ABC triblock copolymers with pH-responsive LCST for controlled drug delivery

Journal of Bioactive and Compatible Polymers

Volumn 26, Issue 2, 2011, Pages 173-190

  Gan, Yan Chang ^a   Yuan, Jin Fang ^a   Liu, Xue Jun ^a   Pan Wang, ^a   Gao, Qing Yu ^a  

^a HENAN UNIVERSITY   (China)

Author keywords

amphiphilic triblock copolymers; controlled drug release; core shell structure; radical polymerization; RAFT; temperature responsive polymeric micelles; thermo responsive nano sized micelles

Indexed keywords

AMPHIPHILIC TRIBLOCK COPOLYMERS; CONTROLLED DRUG RELEASE; CORE-SHELL STRUCTURE; RADICAL POLYMERIZATION; RAFT; TEMPERATURE-RESPONSIVE; THERMO-RESPONSIVE;

ACRYLIC MONOMERS; AMIDES; ATOM TRANSFER RADICAL POLYMERIZATION; BIOCOMPATIBILITY; BLOCK COPOLYMERS; BROMINE COMPOUNDS; CARBOXYLIC ACIDS; CHROMATOGRAPHIC ANALYSIS; COPOLYMERIZATION; CRITICAL MICELLE CONCENTRATION; ESTERS; ETHYLENE; ETHYLENE GLYCOL; FLUORESCENCE; FOURIER TRANSFORM INFRARED SPECTROSCOPY; FREE RADICAL POLYMERIZATION; GEL PERMEATION CHROMATOGRAPHY; HYDROGELS; MICELLES; PLASTIC PRODUCTS; POLYMERS; SIZE EXCLUSION CHROMATOGRAPHY; TRANSMISSION ELECTRON MICROSCOPY;

CONTROLLED DRUG DELIVERY;

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACRYLIC ACID; COPOLYMER; FOLIC ACID; HYDROGEN; METHOXYPOLY[(ETHYLENE GLYCOL)POLY(N ISOPROPYLACRYLAMIDE CO ACRYLIC ACID)POLY(METHYL METHACRYLATE)]; POLY(N ISOPROPYLACRYLAMIDE); UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BIOCOMPATIBILITY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; EMBRYO CELL; FLUORESCENCE; FRAGMENTATION REACTION; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; KIDNEY CELL; LIGHT SCATTERING; LOWER CRITICAL SOLUTION TEMPERATURE; MICELLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PH; POLYMERIZATION; REVERSIBLE ADDITION FRAGMENTATION CHAIN TRANSFER RADICAL POLYMERIZATION; ROOM TEMPERATURE; TEMPERATURE; TRANSMISSION ELECTRON MICROSCOPY;

EID: 79956096433     PISSN: 08839115     EISSN: 15308030     Source Type: Journal    
DOI: 10.1177/0883911511399415     Document Type: Article

References (29)

1. Kohori F., Sakai K., Aoyagi T., Yokoyama M., Sakurai Y. and Okano T. Preparation and characterization of thermally responsive block copolymer micelles comprising poly(N-isopropylacrylamide-b-DL-lactide). J Controlled Release 1998 ; 55: 87-98. (Pubitemid 28477567)
2. Liu XM, Yang YY and Leong KW Thermally responsive polymeric micellar nanoparticles self-assembled from cholesteryl end-capped random poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide): synthesis, temperature-sensitivity, and morphologies. J Colloid Interface Sci 2003 ; 266: 295-303. (Pubitemid 37188389)
3. Oha KT, Kimb D., Youc HH, Ahnc YS and Lee ES pH-Sensitive properties of surface charge-switched multifunctional polymeric micelle. Int J Pharm 2009 ; 376: 134-140.
4. Schmaljohann D. Thermo- and pH-responsive polymers in drug delivery. Adv Drug Delivery Rev 2006 ; 58: 1655-1670. (Pubitemid 44830149)
5. Christophe J. and Lefaux AZ Polyelectrolyte spin assembly: influence of ionic strength on the growth of multilayered thin films. J Polym Sci Part B Polym Phys 2004 ; 42: 3654-3666.
6. Sofia K., Anatol K., Jukka L. and Bengt K. Ultraviolet light treatment of thin high-density polyethylene films monitored with a quartz crystal microbalance. J Appl Polym Sci 2004 ; 92: 2833-2839.
7. Qiao P., Niu QS, Wang ZB and Cao DP Synthesis of thermosensitive micelles based on poly(N-isopropylacrylamide) and poly(L-alanine) for controlled release of adriamycin. Chem Eng J 2010 ; 159: 257-263.
8. Oha KT, Oh YT, Oh NM, Kim K., Lee DH and Lee ES A smart flower-like polymeric micelle for pH-triggered anticancer drug release. Int J Pharm 2009 ; 375: 163-169.
9. Na K., Lee KH, Lee DH and Bae YH Biodegradable thermo-sensitive nanoparticles from poly(L-lactic acid)/poly(ethylene glycol) alternating multi-block copolymer for potential anti-cancer drug carrier. Eur J Pharm Sci 2006 ; 27: 115-122. (Pubitemid 41831246)
10. Bae KH, Choi SH, Park SY, Lee Y. and Park TG Thermosensitive pluronic micelles stabilized by shell cross-linking with gold nanoparticles. Langmuir 2006 ; 22: 6380-6634.
11. Heskins M. and Guillet JE Solution properties of poly (N-isopropylacrylamide). J Macromol Sci Part A Pure Appl Chem 1968 ; 2: 1441-1455.
12. Santos JR, Alves NM and Mano JF New Thermo-responsive hydrogels based on poly(N-isopropylacrylamide)/hyaluronic acid semi-interpenetrated polymer networks: swelling properties and drug release studies. J Bioact Compat Polym 2010 ; 25: 169-184.
13. Wei H., Zhang XZ, Cheng H., Chen WQ, Cheng SX and Zhuo RX Self-assembled thermoresponsive micelles of poly(N-isopropylacrylamide-b-methyl methacrylate). Biomaterials 2006 ; 116: 266-274. (Pubitemid 44827402)
14. Yin XC, Hoffman AS and Stayton PS Poly(N-isopropylacrylamide-co- propylacrylic acid) copolymers that respond sharply to temperature and pH. Am Chem Soc 2006 ; 27: 1381-1385. (Pubitemid 43811191)
15. Mero A., Schiavon O., Pasut G., Veronese FM, Emilitri E. and Ferruti P. A biodegradable polymeric carriers based on PEG for drug delivery. J Bioact Compat Polym 2009 ; 24: 220-234.
16. Park JS and Kataoka K. Precise control of lower critical solution temperature of thermosensitive poly(2-isopropyl-2-oxazoline) via gradient copolymerization with 2-ethyl-2-oxazoline as a hydrophilic comonomer. Macromolecules 2006 ; 39: 6622-6630. (Pubitemid 44555107)
17. Rapoport N. Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery. Prog Polym Sci 2007 ; 32: 962-990. (Pubitemid 47198285)
18. Moghimi S., Hunter A. and Murray J. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 2001 ; 53: 283-318. (Pubitemid 32476118)
19. Katsampas I., Roiter Y., Minko S. and Tsitsilians C. Multifunctional stimuli responsive ABC terpolymers: from three-compartment micelles to three-dimensional network. Macromol Rapid Commun 2005 ; 26: 1371-1376. (Pubitemid 41321662)
20. Lai JT, Filla D. and Ronald S. Functional polymers from novel carboxyl terminated trithiocarbonates as highly efficient RAFT agents. Macromolecules 2002 ; 35: 6754-6756. (Pubitemid 34991086)
21. Wei H., Zhang XZ, Cheng C., Cheng SX and Zhuo RX Self-assembled, thermosensitive micelles of a star block copolymer based on PMMA and PNIPAAm for controlled drug delivery. Biomaterials 2007 ; 28: 99-107. (Pubitemid 44427903)
22. Wei XH, Niu PY, Xu YY, Du YZ, Hu FQ and Yuan H. Salicylic acid-grafted chitosan oligosaccharide nanoparticle for paclitaxel delivery. J Bioact Compat Polym 2010 ; 25: 319-335.
23. Lowe AB and McCormick CL Reversible addition-fragmentation chain transfer (RAFT) radical polymerization and the synthesis of watersoluble (co)polymers under homogeneous conditions in organic and aqueous media. Prog Polym Sci 2007 ; 32: 283-351. (Pubitemid 46329720)
24. Bae Y., Jang WD, Nishiyama N., Fukushima S. and Kataoka K. Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery. Mol Biosyst 2005 ; 1: 242-250. (Pubitemid 41442434)
25. Bulmus V., Ding ZL, Long CJ, Stayton PS and Hoffman AS Site-specific polymer-Streptavidin bioconjugate for pH-controlled binding and triggered release of biotin. Bioconjugate Chem 2000 ; 11: 78-83. (Pubitemid 30063347)
26. Chen G. and Hoffman AS Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH. Nature 1995 ; 373: 49-52.
27. Soppimath KS, Tan DCW and Yang YY pH-Triggered thermally responsive polymer core-shell nanoparticles for drug delivery. Adv Mater 2005 ; 17: 318-323. (Pubitemid 40320152)
28. Rapoport N. Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery. Prog Polym Sci 2007 ; 32: 962-990. (Pubitemid 47198285)
29. Allen C., Maysinger D. and Eisenberg A. Nanoengineering block copolymer aggregates for drug delivery. Colloids Surf B 1999 ; 16: 3-27.