Quantitative determination and pharmacokinetic study of solamargine in rat plasma by liquid chromatography-mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 55, Issue 5, 2011, Pages 1157-1162

  Zheng, Xiao ^a   Xu, Lianming ^b   Liang, Yan ^a   Xiao, Wei ^b   Xie, Lin ^b   Zhang, Yan ^b   Zhao, Li ^b   Cao, Liang ^b   Chen, Jun ^b   Wang, Guangji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b JIANGSU KANION PHARMACEUTICAL CO   (China)

Author keywords

Biosample; LC ESI MS; Pharmacokinetics; Rat plasma; Solamargine

Indexed keywords

ACETIC ACID ETHYL ESTER; ACETONITRILE; FORMIC ACID; SOLAMARGINE; VINCRISTINE;

ACCURACY; ANALYSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENSITY GRADIENT; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROSPRAY; ELUTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; NONHUMAN; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY ANALYSIS;

ANIMALS; CALIBRATION; CHEMISTRY TECHNIQUES, ANALYTICAL; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, LIQUID; FORMIC ACIDS; MASS SPECTROMETRY; MODELS, CHEMICAL; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SOLANACEOUS ALKALOIDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; VINCRISTINE;

EID: 79956116117     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.04.007     Document Type: Article

References (18)

1. Crabbea P.G., Fryer C. Rapid quantitative analysis of solasodine, solasodine glycosides and solasodiene by high-pressure liquid chromatography. J. Chromatogr. A 1980, 187:87-100.
2. Blankemeyer J.T, McWilliams M.L., Rayburn J.R., Weissenberg M., Friedman M. Developmental toxicology of solamargine and solasonine glycoalkaloids in frog embryos. Food Chem. Toxicol. 1998, 36:383-389.
3. Kuo K.W., Hsu S.H., Li Y.P., Lin W.L., Liu L.F., Chang L.C., Lin C.C., Lin C.N., Sheu H.M. Anticancer activity evaluation of the solanum glycoalkaloid solamargine. Triggering apoptosis in human hepatoma cells. Biochem. Pharmacol. 2000, 60:1865-1873.
4. Lee K.R., Kozukue N., Han J.S., Park J.H., Chang E.Y., Baek E.J., Chang J.S., Friedman M. Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells. J. Agric. Food Chem. 2004, 52:2832-2839.
5. Liu L.F., Liang C.H., Shiu L.Y., Lin W.L., Lin C.C., Kuo K.W. Action of solamargine on human lung cancer cells-enhancement of the susceptibility of cancer cells to TNFs. FEBS Lett. 2004, 577:67-74.
6. Liang C.H., Shiu L.Y., Chang L.C., Sheu H.M., Tsai E.M., Kuo K.W. Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer H661 and H69 cells to trastuzumab and epirubicin. Chem. Res. Toxicol. 2008, 21:393-399.
7. Shiu L.Y., Liang C.H., Huang Y.S., Sheu H.M., Kuo K.W. Downregulation of HER2/neu receptor by solamargine enhances anticancer drug-mediated cytotoxicity in breast cancer cells with high-expressing HER2/neu. Cell Biol. Toxicol. 2008, 24:1-10.
8. Li X., Zhao Y., Wu W.K., Liu S., Cui M., Lou H. Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. Life Sci. 2011, 88:314-321.
9. Liang C.H., Shiu L.Y., Chang L.C., Sheu H.M., Kuo K.W. Solamargine upregulation of Fas, downregulation of HER2, and enhancement of cytotoxicity using epirubicin in NSCLC cells. Mol. Nutr. Food Res. 2007, 51:999-1005.
10. Shiu L.Y, Chang L.C., Liang C.H., Huang Y.S., Sheu H.M., Kuo K.W. Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin. Food Chem. Toxicol. 2007, 45:2155-2164.
11. Sun L., Zhao Y., Li X., Yuan H., Cheng A., Lou H. A lysosomal-mitochondrial death pathway is induced by solamargine in human K562 leukemia cells. Toxicol. In Vitro 2010, 24:1504-1511.
12. Sun L., Zhao Y., Yuan H., Li X., Cheng A., Lou H. Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells. Cancer Chemother. Pharmacol. 2010, 67:813-821.
13. Shanker K, Gupta S., Srivastava P., Srivastava S.K., Singh S.C., Gupta M.M. Simultaneous determination of three steroidal glycoalkaloids in Solanum xanthocarpum by high performance thin layer chromatography. J. Pharm. Biomed. Anal. 2011, 54:497-502.
14. Lin Z.J., Li W., Dai G. Application of LC-MS for quantitative analysis and metabolite identification of therapeutic oligonucleotides. J. Pharm. Biomed. Anal. 2007, 44:330-341.
15. Stokvis E., Rosing H., Beijnen J.H. Liquid chromatography-mass spectrometry for the quantitative bioanalysis of anticancer drugs. Mass Spectrom. Rev. 2005, 24:887-917.
16. Xu R.N., Fan L., Rieser M.J., El-Shourbagy T.A. Recent advances in high-throughput quantitative bioanalysis by LC-MS/MS. J. Pharm. Biomed. Anal. 2007, 44:342-355.
17. Paul A.T., Vir S., Bhutani K.K. Liquid chromatography-mass spectrometry-based quantification of steroidal glycoalkaloids from Solanum xanthocarpum and effect of different extraction methods on their content. J. Chromatogr. A 2008, 1208:141-146.
18. Guidance for Industry, Bioanalytical Method Validation, U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), 2001.