Topical erythropoietin promotes wound repair in diabetic rats

Journal of Investigative Dermatology

Volumn 130, Issue 1, 2010, Pages 287-294

  Hamed, Saher ^a,b   Ullmann, Yehuda ^a,b   Masoud, Muhannad ^a   Hellou, Elias ^a   Khamaysi, Ziad ^a   Teot, Luc ^b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b Rambam Health Care Campus ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; HYDROXYPROLINE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN INJURY; TREATMENT DURATION; TREATMENT OUTCOME; WOUND CLOSURE; WOUND HEALING; WOUND HEALING IMPAIRMENT;

ADMINISTRATION, TOPICAL; ANIMALS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; ERYTHROPOIETIN; HYDROXYPROLINE; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; SKIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING; WOUNDS AND INJURIES;

EID: 72049122943     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.219     Document Type: Article

References (35)

1. Aguirre D, Boya P, Bellet D, Faivre S, Troalen F, Benard J et al. (2004) Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian carcinoma. Apoptosis 9:797-805
2. Altavilla D, Saitta A, Cucinotta D, Galeano M, Deodato B, Colonna M et al. (2001) Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse. Diabetes 50:667-674
3. Anagnostou A, Lee ES, Kessimian N, Levinson R, Steiner M (1990) Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells. Proc Natl Acad Sci USA 87:5978-5982
4. Anagnostou A, Liu Z, Steiner M, Chin K, Lee ES, Kessimian N et al. (1994) Erythropoietin receptor mRNA expression in human endothelial cells. Proc Natl Acad Sci USA 91:3974-3978 (Pubitemid 24139555)
5. Bodo E, Kromminga A, Funk W, Laugsch M, Duske U, Jelkmann W et al. (2007) Human hair follicles are an extrarenal source and a nonhema-topoietic target of erythropoietin. FASEB J 21:3346-3354 (Pubitemid 47565553)
6. Brem H, Balledux J, Bloom T, Kerstein MD, Hollier L (2000) Healing of diabetic foot ulcers and pressure ulcers with human skin equivalent, a new paradigm in wound healing. Arch Surg 135:627-634
7. Brines M, Cerami A (2006) Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise. Kidney Int 70:246-250
8. Brown LF, Yeo KT, Berse B, Yeo TK, Senger DR, Dvorak HF et al. (1992) Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 176:1375-1379
9. Buemi M, Vaccaro M, Sturiale A, Galeano MR, Sansotta C, Cavallari V et al. (2002) Recombinant human erythropoietin influences revascularization and healing in a rat model of random ischaemic flaps. Acta Derm Venereol 82:411-417
10. Buemi M, Galeano M, Sturiale A, Ientile R, Crisafulli C, Parisi A et al. (2004) Recombinant human erythropoietin stimulates angiogenesis and healing of ischemic skin wounds. Shock 22:169-173 (Pubitemid 40228196)
11. Clark R (1985) Cutaneous tissue repair: basic biological consideration I. J Am Acad Dermatol 13:701-725
12. Corral CJ, Siddiqui A, Wu L (1999) Vascular endothelial growth factor is more important than basic fibroblastic growth factor during ischemic wound healing. Arch Surg 134:200-205
13. Danielsen AJ, Maihle NJ (2002) The EGF/ErbB receptor family and apoptosis. Growth Factors 20:1-15
14. Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW (1987) Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. Results of a combined phase I and II clinical trial. N Engl J Med 316:73-78
15. Farahani RM, Kloth LC (2008) The hypothesis of 'biophysical matrix contraction': wound contraction revisited. Int Wound J 5:477-482
16. Galeano M, Altavilla D, Cucinotta D, Russo GT, Calo M, Bitto A et al. (2004) Recombinant human erythropoietin stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetes 53:2509-2517 (Pubitemid 39145612)
17. Galeano M, Altavilla D, Bitto A, Minutoli L, Calo M, Lo Cascio P et al. (2006) Recombinant human erythropoietin improves angiogenesis and wound healing in experimental burn wounds. Crit Care Med 34:1139-1146
18. Ghezzi P, Brines M (2004) Erythropoietin as an antiapoptotic, tissue-protective cytokine. Cell Death Differ 11:S37-44
19. Haroon ZA, Amin K, Jiang X, Arcasoy MO (2003) A novel role for erythropoietin during fibrin-induced wound-healing response. Am J Pathol 63:993-1000
20. Isogai R, Takahashi M, Aisu K, Horiuti Y, Aragane Y, Kawada A et al. (2006) The receptor for erythropoietin is present on cutaneous mast cells. Arch Dermatol Res 297:389-394
21. Jelkmann W (1994) Biology of erythropoietin. Clin Invest 72:S3-10
22. Junod A, Lambert AE, Stauffacher W, Renold AE (1969) Diabetogenic action of streptozotocin: relationship of dose to metabolic response. J Clin Invest 48:2129-2139
23. Li F, Chong ZZ, Maiese K (2004) Erythropoietin on a tightrope: balancing neuronal and vascular protection between intrinsic and extrinsic pathways. Neurosignals 13:265-289
24. Li ZJ, Wang ZZ, Zheng YZ, Xu B, Yang RC, Scadden DT et al. (2005) Kinetic expression of platelet endothelial cell adhesion molecule-1 (PECAM-1/ CD31) during embryonic stem cell differentiation. J Cell Biochem 95:559-570 (Pubitemid 41420185)
25. Mansbridge JN, Liu K, Pinney RE, Patch R, Ratcliffe A, Naughton GK (1999) Growth factors secreted by fibroblasts: role in healing diabetic foot ulcers. Diabetes Obes Metab 1:265-279
26. Mustoe T (2004) Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy. Am J Surg 187:65S-70S
27. Quinn JV (1998) Tissue Adhesives in Wound Care. Electronic book Hamilton, ON: BC Decker
28. Rai NK, Suryabhan Ansari M, Kumar M, Shukla VK, Tripathi K (2005) Effect of glycaemic control on apoptosis in diabetic wounds. J Wound Care 14:277-281
29. Sheetz MJ, King GL (2002) Molecular understanding of hyperglycemia' s adverse effects for diabetic complications. JAMA 288:2579-2588
30. Shukla A, Dubey MP, Srivastava R, Srivastava BS (1998) Differential expression of proteins during healing of cutaneous wounds in experimental norma and chronic models. Biochem Biophys Res Commun 244:434-439
31. Snyder RJ (2005) Treatment of nonhealing ulcers with allografts. Clin Dermatol 23:388-395
32. Stadelmann WK, Digenis AG, Tobin GR (1998) Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg 176:26S-38S
33. Takahashi Y, Takahashi S, Shiga Y, Yoshimi T, Miura T (2000) Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells. J Biol Chem 275:14139-14146
34. Wen TC, Sadamoto Y, Tanaka J, Zhu PX, Nakata K, Ma YJ et al. (2002) Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up-regulating Bcl-xL expression. J Neurosci Res 67:795-803
35. Zhang XW, Xu B (2000) Differential regulation of P53, c-Myc, Bcl-2, Bax and AFP protein expression, and caspase activity during 10-hydroxycamp-tothecin- induced apoptosis in Hep G2 cells. Anticancer Drugs 11:747-756