Phenotypic expressions of childhood wheezing and asthma: Implications for therapy

Journal of Pediatrics

Volumn 158, Issue 6, 2011, Pages

  Chipps, Bradley E ^a   Bacharier, Leonard B ^b   Harder, Julia M ^a  

^a Capital Allergy and Respiratory Disease Center   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; BUDESONIDE; CORTICOSTEROID; FLUTICASONE; FLUTICASONE PROPIONATE; FOOD ALLERGEN; IMMUNOGLOBULIN E; MONTELUKAST; OMALIZUMAB; PLACEBO; PREDNISOLONE; SALMETEROL;

ABSENCE OF SIDE EFFECTS; ADD ON THERAPY; ADENOVIRUS; ALLERGIC ASTHMA; ARTICLE; ASTHMA; CHILDHOOD DISEASE; CLINICAL TRIAL; CORONAVIRUS; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFICACY; ECZEMA; FOOD ALLERGY; FORCED EXPIRATORY VOLUME; GENE EXPRESSION; HAY FEVER; HUMAN; HUMAN METAPNEUMOVIRUS; IMMUNOGLOBULIN BLOOD LEVEL; INTERMITTENT ASTHMA; LOW DRUG DOSE; MILD INTERMITTENT ASTHMA; MILD PERSISTENT ASTHMA; MODERATE PERSISTENT ASTHMA; PARAINFLUENZA VIRUS; PHENOTYPE; PRIORITY JOURNAL; REMISSION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RHINOVIRUS; SEVERE PERSISTENT ASTHMA; SKIN TEST; TREATMENT RESPONSE; VIRAL RESPIRATORY TRACT INFECTION; WHEEZING;

EID: 79956042283     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2011.01.057     Document Type: Article

References (36)

1. B.E. Chipps Evaluation of infants and children with refractory lower respiratory tract symptoms Ann Allergy Asthma Immunol 104 2010 279 283
2. National Asthma Education and Prevention Program Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Full Report 2007 August 2007 National Heart, Lung, and Blood Institute Bethesda, MD Available at: www.nhlbi.nih.gov/guidelines/asthma/asthgdln.htm Accessed June 25, 2010
3. N.G. Papadopoulos, and A. Kalobatsou Respiratory viruses in childhood asthma Curr Opin Allergy Clin Immunol 7 2007 91 95 (Pubitemid 46095892)
4. R.J. Kurukulaaratchy, M.H. Fenn, L.M. Waterhouse, S.M. Matthews, S.T. Holgate, and S.H. Arshad Characterization of wheezing phenotypes in the first 10 years of life Clin Exp Allergy 33 2003 573 578 (Pubitemid 36629680)
5. F.D. Martinez, A.L. Wright, L.M. Taussig, C.J. Holberg, M. Halonen, and W.J. Morgan Asthma and wheezing in the first six years of life N Engl J Med 332 1995 133 138
6. L.B. Bacharier, B.R. Phillips, G.R. Bloomberg, R.S. Zeiger, I.M. Paul, and M. Krawiec Severe intermittent wheezing in preschool children: a distinct phenotype J Allergy Clin Immunol 119 2007 604 610
7. A.G. Kaditis, G. Winnie, and G.A. Syrogiannopoulos Anti-inflammatory pharmacotherapy for wheezing in preschool children Pediatr Pulmonol 42 2007 407 420 (Pubitemid 46700939)
8. M. McKean, and F. Ducharme Inhaled steroids for episodic viral wheeze of childhood Cochrane Database Syst Rev 1 2000 CD001107
9. L.B. Bacharier, B.R. Phillips, R.S. Zeiger, S.J. Szefler, F.D. Martinez, and R.F. Lemanske Jr. Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate to severe intermittent wheezing J Allergy Clin Immunol 122 2008 1127 1135
10. F.M. Ducharme, C. Lemire, F.J. Noya, G.M. Davis, N. Alos, and H. Leblond Pre-emptive use of high-dose fluticasone for virus-induced wheezing in young children N Engl J Med 360 2009 409 410
11. H. Bisgaard, M.N. Hermansen, L. Loland, L.B. Halkjaer, and F. Buchvald Intermittent inhaled corticosteroids in infants with episodic wheezing N Engl J Med 354 2006 1998 2005
12. T.W. Guilbert, W.J. Morgan, R.S. Zeiger, D.T. Mauger, S.J. Boehmer, and S.J. Szefler Long-term inhaled corticosteroids in preschool children at high risk for asthma N Engl J Med 354 2006 1985 1997
13. P. Csonka, M. Kaila, P. Laippala, M. Iso-Mustajarvi, T. Vesikari, and P. Ashorn Oral prednisolone in the acute management of children age 6 to 35 months with viral respiratory infection-induced lower airway disease: a randomized, placebo-controlled trial J Pediatr 143 2003 725 730 (Pubitemid 37510639)
14. A. Tal, N. Levy, and J.E. Bearman Methylprednisolone therapy for acute asthma in infants and toddlers: a controlled clinical trial Pediatrics 86 1990 350 356 (Pubitemid 20334965)
15. T. Jartti, P. Lehtinen, T. Vanto, J. Hartiala, T. Vuorinen, and M.J. Mäkelä Evaluation of the efficacy of prednisolone in early wheezing induced by rhinovirus or respiratory syncytial virus Pediatr Infect Dis J 25 2006 482 488 (Pubitemid 43863356)
16. T. Jartti, P. Lehtinen, T. Vanto, T. Vuorinen, H. Hiekkanen, and J. Hartiala Atopic characteristics of wheezing children and responses to prednisolone Pediatr Pulmonol 42 2007 1125 1133 (Pubitemid 350231862)
17. A. Oommen, P.C. Lambert, and J. Grigg Efficacy of a short course of parent-initiated oral prednisolone for viral wheeze in children aged 1-5 years: randomised controlled trial Lancet 362 2003 1433 1438 (Pubitemid 37352878)
18. J. Panickar, M. Lakhanpaul, P.C. Lambert, P. Kenia, T. Stephenson, and A. Smyth Oral prednisolone for preschool children with acute virus-induced wheezing N Engl J Med 360 2009 329 338
19. A. Bush Practice imperfect: treatment for wheezing in preschoolers N Engl J Med 360 2009 4
20. J.J. Zorc, and C.B. Hall Bronchiolitis: recent evidence on diagnosis and management Pediatrics 125 2010 342 349
21. P. Lehtinen, A. Ruohola, T. Vanto, T. Vuorinen, O. Ruuskanen, and T. Jartti Prednisolone reduces recurrent wheezing after a first wheezing episode associated with rhinovirus or eczema J Allergy Clin Immunol 119 2007 570 575
22. B.E. Chipps Determinants of asthma and its clinical course Ann Allergy Asthma Immunol 93 2004 309 315
23. S. Illi, E. von Mutius, S. Lau, B. Niggemann, C. Gruber, U. Wahn Multicentre Allergy Study (MAS) Group Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study Lancet 368 2006 763 770 (Pubitemid 44279054)
24. J.A. Castro-Rodriguez, C.J. Holberg, A.L. Wright, and F.D. Martinez A clinical index to define risk of asthma in young children with recurrent wheezing Am J Respir Crit Care Med 162 2000 1403 1406
25. The Childhood Asthma Management Program Research Group Long-term effects of budesonide or nedocromil in children with asthma N Engl J Med 343 2000 1054 1063
26. R.C. Strunk Childhood Asthma Management Program: lessons learned J Allergy Clin Immunol 119 2007 36 42 (Pubitemid 46037813)
27. R.A. Pauwels, S. Pedersen, W.W. Busse, W.C. Tan, Y.-Z. Chen START Investigators Group Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial Lancet 361 2003 1071 1076 (Pubitemid 36369558)
28. W.W. Busse, S. Pedersen, R.A. Pauwels, W.C. Tan, Y.-Z. Chen, C.J. Lamm the START Investigators Group The Inhaled Steroid Treatment as Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma J Allergy Clin Immunol 121 2008 1167 1174
29. J.A. Castro-Rodriguez, and G.J. Rodrigo Efficacy of inhaled corticosteroids in infants and preschoolers with recurrent wheezing and asthma: a systematic review with metaanalysis Pediatrics 123 2009 e519 e525
30. C.A. Sorkness, R.F. Lemanske, D.T. Mauger, S.J. Boehmer, V.M. Chinchilli, and F.D. Martinez Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial J Allergy Clin Immunol 119 2007 64 72 (Pubitemid 46043379)
31. J.E. Knuffman, C.A. Sorkness, R.F. Lemanske, D.T. Mauger, S.J. Boehmer, and F.D. Martinez Phenotypic predictors of long-term response to inhaled corticosteroid and leukotriene modifier therapies in pediatric asthma J Allergy Clin Immunol 123 2009 411 416
32. R.S. Zeiger, S.J. Szefler, B.R. Phillips, M. Schatz, F.D. Martinez, and V.M. Chinchilli Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma J Allergy Clin Immunol 117 2006 45 52 (Pubitemid 43017138)
33. R. Beasley The burden of asthma with specific reference to the United States J Allergy Clin Immunol 109 2002 5482 5489
34. B.E. Chipps, S.J. Szefler, E.R. Simons, T. Haselkorn, D.R. Mink, and Y. Deniz Demographic and clinical characteristics of children and adolescents with severe or difficult-to-treat asthma J Allergy Clin Immunol 119 2007 1156 1163 (Pubitemid 46654173)
35. R.F. Lemanske, D.T. Mauger, C.A. Sorkness, D.J. Jackson, S.J. Boehmer, and F.D. Martinez Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids N Engl J Med 362 2010 975 985
36. B. Lanier, T. Bridges, M. Kulus, A.F. Taylor, I. Berhane, and C.F. Vidaurre Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma J Allergy Clin Immunol 124 2009 1210 1216