Advances on the Pharmacological Effects of Red Yeast Rice

Chinese Journal of Natural Medicines

Volumn 9, Issue 3, 2011, Pages 161-166

  Li, Xue Mei ^a,b   Shen, Xing Hai ^a   Duan, Zhen Wen ^a,b   Guo, Shu Ren ^a,b  

^a PEKING UNIVERSITY   (China)

^b Luye Pharma Group   (China)

Author keywords

Bioactive component; Monascus; Pharmacological effect; Red yeast rice

Indexed keywords

ANKAFLAVIN; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; DIMERUMIC ACID; INDOMETACIN; MEVINOLIN; MONANKARIN A; MONANKARIN B; MONANKARIN C; MONANKARIN D; MONANKARIN E; MONANKARIN F; MONASCIN; MONASCOPYRIDINE C; MONASCOPYRIDINE D; MONASCORBURAMINE; MONASCORBURIN; MONASCUMIC ACID; MONOAMINE OXIDASE INHIBITOR; RUBROPUNCTAMINE; RUBROPUNCTATIN; UNCLASSIFIED DRUG; XANTHOMONASIN A; XANTHOMONASIN B; XUEZHIKANG;

ADIPOCYTE; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; CELL PROLIFERATION; CHOLESTEROL BLOOD LEVEL; DRUG MECHANISM; ENZYME INHIBITION; FERMENTATION; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID PEROXIDATION; MONASCUS; NONHUMAN; OSTEOBLAST; OSTEOPOROSIS; REVIEW; RICE; STREPTOZOCIN DIABETES; TUMOR CELL;

EID: 79956041031     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.3724/SP.J.1009.2011.00161     Document Type: Review

References (30)

1. Lin YL, Wang TH, Lee MH, et al. Biologically active components and nutraceuticals in the Monascus-fermented rice: a review [J]. Appl Microbiol Biotechnol 2008, 77(5):965-973.
2. Ma J, Li Y, Ye Q, et al. Constituents of Red Yeast Rice, a traditional Chinese food and medicine [J]. J Agric Food Chem 2000, 48(11):5220-5225.
3. Herber D, Yip I, Ashley JM, et al. Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement [J]. Am J Clin Nutr 1999, 69(2):231-236.
4. Net resources international Rasilez - Innovative Treatment for Hypertension: [OL]. [2011-2-28] http://www.drugdevelopment-technology.com/projects/rasilez/.
5. Hsieh PS, Tai YH Aqueous extract of Monascus purpureus M9011 prevents and reverses fructose-induced hypertension in rats [J]. J Agric Food Chem 2003, 51(14):3945-3950.
6. Kohama Y, Matsumoto S, Mimura T, et al. Isolation and identification of hypotensive principles in red-mold rice [J]. Chem Pharm Bull 1987, 35(6):2484-2489.
7. Kuba M, Tanaka K, Sesoko M, et al. Angiotensin I-converting enzyme inhibitory peptides in red-mold rice made by Monascus purpureus [J]. Process Biochem 2009, 44(10):1139-1143.
8. Su CF, Liu IM, Cheng JT Improvement of insulin resistance by Hon-Chi in fructose-rich chow-fed rats [J]. Food Chem 2007, 104(1):45-52.
9. Chen CC, Liu IM Release of acetylcholine by Hon-Chi to raise insulin secretion in Wistar rats [J]. Neurosci Lett 2006, 404(1-2):117-121.
10. Jeon T, Hwang SG, Hirai S, et al. Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells [J]. Life Sci 2004, 75(26):3195-3203.
11. Chen WP, Ho BY, Lee CH, et al. Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet [J]. Int J Obesity 2008, 32:1694-1704.
12. Business Standard Cancer to become the leading cause of death worldwide: report [OL]. Press Trust of India/Boston (2010-8-17) [2011-2-27] http://www.business-standard.com/india/news/cancer-to-becomeleading-causedeath-worldwide-report/105458/on.
13. Akihisa T, Tokudab H, Ukiyaa M, et al. Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (Red-Mold Rice) [J]. Chem Biodivers 2005, 2(10):1305-1309.
14. Yasukawa K, Takahashi M, Natori S, et al. Azaphilones inhibit tumor promotion by 12-O-tetra-decanoylphorbol-13-acetate in two-stage carcinogenesis in mice [J]. Oncology 1994, 51:108-112.
15. Yasukawa K, Takahashi M, Yamanouchi S, et al. Inhibitory effect of oral administration of Monascus pigment on tumor promotion in two-stage carcinogenesis in mouse skin [J]. Oncology 1996, 53:247-249.
16. Su NW, Lin YL, Lee MH, et al. Ankaflavin from Monascus-fermented red rice exhibits selective cytotoxic effect and induces cell death on Hep G2 cells [J]. J Agric Food Chem 2005, 53(6):1949-1954.
17. Knecht A, Cramer B, Humpf HU New Monascus metabolites: structure elucidation and toxicological properties studied with immortalized human kidney epithelial cells [J]. Mol Nutr Food 2006, 50(3):314-321.
18. Ho BY, Pan TM The Monascus metabolite monacolin K reduces tumor progression and metastasis of Lewis lung carcinoma cells [J]. J Agric Food Chem 2009, 57(18):8258-8265.
19. Hong MY, Navindra PS, Zhang Y, et al. Anticancer effects of Chinese red yeast versus monacolin K alone on colon cancer cells [J]. J Nutr Biochem 2008, 19(7):448-458.
20. Hong MY, Seeram NP, Zhang Y, et al. Chinese red yeast rice versus lovastatin effects on prostate cancer cells with and without androgen receptor overexpression [J]. J Med Food 2008, 11(4):657-666.
21. Hossain CF, Okuyama E, Yamazaki M A new series of coumarin derivatives having monoamine oxidase inhibitory activity from Monascus anka [J]. Chem Pharm Bull 1996, 44(8):1535-1539.
22. Akihisa T, Tokuda H, Yasukawa K, et al. Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects [J]. J Agric Food Chem 2005, 53(3):562-565.
23. Aniya Y, Ohtani II, Higa T, et al. Dimerumic acid as an antioxidant of the mold, Monascus anka [J]. Free Radic Biol Med 2000, 28(6):999-1004.
24. Taira J, Miyagi C, Aniya Y Dimerumic acid as an antioxidant from the mold, Monascus anka: the inhibition mechanisms against lipid peroxidation and hemeprotein-mediated oxidation [J]. Biochem Pharmacol 2002, 63(5):1019-1026.
25. Cordle A, Landreth G 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate β-amyloid-induced microglial inflammatory responses [J]. J Neurosci 2005, 25(2):299-307.
26. Lee CL, Wang JJ, Pan TM Red mold rice extract represses amyloid beta peptide-induced neurotoxicity via potent synergism of anti-inflammatory and antioxidative effect [J]. Appl Microbiol Biotechnol 2008, 79(5):829-841.
27. Lee CL, Kuo TF, Wu CL, et al. Red mold rice promotes neuroprotective sAPPalpha secretion instead of Alzhermer's risk factors and amyloid beta expression in hyperlipidemic Aβ40-infused rats [J]. J Agric Food Chem 2010, 58(4):2230-2238.
28. Gutierrez GE, Mundy B, Rossini G, et al. Red yeast rice stimulates bone formation in rats [J]. Nutr Res 2006, 26(3):124-129.
29. Wong RWK, Rabie B Chinese red yeast rice (Monascus purpureus-fermented rice) promotes bone formation [J]. Chin Med 2008, 3:4. 10.1186/1749-8546-3-4.
30. Cho YE, Alcantara E, Kumaran S, et al. Red yeast rice stimulates osteoblast proliferation and increases alkaline phosphatase activity in MC3T3-E1 cells [J]. Nutr Res 2010, 30(7):501-510.