A reduction in selective immune pressure during the course of chronic hepatitis C correlates with diminished biochemical evidence of hepatic inflammation

Virology

Volumn 361, Issue 1, 2007, Pages 27-33

  Hanada, Kousuke ^a   Tanaka, Yasuhito ^b   Mizokami, Masashi ^b   Gojobori, Takashi ^a   Alter, Harvey J ^c  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Alanine aminotransferase (ALT); E2; Evolution; HCV; Immune response; Persistent infection; Positive selection; RNA virus; Selective pressure

Indexed keywords

AMINOTRANSFERASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; FOLLOW UP; GENOTYPE; HEPATITIS C; HUMAN; IMMUNE RESPONSE; LIVER NECROSIS; MALE; PERSISTENT INFECTION; PRIORITY JOURNAL; RACE DIFFERENCE;

AGED; AGED, 80 AND OVER; ALANINE TRANSAMINASE; EPITOPES, B-LYMPHOCYTE; EVOLUTION, MOLECULAR; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INFLAMMATION; LIVER; MALE; MIDDLE AGED; PHYLOGENY; SELECTION (GENETICS); TIME FACTORS; VIRAL ENVELOPE PROTEINS;

HEPATITIS C VIRUS; RNA VIRUSES;

EID: 34047271100     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2006.10.041     Document Type: Article

References (30)

1. Alter H.J., Purcell R.H., Shih J.W., Melpolder J.C., Houghton M., Choo Q.L., and Kuo G. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N. Engl. J. Med. 321 (1989) 1494-1500
2. Chang K.M., Rehermann B., McHutchison J.G., Pasquinelli C., Southwood S., Sette A., and Chisari F.V. Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus. J. Clin. Invest. 100 (1997) 2376-2385
3. Chen S., and Wang Y.H. Multigene tracking of quasispecies in viral persistence and clearance of hepatitis C virus. World J. Gastroenterol. 11 (2005) 2874-2884
4. Choo Q.L., Kuo G., Weiner A.J., Overby L.R., Bradley D.W., and Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244 (1989) 359-362
5. Christie J.M., Chapel H., Chapman R.W., and Rosenberg W.M. Immune selection and genetic sequence variation in core and envelope regions of hepatitis C virus. Hepatology 30 (1999) 1037-1044
6. Ehl S., Klenerman P., Zinkernagel R.M., and Bocharov G. The impact of variation in the number of CD8(+) T-cell precursors on the outcome of virus infection. Cell. Immunol. 189 (1998) 67-73
7. Farci P., Alter H.J., Wong D.C., Miller R.H., Govindarajan S., Engle R., Shapiro M., and Purcell R.H. Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 7792-7796
8. Farci P., Shimoda A., Coiana A., Diaz G., Peddis G., Melpolder J.C., Strazzera A., Chien D.Y., Munoz S.J., Balestrieri A., Purcell R.H., and Alter H.J. The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies. Science 288 (2000) 339-344
9. Franco A., Ferrari C., Sette A., and Chisari F.V. Viral mutations, T cell receptor antagonism and escape from the immune response. In: Sher A., and Ahmed R. (Eds). Current Opinion in Immunology (1995), Current Biology Ltd., London 524-531
10. Kiyosawa K., Sodeyama T., Tanaka E., Nakano Y., Furuta S., Nishioka K., Purcell R.H., and Alter H.J. Hepatitis C in hospital employees with needlestick injuries. Ann. Intern. Med. 115 (1991) 367-369
11. Klenerman P., Lechner F., Kantzanou M., Ciurea A., Hengartner H., and Zinkernagel R. Viral escape and the failure of cellular immune responses. Science 289 (2000) 2003
12. Knodell R.G., Ishak K.G., Black W.C., Chen T.S., Craig R., Kaplowitz N., Kiernan T.W., and Wollman J. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1 (1981) 431-435
13. Manzin A., Solforosi L., Debiaggi M., Zara F., Tanzi E., Romano L., Zanetti A.R., and Clementi M. Dominant role of host selective pressure in driving hepatitis C virus evolution in perinatal infection. J. Virol. 74 (2000) 4327-4334
14. Matsuoka S., Tatara K., Hayabuchi Y., Taguchi Y., Mori K., Honda H., Itou S., Yuasa Y., and Kuroda Y. Serologic, virologic, and histologic characteristics of chronic phase hepatitis C virus disease in children infected by transfusion. Pediatrics 94 (1994) 919-922
15. Missale G., Cariani E., and Ferrari C. Role of viral and host factors in HCV persistence: which lesson for therapeutic and preventive strategies?. Dig. Liver Dis. 36 (2004) 703-711
16. Pradat P., Alberti A., Poynard T., Esteban J.I., Weiland O., Marcellin P., Badalamenti S., and Trepo C. Predictive value of ALT levels for histologic findings in chronic hepatitis C: a European collaborative study. Hepatology 36 (2002) 973-977
17. Rambaut A. Estimating the rate of molecular evolution: incorporating non-contemporaneous sequences into maximum likelihood phylogenies. Bioinformatics 16 (2000) 395-399
18. Sheridan I., Pybus O.G., Holmes E.C., and Klenerman P. High resolution phylogenetic analysis of Hepatitis C virus adaptation and its relationship to disease progression. J. Virol. 78 (2004) 3447-3454
19. Shimizu Y.K., Hijikata M., Iwamoto A., Alter H.J., Purcell R.H., and Yoshikura H. Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses. J. Virol. 68 (1994) 1494-1500
20. Suzuki Y., and Gojobori T. A method for detecting positive selection at single amino acid sites. Mol. Biol. Evol. 16 (1999) 1315-1328
21. Suzuki Y., and Gojobori T. Positively selected amino acid sites in the entire coding region of hepatitis C virus subtype 1b. Gene 3 276 (2001) 83-87
22. Takaki A., Wiese M., Maertens G., Depla E., Seifert U., Liebetrau A., Miller J.L., Manns M.P., and Rehermann B. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat. Med. 6 (2000) 578-582
23. Thompson J.D., Higgins D.G., and Gibson T.J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22 (1994) 4673-4680
24. Wang H., Bian T., Merrill S.J., and Eckels D.D. equence variation in the gene encoding the nonstructural 3 protein of hepatitis C virus: evidence for immune selection. J. Mol. Evol. 54 (2002) 465-473
25. Wedemeyer H., He X.S., Nascimbeni M., Davis A.R., Greenberg H.B., Hoofnagle J.H., Liang T.J., Alter H.J., and Rehermann B. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J. Immunol. 169 (2002) 3447-3458
26. Weiner A.J., Geysen H.M., Christopherson C., Hall J.E., Mason T.J., Saracco G., Bonino F., Crawford K., Marion C.D., Crawford K.A., Brunetto M., Barr P.J., Miyamura T., Hutchinson J.M., and Houghton M. Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 3468-3472
27. WHO. Hepatitis C: global update. Wkly. Epidemiol. Rec. 72 (1997) 341-344
28. Yang Z., Kumar S., and Nei M. A new method of inference of ancestral nucleotide and amino acid sequences. Genetics 141 (1995) 1641-1650
29. Zhang J. Rates of conservative and radical nonsynonymous nucleotide substitutions in mammalian nuclear genes. J. Mol. Evol. 50 (2000) 56-68
30. Zhang J., Rosenberg H.F., and Nei M. Positive Darwinian selection after gene duplication in primate ribonuclease genes. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 3708-3713