Neurobehavior of preterm infants at 36 weeks postconception as a function of morphine analgesia

American Journal of Perinatology

Volumn 24, Issue 9, 2007, Pages 511-517

  Rao, Rakesh ^a   Sampers, Jackie S ^b   Kronsberg, Shari S ^c   Brown, Josephine V ^d   Desai, Nirmala S ^e   Anand, K J S ^f  

^a Division of Newborn Medicine   (United States)

^b Department of Special Education and Rehabilitation Counseling ^*  (United States)

^c MARYLAND MEDICAL RESEARCH INSTITUTE   (United States)

^d GEORGIA STATE UNIVERSITY   (United States)

^e Division of Neonatology   (United States)

^f ARKANSAS CHILDREN S HOSPITAL   (United States)

Author keywords

Morphine analgesia; Neonatal Medical Index (NMI); Neurobehavioral; Neurobehavioral Assessment of the Preterm Infant (NAPI); Prematurity

Indexed keywords

MORPHINE; PLACEBO; STEROID;

ANALGESIA; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DISEASE SEVERITY; FEMALE; GESTATIONAL AGE; HUMAN; INFANT; LENGTH OF STAY; LUNG DYSPLASIA; LUNG VENTILATION; MAJOR CLINICAL STUDY; MALE; NEONATAL MEDICAL INDEX; NEUROBEHAVIORAL ASSESSMENT OF THE PRETERM INFANT; NEWBORN; OUTCOME ASSESSMENT; PERINATAL PERIOD; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; REGRESSION ANALYSIS; SCORING SYSTEM; SEPSIS;

ANALGESICS, OPIOID; FEMALE; GESTATIONAL AGE; HUMANS; INFANT BEHAVIOR; INFANT, NEWBORN; INFANT, PREMATURE; MALE; MORPHINE; NEUROLOGIC EXAMINATION; PREMATURE BIRTH; RESPIRATION, ARTIFICIAL;

EID: 35448947221     PISSN: 07351631     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-986675     Document Type: Article

References (41)

1. Msall ME. Neurodevelopmental surveillance in the first 2 years after extremely preterm birth: Evidence, challenges, and guidelines. Early Hum Dev 2006;82:157-166
2. Constantinou JC, Adamson-Macedo, Ariagno RL, Fleisher BE. Neurobehavioral assessment predicts differential outcome between VLBW and ELBW preterm infants. J Perinatol 2005;12:788-793
3. Low JA, Galbraith RS, Muir DW, Broekhoven LH, Wilkinson JW, Karchmar EJ. The contribution of fetal-newborn complications to motor and cognitive deficits. Dev Med Child Neurol 1985;27:578-587
4. Ross G. Use of Bayley Scales to characterize abilities of premature infants. Child Dev 1985;56:835-842
5. American Academy of Pediatrics Committee on Fetus and Newborn, Committee on Drugs. Section on Anesthesiology, Section on Surgery, Canadian Pediatric Society, Fetus and Newborn Committee. Prevention and management of pain and stress in the neonate. Pediatrics 2000;105:454-461
6. Pokela ML. Pain relief can reduce hypoxemia in distressed neonates during routine treatment procedures. Pediatrics 1994;93:379-383
7. Goldstein RF, Brazy JE. Narcotic sedation stabilizes arterial blood pressure fluctuations in sick premature infants. J Perinatol 1991;11:365-371
8. Orsini AJ, Leef KH, Costarino A, Dettorre MD, Stefano JL. Routine use of fentanyl infusions for pain and stress reduction in infants with respiratory distress syndrome. J Pediatr 1996;129:140-145
9. Anand KJS, McIntosh N, Lagercrantz H, Young TE, Vasa RK, Barton BA. Analgesia and sedation in ventilated preterm neonates: results from the pilot NOPAIN trial. Arch Pediatr Adolesc Med 1999;153:331-338
10. Simons SHP, van Dijk M, van Lingen RA, et al. Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. JAMA 2003;290:2419-2427
11. Taddio A. Opioid analgesia for infants in the neonatal intensive care unit. Clin Perinatol 2002;29:493-509
12. Andrews K, Fitzgerald M. The cutaneous withdrawal reflex in human neonates: sensitization, receptive fields, and the effects of contralateral stimulation. Pain 1994;56:95-101
13. Taddio A, Katz J, Ilersich AL, Koren G. Effect of neonatal circumcision on pain response during subsequent routine vaccination. Lancet 1997;349:599-603
14. Grunau RE, Oberlander TF, Whitfield MF, Fitzgerald C, Lee SK. Demographic and Therapeutic Determinants of Pain Reactivity in Very Low Birth Weight Neonates at 32 Weeks Postconceptional Age. Pediatrics 2001;107:105-112
15. Johnston CC, Stevens BJ. Experience in a neonatal intensive care unit affects pain response. Pediatrics 1996;98:925-930
16. Anand KJ, Hall RW, Desai N, et al, for the NEOPAIN Trial Investigators Group. Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial. Lancet 2004;363:1673-1682
17. Korner AF, Brown JV, Thom VA, Constantinou JC. The Neurobehavioral Assessment of the Preterm Infant: Manual, Revised 2nd edition. (2000). Van Nuys, CA: Child Development Media (distributor)
18. Korner AF, Constantinou J, Dimicili S, Brown BW Jr, Thom VA. Establishing the reliability and developmental validity of a neurobehavioral assessment for preterm infants: a methodological process. Child Dev 1991;62:1200-1208
19. Schade JG, Joyce BA, Gerkensmeyer J, Keck JF. Comparison of three preverbal scales for postoperative pain assessment in a diverse pediatric sample. J Pain Symptom Manage 1996;12:348-359
20. Snider L, Tremblay S, Limperopoulos C, Majnemer A, Filion F, Johnston C. Construct validity of the Neurobehavioral Assessment of Preterm Infants. Phys Occup Ther Pediatr 2005;25:81-95
21. Senn TE, Espy KA. Effects of neurobehavioral assessment on feeding and weight gain in preterm neonates. J Dev Behav Pediatr 2003;24:85-88
22. Korner AF. Reliable individual differences in preterm infants' excitation management. Child Dev 1996;67:1793-1805
23. Korner AF, Brown BW, Dimiceli S, et al. Stable individual differences in developmentally changing preterm infants: a replicated study. Child Dev 1989;60:502-513
24. Hyman C, Snider LM, Majnemer A, Mazer B. Concurrent validity of the Neurobehavioral Assessment for Pre-Term infants (NAPI) at term age. Pediatric Rehabilitation 2005;8:225-234
25. Korner AF, Stevenson DK, Forrest T, Constantiou J, Dimiceli S, Brown BW. Preterm medical complications differentially affect neurobehavioral functions: Results from a new neonatal medical index. Infant Behav Dev 1994;17:37-43
26. Korner AF, Stevenson DK, Kraemer HC, et al. Prediction of the development of low-birth weight preterm infants by a new neonatal medical index. J Dev Behav Pediatr 1993;14:106-111
27. International Neonatal Network. CRIB Investigator's Group. The CRIB (Clinical Risk Index for Babies) score: a tool for assessing initial neonatal risk and comparing performance of neonatal intensive care units. Lancet 1993;342:193-198
28. De Courcy-Wheeler RHB, Wolfe CDA, Fitzgerald MS, Goodman JDS, Gamsu HR. Use of the CRIB (Clinical Risk Index for Babies) score in prediction of neonatal mortality and morbidity. Arch Dis Child 1995;73:F32-F36
29. Anand KJS, Coskun V, Thrivikraman V, Nemeroffs CB, Plotsky PM. Long-term behavioral effects of repetitive pain in neonatal rat pups. Physiol Behav 1999;66:627-637
30. Bhutta AT, Rovnaghi C, Simpson PM, Gossett JM, Scalzo FM, Anand KJS. Interactions of inflammatory pain and morphine in infant rats: long term behavioral effects. Physiol Behav 2001;73:51-58
31. Carbajal R, Lenclen R, Jugie M, Paupe A, Barton BA, Anand KJS. Morphine does not provide adequate analgesia for acute procedural pain among preterm neonates. Pediatrics 2005;115:1494-1500
32. Dyke MP, Kohan R, Evans S. Morphine increases synchronous ventilation in preterm infants. J Paediatr Child Health 1995;31:176-179
33. Anand KJ. Consensus statement for the prevention and management of pain in the newborn. Arch Pediatr Adolesc Med 2001;155:173-180
34. Grunau R. Early pain in preterm infants: a model of long-term effects. Clin Perinatol 2002;29:373-394
35. Anand KJS, Aranda JV, Berde CB, et al. Summary proceedings from the Neonatal Pain-Control Group. Pediatrics 2006;117:9-22
36. van Lingen RA, Simons SHP, Anderson BJ, Tibboel D. The effects of analgesia in the vulnerable infant during the perinatal period. Clin Perinatol 2002;29:511-534
37. Merritt TA, Pillers D, Prows SL. Early NICU discharge of very low birth weight infants: a criteria review and analysis. Semin Neonatol 2003;8:95-115
38. Michael Cotten C, Oh W, McDonald S, et al, for NICHD Neonatal Research Network. Prolonged hospital stay for extremely premature infants: risk factors, center differences, and the impact of mortality on selecting a best-performing center. J Perinatol 2005;25:650-655
39. Infant Mortality and low birth weight among black and white infants - United States, 1980-2000. MMWR Morb Mortal Wkly Rep 2002;51(27):589-592
40. Alexander GR, Kogan M, Bader D, et al. US birth weight/gestational age-specific neonatal mortality: 1995-1997 rates for whites, Hispanics, and blacks. Pediatrics 2003;111:61-66
41. Bayley N. Bayley Scales of Infant Development. 2nd ed. San Antonio: The Psychological Corporation; 1993