Identification and characterization of a Ross River virus variant that grows persistently in macrophages, shows altered disease kinetics in a mouse model, and exhibits resistance to type I interferon

Journal of Virology

Volumn 85, Issue 11, 2011, Pages 5651-5663

  Lidbury, Brett A ^a   Rulli, Nestor E ^a,b,c,d   Musso, Cristina M ^a   Cossetto, Susan B ^a   Zaid, Ali ^a,b   Suhrbier, Andreas ^c   Rothenfluh, Harald S ^e   Rolph, Michael S ^a,c   Mahalingam, Suresh ^a,b,c  

^a UNIVERSITY OF CANBERRA   (Australia)

^b UNIVERSITY OF WOLLONGONG   (Australia)

^c GRIFFITH UNIVERSITY   (Australia)

^d UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

^e Australian National University   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; INTERFERON; NONSTRUCTURAL PROTEIN; NONSTRUCTURAL PROTEIN 1; NUCLEOTIDE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ALPHAVIRUS INFECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LINE; CELL STRAIN RAW264.7; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE SEVERITY; E2 GENE; IN VITRO STUDY; MACROPHAGE; MACROPHAGE ACTIVATION; MOLECULAR EVOLUTION; MORTALITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ROSS RIVER ALPHA VIRUS; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; VIROGENESIS; VIRUS GENE; VIRUS GENOME; VIRUS IDENTIFICATION; VIRUS ISOLATION;

ADAPTATION, BIOLOGICAL; ALPHAVIRUS INFECTIONS; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; IMMUNE EVASION; INTERFERON TYPE I; MACROPHAGES; MICE; MUTATION, MISSENSE; ROSS RIVER VIRUS; SERIAL PASSAGE; SURVIVAL ANALYSIS; VIRAL PLAQUE ASSAY; VIRAL PROTEINS;

CHIKUNGUNYA VIRUS; MUS; O'NYONG-NYONG VIRUS; RNA VIRUSES; ROSS RIVER VIRUS;

EID: 79956135724     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01189-10     Document Type: Article

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