Cell-based models of blood-brain barrier penetration

Therapeutic Delivery

Volumn 2, Issue 5, 2011, Pages 549-553

  Vastag, Monika ^a   Hellinger, Éva ^a   Bakk, Mónika L ^a   Tihanyi, Károly ^a  

^a GEDEON RICHTER LTD   (Hungary)

Author keywords

bloodbrain barrier; brain:plasma ratio; cell based bloodbrain barrier model; CNS penetration; efflux; surrogate bloodbrain barrier model

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5;

BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CAPILLARY ENDOTHELIUM; ENDOTHELIUM CELL; EPITHELIUM CELL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

EID: 79956156964     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.11.35     Document Type: Review

References (21)

1. Hammarlund-Udenas M, Fridén M, Syvanen S, Anubha G. On the rate and extent of drug delivery to the brain. Pharm. Res. 25(8), 1737-1749 (2008).
2. Reichel A. Addressing central nervous system (CNS) penetration in drug discovery: Basics and implications of the evolving new concept. Chem. Biodivers. 6(11), 2030-2049 (2009).
3. Butt AM, Jones HC, Abbott NJ. Electrical resistance across the blood-brain barrier in anaesthetized rats: A developmental study. J. Physiol. 429, 47-62 (1990). (Pubitemid 20327537)
4. Ohno K, Pettigrew KD, Rapoport SI. Lower limits of cerebrovascular permeability to nanoelectrolytes in the conscious rat. Am. J. Physiol. 235(3), H299-H307 (1978). (Pubitemid 9159902)
5. Gumbleton M, Audus KL. Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier. J. Pharm. Sci. 90(11), 1681-1698 (2001). (Pubitemid 33062590)
6. Terasaki T, Ohtsuki S, Hori S, Takanaga H, Nakashima E, Hosoya K. New approaches to in vitro models of blood-brain barrier drug transport. Drug Discov. Today 8(20), 944-954 (2003). (Pubitemid 37230014)
7. Ohtsuki S, Terasaki T. Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm. Res. 24(9), 1745-1758 (2007). (Pubitemid 47206624)
8. Dauchy S, Dutheil F, Weaver RJ et al. ABC transporters, cytochromes P450 and their main transcription factors: Expression at the human blood-brain barrier. J. Neurochem. 107(6), 1518-1528 (2008).
9. Warren MS, Zerangue N, Woodford K et al. Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human. Pharmacol. Res. 59(6), 404-413 (2009).
10. Deli MA, Ábrahám CS, Kataoka Y, Niwa M. Permeability studies on in vitro blood-brain barrier models: Physiology, pathology, and pharmacology. Cell. Mol. Neurobiol. 25(19), 59-127 (2005). (Pubitemid 40558585)
11. Abbott NJ, Dolman DE, Patabendige AK. Assays to predict permeation across the blood-brain barrier, and distribution to brain. Curr. Drug Metab. 9(9), 901-910 (2008).
12. Gaillard PJ, de Boer AG. Relationship between permeability status of the blood-brain barrier and in vitro permeability coefficient of a drug. Eur. J. Pharm. Sci. 12(2), 95-102 (2000).
13. Lohmann C, Hüwel S, Galla H-J. Predicting blood-brain barrier permeability of drugs: Evaluation of different in vitro assays. J. Drug Target. 10(4), 263-276 (2002). (Pubitemid 34746308)
14. Zhang Y, Li CSW, Ye Y et al. Porcine brain microvessel endothelial cells as an in vitro model to predict in vivo blood-brain barrier permeability. Drug Metab. Dispos. 34(11), 1935-1943 (2006). (Pubitemid 44771724)
15. Culot M, Lundquist S, Vanuxeem D et al. An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening. Toxicol. In Vitro 22(3), 799-811 (2008).
16. Nakagawa S, Deli MA, Kawaguchi H et al. A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes. Neurochem. Int. 54(3-4), 253-263 (2009).
17. Hellinger E, Bakk ML, Pócza P, Tihanyi K, Vastag M. Drug penetration model of vinblastine-treated Caco-2 cultures. Eur. J. Pharm. Sci. 41(1), 96-106 (2010).
18. Perriere N, Yousif S, Cazaubon S et al. A functional in vitro model of rat blood-brain barrier for molecular analysis of efflux transporters. Brain Res. 1150, 1-13 (2007). (Pubitemid 46711185)
19. Bachmeier CJ, Trickler WJ, Miller DW. Comparison of drug efflux transport kinetics in various blood-brain barrier models. Drug Metab. Dispos. 34(6), 998-1003 (2006). (Pubitemid 43763757)
20. Garberg P, Ball M, Borg N et al. In vitro models for the blood-brain barrier. Toxicol. In Vitro 19(3), 299-334 (2005). (Pubitemid 40248750)
21. Summerfield SG, Read K, Begley DJ et al. Central nervous system drug disposition: The relationship between in situ brain permeability and brain free fraction. J. Pharmacol. Exp. Ther. 322(1), 205-213 (2007). (Pubitemid 46956363)