Metabonomics study of the protective effects of green tea polyphenols on aging rats induced by d-galactose

Journal of Pharmaceutical and Biomedical Analysis

Volumn 55, Issue 5, 2011, Pages 1067-1074

  Fu, Chunwang ^a   Wang, Tiejie ^b   Wang, Yang ^a   Chen, Xiaohui ^a   Jiao, Jian ^a   Ma, Feng ^a   Zhong, Min ^b   Bi, Kaishun ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Shenzhen Institute for Drug Control   (China)

Author keywords

Anti aging; D Galactose; Green tea polyphenols; Metabonomics; UPLC MS

Indexed keywords

GALACTOSE; GREEN TEA EXTRACT; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLCHOLINE; PHYTOSPHINGOSINE; POLYPHENOL DERIVATIVE; SPHINGANINE; TRYPTOPHAN;

AGING; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ARTICLE; BIOCHEMISTRY; BLOOD SAMPLING; CONTROLLED STUDY; DRUG MECHANISM; DRUG MEGADOSE; HISTOPATHOLOGY; LOW DRUG DOSE; MALE; MASS SPECTROMETRY; NONHUMAN; PHOSPHOLIPID METABOLISM; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RAT; TEA; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

AGING; ANIMALS; BIOLOGICAL MARKERS; CHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; FLAVONOIDS; GALACTOSE; MALE; MASS SPECTROMETRY; METABOLOMICS; PHENOLS; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, WISTAR; TEA;

EID: 79956110408     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.03.011     Document Type: Article

References (27)

1. Kawakami K., Kadota J., Iida K., Shirai R., Abe K., Kohno S. Reduced immune function and malnutrition in the elderly. Tohoku J. Exp. Med. 1999, 187:157-171.
2. Harman D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 1956, 11:298-300.
3. Murali G., Panneerselvam C. Age-associated oxidative macromolecular damages in rat brain regions: role of glutathione monoester. J. Gerontol. A: Biol. Sci. Med. Sci. 2007, 62:824-830.
4. Haripriya D., Sangeetha P., Kanchana A., Balu M., Panneerselvam C. Modulation of age-associated oxidative DNA damage in rat brain cerebral cortex, striatum and hippocampus by l-carnitine. Exp. Gerontol. 2005, 40:129-135.
5. Johnson F.B., Sinclair D.A., Guarente L. Molecular biology of aging. Cell 1999, 96:291-302.
6. Rice-Evans C.A., Diplock A.T. Current status of antioxidant therapy. Free Radic. Biol. Med. 1993, 15:77-96.
7. Cabrera C., Artacho R., Giménez R. Beneficial effects of green tea-a review. J. Am. Coll. Nutr. 2006, 25:79-99.
8. Higdon J.V., Frei B. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit. Rev. Food Sci. Nutr. 2003, 43:89-143.
9. Meng Q., Velalar C.N., Ruan.R. Effects of epigallocatechin-3-gallate on mitochondrial integrity and antioxidative enzyme activity in the aging process of human fibroblast. Free Radic. Biol. Med. 2008, 44:1032-1041.
10. Yokozawa T., Nakagawa T., Kitani K. Antioxidative activity of green tea polyphenol in cholesterol-fed rats. J. Agric. Food. Chem. 2002, 50:3549-3552.
11. Lambert J.D., Yang C.S. Cancer chemopreventive activity and bioavailability of tea and tea polyphenols. Mutat. Res. 2003, 523:201-208.
12. Nicholson J.K., Lindon J.C., Holmes E. Metabonomics: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999, 29:1181-1189.
13. Yin P.Y., Mohemaiti P., Chen J., Zhao X.J., Lu X., Yimiti A., Upur H., Xu G.W. Serum metabolic profiling of abnormal savda by liquid chromatography/mass spectrometry. J. Chromatogr. B 2008, 871:322-327.
14. Kellert M., Wagner S., Lutz U., Lutz W.K. Biomarkers of furan exposure by metabolic profiling of rat urine with liquid chromatography-tandem mass spectrometry and principal component analysis. Chem. Res. Toxicol. 2008, 21:761-768.
15. Li N.J., Liu W.T., Li W., Li S.Q., Chen X.H., Bi K.S., He P. Plasma metabolic profiling of Alzheimer's disease by liquid chromatography/mass spectrometry. Clin. Biochem. 2010, 43:992-997.
16. Huo T.G., Cai S., Lu X.M., Sha Y., Yu M.Y., Li F.M. Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride. J. Pharm. Biomed. Anal. 2009, 49:976-982.
17. Zhang Q., Li X.K., Cui X., Zuo P.P. d-galactose injured neurogenesis in the hippocampus of adult mice. Neurol. Res. 2005, 27:552-556.
18. Cui X., Zuo P.P., Zhang Q., Li X.K., Hu Y.Z., Long J.G. Chronic systemic d-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. J. Neurosci. Res. 2006, 84:647-654.
19. Zheng J.Y., Fu Y.R., Li M., Gao K.S., Zhang X.G. Effect of LTA isolated from bifidobacteria on d-galactose-induced aging. Exp. Gerontol. 2009, 44:760-765.
20. Wiklund S., Johansson E., Mellerowicz E.J., Edlund U., Shockcor J.P., Gottfries J., Moritz T., Trygg J. Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal. Chem. 2008, 80:115-122.
21. Lee E.S., Charlton C.G. 1-Methyl-4-phenyl-pyridinium increases S-adenosyl-l-methionine dependent phospholipid methylation. Pharmacol. Biochem. Behav. 2001, 70:105-114.
22. Venable M.E., Lee J.Y., Smyth M.J., Bielawska A., Obeid L.M. Role of ceramide in cellular senescence. J. Biol. Chem. 1995, 270:30701-30708.
23. Hannun Y.A., Obeid L.M. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 2002, 277:25847-25850.
24. Sawai H., Hannun Y.A. Ceramide and sphingomyelinases in the regulation of stress responses. Chem. Phys. Lipids 1999, 102:141-147.
25. van Meer G., Holthuis J.C. Sphingolipid transport in eukaryotic cells. Biochim. Biophys. Acta 2000, 1486:145-170.
26. Perrotta C., De P.C., Falcone S., Sciorati C., Clementi E. Nitric oxide, ceramide and sphingomyelinase-coupled receptors: a tale of enzymes and messengers coordinating cell death, survival and differentiation. Life Sci. 2005, 77:1732-1739.
27. Obeid L.M., Hannun Y.A. Ceramide, stress, and a " LAG" in aging. Sci Aging Knowl. Environ. 2003, 2003:PE27.