Pigment epithelial-derived factor inhibits c-FLIP expression and assists ciglitazone-induced apoptosis in hepatocellular carcinoma

Anticancer Research

Volumn 31, Issue 4, 2011, Pages 1173-1180

  Lai, Li Ju ^a,b,c   Ho, Tsung Chuan ^d  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d MACKAY MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; c FLIP; HCC; Hepatocellular carcinoma; p38; PEDF; PPAR

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 8; CIGLITAZONE; FLICE INHIBITORY PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PIGMENT EPITHELIUM DERIVED FACTOR; PROCASPASE 8;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEPATOMA CELL; IMMUNOBLOTTING; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; CELL PROLIFERATION; EYE PROTEINS; HUMANS; HYPOGLYCEMIC AGENTS; LIVER NEOPLASMS; MAP KINASE KINASE 4; NERVE GROWTH FACTORS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PPAR GAMMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERPINS; THIAZOLIDINEDIONES;

EID: 79956064667     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W and Bouck NP: Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 285: 245-248, 1999. (Pubitemid 29329995)
2. Tombran-Tink J, Mazuruk K, Rodriguez IR, Chung D, Linker T, Englander E and Chader GJ: Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin. Mol Vis 2: 11, 1996.
3. Sawant S, Aparicio S, Tink AR, Lara N, Barnstable CJ and Tombran-Tink J: Regulation of factors controlling angiogenesis in liver development: a role for PEDF in the formation and maintenance of normal vasculature. Biochem Biophys Res Commun 325: 408-413, 2004. (Pubitemid 39458010)
4. Petersen SV, Valnickova Z and Enghild JJ: Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization. Biochem J 374: 199-206, 2003. (Pubitemid 37046944)
5. Matsumoto K, Ishikawa H, Nishimura D, Hamasaki K, Nakao K and Eguchi K: Antiangiogenic property of pigment epithelium-derived factor in hepatocellular carcinoma. Hepatology 40: 252-259, 2004.
6. Ho TC, Chen SL, Shih SC, Wu JY, Han WH, Cheng HC, Yang SL and Tsao YP: Pigment epithelium-derived factor is an intrinsic antifibrosis factor targeting hepatic stellate cells. Am J Pathol 177: 1798-1811, 2010.
7. Wang L, Schmitz V, Perez-Mediavilla A, Izal I, Prieto J and Qian C: Suppression of angiogenesis and tumor growth by adenoviral-mediated gene transfer of pigment epithelium-derived factor. Mol Ther 8: 72-79, 2003. (Pubitemid 36939298)
8. Zaichuk TA, Shroff EH, Emmanuel R, Filleur S, Nelius T and Volpert OV: Nuclear factor of activated T-cells balances angiogenesis activation and inhibition. J Exp Med 199: 1513-1522, 2004.
9. Ho TC, Chen SL, Yang YC, Lo TH, Hsieh JW, Cheng HC and Tsao YP: Cytosolic phospholipase A2-α is an early apoptotic activator in PEDF-induced endothelial cell apoptosis. Am J Physiol Cell Physiol 296: C273-284, 2009.
10. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schröter M, Burns K, Mattmann C, Rimoldi D, French LE and Tschopp J: Inhibition of death receptor signals by cellular FLIP. Nature 388: 190-195, 1997. (Pubitemid 27297457)
11. Shu HB, Halpin DR and Goeddel DV: Casper is a FADD- and caspase-related inducer of apoptosis. Immunity 6: 751-763, 1997. (Pubitemid 27305737)
12. Scaffidi C, Schmitz I, Krammer PH and Peter ME: The role of c-FLIP in modulation of CD95-induced apoptosis. J Biol Chem 274: 1541-1548, 1999.
13. Okano H, Shiraki K, Inoue H, Kawakita T, Yamanaka T, Deguchi M, Sugimoto K, Sakai T, Ohmori S, Fujikawa K, Murata K and Nakano T: Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma. Lab Invest 83: 1033-1043, 2003. (Pubitemid 36899070)
14. Du X, Bao G, He X, Zhao H, Yu F, Qiao Q, Lu J and Ma Q: Expression and biological significance of c-FLIP in human hepatocellular carcinomas. J Exp Clin Cancer Res 28: 1-8, 2009.
15. Ganten TM, Haas TL, Sykora J, Stahl H, Sprick MR, Fas SC, Krueger A, Weigand MA, Grosse-Wilde A, Stremmel W, Krammer PH and Walczak H: Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. Cell Death Differ 11: S86-96, 2004.
16. Lu G, Liu Y, Ji B, Wei F, Hao C and Wang G: Synergistic effect of celecoxib on TRAIL-induced apoptosis in hepatocellular carcinoma cells. Cancer Invest 28: 629-634, 2010.
17. Tsao YP, Ho TC, Chen SL and Cheng HC: Pigment epithelium-derived factor inhibits oxidative stress-induced cell death by activation of extracellular signal-regulated kinases in cultured retinal pigment epithelial cells. Life Sci 79: 545-550, 2006.
18. Zhou XD, Yu JP, Chen HX, Yu HG and Luo HS: Expression of cellular FLICE-inhibitory protein and its association with p53 mutation in colon cancer. World J Gastroenterol 11: 2482-2485, 2005.
19. Yu J, Qiao L, Zimmermann L, Ebert MP, Zhang H, Lin W, Röcken C, Malfertheiner P and Farrell GC: Troglitazone inhibits tumor growth in hepatocellular carcinoma in vitro and in vivo. Hepatology 45: 134-143, 2006. (Pubitemid 43733600)
20. Yu J, Shen B, Chu ES, Teoh N, Cheung KF, Wu CW, Wang S, Lam CN, Feng H, Zhao J, Cheng AS, To KF, Chan HL and Sung JJ: Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro. Hepatology 51: 2008-2019, 2010.
21. Krueger A, Schmitz I, Baumann S, Krammer PH and Kirchhoff S: Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J Biol Chem 276: 20633-20640, 2001.
22. Kang HY, Lee JY, Lee JS and Choi YM: Peroxisome proliferator-activated receptors-gamma activator, ciglitazone, inhibits human melanocyte growth through induction of apoptosis. Arch Dermatol Res 297: 472-476, 2006.
23. Fabregat I: Dysregulation of apoptosis in hepatocellular carcinoma cells. World J Gastroenterol 15: 513-520, 2009.
24. Kanda S, Mochizuki Y, Nakamura T, Miyata Y, Matsuyama T and Kanetake H: Pigment epithelium-derived factor inhibits fibroblast-growth-factor-2-induced capillary morphogenesis of endothelial cells through Fyn. J Cell Sci 118: 961-970, 2005. (Pubitemid 40484886)
25. Sen U, Rodriguez WE, Tyagi N, Kumar M, Kundu S and Tyagi SC: Ciglitazone, a PPARgamma agonist, ameliorates diabetic nephropathy in part through homocysteine clearance. Am J Physiol Endocrinol Metab 295: E1205-1212, 2008.
26. Galli A, Ceni E, Mello T, Polvani S, Tarocchi M, Buccoliero F, Lisi F, Cioni L, Ottanelli B, Foresta V, Mastrobuoni G, Moneti G, Pieraccini G, Surrenti C and Milani S: Thiazolidinediones inhibit hepatocarcinogenesis in hepatitis B virus-transgenic mice by peroxisome proliferator-activated receptor gamma-independent regulation of nucleophosmin. Hepatology 52: 493-505, 2010.
27. Smith MT: Mechanisms of troglitazone hepatotoxicity. Chem Res Toxicol 16: 679-687, 2003.
28. Berger J and Moller DE: The mechanisms of action of PPARs. Annu Rev Med 53: 409-435, 2002. (Pubitemid 34177889)
29. Berger J, Bailey P, Biswas C, Cullinan CA, Doebber TW, Hayes NS, Saperstein R, Smith RG and Leibowitz MD: Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice. Endocrinology 137: 4189-4195, 1996. (Pubitemid 26321865)
30. Willson TM, Lambert MH and Kliewer SA: Peroxisome proliferator-activated receptor gamma and metabolic disease. Annu Rev Biochem 70: 341-367, 2001. (Pubitemid 32662214)
31. Takano S, Kubota T, Nishibori H, Hasegawa H, Ishii Y, Nitori N, Ochiai H, Okabayashi K, Kitagawa Y, Watanabe M and Kitajima M: Pioglitazone, a ligand for peroxisome proliferator-activated receptor-gamma acts as an inhibitor of colon cancer liver metastasis. Anticancer Res 28: 3593-3599, 2008.
32. Yang SL, Chen SL, Wu JY, Ho TC and Tsao YP: Pigment epithelium-derived factor induces interleukin-10 expression in human macrophages by induction of PPAR gamma. Life Sci 87: 26-35, 2010.
33. Sanagi T, Yabe T and Yamada H: The regulation of pro-inflammatory gene expression induced by pigment epithelium-derived factor in rat cultured microglial cells. Neurosci Lett 380: 105-110, 2005. (Pubitemid 40602338)