Decreased proliferation Kinetics of mouse myoblasts overexpressing FRG1

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Chen, Steven C ^a   Frett, Ellie ^a,d   Marx, Joseph ^a   Bosnakovski, Darko ^b   Reed, Xylena ^a,e   Kyba, Michael ^b   Kennedy, Brian K ^a,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOBLASTOMA PROTEIN; FRG1 PROTEIN, HUMAN; NUCLEAR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DIAPHRAGM MUSCLE; DYSTROPHY; FASCIOSCAPULOHUMERAL MUSCULAR DYSTROPHY REGION GENE 1; GENE; GENE OVEREXPRESSION; MOUSE; MYOBLAST; NONHUMAN; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE SATELLITE CELL; ANIMAL; BIOSYNTHESIS; CELL LINE; FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY; KINETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

MUS; MUS MUSCULUS;

ANIMALS; CELL LINE; CELL PROLIFERATION; G1 PHASE; KINETICS; MICE; MUSCULAR DYSTROPHY, FACIOSCAPULOHUMERAL; MYOBLASTS; NUCLEAR PROTEINS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN;

EID: 79956137778     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019780     Document Type: Article

References (59)

1. van der Maarel SM, Frants RR, Padberg GW, (2007) Facioscapulohumeral muscular dystrophy. Biochim Biophys Acta 1772: 186-194.
2. Lunt PW, Jardine PE, Koch MC, Maynard J, Osborn M, et al. (1995) Correlation between fragment size at D4F104S1 and age at onset or at wheelchair use, with a possible generational effect, accounts for much phenotypic variation in 4q35-facioscapulohumeral muscular dystrophy (FSHD). Hum Mol Genet 4: 951-958.
3. Tawil R, Forrester J, Griggs RC, Mendell J, Kissel J, et al. (1996) Evidence for anticipation and association of deletion size with severity in facioscapulohumeral muscular dystrophy. The FSH-DY Group. Ann Neurol 39: 744-748.
4. Ricci E, Galluzzi G, Deidda G, Cacurri S, Colantoni L, et al. (1999) Progress in the molecular diagnosis of facioscapulohumeral muscular dystrophy and correlation between the number of KpnI repeats at the 4q35 locus and clinical phenotype. Ann Neurol 45: 751-757.
5. Tawil R, Van Der Maarel SM, (2006) Facioscapulohumeral muscular dystrophy. Muscle Nerve 34: 1-15.
6. Sarfarazi M, Wijmenga C, Upadhyaya M, Weiffenbach B, Hyser C, et al. (1992) Regional mapping of facioscapulohumeral muscular dystrophy gene on 4q35: combined analysis of an international consortium. Am J Hum Genet 51: 396-403.
7. Wijmenga C, Frants RR, Brouwer OF, Moerer P, Weber JL, et al. (1990) Location of facioscapulohumeral muscular dystrophy gene on chromosome 4. Lancet 336: 651-653.
8. Wijmenga C, Hewitt JE, Sandkuijl LA, Clark LN, Wright TJ, et al. (1992) Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy. Nat Genet 2: 26-30.
9. van Deutekom JC, Wijmenga C, van Tienhoven EA, Gruter AM, Hewitt JE, et al. (1993) FSHD associated DNA rearrangements are due to deletions of integral copies of a 3.2 kb tandemly repeated unit. Hum Mol Genet 2: 2037-2042.
10. de Greef JC, Frants RR, van der Maarel SM, (2008) Epigenetic mechanisms of facioscapulohumeral muscular dystrophy. Mutat Res 647: 94-102.
11. Gabriels J, Beckers MC, Ding H, De Vriese A, Plaisance S, et al. (1999) Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. Gene 236: 25-32.
12. Beckers M, Gabriels J, van der Maarel S, De Vriese A, Frants RR, et al. (2001) Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. Gene 264: 51-57.
13. Clapp J, Mitchell LM, Bolland DJ, Fantes J, Corcoran AE, et al. (2007) Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. Am J Hum Genet 81: 264-279.
14. Ansseau E, Laoudj-Chenivesse D, Marcowycz A, Tassin A, Vanderplanck C, et al. (2009) DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation. PLoS One 4: e7482.
15. Snider L, Geng LN, Lemmers RJ, Kyba M, Ware CB, et al. (2010) Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene. PLoS Genet 6: e1001181.
16. Kowaljow V, Marcowycz A, Ansseau E, Conde CB, Sauvage S, et al. (2007) The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein. Neuromuscul Disord 17: 611-623.
17. Bosnakovski D, Xu Z, Gang EJ, Galindo CL, Liu M, et al. (2008) An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies. Embo J 27: 2766-2779.
18. Snider L, Asawachaicharn A, Tyler AE, Geng LN, Petek LM, et al. (2009) RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy. Hum Mol Genet 18: 2414-2430.
19. Lemmers RJ, van der Vliet PJ, Klooster R, Sacconi S, Camano P, et al. A unifying genetic model for facioscapulohumeral muscular dystrophy. Science 329: 1650-1653.
20. Caretti G, Di Padova M, Micales B, Lyons GE, Sartorelli V, (2004) The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev 18: 2627-2638.
21. Laible G, Wolf A, Dorn R, Reuter G, Nislow C, et al. (1997) Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres. Embo J 16: 3219-3232.
22. Forlani G, Giarda E, Ala U, Di Cunto F, Salani M, et al. The MeCP2/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis. Hum Mol Genet 19: 3114-3123.
23. Donohoe ME, Zhang LF, Xu N, Shi Y, Lee JT, (2007) Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell 25: 43-56.
24. Lehming N, Le Saux A, Schuller J, Ptashne M, (1998) Chromatin components as part of a putative transcriptional repressing complex. Proc Natl Acad Sci U S A 95: 7322-7326.
25. Lomberk G, Wallrath L, Urrutia R, (2006) The Heterochromatin Protein 1 family. Genome Biol 7: 228.
26. Erard MS, Belenguer P, Caizergues-Ferrer M, Pantaloni A, Amalric F, (1988) A major nucleolar protein, nucleolin, induces chromatin decondensation by binding to histone H1. Eur J Biochem 175: 525-530.
27. Bodega B, Ramirez GD, Grasser F, Cheli S, Brunelli S, et al. (2009) Remodeling of the chromatin structure of the facioscapulohumeral muscular dystrophy (FSHD) locus and upregulation of FSHD-related gene 1 (FRG1) expression during human myogenic differentiation. BMC Biol 7: 41.
28. Gabellini D, Green MR, Tupler R, (2002) Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle. Cell 110: 339-348.
29. Petrov A, Allinne J, Pirozhkova I, Laoudj D, Lipinski M, et al. (2008) A nuclear matrix attachment site in the 4q35 locus has an enhancer-blocking activity in vivo: implications for the facio-scapulo-humeral dystrophy. Genome Res 18: 39-45.
30. Petrov A, Pirozhkova I, Carnac G, Laoudj D, Lipinski M, et al. (2006) Chromatin loop domain organization within the 4q35 locus in facioscapulohumeral dystrophy patients versus normal human myoblasts. Proc Natl Acad Sci U S A 103: 6982-6987.
31. Pirozhkova I, Petrov A, Dmitriev P, Laoudj D, Lipinski M, et al. (2008) A functional role for 4qA/B in the structural rearrangement of the 4q35 region and in the regulation of FRG1 and ANT1 in facioscapulohumeral dystrophy. PLoS One 3: e3389.
32. Osborne RJ, Welle S, Venance SL, Thornton CA, Tawil R, (2007) Expression profile of FSHD supports a link between retinal vasculopathy and muscular dystrophy. Neurology 68: 569-577.
33. Gabellini D, D'Antona G, Moggio M, Prelle A, Zecca C, et al. (2006) Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1. Nature 439: 973-977.
34. Liu Q, Jones TI, Tang VW, Brieher WM, Jones PL, Facioscapulohumeral muscular dystrophy region gene-1 (FRG-1) is an actin-bundling protein associated with muscle-attachment sites. J Cell Sci 123: 1116-1123.
35. Hanel ML, Sun CY, Jones TI, Long SW, Zanotti S, et al. Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) is a dynamic nuclear and sarcomeric protein. Differentiation.
36. Hanel ML, Wuebbles RD, Jones PL, (2009) Muscular dystrophy candidate gene FRG1 is critical for muscle development. Dev Dyn 238: 1502-1512.
37. Wuebbles RD, Long SW, Hanel ML, Jones PL, (2010) Testing the effects of FSHD candidate gene expression in vertebrate muscle development. Int J Clin Exp Pathol 3: 386-400.
38. D'Antona G, Brocca L, Pansarasa O, Rinaldi C, Tupler R, et al. (2007) Structural and functional alterations of muscle fibres in the novel mouse model of facioscapulohumeral muscular dystrophy. J Physiol 584: 997-1009.
39. Frock RL, Kudlow BA, Evans AM, Jameson SA, Hauschka SD, et al. (2006) Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes Dev 20: 486-500.
40. Neville C, Rosenthal N, McGrew M, Bogdanova N, Hauschka S, (1997) Skeletal muscle cultures. Methods Cell Biol 52: 85-116.
41. Kudlow BA, Jameson SA, Kennedy BK, (2005) HIV protease inhibitors block adipocyte differentiation independently of lamin A/C. Aids 19: 1565-1573.
42. van Koningsbruggen S, Dirks RW, Mommaas AM, Onderwater JJ, Deidda G, et al. (2004) FRG1P is localised in the nucleolus, Cajal bodies, and speckles. J Med Genet 41: e46.
43. Frolov MV, Dyson NJ, (2004) Molecular mechanisms of E2F-dependent activation and pRB-mediated repression. J Cell Sci 117: 2173-2181.
44. Trimarchi JM, Lees JA, (2002) Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol 3: 11-20.
45. Watchko JF, O'Day TL, Hoffman EP, (2002) Functional characteristics of dystrophic skeletal muscle: insights from animal models. J Appl Physiol 93: 407-417.
46. Mittelbronn M, Sullivan T, Stewart CL, Bornemann A, (2008) Myonuclear degeneration in LMNA null mice. Brain Pathol 18: 338-343.
47. Melone MA, Peluso G, Petillo O, Galderisi U, Cotrufo R, (1999) Defective growth in vitro of Duchenne Muscular Dystrophy myoblasts: the molecular and biochemical basis. J Cell Biochem 76: 118-132.
48. van Koningsbruggen S, Straasheijm KR, Sterrenburg E, de Graaf N, Dauwerse HG, et al. (2007) FRG1P-mediated aggregation of proteins involved in pre-mRNA processing. Chromosoma 116: 53-64.
49. Day JW, Ranum LP, (2005) RNA pathogenesis of the myotonic dystrophies. Neuromuscul Disord 15: 5-16.
50. Ranum LP, Day JW, (2004) Myotonic dystrophy: RNA pathogenesis comes into focus. Am J Hum Genet 74: 793-804.
51. Mumberg D, Wick M, Burger C, Haas K, Funk M, et al. (1997) Cyclin ET, a new splice variant of human cyclin E with a unique expression pattern during cell cycle progression and differentiation. Nucleic Acids Res 25: 2098-2105.
52. Sewing A, Ronicke V, Burger C, Funk M, Muller R, (1994) Alternative splicing of human cyclin E. J Cell Sci 107 (Pt 2): 581-588.
53. Porter DC, Keyomarsi K, (2000) Novel splice variants of cyclin E with altered substrate specificity. Nucleic Acids Res 28: E101.
54. Klooster R, Straasheijm K, Shah B, Sowden J, Frants R, et al. (2009) Comprehensive expression analysis of FSHD candidate genes at the mRNA and protein level. Eur J Hum Genet 17: 1615-1624.
55. Masny PS, Chan OY, de Greef JC, Bengtsson U, Ehrlich M, et al. (2009) Analysis of allele-specific RNA transcription in FSHD by RNA-DNA FISH in single myonuclei. Eur J Hum Genet.
56. Barro M, Carnac G, Flavier S, Mercier J, Vassetzky Y, et al. (2008) Myoblasts from affected and non affected FSHD muscles exhibit morphological differentiation defects. J Cell Mol Med.
57. Kyba M, Perlingeiro RC, Daley GQ, (2002) HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell 109: 29-37.
58. Rabinovitch PS, (1994) DNA content histogram and cell-cycle analysis. Methods Cell Biol 41: 263-296.
59. Schorl C, Sedivy JM, (2007) Analysis of cell cycle phases and progression in cultured mammalian cells. Methods 41: 143-150.