 , pp. 239-250
    • Larsson, A.1    Jerlhag, E.2    Svensson, L.3    Soderpalm, B.4    Engel, J.A.5
  • 51
    • 77950843231 scopus 로고    scopus 로고
    • Low novelty seeking and high self-directedness scores in alcohol-depen-dent patients without comorbid psychiatric disorders homozygous for the a10 allele of the dopamine transporter gene
    • Anghelescu I, Klawe C, Singer P, Fehr C, Hiemke C, Quante A, Regen F, Dahmen N Szegedi A: Low novelty seeking and high self-directedness scores in alcohol-depen-dent patients without comorbid psychiatric disorders homozygous for the a10 allele of the dopamine transporter gene. World J Biol Psychiatry 2010; 11: 382-389.
    • (2010) World J Biol Psychiatry , vol.11 , pp. 382-389
    • Anghelescu, I.1    Klawe, C.2    Singer, P.3    Fehr, C.4    Hiemke, C.5    Quante, A.6    Regen, F.7    Dahmen Szegedi N, A.8
  • 52
    • 34247223114 scopus 로고    scopus 로고
    • Temperament and character in pathological gambling
    • Nordin C, Nylander PO: Temperament and character in pathological gambling. J Gambl Stud 2007; 23: 13-120.
    • (2007) J Gambl Stud , vol.23 , pp. 13-120
    • Nordin, C.1    Nylander, P.O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.