The effect of recombinant human erythropoietin on ischemia-reperfusion injury: An experimental study in a rat TRAM flap model

Plastic and Reconstructive Surgery

Volumn 120, Issue 7, 2007, Pages 1774-1781

  Kim, Eun Key ^a   Hong, Joon Pio ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

EPOSIS; MALONALDEHYDE; MYELOPEROXIDASE; NITRIC OXIDE; RECOMBINANT ERYTHROPOIETIN; UNCLASSIFIED DRUG; WATER;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; GRAFT SURVIVAL; HEMATOCRIT; HISTOPATHOLOGY; LIPID PEROXIDATION; MUSCLE ISCHEMIA; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; SURVIVAL RATE; TISSUE WATER; TRANSVERSE RECTUS ABDOMINIS MUSCULOCUTANEOUS FLAP;

ANIMALS; APOPTOSIS; CHEMOTAXIS, LEUKOCYTE; DRUG EVALUATION, PRECLINICAL; ERYTHROPOIETIN, RECOMBINANT; HEMATOCRIT; HUMANS; INFLAMMATION; MALONDIALDEHYDE; NEOVASCULARIZATION, PHYSIOLOGIC; NEUTROPHILS; NITRIC OXIDE; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; RECTUS ABDOMINIS; REPERFUSION INJURY; SURGICAL FLAPS;

EID: 37349116672     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.prs.0000287131.53488.c4     Document Type: Article

References (31)

1. Fisher, W. J. Erythropoietin: Physiology and pharmacology update. Exp. Biol. Med. 228: 1, 2003.
2. Digicaylioglu, M., and Lipton, S. A. Erythropoietin mediated neuroprotection involves cross-talk between Jak2 and NFkappaB singling cascades. Nature 412: 641, 2001.
3. Akimoto, T., Kusano, E., Inaba, T., et al. Erythropoietin regulates vascular smooth muscle cell apoptosis by a phosphatidylinositol 3 kinase-dependent pathway. Kidney Int. 58: 269, 2000.
4. Ammarguellat, F., Llovera, M., Kelly, P. A., and Goffin, B. Low doses of EPO activate MAP kinases but not JAK2-STAT5 in rat vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 284: 1031, 2001.
5. Tramontano, A. F., Muniyappa, R., Black, A. D., et al. Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway. Biochem. Biophys. Res. Commun. 308: 990, 2003.
6. Shi, Y., Rafiee, P., Su, J., Pritchard, K. A., Jr., Tweddell, J. S., and Baker, J. E. Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channels. Basic Res. Cardiol. 99: 173, 2004.
7. Moon, C., Krawczyk, M., Ahn, D., et al. Erythropoietin reduces myocardial infarction and left ventricular functional decline after coronary artery ligation in rats. Proc. Natl. Acad. Sci. U.S.A. 100: 11612, 2003.
8. Parsa, C. J., Kim, J., Riel, R. U., et al. Cardioprotective effects of erythropoietin in the reperfused ischemic heart: A potential role for cardiac fibroblasts. J. Biol. Chem. 279: 20655, 2004.
9. Patel, N. S., Sharples, E. J., Cuzzocrea, S., et al. Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/ reperfusion in the mouse kidney in vivo. Kidney Int. 66: 983, 2004.
10. Zamboni, W. A., Roth, A. C., Russel, R. C., Graham, B., Suchy, H., and Kucan, J. O. Morphologic analysis of the microcirculation during reperfusion of ischemic skeletal muscle and the effect of hyperbaric oxygen. Plast. Reconstr. Surg. 91: 1110, 1993.
11. Buras, J. Basic mechanisms of hyperbaric oxygen in the treatment of ischemia-reperfusion injury. Int. Anesthesiol. Clin. 38: 91, 2000.
12. Centinkale, O., Bilgic, L., Bolayirli, M., Sengul, R., Ayan, F., and Burcak, G. Involvement of neutrophils in ischemiareperfusion injury of inguinal island flap in rats. Plast. Reconstr. Surg. 102: 153, 1998.
13. Kerrigan, C. L., and Stotland, M. A. Ischemia-reperfusion injury: A review. Microsurgery 14: 165, 1993.
14. Zimmerman, G. A., Prescott, S. M., and McIntyre, T. M. Endothelial cell interaction with granulocytes: Tethering and signaling molecules. Immunol. Today 13: 93, 1992.
15. Cheung, W. K., Goon, B. L., Guilfoyle, M. C., and Wacholtz, M. C. Pharmacokinetics and pharmacodynamics of recombinant human erythropoietin after single and multiple subcutaneous doses to healthy subjects. Clin. Pharmacol. Ther. 64: 412, 1998.
16. Saray, A., Ozakpinar, R., Koc, C., Serel, S., Sen, Z., and Can, Z. Effect of chronic and short-term erythropoietin treatment on random flap survival in rats: An experimental study. Laryngoscope 113: 85, 2003.
17. Rui, T., Feng, Q., Lei, M., et al. Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/ reperfusion via induction of AP-1. Cardiovasc. Res. 65: 719, 2005.
18. Bogdon, C. Nitric oxide and the immune response. Nat. Immunol. 2: 907, 2001.
19. Haroon, Z. A., Amin, K., Jiang, X., and Arcasoy, M. O. A novel role for erythropoietin during fibrin-induced wound-healing response. Am. J. Pathol. 163: 993, 2003.
20. Squadrito, F., Altavilla, D., Squadrito, G., et al. Recombinant human erythropoietin inhibits iNOS activity and reverts vascular dysfunction in splanchnic artery occlusion shock. Br. J. Pharmacol. 127: 482, 1999.
21. Santhanam, A. V., Smith, L. A., Akiyama, M., Rosales, A. G., Bailey, K. R., and Katusic, Z. S. Role of endothelial NO synthase phosphorylation in cerebrovascular protective effect of recombinant erythropoietin during subarachnoid hemorrhage-induced cerebral vasospasm. Stroke 36: 2731, 2005.
22. Buemi, M., Galeano, M., Sturiale, A., et al. Recombinant human erythropoietin stimulates angiogenesis and healing of ischemic skin wounds. Shock 22: 169, 2004.
23. Bikfalvi, A., and Han, Z. C. Angiogenic factors are hematopoietic growth factors and vice versa. Leukemia 8: 523, 1994.
24. Buemi, M., Vaccaro, M., Sturiale, A., et al. Recombinant human erythropoietin influences revascularization and healing in a rat model of random ischaemic flaps. Acta Dermatol. Venereol. 82: 411, 2002.
25. Jaquet, K., Krause, K., Tawakol-Khodai, M., Geidel, S., and Kuck, K. H. Erythropoietin and VEGF exhibit equal angiogenic potential. Microvasc. Res. 64: 326, 2002.
26. Galeano, M., Altavilla, D., Cucinotta, D., et al. Recombinant human erythropoietin stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetes 53: 2509, 2004.
27. Siverberg, D. D., Wexler, D., Sheps, D., et al. The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: A randomized controlled study. J. Am. Coll. Cardiol. 37: 1775, 2001.
28. Hayashi, T., Suzuki, A., Shoji, T., et al. Cardiovascular effect of normalizing the hematocrit level during erythropoietin therapy in predialysis patients with chronic renal failure. Am. J. Kidney Dis. 35: 250, 2000.
29. Olivetti, G., Abbi, R., Quaini, F., et al. Apoptosis in the failing human heart. N. Engl. J. Med. 336: 1131, 1997.
30. van der Meer, P., Voors, A. A., Lipsic, E., van Gilst, W. H., and van Veldhuisen, D. J. Erythropoietin in cardiovascular diseases. Eur. Heart J. 25: 285, 2004.
31. Scarabelli, T. M., Stephanou, A., Pasini, E., et al. Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. Circ. Res. 90: 745, 2002.