Liquid chromatography-tandem mass spectrometry method for measurement of nicotine N-glucuronide: A marker for human UGT2B10 inhibition

Journal of Pharmaceutical and Biomedical Analysis

Volumn 55, Issue 5, 2011, Pages 964-971

  Guo, Jian ^a   Zhou, Diansong ^a   Grimm, Scott W ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

LC MS MS; Nicotine N glucuronide; UGT2B10

Indexed keywords

AMITRIPTYLINE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; HECOGENIN; IMIPRAMINE; LAMOTRIGINE; NICOTINE; PERCHLORIC ACID; TRIFLUOPERAZINE;

ACCURACY; ARTICLE; CALIBRATION; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROSPRAY; HUMAN; HUMAN CELL; IC 50; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; MONITORING; MULTIPLE SCLEROSIS; POSITIVE ION ELECTROSPRAY; PRECIPITATION; PRIORITY JOURNAL; PRODUCTIVITY; QUALITY CONTROL; ROOM TEMPERATURE; SAMPLE; SENSITIVITY AND SPECIFICITY; SOLUTION AND SOLUBILITY; STANDARD; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

AMITRIPTYLINE; CALIBRATION; CHROMATOGRAPHY, LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GLUCURONATES; GLUCURONOSYLTRANSFERASE; HUMANS; IMIPRAMINE; INHIBITORY CONCENTRATION 50; KINETICS; MICROSOMES, LIVER; NICOTINE; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TEMPERATURE; TRIFLUOPERAZINE;

EID: 79956123223     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.03.034     Document Type: Article

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