Synthesis of (E)-3′-phosphonoalkenyl modified nucleoside phosphonates via a highly stereoselective olefin cross-metathesis reaction

Journal of Organic Chemistry

Volumn 76, Issue 10, 2011, Pages 3742-3753

  Huang, Qiuya ^a   Herdewijn, Piet ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

IN-VITRO; INTRAMOLECULAR CYCLIZATIONS; MODIFIED NUCLEOSIDES; OLEFIN CROSS-METATHESIS; PHOSPHONATES; STEREO-SELECTIVE; SUGAR MOIETY;

BIOMOLECULES; OLEFINS; STEREOSELECTIVITY; SUGARS; SYNTHESIS (CHEMICAL);

CYCLIZATION;

1 (ADENIN 9 YL) 3 PHOSPHONOPROPYL BETA DEXTRO ERYTHROFURANOSE; 1 (ADENIN 9 YL) 3 PHOSPHONOVINYL BETA DEXTRO ERYTHROFURANOSE; 1 (THYMIN 9 YL) 3 PHOSPHONOPROPYL BETA DEXTRO ERYTHROFURANOSE; 1 (THYMIN 9 YL) 3 PHOSPHONOVINYL BETA DEXTRO ERYTHROFURANOSE; 3' PHOSPHONOALKENYL DERIVATIVE; 3' PHOSPHONOALKYL DERIVATIVE; [[1 ADENIN 9 YL) 5 DEOXY 5 METHYL] BETA DEXTRO APIOFURANOSYL] 3,6 CYCLOMONOPHOSPHONIC ACID SODIUM; [[1 THYMIN 9 YL) 5 DEOXY 5 METHYL] BETA DEXTRO APIOFURANOSYL] 3,6 CYCLOMONOPHOSPHONIC ACID SODIUM; ALKENE; ANTIVIRUS AGENT; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CROSS METATHESIS REACTION; CYCLIZATION; DRUG SYNTHESIS; GLYCOSYLATION; HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; NONHUMAN; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; STEREOCHEMISTRY;

ALKENES; ANTIVIRAL AGENTS; CYCLIZATION; NUCLEOSIDES; PHOSPHONIC ACIDS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; VIRUSES;

EID: 79956097507     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo200033p     Document Type: Article

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