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Bioorganic Chemistry

Volumn 39, Issue 3, 2011, Pages 120-126

The role of the active site residues in human galactokinase: Implications for the mechanisms of GHMP kinases

(4) Megarity, Clare F a Huang, Meilan a Warnock, Claire a Timson, David J a

a QUEEN'S UNIVERSITY BELFAST (United Kingdom)

Author keywords

Active site base; Enzyme mechanism; Galactokinase; Galactosemia; GHMP kinase; Protein stability

Indexed keywords

ALANINE; ARGININE; ASPARAGINE; GALACTOKINASE; GALACTOSE; HOMOSERINE KINASE;

ARTICLE; CALCULATION; CATALYSIS; HUMAN; MOLECULAR MECHANICS; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTON TRANSPORT; QUANTUM MECHANICS; WILD TYPE;

ADENOSINE TRIPHOSPHATE; AMINO ACIDS; BINDING SITES; BIOCATALYSIS; CATALYTIC DOMAIN; ESCHERICHIA COLI; GALACTOKINASE; GALACTOSEMIAS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTONS; SUBSTRATE SPECIFICITY;

EID: 79956188833 PISSN: 00452068 EISSN: 10902120 Source Type: Journal
DOI: 10.1016/j.bioorg.2011.03.001 Document Type: Article

Times cited : (18)

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