Aggretin, a Heterodimeric C-type Lectin from Calloselasma rhodostoma (Malayan Pit Viper), Stimulates Platelets by Binding to α 2β1 Integrin and Glycoprotein Ib, Activating Syk and Phospholipase Cγ2, but Does Not Involve the Glycoprotein VI/Fc Receptor γ Chain Collagen Receptor

Journal of Biological Chemistry

Volumn 276, Issue 24, 2001, Pages 20882-20889

  Navdaev, Alexei ^a   Clemetson, Jeannine M ^a   Polgár, János ^a,d   Kehrel, Beate E ^b   Glauner, Martin ^b   Magnenat, Edith ^c   Wells, Timothy N C ^c   Clemetson, Kenneth J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELL MEMBRANES; CHEMICAL ACTIVATION; MONOCLONAL ANTIBODIES; PHOSPHATES;

PLATELETS;

COLLAGEN;

AGGRETIN; ALPHA2 INTEGRIN; BETA1 INTEGRIN; FC RECEPTOR; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IB; INTEGRIN; LECTIN; PHOSPHOLIPASE C; UNCLASSIFIED DRUG; VIPER VENOM; COLLAGEN; COLLAGEN RECEPTOR; CONVULXIN; ENZYME PRECURSOR; ISOENZYME; PHOSPHOLIPASE C GAMMA; PHOSPHOTYROSINE; PROTEIN KINASE SYK; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE; RHODOCYTIN PROTEIN, CALLOSELASMA RHODOSTOMA; SIGNAL PEPTIDE; SNAKE VENOM; THROMBIN RECEPTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; TOXIN ANALYSIS; AFFINITY CHROMATOGRAPHY; AGKISTRODON; AMINO ACID SEQUENCE; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; DRUG EFFECT; HUMAN; IN VITRO STUDY; ISOLATION AND PURIFICATION; MOLECULAR GENETICS; PHOSPHORYLATION; PHYSIOLOGY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; THROMBOCYTE;

CALLOSELASMA RHODOSTOMA; CROTALINAE; SERPENTES; VERTEBRATA; VIPER;

AGKISTRODON; AMINO ACID SEQUENCE; ANIMALS; BLOOD PLATELETS; CHROMATOGRAPHY, AFFINITY; COLLAGEN; CROTALID VENOMS; ENZYME PRECURSORS; HUMANS; INTEGRINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOENZYMES; LECTINS; LECTINS, C-TYPE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PHOSPHOTYROSINE; PLATELET ACTIVATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PROTEIN SUBUNITS; PROTEIN-TYROSINE KINASES; RECEPTORS, COLLAGEN; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; VIPER VENOMS;

EID: 0035877664     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101585200     Document Type: Article

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