Formation and characterization of DNA-polymer-condensates based on poly(2-methyl-2-oxazoline) grafted poly(l-lysine) for non-viral delivery of therapeutic DNA

Biomaterials

Volumn 32, Issue 22, 2011, Pages 5291-5303

  von Erlach, Thomas ^a   Zwicker, Sven ^a   Pidhatika, Bidhari ^a   Konradi, Rupert ^a   Textor, Marcus ^a   Hall, Heike ^a   Lühmann, Tessa ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Biocompatibility; DNA Delivery; PMOXA; Polymeric gene therapy; Serum stability

Indexed keywords

2-METHYL-2-OXAZOLINE; CELL VIABILITY; CHARGE RATIO; DNA DELIVERY; GENE DELIVERY SYSTEMS; GRAFTING DENSITIES; HYDRODYNAMIC DIAMETER; L-LYSINE; NONVIRAL; PERINUCLEAR REGION; PLASMID DNA; PMOXA; POLYMERIC GENE THERAPY; SERUM STABILITY; TRANSFECTION EFFICIENCY;

AMINO ACIDS; BIOCOMPATIBILITY; BODY FLUIDS; COPOLYMERIZATION; COPOLYMERS; DRUG THERAPY; FUNCTIONAL POLYMERS; GENE THERAPY; GENE TRANSFER; GRAFTING (CHEMICAL); MOLECULAR WEIGHT; NITROGEN COMPOUNDS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES;

DNA;

COPOLYMER; DEOXYRIBONUCLEASE I; DNA; PLASMID DNA; POLY(LYSINE) GRAFT POLY(2 METHYL 2 OXAZOLINE); UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; DENSITY; HYDRODYNAMICS; INTERNALIZATION; MOLECULAR WEIGHT; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL;

ANIMALS; CERCOPITHECUS AETHIOPS; CHITIN; COS CELLS; DNA; GENE THERAPY; GENE TRANSFER TECHNIQUES; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POLYLYSINE; POLYMERS;

EID: 79956151033     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.03.080     Document Type: Article

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